Stephen E Kimmel

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Randomized trial of lottery-based incentives to improve warfarin adherence
    Stephen E Kimmel
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Am Heart J 164:268-74. 2012
  2. ncbi Warfarin therapy: in need of improvement after all these years
    Stephen E Kimmel
    University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Expert Opin Pharmacother 9:677-86. 2008
  3. ncbi Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Alec B Platt
    MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 137:883-9. 2010
  4. ncbi The effect of selective serotonin re-uptake inhibitors on the risk of myocardial infarction in a cohort of patients with depression
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and Cardiovascular Division at the Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Br J Clin Pharmacol 72:514-7. 2011
  5. ncbi Methylphenidate and risk of serious cardiovascular events in adults
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
    Am J Psychiatry 169:178-85. 2012
  6. ncbi Risk factors for nonadherence to warfarin: results from the IN-RANGE study
    Alec B Platt
    Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
    Pharmacoepidemiol Drug Saf 17:853-60. 2008
  7. ncbi Blood urea nitrogen/creatinine ratio identifies a high-risk but potentially reversible form of renal dysfunction in patients with decompensated heart failure
    Meredith A Brisco
    Department of Medicine, Cardiovascular Division, University of Pennsylvania, Philadelphia, PA, USA
    Circ Heart Fail 6:233-9. 2013
  8. ncbi Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
  9. ncbi Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
  10. ncbi Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 19:555-62. 2010

Collaborators

Detail Information

Publications95

  1. ncbi Randomized trial of lottery-based incentives to improve warfarin adherence
    Stephen E Kimmel
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Am Heart J 164:268-74. 2012
    ..Efforts to improve adherence have typically been either ineffective or too complex to implement in clinical practice. Lottery-based incentive interventions could be a scalable approach to improving adherence...
  2. ncbi Warfarin therapy: in need of improvement after all these years
    Stephen E Kimmel
    University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Expert Opin Pharmacother 9:677-86. 2008
    ..As a result, warfarin is a leading cause of serious medication-related adverse events, and its efficacy is also suboptimal...
  3. ncbi Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Alec B Platt
    MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 137:883-9. 2010
    ..Currently, no comprehensive screening tool exists to help providers assess the risk of nonadherence at the time of initiation of warfarin therapy...
  4. ncbi The effect of selective serotonin re-uptake inhibitors on the risk of myocardial infarction in a cohort of patients with depression
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and Cardiovascular Division at the Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Br J Clin Pharmacol 72:514-7. 2011
    ..To evaluate whether selective serotonin re-uptake inhibitor (SSRI) exposure influences the risk of myocardial infarction (MI) in patients with depression...
  5. ncbi Methylphenidate and risk of serious cardiovascular events in adults
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
    Am J Psychiatry 169:178-85. 2012
    ..The authors sought to determine whether use of methylphenidate in adults is associated with elevated rates of serious cardiovascular events compared with rates in nonusers...
  6. ncbi Risk factors for nonadherence to warfarin: results from the IN-RANGE study
    Alec B Platt
    Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
    Pharmacoepidemiol Drug Saf 17:853-60. 2008
    ..Warfarin is widely used to prevent stroke and venous thromboembolism despite its narrow therapeutic window. Warfarin nonadherence is a substantial problem, but risk factors have not been well elucidated...
  7. ncbi Blood urea nitrogen/creatinine ratio identifies a high-risk but potentially reversible form of renal dysfunction in patients with decompensated heart failure
    Meredith A Brisco
    Department of Medicine, Cardiovascular Division, University of Pennsylvania, Philadelphia, PA, USA
    Circ Heart Fail 6:233-9. 2013
    ..The goal of this study was to evaluate whether elevated admission blood urea nitrogen/creatinine ratio (BUN/Cr) could identify decompensated heart failure patients likely to experience improvement in renal function (IRF) with treatment...
