Research Topics
Genomes and Genes | Jason M KinchenSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
A pathway for phagosome maturation during engulfment of apoptotic cellsJason M Kinchen
Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
Nat Cell Biol 10:556-66. 2008..Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5(GDP), thus providing a mechanism for Rab5 recruitment to the nascent phagosome...
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMOColin D deBakker
Department of Microbiology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
Curr Biol 14:2208-16. 2004..However, the components upstream of ELMO and Dock180 during engulfment remain elusive...- Tales of cannibalism, suicide, and murder: Programmed cell death in C. elegansJason M Kinchen
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11743, USA
Curr Top Dev Biol 65:1-45. 2005..It is our purpose in this Chapter to familiarize the reader with the topic of programmed cell death in C. elegans and its relevance to current research in the fields of apoptosis and cell corpse clearance... - Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegansJason M Kinchen
Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11743, USA
Nature 434:93-9. 2005.... - Journey to the grave: signaling events regulating removal of apoptotic cellsJason M Kinchen
Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
J Cell Sci 120:2143-9. 2007..The recent molecular delineation of the phagocytic process and the identification of novel signaling proteins involved in engulfment have provided an exciting new platform for future studies into this biologically important process... - Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cellsJason M Kinchen
Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA
Nature 464:778-82. 2010..Taken together, these data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses... 
A model to die for: signaling to apoptotic cell removal in worm, fly and mouseJason M Kinchen
Department of Microbiology, Center for Cell Clearance, University of Virginia, Charlottesville, 22908, USA
Apoptosis 15:998-1006. 2010..In this review, we survey current knowledge of phagocytic pathways derived from studies in the nematode (Caenorhabditis elegans), the fly (Drosophila melanogaster), and mouse (Mus musculus) model systems...- Phagosome maturation: going through the acid testJason M Kinchen
Beirne B Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22902, USA
Nat Rev Mol Cell Biol 9:781-95. 2008..This suggests that a machinery that is distinct from receptor-mediated endocytosis is used in phagosome maturation... - PH domain of ELMO functions in trans to regulate Rac activation via Dock180Mingjian Lu
Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
Nat Struct Mol Biol 11:756-62. 2004..These data reveal a new mode of action of PH domains and a novel, evolutionarily conserved mechanism by which a bipartite GEF can activate Rac... - A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFsMingjian Lu
Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908 USA
Curr Biol 15:371-7. 2005..This steric-inhibition model may be a general mechanism for regulating multiple SH3-domain-containing Dock180 family members and may have implications for a variety of biological processes... - Characterization of a novel interaction between ELMO1 and ERM proteinsCynthia M Grimsley
Beirne Carter Center for Immunology Research, and Department of Microbiology, University of Virginia, Lane Road, Charlottesville, VA 22903, USA
J Biol Chem 281:5928-37. 2006..Together these data suggest that ELMO1-mediated cytoskeletal changes may be coordinated with ERM protein crosslinking activity during dynamic cellular functions... - Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 proteinDaeho Park
Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA
Nature 477:220-4. 2011..As Ucp2 is linked to metabolic diseases and atherosclerosis, this newly discovered role for Ucp2 in apoptotic cell clearance has implications for the complex aetiology and pathogenesis of these diseases... - Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivoMichael R Elliott
Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
Nature 467:333-7. 2010..Collectively, these findings uncover a selective requirement for ELMO1 in Sertoli-cell-mediated removal of apoptotic germ cells and make a compelling case for a relationship between engulfment and tissue homeostasis in vivo... - Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosisFaraaz B Chekeni
Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
Nature 467:863-7. 2010..Collectively, these data identify PANX1 as a plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechanism of PANX1 activation by caspases... - Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migrationCynthia M Grimsley
Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 279:6087-97. 2004..This finding suggests that Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 rather than generalized Rac activation plays a role in cell migration... - Phagocytic signaling: you can touch, but you can't eatJason M Kinchen
Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
Curr Biol 18:R521-4. 2008.... - Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusionAmelia E Hochreiter-Hufford
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA
Nature 497:263-7. 2013.... - Caenorhabditis is a metazoan host for LegionellaAnn Karen C Brassinga
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Cell Microbiol 12:343-61. 2010..pneumophila to subvert host cell signalling and evade mammalian immune responses evolved through the natural selection associated with cycling between protozoan and metazoan hosts...