S E Kimmel

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Trends in the use of percutaneous closure of patent foramen ovale and atrial septal defect in adults, 1998-2004
    Alexander R Opotowsky
    JAMA 299:521-2. 2008
  2. ncbi request reprint The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Stephen E Kimmel
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Intern Med 167:229-35. 2007
  3. ncbi request reprint Mortality and adverse events after protamine administration in patients undergoing cardiopulmonary bypass
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Anesth Analg 94:1402-8, table of contents. 2002
  4. ncbi request reprint Relationship between coronary angioplasty laboratory volume and outcomes after hospital discharge
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Am Heart J 143:833-40. 2002
  5. ncbi request reprint Enhancement of medication recall using medication pictures and lists in telephone interviews
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 12:1-8. 2003
  6. ncbi request reprint Epidemiologic review of the calcium channel blocker drugs. An up-to-date perspective on the proposed hazards
    J R Kizer
    MSc, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 161:1145-58. 2001
  7. ncbi request reprint Apolipoprotein E genotype and warfarin dosing among Caucasians and African Americans
    S E Kimmel
    Department of Medicine, School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Pharmacogenomics J 8:53-60. 2008
  8. ncbi request reprint Risk of acute first myocardial infarction and use of nicotine patches in a general population
    S E Kimmel
    Center for Clinical Epidmiology and Biostatistics and Department of Biostatistics and Epidmiology, University Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    J Am Coll Cardiol 37:1297-302. 2001
  9. ncbi request reprint The effects of contemporary use of coronary stents on in-hospital mortality. Registry Committee of the Society for Cardiac Angiography and Interventions
    S E Kimmel
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    J Am Coll Cardiol 37:499-504. 2001
  10. ncbi request reprint Effects of coronary stents on cardiovascular outcomes in broad-based clinical practice
    S E Kimmel
    University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 717 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 160:2593-9. 2000

Detail Information

Publications97

  1. doi request reprint Trends in the use of percutaneous closure of patent foramen ovale and atrial septal defect in adults, 1998-2004
    Alexander R Opotowsky
    JAMA 299:521-2. 2008
  2. ncbi request reprint The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Stephen E Kimmel
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Intern Med 167:229-35. 2007
    ..Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control...
  3. ncbi request reprint Mortality and adverse events after protamine administration in patients undergoing cardiopulmonary bypass
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Anesth Analg 94:1402-8, table of contents. 2002
    ..Further studies to confirm these findings and development and testing of protamine alternatives or prophylactic therapies are required to determine if mortality can be reduced...
  4. ncbi request reprint Relationship between coronary angioplasty laboratory volume and outcomes after hospital discharge
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Am Heart J 143:833-40. 2002
    ....
  5. ncbi request reprint Enhancement of medication recall using medication pictures and lists in telephone interviews
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 12:1-8. 2003
    ..To determine the effect of reading medication lists and providing medication pictures on recall of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) during telephone interviews in a case-control study...
  6. ncbi request reprint Epidemiologic review of the calcium channel blocker drugs. An up-to-date perspective on the proposed hazards
    J R Kizer
    MSc, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 161:1145-58. 2001
    ..Remaining questions await completion of ongoing trials to better define the indications for these agents...
  7. ncbi request reprint Apolipoprotein E genotype and warfarin dosing among Caucasians and African Americans
    S E Kimmel
    Department of Medicine, School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Pharmacogenomics J 8:53-60. 2008
    ..APOE polymorphisms thus may be important determinants of warfarin maintenance dose and could explain at least some of the observed racial differences in dose requirements...
  8. ncbi request reprint Risk of acute first myocardial infarction and use of nicotine patches in a general population
    S E Kimmel
    Center for Clinical Epidmiology and Biostatistics and Department of Biostatistics and Epidmiology, University Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    J Am Coll Cardiol 37:1297-302. 2001
    ..To determine if nicotine patches, both as prescribed and used over-the-counter, increase the risk of first myocardial infarction (MI)...
  9. ncbi request reprint The effects of contemporary use of coronary stents on in-hospital mortality. Registry Committee of the Society for Cardiac Angiography and Interventions
    S E Kimmel
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    J Am Coll Cardiol 37:499-504. 2001
    ..This study was designed to determine the effect of coronary stents on in-hospital mortality...