  8. ncbi Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
    ..We sought to examine the validity of specific hospital discharge codes in identifying drug toxicity precipitating hospitalization, among elderly users of high-risk medications...
  9. ncbi Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
    ..The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin...
  10. ncbi Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 19:555-62. 2010
    ..This study examined the positive predictive value (PPV) of hospitalization and emergency department encounter diagnoses in identifying SD/VA events originating in the outpatient setting...
  11. ncbi Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Clin Pharmacol 58:81-7. 2004
    ..To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol...
  12. ncbi Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:328-35. 2008
    ..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity...
  13. ncbi Cardiovascular events and death in children exposed and unexposed to ADHD agents
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 6021, USA
    Pediatrics 127:1102-10. 2011
    ..The objective of this study was to compare the rate of severe cardiovascular events and death in children who use attention-deficit/hyperactivity disorder (ADHD) medications versus nonusers...
  14. ncbi Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study
    Catherine S Parker
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Gen Intern Med 22:1254-9. 2007
    ..Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied...
  15. ncbi Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction
    Stephen E Kimmel
    University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
    Ann Intern Med 142:157-64. 2005
    ..Cardiovascular effects among the COX-2 inhibitors seem different, but further studies, preferably randomized trials, are needed to fully understand the spectrum of effects of COX-2 inhibitors and potential differences among them...
  16. ncbi Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research Database
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 17:1131-6. 2008
    ....
  17. ncbi Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding events
    Joshua P Metlay
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Gen Intern Med 23:1589-94. 2008
    ..Adverse drug events are an important cause of preventable hospitalizations...
  18. ncbi Clinical characteristics and outcomes of patients with improvement in renal function during the treatment of decompensated heart failure
    Jeffrey M Testani
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Card Fail 17:993-1000. 2011
    ..Our aim was to further characterize IRF and its associated mortality risk...
  19. ncbi New genetic variant that might improve warfarin dose prediction in African Americans
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Pittsburgh, PA 19104 6021, USA
    Br J Clin Pharmacol 70:393-9. 2010
    ..However, these factors seem to explain less of the dose variability in African Americans who have a lower prevalence of the CYP2C9*2 and *3 and VKORC1 1173T alleles...
  20. ncbi Single procedure efficacy of isolating all versus arrhythmogenic pulmonary veins on long-term control of atrial fibrillation: a prospective randomized study
    Sanjay Dixit
    Cardiovascular Division, Hospital of The University of Pennsylvania and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Heart Rhythm 5:174-81. 2008
    ..Current atrial fibrillation (AF) ablation involves isolation of all pulmonary veins (PVs) with or without additional linear lesions. However, whether such extensive ablation is necessary is unclear...
  21. ncbi Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, and Department of Medicine, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Am J Cardiol 99:951-5. 2007
    ....
  22. ncbi Impact of worsening renal function during the treatment of decompensated heart failure on changes in renal function during subsequent hospitalization
    Jeffrey M Testani
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am Heart J 161:944-9. 2011
    ..We hypothesized that if WRF is significantly influenced by factors intrinsic to the patient, then WRF during an index hospitalization should predict WRF during subsequent hospitalization...
  23. ncbi Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 129:1865-74. 2005
    ..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs...
  24. ncbi The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Stephen E Kimmel
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Intern Med 167:229-35. 2007
    ..Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control...
  25. ncbi A test of financial incentives to improve warfarin adherence
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    BMC Health Serv Res 8:272. 2008
    ..Novel methods are needed to improve adherence for warfarin. We conducted two pilot studies to determine whether a lottery-based daily financial incentive is feasible and improves warfarin adherence and anticoagulation control...
  26. ncbi Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus
    William H Sauer
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Am J Cardiol 97:651-4. 2006
    ....
  27. ncbi Cardiovascular safety of ADHD medications: rationale for and design of an investigator-initiated observational study
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 19:934-41. 2010
    ....
