Jason M Kinchen

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc A pathway for phagosome maturation during engulfment of apoptotic cells
    Jason M Kinchen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Nat Cell Biol 10:556-66. 2008
  2. ncbi request reprint Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO
    Colin D deBakker
    Department of Microbiology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 14:2208-16. 2004
  3. ncbi request reprint Tales of cannibalism, suicide, and murder: Programmed cell death in C. elegans
    Jason M Kinchen
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11743, USA
    Curr Top Dev Biol 65:1-45. 2005
  4. ncbi request reprint Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
    Jason M Kinchen
    Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11743, USA
    Nature 434:93-9. 2005
  5. ncbi request reprint Journey to the grave: signaling events regulating removal of apoptotic cells
    Jason M Kinchen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Sci 120:2143-9. 2007
  6. pmc Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells
    Jason M Kinchen
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 464:778-82. 2010
  7. doi request reprint A model to die for: signaling to apoptotic cell removal in worm, fly and mouse
    Jason M Kinchen
    Department of Microbiology, Center for Cell Clearance, University of Virginia, Charlottesville, 22908, USA
    Apoptosis 15:998-1006. 2010
  8. pmc Phagosome maturation: going through the acid test
    Jason M Kinchen
    Beirne B Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22902, USA
    Nat Rev Mol Cell Biol 9:781-95. 2008
  9. ncbi request reprint PH domain of ELMO functions in trans to regulate Rac activation via Dock180
    Mingjian Lu
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Struct Mol Biol 11:756-62. 2004
  10. ncbi request reprint A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs
    Mingjian Lu
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908 USA
    Curr Biol 15:371-7. 2005

Collaborators

Detail Information

Publications18

  1. pmc A pathway for phagosome maturation during engulfment of apoptotic cells
    Jason M Kinchen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Nat Cell Biol 10:556-66. 2008
    ..Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5(GDP), thus providing a mechanism for Rab5 recruitment to the nascent phagosome...
  2. ncbi request reprint Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO
    Colin D deBakker
    Department of Microbiology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 14:2208-16. 2004
    ..However, the components upstream of ELMO and Dock180 during engulfment remain elusive...
  3. ncbi request reprint Tales of cannibalism, suicide, and murder: Programmed cell death in C. elegans
    Jason M Kinchen
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11743, USA
    Curr Top Dev Biol 65:1-45. 2005
    ..It is our purpose in this Chapter to familiarize the reader with the topic of programmed cell death in C. elegans and its relevance to current research in the fields of apoptosis and cell corpse clearance...
  4. ncbi request reprint Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
    Jason M Kinchen
    Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11743, USA
    Nature 434:93-9. 2005
    ....
  5. ncbi request reprint Journey to the grave: signaling events regulating removal of apoptotic cells
    Jason M Kinchen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Sci 120:2143-9. 2007
    ..The recent molecular delineation of the phagocytic process and the identification of novel signaling proteins involved in engulfment have provided an exciting new platform for future studies into this biologically important process...
  6. pmc Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells
    Jason M Kinchen
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 464:778-82. 2010
    ..Taken together, these data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses...
  7. doi request reprint A model to die for: signaling to apoptotic cell removal in worm, fly and mouse
    Jason M Kinchen
    Department of Microbiology, Center for Cell Clearance, University of Virginia, Charlottesville, 22908, USA
    Apoptosis 15:998-1006. 2010
    ..In this review, we survey current knowledge of phagocytic pathways derived from studies in the nematode (Caenorhabditis elegans), the fly (Drosophila melanogaster), and mouse (Mus musculus) model systems...
  8. pmc Phagosome maturation: going through the acid test
    Jason M Kinchen
    Beirne B Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22902, USA
    Nat Rev Mol Cell Biol 9:781-95. 2008
    ..This suggests that a machinery that is distinct from receptor-mediated endocytosis is used in phagosome maturation...
  9. ncbi request reprint PH domain of ELMO functions in trans to regulate Rac activation via Dock180
    Mingjian Lu
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Struct Mol Biol 11:756-62. 2004
    ..These data reveal a new mode of action of PH domains and a novel, evolutionarily conserved mechanism by which a bipartite GEF can activate Rac...
  10. ncbi request reprint A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs
    Mingjian Lu
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908 USA
    Curr Biol 15:371-7. 2005
    ..This steric-inhibition model may be a general mechanism for regulating multiple SH3-domain-containing Dock180 family members and may have implications for a variety of biological processes...
  11. ncbi request reprint Characterization of a novel interaction between ELMO1 and ERM proteins
    Cynthia M Grimsley
    Beirne Carter Center for Immunology Research, and Department of Microbiology, University of Virginia, Lane Road, Charlottesville, VA 22903, USA
    J Biol Chem 281:5928-37. 2006
    ..Together these data suggest that ELMO1-mediated cytoskeletal changes may be coordinated with ERM protein crosslinking activity during dynamic cellular functions...
  12. pmc Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein
    Daeho Park
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 477:220-4. 2011
    ..As Ucp2 is linked to metabolic diseases and atherosclerosis, this newly discovered role for Ucp2 in apoptotic cell clearance has implications for the complex aetiology and pathogenesis of these diseases...
  13. pmc Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo
    Michael R Elliott
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 467:333-7. 2010
    ..Collectively, these findings uncover a selective requirement for ELMO1 in Sertoli-cell-mediated removal of apoptotic germ cells and make a compelling case for a relationship between engulfment and tissue homeostasis in vivo...
  14. pmc Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
    Amelia E Hochreiter-Hufford
    Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 497:263-7. 2013
    ....
  15. pmc Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis
    Faraaz B Chekeni
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 467:863-7. 2010
    ..Collectively, these data identify PANX1 as a plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechanism of PANX1 activation by caspases...
  16. pmc Phagocytic signaling: you can touch, but you can't eat
    Jason M Kinchen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 18:R521-4. 2008
    ....
  17. ncbi request reprint Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
    Cynthia M Grimsley
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 279:6087-97. 2004
    ..This finding suggests that Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 rather than generalized Rac activation plays a role in cell migration...
  18. pmc Caenorhabditis is a metazoan host for Legionella
    Ann Karen C Brassinga
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Cell Microbiol 12:343-61. 2010
    ..pneumophila to subvert host cell signalling and evade mammalian immune responses evolved through the natural selection associated with cycling between protozoan and metazoan hosts...