  10. ncbi request reprint Effects of coronary stents on cardiovascular outcomes in broad-based clinical practice
    S E Kimmel
    University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 717 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 160:2593-9. 2000
    ....
  11. ncbi request reprint The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirin
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Am Coll Cardiol 43:985-90. 2004
    ....
  12. ncbi request reprint Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota
    S E Kimmel
    Department of Medicine, Hospital of the University of Pennsylvania, and Center for Clinical Epidemiology, and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Cardiol 84:304-8. 1999
    ..Further study is needed to test these hypotheses...
  13. ncbi request reprint Parenteral ketorolac and risk of myocardial infarction
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pharmacoepidemiol Drug Saf 11:113-9. 2002
    ..To examine the effects of ketorolac, a non-aspirin non-steroidal anti-inflammatory drug (NANSAID) with antiplatelet properties, on the risk of in-hospital myocardial infarction (MI)...
  14. ncbi request reprint Warfarin response and vitamin K epoxide reductase complex 1 in African Americans and Caucasians
    H Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, and Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 81:742-7. 2007
    ..However, these polymorphisms may not be as useful in predicting over-anticoagulation among African Americans...
  15. pmc Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans
    H Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 84:332-9. 2008
    ..The dosing algorithms explained <45% of the observed variability in Caucasians, and the algorithms performed only marginally better for African Americans when compared with giving 5 mg empirically...
  16. pmc Warfarin with fluoroquinolones, sulfonamides, or azole antifungals: interactions and the risk of hospitalization for gastrointestinal bleeding
    H Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 84:581-8. 2008
    ..Warfarin users who had received an anti-infective agent showed a substantially increased risk of GI bleeding. However, a drug-drug interaction with warfarin was evident only for co-trimoxazole and fluconazole...
  17. ncbi request reprint Risk factors for clinically important adverse events after protamine administration following cardiopulmonary bypass
    S E Kimmel
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    J Am Coll Cardiol 32:1916-22. 1998
    ..The purpose of this study was to determine risk factors for adverse events following protamine administration after cardiopulmonary bypass...
  18. ncbi request reprint A simplified lesion classification for predicting success and complications of coronary angioplasty. Registry Committee of the Society for Cardiac Angiography and Intervention
    R J Krone
    Department of Medicine, Washington University, St Louis, Missouri 63110 1093, USA
    Am J Cardiol 85:1179-84. 2000
    ..659, 0.693, respectively). The SCAI classification was preferred for predicting major complications and in-hospital death and was similar to the ACC/AHA classification for predicting emergency bypass surgery...
  19. ncbi request reprint Selective serotonin reuptake inhibitors and myocardial infarction
    W H Sauer
    Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Circulation 104:1894-8. 2001
    ..This could be attributable to the inhibitory effect SSRIs have on serotonin-mediated platelet activation or possibly amelioration of other factors associated with increased risk for MI in depression...
  20. ncbi request reprint Paying people to lose weight and stop smoking
    Kevin G Volpp
    LDI Center for Health Incentives University of Pennsylvania School of Medicine the Wharton School and Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA
    LDI Issue Brief 14:1-4. 2009
    ..This Issue Brief explores the use of financial incentives to motivate and sustain smoking cessation and weight loss...
  21. pmc Is thirty-day hospital mortality really lower for black veterans compared with white veterans?
    Kevin G Volpp
    Philadelphia Veterans Affairs Medical Center, University and Woodland Avenue, Philadelphia, PA 19104, USA
    Health Serv Res 42:1613-31. 2007
    ....
  22. pmc Risk of myocardial infarction associated with chronic hepatitis C virus infection: a population-based cohort study
    K A Forde
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Viral Hepat 19:271-7. 2012
    ..16; 95% CI, 0.77-1.74). In conclusion, HCV infection was not associated with an increased risk of incident MI...
  23. doi request reprint Building physician work hour regulations from first principles and best evidence
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Veterans Administration Hospital, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    JAMA 300:1197-9. 2008
  24. ncbi request reprint Internal medicine and general surgery residents' attitudes about the ACGME duty hours regulations: a multicenter study
    Jennifer S Myers
    Division of General Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Acad Med 81:1052-8. 2006
    ..To assess internal medicine and general surgery residents' attitudes about the effects of the Accreditation Council for Graduate Medical Education duty hours regulations on medical errors, quality of patient care, and residency experiences...