  28. ncbi The effect of primary graft dysfunction on survival after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 719 Blockley Hall, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 171:1312-6. 2005
    ..Primary graft dysfunction is a severe acute lung injury syndrome after lung transplantation. Long-term outcomes of subjects with primary graft dysfunction have not been studied...
  29. ncbi Class effect of angiotensin-converting enzyme inhibitors on prevention of myocardial infarction
    William H Sauer
    Cardiovascular Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
    Am J Cardiol 94:1171-3. 2004
    ..The present study examined this question and found no correlation between tissue ACE affinity and risk of first nonfatal myocardial infarction in patients who have hypertension...
  30. ncbi Genetic warfarin dosing: tables versus algorithms
    Brian S Finkelman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Am Coll Cardiol 57:612-8. 2011
    ..The aim of this study was to compare the accuracy of genetic tables and formal pharmacogenetic algorithms for warfarin dosing...
  31. ncbi Factors associated with the use of corticosteroids in the initial management of idiopathic pulmonary fibrosis
    Jeffrey C Munson
    Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 19:756-62. 2010
    ..The factors that are associated with the decision to prescribe corticosteroids have not been examined...
  32. ncbi Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarction
    William H Sauer
    Cardiovascular Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
    Circulation 108:32-6. 2003
    ..There was no association detected between non-SSRI antidepressant use and MI. CONCLUSIONS: Increasing serotonin transporter affinity correlates with greater MI protection with SSRI but not other antidepressant exposure...
  33. ncbi Amphetamines, atomoxetine and the risk of serious cardiovascular events in adults
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e52991. 2013
    ..To compare the incidence rates of serious cardiovascular events in adult initiators of amphetamines or atomoxetine to rates in non-users...
  34. ncbi Factors associated with the initiation of proton pump inhibitors in corticosteroid users
    Jeffrey C Munson
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 21:366-74. 2012
    ..How physicians select patients for co-therapy may have implications for potential additive or synergistic toxicities...
  35. ncbi Exogenous estrogen does not attenuate the association between rofecoxib and myocardial infarction in perimenopausal women
    Kelly C Wade
    Department of Pediatrics, Children s Hospital of Philadelphia Newborn Care, Pennsylvania Hospital, 800 Spruce St, Philadelphia, PA 19107, USA
    J Cardiovasc Pharmacol 57:194-200. 2011
    ..19; 95% CI, 0.91–1.57). Although estrogen use was associated with a lower risk of MI, it did not seem to attenuate the association between rofecoxib and MI...
  36. ncbi Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposure
    James D Lewis
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 15:39-45. 2006
    ..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse...
  37. ncbi The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirin
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Am Coll Cardiol 43:985-90. 2004
    ....
  38. ncbi Medication safety in older adults: home-based practice patterns
    Joshua P Metlay
    Penn Program for the Reduction in Medication Errors, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 53:976-82. 2005
    ..To identify the current state of medication-taking practices of community-dwelling older adults on high-risk medications...
  39. ncbi Potential limitations of electronic database studies of prescription non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and risk of myocardial infarction (MI)
    Leonard Ilkhanoff
    Department of Medicine, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:513-22. 2005
    ..Further studies-preferably randomized trials-are needed to address the risk-benefit ratio of NANSAID use...
  40. ncbi Safety of saxagliptin: rationale for and design of a series of postmarketing observational studies
    Vincent Lo Re
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 21:1202-15. 2012
    ..To describe the design and rationale of a series of postmarketing studies to examine the safety of saxagliptin, an oral dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus, in real-world settings...
  41. ncbi Bleeding risk of platelet glycoprotein IIb/IIIa receptor antagonists in broad-based practice (results from the Society for Cardiac Angiography and Interventions Registry)
    Phillip A Horwitz
    Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Cardiol 91:803-6. 2003
    ..Assuming these agents are as effective as shown in these trials, the risk-benefit ratio of GP IIb/IIIa inhibitors in broad-based PCI practice should be favorable...
