Randall J Kimple

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Is radiation dose reduction the right answer for HPV-positive head and neck cancer?
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA Electronic address
    Oral Oncol 50:560-4. 2014
  2. doi request reprint First use of electromagnetic setup and real-time tracking in a pediatric patient with vaginal rhabdomyosarcoma
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Electronic address
    Pract Radiat Oncol 1:47-51. 2011
  3. pmc Enhanced radiation sensitivity in HPV-positive head and neck cancer
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, 3107 WIMR, 1111 Highland Avenue, Madison, WI 53705, USA
    Cancer Res 73:4791-800. 2013
  4. pmc Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin, Madison, WI 53705, USA
    Clin Cancer Res 19:855-64. 2013
  5. doi request reprint A 10-year analysis of American Society For Radiation Oncology Junior Faculty Career Development Awards
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin, Madison, WI 53705, USA
    Int J Radiat Oncol Biol Phys 85:924-8. 2013
  6. pmc Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison 53705, USA
    Oncologist 17:1496-503. 2012
  7. doi request reprint Strategizing the clone wars: pharmacological control of cellular sensitivity to radiation
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin Madison, WI 53792, USA
    Mol Interv 10:341-53. 2010
  8. doi request reprint Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancer
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Ann Surg Oncol 18:939-45. 2011
  9. pmc Lapatinib in combination with radiation diminishes tumor regrowth in HER2+ and basal-like/EGFR+ breast tumor xenografts
    Maria J Sambade
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC 27599 7295, USA
    Int J Radiat Oncol Biol Phys 77:575-81. 2010
  10. pmc Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA
    Clin Cancer Res 16:912-23. 2010

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Is radiation dose reduction the right answer for HPV-positive head and neck cancer?
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA Electronic address
    Oral Oncol 50:560-4. 2014
    ....
  2. doi request reprint First use of electromagnetic setup and real-time tracking in a pediatric patient with vaginal rhabdomyosarcoma
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Electronic address
    Pract Radiat Oncol 1:47-51. 2011
    ..The Calypso system was used to improve patient setup, to limit anesthesia, to provide for real-time tracking of target location, and to minimize the need for daily portal imaging studies and their associated extraneous radiation dose. ..
  3. pmc Enhanced radiation sensitivity in HPV-positive head and neck cancer
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, 3107 WIMR, 1111 Highland Avenue, Madison, WI 53705, USA
    Cancer Res 73:4791-800. 2013
    ..This issue is under active investigation in a series of clinical trials attempting to de-escalate radiation (and chemotherapy) in selected patients with HPV+ HNC in light of their favorable overall survival outcome...
  4. pmc Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin, Madison, WI 53705, USA
    Clin Cancer Res 19:855-64. 2013
    ....
  5. doi request reprint A 10-year analysis of American Society For Radiation Oncology Junior Faculty Career Development Awards
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin, Madison, WI 53705, USA
    Int J Radiat Oncol Biol Phys 85:924-8. 2013
    ..4 million. This study aimed to evaluate the impact of these awards on the grantees' career development, including current position, publications, and subsequent independent grant funding...
  6. pmc Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison 53705, USA
    Oncologist 17:1496-503. 2012
    ..Sequential tumor biopsies were obtained to evaluate changes in biomarkers, such as epidermal growth factor receptor (EGFR) and human EGFR-2 (HER2) signaling pathways...
  7. doi request reprint Strategizing the clone wars: pharmacological control of cellular sensitivity to radiation
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin Madison, WI 53792, USA
    Mol Interv 10:341-53. 2010
    ....
  8. doi request reprint Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancer
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Ann Surg Oncol 18:939-45. 2011
    ..This study details our completed, single-institution trial...
  9. pmc Lapatinib in combination with radiation diminishes tumor regrowth in HER2+ and basal-like/EGFR+ breast tumor xenografts
    Maria J Sambade
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC 27599 7295, USA
    Int J Radiat Oncol Biol Phys 77:575-81. 2010
    ..To determine whether lapatinib, a dual epidermal growth factor receptor (EGFR)/HER2 kinase inhibitor, can radiosensitize EGFR+ or HER2+ breast cancer xenografts...
  10. pmc Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA
    Clin Cancer Res 16:912-23. 2010
    ..We investigated the effects of inhibition of EGFR/HER2 signaling on pancreatic cancer to elucidate the role(s) of EGFR/HER2 in radiosensitization and to provide evidence in support of further clinical investigations...
  11. doi request reprint Association of p16(INK4a) overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue
    Stephen L Harris
    Department of Radiation Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Head Neck 33:1622-7. 2011
    ..The aim of this study was to examine biomolecular profiles in a cohort of young adults with squamous cell cancers (SCCs) of the oral tongue...