  25. pmc Patient opinions regarding 'pay for performance for patients'
    Judith A Long
    Philadelphia VA Center for Health Equity Research and Promotion, Philadelphia, PA, USA
    J Gen Intern Med 23:1647-52. 2008
    ..Many large employers and payers are turning to pay for performance for patients (P4P4P) to reduce health costs and improve the health of their covered populations. How these programs may be perceived by patients is unknown...
  26. ncbi request reprint A randomized controlled trial of financial incentives for smoking cessation
    Kevin G Volpp
    CHERP, Philadelphia Veterans Affairs Medical Center, University and Woodland Ave, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 15:12-8. 2006
    ..The objective of this study was to determine whether modest financial incentives increase the rate of smoking cessation program enrollment, completion, and quit rates in a outpatient clinical setting...
  27. ncbi request reprint Effect of cuts in Medicare reimbursement on process and outcome of care for acute myocardial infarction patients
    Kevin G Volpp
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, PA, USA
    Circulation 112:2268-75. 2005
    ....
  28. pmc Short- and long-term mortality after an acute illness for elderly whites and blacks
    Daniel Polsky
    VA Center for Health Equity Research and Promotion, Department of General Internal Medicine, University of Pennsylvania School of Medicine, Wharton School, University of Pennsylvania, Philadelphia, PA 19104, USA
    Health Serv Res 43:1388-402. 2008
    ..To estimate racial differences in mortality at 30 days and up to 2 years following a hospital admission for the elderly with common medical conditions...
  29. ncbi request reprint Mortality among hospitalized Medicare beneficiaries in the first 2 years following ACGME resident duty hour reform
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Veterans Administration Hospital, Philadelphia, Pennsylvania 19104 6021, USA
    JAMA 298:975-83. 2007
    ..The association of duty hour reform with mortality among patients in teaching hospitals nationally has not been well established...
  30. pmc Financial incentive-based approaches for weight loss: a randomized trial
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    JAMA 300:2631-7. 2008
    ..Identifying effective obesity treatment is both a clinical challenge and a public health priority due to the health consequences of obesity...
  31. pmc The Hospital Compare mortality model and the volume-outcome relationship
    Jeffrey H Silber
    Center for Outcomes Research, 3535 Market Street, Suite 1029, Philadelphia, PA 19104, USA
    Health Serv Res 45:1148-67. 2010
    ..We ask whether Medicare's Hospital Compare random effects model correctly assesses acute myocardial infarction (AMI) hospital mortality rates when there is a volume-outcome relationship...
  32. ncbi request reprint Mortality among patients in VA hospitals in the first 2 years following ACGME resident duty hour reform
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Veterans Administration Hospital, Philadelphia, Pennsylvania 19104 6021, USA
    JAMA 298:984-92. 2007
    ..The association of these changes with mortality among hospitalized patients has not been well established...
  33. pmc A test of financial incentives to improve warfarin adherence
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    BMC Health Serv Res 8:272. 2008
    ..Novel methods are needed to improve adherence for warfarin. We conducted two pilot studies to determine whether a lottery-based daily financial incentive is feasible and improves warfarin adherence and anticoagulation control...
  34. pmc Prolonged hospital stay and the resident duty hour rules of 2003
    Jeffrey H Silber
    Center for Outcomes Research, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Med Care 47:1191-200. 2009
    ..Resident duty hour reforms of 2003 had the potential to create a major impact on the delivery of inpatient care...
  35. pmc Effect of work-hours regulations on intensive care unit mortality in United States teaching hospitals
    Meeta Prasad
    Division of Pulmonary, Allergy, and Critical Care Medicine MP, JDC, JMK, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:2564-9. 2009
    ..The United States instituted restrictions on resident work-hours in July 2003. The clinical impact of this reform on critically ill patients is unknown...
  36. pmc Did duty hour reform lead to better outcomes among the highest risk patients?
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Veterans Administration Hospital, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Gen Intern Med 24:1149-55. 2009
    ..Earlier work demonstrated that ACGME duty hour reform did not adversely affect mortality, with slight improvement noted among specific subgroups...
  37. pmc Hospital teaching intensity, patient race, and surgical outcomes
    Jeffrey H Silber
    Center for Outcomes Research, The Children s Hospital of Philadelphia, 3535 Market St, Ste 1029, Philadelphia, PA 19104, USA
    Arch Surg 144:113-20; discussion 121. 2009
    ....