  42. ncbi Antidepressants and the risk of sudden cardiac death and ventricular arrhythmia
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 20:903-13. 2011
    ..To examine the association between exposure to antidepressants and emergency department or inpatient admission for sudden cardiac death and ventricular arrhythmia (SD/VA), and to examine the impact of dose and cytochrome P-450 inhibition...
  43. ncbi Relationship between coronary angioplasty laboratory volume and outcomes after hospital discharge
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Am Heart J 143:833-40. 2002
    ....
  44. ncbi Incidence and prevalence of abnormal liver associated enzymes in patients with atrial fibrillation in a routine clinical care population
    George A Makar
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:43-51. 2008
    ..The aim of this study was to estimate the prevalence and incidence of alanine aminotransferase (ALT) elevations in a cohort with AF...
  45. ncbi Epidemiologic features of the presentation of critical congenital heart disease: implications for screening
    Amy H Schultz
    Department of, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 121:751-7. 2008
    ..These descriptive parameters must be defined to evaluate the impact and feasibility of any proposed screening strategy...
  46. ncbi Adverse events after protamine administration following cardiopulmonary bypass in infants and children
    Harry A Seifert
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Anesth Analg 97:383-9, table of contents. 2003
    ..Female sex, larger protamine dose, and smaller heparin dose were each associated with increased risk. The development of protamine alternatives or prophylactic therapies may be useful for reducing the frequency of these events...
  47. ncbi Impact of changes in blood pressure during the treatment of acute decompensated heart failure on renal and clinical outcomes
    Jeffrey M Testani
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Eur J Heart Fail 13:877-84. 2011
    ..Our secondary aim was to evaluate the prognostic significance of this potentially treatment-induced form of WRF...
  48. ncbi Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity
    Carmel Kealey
    University of Pennsylvania, Department of Pharmacology and Center for Pharmacogenetics, School of Medicine, Philadelphia, PA, USA
    Pharmacogenomics 8:217-25. 2007
    ..0 and 3.0 were genotyped. Warfarin sensitivity stratified by genotype was investigated using univariate and multivariate analyses...
  49. ncbi Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom
    Sinead M Langan
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Invest Dermatol 132:556-62. 2012
    ..These findings suggest that screening for metabolic disease should be considered for psoriasis, especially when it is severe...
  50. ncbi Enhancement of medication recall using medication pictures and lists in telephone interviews
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 12:1-8. 2003
    ..To determine the effect of reading medication lists and providing medication pictures on recall of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) during telephone interviews in a case-control study...
  51. ncbi Influence of renal dysfunction phenotype on mortality in the setting of cardiac dysfunction: analysis of three randomized controlled trials
    Jeffrey M Testani
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Eur J Heart Fail 13:1224-30. 2011
    ..We hypothesized that RI occurring in the presence of renal neurohormonal activation may be prognostically more important than RI in the absence of renal neurohormonal activation...
  52. ncbi Construct validity of the definition of primary graft dysfunction after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 29:1231-9. 2010
    ..This study tested the discriminant validity of International Society for Heart and Lung Transplantation (ISHLT) primary graft dysfunction (PGD) grades with lung injury biomarker profiles and survival...
  53. ncbi Parenteral ketorolac and risk of myocardial infarction
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pharmacoepidemiol Drug Saf 11:113-9. 2002
    ..To examine the effects of ketorolac, a non-aspirin non-steroidal anti-inflammatory drug (NANSAID) with antiplatelet properties, on the risk of in-hospital myocardial infarction (MI)...
  54. ncbi The effect of cardiac troponin testing on clinical care in a veterans population: a randomized controlled trial
    Michael Berkwits
    Philadelphia VA Medical Center and the Division of General Internal Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA
    J Gen Intern Med 20:584-92. 2005
    ..Cardiac troponin is more accurate than creatine kinase (CK) testing for detecting myocardial injury in patients with acute coronary syndromes (ACS), but its effects on clinical care compared with CK testing alone is open to question...