  12. ncbi request reprint Applicability of randomized trials in radiation oncology to standard clinical practice
    Smith Apisarnthanarax
    Department of Radiation Oncology, University of Pennsylvania, Abramson Cancer Center, Philadelphia, PA, USA
    Cancer 119:3092-9. 2013
    ..The authors of this report assessed the availability and applicability of randomized evidence guiding medical decisions in a cohort of patients who were evaluated for consideration of definitive management in a radiation oncology clinic...
  13. doi request reprint Phase 2 study of pre-excision single-dose intraoperative radiation therapy for early-stage breast cancers: six-year update with application of the ASTRO accelerated partial breast irradiation consensus statement criteria
    Noam A Vanderwalde
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer 119:1736-43. 2013
    ..Intraoperative radiation therapy (IORT) allows delivery of high-dose radiation at the time of lumpectomy, potentially sparing adjuvant daily radiation. A phase 2 study of pre-excision IORT was performed for early-stage breast cancer...
  14. doi request reprint Review of the clinical and biologic aspects of human papillomavirus-positive squamous cell carcinomas of the head and neck
    Grace C Blitzer
    Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin
    Int J Radiat Oncol Biol Phys 88:761-70. 2014
    ..Until the results of ongoing trials are known, treatment of HPV-positive HNC should not differ in clinical practice from treatment of similar non-HPV related cancers. ..
  15. pmc Cosmetic outcomes for accelerated partial breast irradiation before surgical excision of early-stage breast cancer using single-dose intraoperative radiotherapy
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Radiat Oncol Biol Phys 79:400-7. 2011
    ..Determine cosmetic outcome and toxicity profile of intraoperative radiation delivered before tumor excision for patients with early-stage breast cancer...
  16. pmc HPV-associated head and neck cancer: molecular and nano-scale markers for prognosis and therapeutic stratification
    Adam J Kimple
    School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Sensors (Basel) 12:5159-69. 2012
    ..This review discusses the various biomarkers currently in use for identification of patients with HPV-positive cancers with a focus on the advantages and limitations of molecular and nano-scale markers...
  17. pmc Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK
    Maria J Sambade
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC 27599, USA
    Radiother Oncol 93:639-44. 2009
    ..The purpose of this study was to identify the downstream signaling pathways responsible for lapatinib-mediated radiosensitization in breast cancer...
  18. ncbi request reprint Influence of handling conditions on the establishment and propagation of head and neck cancer patient derived xenografts
    Andrew P Stein
    Department of Human Oncology, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America McArdle Laboratory for Cancer Research and Department of Oncology, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States of America
    PLoS ONE 9:e100995. 2014
    ..We tested the hypothesis that the time from tumor excision to implantation is crucial for PDX passaging and establishment...
  19. pmc The role of chemoradiation for patients with resectable or potentially resectable pancreatic cancer
    Randall J Kimple
    Department of Human Oncology, University of Wisconsin, Madison, WI, USA
    Expert Rev Anticancer Ther 12:469-80. 2012
    ..Our review confirms that despite several randomized clinical trials, the optimal adjuvant treatment approach for these patients remains unclear...
  20. pmc Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032
    Maria J Sambade
    Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Radiother Oncol 98:394-9. 2011
    ..To assess the relative radiosensitivities of a large collection of melanoma cell lines and to determine whether pharmacologic inhibition of mutant B-RAF with PLX-4032 can radiosensitize B-Raf+ melanoma cells...
  21. doi request reprint Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers
    Stephen L Harris
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Head Neck 32:499-503. 2010
    ..Young patients represent an increasing subgroup with head and neck cancer...
  22. ncbi request reprint Concurrent temozolomide and radiation, a reasonable option for elderly patients with glioblastoma multiforme?
    Randall J Kimple
    Departments of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Clin Oncol 33:265-70. 2010
    ..We began this study to describe our results and toxicities in the over 70 population treated with concurrent temozolomide and radiation for GBM, and to describe our outcomes treating elderly patients with GBM regardless of therapy...
  23. ncbi request reprint Prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in the United States across time
    Andrew P Stein
    Departments of Oncology, Human Oncology, and Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, United States
    Chem Res Toxicol 27:462-9. 2014
    ..4% in 1990-1999 and finally to 65.4% for 2000-present. In this manner, our study provides further evidence to support the hypothesis that HPV-associated OPSCCs are driving the increasing incidence of OPSCC over time in the United States...
  24. doi request reprint Normal tissue tolerance for high-grade gliomas: is it an issue?
    David E Morris
    Department of Radiation Oncology, UNC School of Medicine, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
    Semin Radiat Oncol 19:187-92. 2009
    ....