  38. doi request reprint A randomized, controlled trial of financial incentives for smoking cessation
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, USA
    N Engl J Med 360:699-709. 2009
    ....
  39. pmc Impact of a prescription copayment increase on lipid-lowering medication adherence in veterans
    Jalpa A Doshi
    Center for Health Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Circulation 119:390-7. 2009
    ..We examined the impact of the copayment increase on lipid-lowering medication adherence...
  40. pmc P4P4P: an agenda for research on pay-for-performance for patients
    Kevin G Volpp
    Center for Health Incentives, Leonard Davis Institute of Health Economics, Wharton School, University of Pennsylvania, USA
    Health Aff (Millwood) 28:206-14. 2009
    ..Patient-targeted incentives have great potential, and systematic testing will help determine how they can best be used to improve population health...
  41. ncbi request reprint An empirical comparison of several clustered data approaches under confounding due to cluster effects in the analysis of complications of coronary angioplasty
    J A Berlin
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Biometrics 55:470-6. 1999
    ..While conditional approaches provide estimates of the within-cluster effect, they do not provide information about among-center effects. We recommend using the decomposition approach, as it provides both types of estimates...
  42. ncbi request reprint Adjustments for center in multicenter studies: an overview
    A R Localio
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 606 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Ann Intern Med 135:112-23. 2001
    ..This paper uses examples from the recent biomedical literature to highlight the issues and analytic options...
  43. ncbi request reprint Did postoperative mortality increase after the implementation of the Medicare Balanced Budget Act?
    Meena Seshamani
    Philadelphia Veterans Affairs Medical Center, and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Med Care 44:527-33. 2006
    ..The Balanced Budget Act (BBA) of 1997 was a cost-saving measure designed to reduce Medicare reimbursements by $116.4 billion from 1998 to 2002. Resulting financial strain could adversely affect the quality of patient care in hospitals...
  44. ncbi request reprint Incidence and prognostic value of low plasma ionized calcium concentration in cats with acute pancreatitis: 46 cases (1996-1998)
    S E Kimmel
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA
    J Am Vet Med Assoc 219:1105-9. 2001
    ..A grave prognosis and aggressive medical treatment are warranted for cats with AP that have a plasma ionized calcium concentration < or = 1.00 mmol/L...
  45. pmc To leave or to lie? Are concerns about a shift-work mentality and eroding professionalism as a result of duty-hour rules justified?
    Julia E Szymczak
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Milbank Q 88:350-81. 2010
    ..In this qualitative study, we explore how medical and surgical residents perceive and respond to DHR by examining the "local" organizational culture in which their work is embedded...
  46. ncbi request reprint A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension
    I M Robbins
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, and Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Eur Respir J 27:578-84. 2006
    ..Further clinical trials of aspirin in patients with idiopathic pulmonary arterial hypertension should be performed...
  47. pmc Validity of The Health Improvement Network (THIN) for the study of psoriasis
    N M Seminara
    Department of Dermatology, University of Pennsylvania, Philadelphia, 19104, USA
    Br J Dermatol 164:602-9. 2011
    ..Psoriasis is a common disease frequently studied in large databases. To date the validity of psoriasis information has not been established in The Health Improvement Network (THIN)...
  48. ncbi request reprint Accuracy of initial stroke subtype diagnosis. a decision analysis
    S E Kasner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cerebrovasc Dis 10:18-24. 2000
    ..Several candidate diagnostic tests might be useful for early determination of subtype, but there is no consensus on what level of accuracy is required to be useful in the selection of patients for subtype-specific studies or therapies...
  49. ncbi request reprint Failure-to-rescue: comparing definitions to measure quality of care
    Jeffrey H Silber
    Center for Outcomes Research, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Med Care 45:918-25. 2007
    ..This study examines the reliability and validity of different FTR measures currently in use...
  50. ncbi request reprint Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity
    Carmel Kealey
    University of Pennsylvania, Department of Pharmacology and Center for Pharmacogenetics, School of Medicine, Philadelphia, PA, USA
    Pharmacogenomics 8:217-25. 2007
    ..0 and 3.0 were genotyped. Warfarin sensitivity stratified by genotype was investigated using univariate and multivariate analyses...
  51. pmc Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study
    Catherine S Parker
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Gen Intern Med 22:1254-9. 2007
    ..Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied...