  55. ncbi Usefulness of the TIMI risk score in predicting both short- and long-term outcomes in the Veterans Affairs Non-Q-Wave Myocardial Infarction Strategies In-Hospital (VANQWISH) Trial
    Frederick F Samaha
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Cardiol 90:922-6. 2002
    ..76). No significant difference in outcomes between strategies was detected for a score > or =3. The TIMI risk score provides moderate incremental prognostic information in high-risk patients, during both short- and long-term follow-up...
  56. ncbi Cisapride and ventricular arrhythmia
    Sean Hennessy
    Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Br J Clin Pharmacol 66:375-85. 2008
    ..We aimed to examine the association between cisapride and ventricular arrhythmia, and examine the relationship to dose and CYP3A4 inhibitors...
  57. ncbi Prognostic importance of early worsening renal function after initiation of angiotensin-converting enzyme inhibitor therapy in patients with cardiac dysfunction
    Jeffrey M Testani
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Circ Heart Fail 4:685-91. 2011
    ....
  58. ncbi The role of risk stratification in the decision to provide upstream versus selective glycoprotein IIb/IIIa inhibitors for acute coronary syndromes: a cost-effectiveness analysis
    Ruchira Glaser
    Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 47:529-37. 2006
    ....
  59. ncbi Potential effects of aggressive decongestion during the treatment of decompensated heart failure on renal function and survival
    Jeffrey M Testani
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 122:265-72. 2010
    ..We hypothesized that hemoconcentration would be associated with worsening renal function and possibly would provide insight into the relationship between aggressive decongestion and outcomes...
  60. ncbi Cigarette yield and the risk of myocardial infarction in smokers
    William H Sauer
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Intern Med 162:300-6. 2002
    ..001 for the trend). CONCLUSIONS: Smoking higher-yield cigarettes is associated with an increased risk of MI, and there is a dose-response relationship between total tar consumption per day and MI...
  61. ncbi Characteristics of patients with improvement or worsening in renal function during treatment of acute decompensated heart failure
    Jeffrey M Testani
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Cardiol 106:1763-9. 2010
    ..In conclusion, the changes in renal function, regardless of the direction, likely identify a population with an advanced disease state and a poor prognosis...
  62. ncbi One-year clinical outcomes of protected and unprotected left main coronary artery stenting
    Michael P Kelley
    Hospital of the University of Pennsylvania, University Health System, 9 Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Eur Heart J 24:1554-9. 2003
    ..Stenting for unprotected LMCA disease in a high-risk population should only be considered in the absence of other revascularization options. Further studies are needed to evaluate the role of stenting for unprotected LMCA disease...
  63. ncbi Comparison of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the primary prevention of myocardial infarction in hypertensive patients
    Jefferson T Baer
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Cardiol 94:479-81. 2004
    ..In the present case-control study, we found no difference between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the primary prevention of nonfatal myocardial infarction among patients with hypertension...
  64. ncbi Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trial
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pharmacotherapy 26:1342-7. 2006
    ..To measure the effectiveness of a multifaceted educational intervention to improve ambulatory hypertension control...
  65. ncbi Role of computerized physician order entry systems in facilitating medication errors
    Ross Koppel
    Department of Sociology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 USA
    JAMA 293:1197-203. 2005
    ..Published studies report that CPOE reduces medication errors up to 81%. Few researchers, however, have focused on the existence or types of medication errors facilitated by CPOE...
  66. ncbi Impact of primary graft failure on outcomes following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 127:161-5. 2005
    ..Primary graft failure (PGF) is a severe acute lung injury syndrome that occurs following lung transplantation. We compared the clinical outcomes of patients who developed PGF with those who did not...
  67. ncbi Stress test criteria used in the conservative arm of the FRISC-II trial underdetects surgical coronary artery disease when applied to patients in the VANQWISH trial
    Abhinav Goyal
    University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 39:1601-7. 2002
    ..A lower threshold for catheterization in the FRISC-II conservative patients might have improved their outcomes and therefore diminished the putative benefit of an invasive strategy...
  68. ncbi Effect of treatment guidelines on the initial management of idiopathic pulmonary fibrosis
    Jeffrey C Munson
    Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Br J Clin Pharmacol 70:118-25. 2010
    ..It is not known how the use of corticosteroids and cytotoxic agents in the treatment of IPF has changed over time and whether published guidelines have altered prescribing practices...
  69. ncbi Predictors of complications following sheath removal with percutaneous coronary intervention
    Linda M Sulzbach-Hoke
    Cardiac Intermediate Care Unit, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cardiovasc Nurs 25:E1-8. 2010
    ..The purpose of this study was to examine predictors of vascular complications following sheath removal for percutaneous coronary intervention...
  70. ncbi Gender differences in cardiac remodeling and clinical outcomes in chronic stable angina pectoris (from the ACTION Trial)
    Bonnie Ky
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 105:943-7. 2010
    ..These findings may reflect inherent gender-based differences in ischemic heart disease and cardiac remodeling and might help to identify women at high risk...
  71. ncbi Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 120:310-7. 2009
    ..However, circulating NRG-1 has not been studied in human heart disease. We used a novel immunoassay to test whether circulating NRG-1beta is associated with disease severity and clinical outcomes in chronic heart failure...
  72. ncbi Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure
    Jeffrey M Testani
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 58:375-82. 2011
    ....
  73. ncbi Ethnic differences in warfarin maintenance dose requirement and its relationship with genetics
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 826 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Pharmacogenomics 9:1331-46. 2008
    ....
  74. ncbi Percutaneous closure of patent foramen ovale and atrial septal defect in adults: the impact of clinical variables and hospital procedure volume on in-hospital adverse events
    Alexander R Opotowsky
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am Heart J 157:867-74. 2009
    ..There are no population-based estimates of in-hospital adverse event rates of percutaneous PFO/ASD closure...
  75. ncbi Impact of a prescription copayment increase on lipid-lowering medication adherence in veterans
    Jalpa A Doshi
    Center for Health Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Circulation 119:390-7. 2009
    ..We examined the impact of the copayment increase on lipid-lowering medication adherence...
  76. ncbi Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial
    Scott E Kasner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Stroke 33:130-4. 2002
    ..Elevated core body temperature (CBT), even if mild, may exacerbate neuronal injury and worsen outcome, whereas hypothermia is potentially neuroprotective. The antipyretic effects of acetaminophen were hypothesized to reduce CBT...
  77. ncbi Clinical risk factors for primary graft failure following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelhia, 19104, USA
    Chest 124:1232-41. 2003
    ..s: Primary graft failure (PGF) is a devastating acute lung injury syndrome following lung transplantation. We sought to identify donor, recipient, and operative risk factors for its development...
  78. ncbi Statistical design of personalized medicine interventions: the Clarification of Optimal Anticoagulation through Genetics (COAG) trial
    Benjamin French
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    Trials 11:108. 2010
    ....
  79. ncbi Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis
    Steven M Kawut
    Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, USA
    Chest 123:344-50. 2003
    ..The goal of this study was to determine whether the survival of patients with pulmonary hypertension related to systemic sclerosis (SScPH) was different from that of patients with other forms of pulmonary arterial hypertension...
  80. ncbi Comparison of cool tip versus 8-mm tip catheter in achieving electrical isolation of pulmonary veins for long-term control of atrial fibrillation: a prospective randomized pilot study
    Sanjay Dixit
    Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Cardiovasc Electrophysiol 17:1074-9. 2006
    ..To compare safety and efficacy of 8-mm versus cooled tip catheter in achieving electrical isolation (EI) of pulmonary veins (PV) for long-term control of atrial fibrillation (AF)...