  52. ncbi request reprint ACCF/AHA/SCAI 2007 update of the Clinical Competence Statement on Cardiac Interventional Procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and
    Spencer B King
    Circulation 116:98-124. 2007
  53. doi request reprint Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
    ..We sought to examine the validity of specific hospital discharge codes in identifying drug toxicity precipitating hospitalization, among elderly users of high-risk medications...
  54. doi request reprint Epidemiologic features of the presentation of critical congenital heart disease: implications for screening
    Amy H Schultz
    Department of, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 121:751-7. 2008
    ..These descriptive parameters must be defined to evaluate the impact and feasibility of any proposed screening strategy...
  55. pmc Warfarin therapy: in need of improvement after all these years
    Stephen E Kimmel
    University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Expert Opin Pharmacother 9:677-86. 2008
    ..As a result, warfarin is a leading cause of serious medication-related adverse events, and its efficacy is also suboptimal...
  56. doi request reprint Single procedure efficacy of isolating all versus arrhythmogenic pulmonary veins on long-term control of atrial fibrillation: a prospective randomized study
    Sanjay Dixit
    Cardiovascular Division, Hospital of The University of Pennsylvania and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Heart Rhythm 5:174-81. 2008
    ..Current atrial fibrillation (AF) ablation involves isolation of all pulmonary veins (PVs) with or without additional linear lesions. However, whether such extensive ablation is necessary is unclear...
  57. ncbi request reprint Incidence and prevalence of abnormal liver associated enzymes in patients with atrial fibrillation in a routine clinical care population
    George A Makar
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:43-51. 2008
    ..The aim of this study was to estimate the prevalence and incidence of alanine aminotransferase (ALT) elevations in a cohort with AF...
  58. ncbi request reprint Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial
    Scott E Kasner
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Stroke 33:130-4. 2002
    ..Elevated core body temperature (CBT), even if mild, may exacerbate neuronal injury and worsen outcome, whereas hypothermia is potentially neuroprotective. The antipyretic effects of acetaminophen were hypothesized to reduce CBT...
  59. doi request reprint Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:328-35. 2008
    ..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity...
  60. ncbi request reprint ACCF/AHA/SCAI 2007 update of the clinical competence statement on cardiac interventional procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and
    Spencer B King
    J Am Coll Cardiol 50:82-108. 2007
  61. ncbi request reprint Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, and Department of Medicine, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Am J Cardiol 99:951-5. 2007
    ....
  62. ncbi request reprint Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trial
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pharmacotherapy 26:1342-7. 2006
    ..To measure the effectiveness of a multifaceted educational intervention to improve ambulatory hypertension control...
  63. ncbi request reprint Class effect of angiotensin-converting enzyme inhibitors on prevention of myocardial infarction
    William H Sauer
    Cardiovascular Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Am J Cardiol 94:1171-3. 2004
    ..The present study examined this question and found no correlation between tissue ACE affinity and risk of first nonfatal myocardial infarction in patients who have hypertension...
  64. ncbi request reprint Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    Muredach P Reilly
    Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Endocrinol Metab 89:3872-8. 2004
    ..Whether leptin signaling promotes atherosclerosis directly or represents a therapeutic target for the prevention of atherosclerotic cardiovascular disease remains to be explored...
  65. pmc Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Clin Pharmacol 58:81-7. 2004
    ..To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol...
  66. ncbi request reprint Association between pulmonary fibrosis and coronary artery disease
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Arch Intern Med 164:551-6. 2004
    ..Moreover, fibrotic lung diseases exhibit systemic effects and have the potential to affect the vasculature beyond the lung. The existence of a relationship between the two, however, has not been studied...
  67. pmc Giving aspirin and ibuprofen after myocardial infarction
    Stephen E Kimmel
    BMJ 327:1298-9. 2003
  68. ncbi request reprint Clinical risk factors for primary graft failure following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelhia, 19104, USA
    Chest 124:1232-41. 2003
    ..s: Primary graft failure (PGF) is a devastating acute lung injury syndrome following lung transplantation. We sought to identify donor, recipient, and operative risk factors for its development...
  69. ncbi request reprint One-year clinical outcomes of protected and unprotected left main coronary artery stenting
    Michael P Kelley
    Hospital of the University of Pennsylvania, University Health System, 9 Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Eur Heart J 24:1554-9. 2003
    ..To evaluate outcomes for left main coronary artery (LMCA) stenting and compare results between protected (left coronary grafted) and unprotected LMCA stenting in the current bare-metal stent era...
  70. ncbi request reprint Adverse events after protamine administration following cardiopulmonary bypass in infants and children
    Harry A Seifert
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Anesth Analg 97:383-9, table of contents. 2003
    ..47; 95% CI, 1.66-32.8), after larger doses of protamine (OR, 1.88; 95% CI, 1.03-3.63), or after smaller doses of heparin (OR, 0.49; 95% CI, 0.17-0.67)...
  71. ncbi request reprint Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarction
    William H Sauer
    Cardiovascular Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Circulation 108:32-6. 2003
    ..These drugs differ in their affinity for the platelet serotonin transporter and therefore may vary in their effects on MI protection...
  72. ncbi request reprint Bleeding risk of platelet glycoprotein IIb/IIIa receptor antagonists in broad-based practice (results from the Society for Cardiac Angiography and Interventions Registry)
    Phillip A Horwitz
    Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Cardiol 91:803-6. 2003
    ..Assuming these agents are as effective as shown in these trials, the risk-benefit ratio of GP IIb/IIIa inhibitors in broad-based PCI practice should be favorable...
  73. pmc Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    BMJ 325:1070. 2002
    ..To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls...
  74. ncbi request reprint Usefulness of the TIMI risk score in predicting both short- and long-term outcomes in the Veterans Affairs Non-Q-Wave Myocardial Infarction Strategies In-Hospital (VANQWISH) Trial
    Frederick F Samaha
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Cardiol 90:922-6. 2002
    ..76). No significant difference in outcomes between strategies was detected for a score > or =3. The TIMI risk score provides moderate incremental prognostic information in high-risk patients, during both short- and long-term follow-up...
  75. ncbi request reprint Racial differences in the prevalence of cardiac sources of embolism in subjects with unexplained stroke or transient ischemic attack evaluated by transesophageal echocardiography
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    Am J Cardiol 90:395-400. 2002
    ....
  76. ncbi request reprint Stress test criteria used in the conservative arm of the FRISC-II trial underdetects surgical coronary artery disease when applied to patients in the VANQWISH trial
    Abhinav Goyal
    University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 39:1601-7. 2002
    ....
  77. ncbi request reprint Cigarette yield and the risk of myocardial infarction in smokers
    William H Sauer
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Intern Med 162:300-6. 2002
    ..Although cigarette smoking is a major risk factor for acute myocardial infarction (MI), cigarette tar yield has not been clearly demonstrated to affect MI risk...
  78. ncbi request reprint Impact of primary graft failure on outcomes following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 127:161-5. 2005
    ..Primary graft failure (PGF) is a severe acute lung injury syndrome that occurs following lung transplantation. We compared the clinical outcomes of patients who developed PGF with those who did not...
  79. ncbi request reprint Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction
    Stephen E Kimmel
    University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Ann Intern Med 142:157-64. 2005
    ..Some of these mechanisms could increase risk (for example, inhibition of prostacyclin production), and some could decrease risk (for example, inhibition of inflammation)...
  80. ncbi request reprint Comparison of cool tip versus 8-mm tip catheter in achieving electrical isolation of pulmonary veins for long-term control of atrial fibrillation: a prospective randomized pilot study
    Sanjay Dixit
    Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Cardiovasc Electrophysiol 17:1074-9. 2006
    ..To compare safety and efficacy of 8-mm versus cooled tip catheter in achieving electrical isolation (EI) of pulmonary veins (PV) for long-term control of atrial fibrillation (AF)...
  81. ncbi request reprint Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus
    William H Sauer
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Am J Cardiol 97:651-4. 2006
    ....
  82. ncbi request reprint Can atorvastatin improve the response to sildenafil in men with erectile dysfunction not initially responsive to sildenafil? Hypothesis and pilot trial results
    Howard C Herrmann
    Hospital of the University of Pennsylvania, Philadelphia, 19104, USA
    J Sex Med 3:303-8. 2006
    ..Erectile dysfunction (ED) may be one manifestation of a generalized vascular disorder characterized by endothelial dysfunction. Statin drugs may improve endothelial function, even before altering the lipid profile...