  81. ncbi Can atorvastatin improve the response to sildenafil in men with erectile dysfunction not initially responsive to sildenafil? Hypothesis and pilot trial results
    Howard C Herrmann
    Hospital of the University of Pennsylvania, Philadelphia, 19104, USA
    J Sex Med 3:303-8. 2006
    ..Erectile dysfunction (ED) may be one manifestation of a generalized vascular disorder characterized by endothelial dysfunction. Statin drugs may improve endothelial function, even before altering the lipid profile...
  82. ncbi Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    BMJ 325:1070. 2002
    ..To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls...
  83. ncbi Mortality and adverse events after protamine administration in patients undergoing cardiopulmonary bypass
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Anesth Analg 94:1402-8, table of contents. 2002
    ..IMPLICATIONS: A retrospective cohort study demonstrated an association between adverse events after a protamine administration and increased in-hospital mortality...
  84. ncbi Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    Muredach P Reilly
    Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Endocrinol Metab 89:3872-8. 2004
    ..Whether leptin signaling promotes atherosclerosis directly or represents a therapeutic target for the prevention of atherosclerotic cardiovascular disease remains to be explored...
  85. ncbi Giving aspirin and ibuprofen after myocardial infarction
    Stephen E Kimmel
    BMJ 327:1298-9. 2003
  86. ncbi Association between pulmonary fibrosis and coronary artery disease
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Arch Intern Med 164:551-6. 2004
    ..Further research is necessary to confirm this relationship and to explore the pathologic processes underlying, and potentially linking, these 2 conditions...
  87. ncbi Hemodynamics and survival of patients with portopulmonary hypertension
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Liver Transpl 11:1107-11. 2005
    ..Future studies of the specific mechanisms of and therapy for pulmonary arterial hypertension should focus on the distinctions between the different forms of this disease...
  88. ncbi Comparing the standard rating scale and the magnifier scale for assessing risk perceptions
    Andrea D Gurmankin
    Department of Society, Human Development and Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Med Decis Making 25:560-70. 2005
    ..The authors tested whether the magnifier scale lowers risk perceptions for low-probability (in 0%-1% magnifying glass section of scale) but not high-probability (>1%) events compared to a standard rating scale (SRS)...
  89. ncbi ACCF/AHA/SCAI 2007 update of the Clinical Competence Statement on Cardiac Interventional Procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and
    Spencer B King
    Circulation 116:98-124. 2007
  90. ncbi ACCF/AHA/SCAI 2007 update of the clinical competence statement on cardiac interventional procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and
    Spencer B King
    J Am Coll Cardiol 50:82-108. 2007
  91. ncbi Evaluation of the Society for Coronary Angiography and Interventions' lesion classification system in 14,133 patients with percutaneous coronary interventions in the current stent era
    Ronald J Krone
    Department of Medicine, Washington University, St Louis, Missouri, USA
    Catheter Cardiovasc Interv 55:1-7. 2002
    ..In the current PCI device era, the simpler SCAI classification using 7 variables predicted interventional success and complications as well as or better than the ACC/AHA system requiring 26...
  92. ncbi Is improved survival a class effect of angiotensin-converting enzyme inhibitors?
    Sean Hennessy
    Ann Intern Med 141:157-8. 2004
  93. ncbi Limitations of current risk-adjustment models in the era of coronary stenting
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Medical College, Cornell University, New York, NY, USA
    Am Heart J 145:683-92. 2003
    ..Yet the accuracy of these models in contemporary interventional practice--characterized by the widespread use of stents and novel adjuvant pharmacotherapies--has not been sufficiently studied...
  94. ncbi Trends in the use of percutaneous closure of patent foramen ovale and atrial septal defect in adults, 1998-2004
    Alexander R Opotowsky
    JAMA 299:521-2. 2008
  95. ncbi Racial differences in the prevalence of cardiac sources of embolism in subjects with unexplained stroke or transient ischemic attack evaluated by transesophageal echocardiography
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    Am J Cardiol 90:395-400. 2002
    ....