  83. ncbi request reprint The role of risk stratification in the decision to provide upstream versus selective glycoprotein IIb/IIIa inhibitors for acute coronary syndromes: a cost-effectiveness analysis
    Ruchira Glaser
    Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 47:529-37. 2006
    ....
  84. ncbi request reprint Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 129:1865-74. 2005
    ..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs...
  85. ncbi request reprint Comparison of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the primary prevention of myocardial infarction in hypertensive patients
    Jefferson T Baer
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Cardiol 94:479-81. 2004
    ..In the present case-control study, we found no difference between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the primary prevention of nonfatal myocardial infarction among patients with hypertension...
  86. ncbi request reprint Comparing the standard rating scale and the magnifier scale for assessing risk perceptions
    Andrea D Gurmankin
    Department of Society, Human Development and Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Med Decis Making 25:560-70. 2005
    ..The authors tested whether the magnifier scale lowers risk perceptions for low-probability (in 0%-1% magnifying glass section of scale) but not high-probability (>1%) events compared to a standard rating scale (SRS)...
  87. ncbi request reprint Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposure
    James D Lewis
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 15:39-45. 2006
    ..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse...
  88. ncbi request reprint Hemodynamics and survival of patients with portopulmonary hypertension
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Liver Transpl 11:1107-11. 2005
    ..Future studies of the specific mechanisms of and therapy for pulmonary arterial hypertension should focus on the distinctions between the different forms of this disease...
  89. ncbi request reprint Role of computerized physician order entry systems in facilitating medication errors
    Ross Koppel
    Department of Sociology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 USA
    JAMA 293:1197-203. 2005
    ..Published studies report that CPOE reduces medication errors up to 81%. Few researchers, however, have focused on the existence or types of medication errors facilitated by CPOE...
  90. pmc The effect of primary graft dysfunction on survival after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 719 Blockley Hall, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 171:1312-6. 2005
    ..Primary graft dysfunction is a severe acute lung injury syndrome after lung transplantation. Long-term outcomes of subjects with primary graft dysfunction have not been studied...
  91. ncbi request reprint Medication safety in older adults: home-based practice patterns
    Joshua P Metlay
    Penn Program for the Reduction in Medication Errors, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 53:976-82. 2005
    ..To identify the current state of medication-taking practices of community-dwelling older adults on high-risk medications...
  92. ncbi request reprint Potential limitations of electronic database studies of prescription non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and risk of myocardial infarction (MI)
    Leonard Ilkhanoff
    Department of Medicine, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:513-22. 2005
    ..In the 'Confounding Assessment Analysis #2,' we also adjusted for body mass index (BMI) and physical activity. In the 'Interaction Assessment Analysis,' we stratified on aspirin use and repeated the latter analysis...
  93. pmc The effect of cardiac troponin testing on clinical care in a veterans population: a randomized controlled trial
    Michael Berkwits
    Philadelphia VA Medical Center and the Division of General Internal Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA
    J Gen Intern Med 20:584-92. 2005
    ..Cardiac troponin is more accurate than creatine kinase (CK) testing for detecting myocardial injury in patients with acute coronary syndromes (ACS), but its effects on clinical care compared with CK testing alone is open to question...
  94. ncbi request reprint Evaluation of the Society for Coronary Angiography and Interventions' lesion classification system in 14,133 patients with percutaneous coronary interventions in the current stent era
    Ronald J Krone
    Department of Medicine, Washington University, St Louis, Missouri, USA
    Catheter Cardiovasc Interv 55:1-7. 2002
    ..In the current PCI device era, the simpler SCAI classification using 7 variables predicted interventional success and complications as well as or better than the ACC/AHA system requiring 26...
  95. ncbi request reprint Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis
    Steven M Kawut
    Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, USA
    Chest 123:344-50. 2003
    ..The goal of this study was to determine whether the survival of patients with pulmonary hypertension related to systemic sclerosis (SScPH) was different from that of patients with other forms of pulmonary arterial hypertension...
  96. ncbi request reprint Limitations of current risk-adjustment models in the era of coronary stenting
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Medical College, Cornell University, New York, NY, USA
    Am Heart J 145:683-92. 2003
    ..Yet the accuracy of these models in contemporary interventional practice--characterized by the widespread use of stents and novel adjuvant pharmacotherapies--has not been sufficiently studied...
  97. ncbi request reprint Is improved survival a class effect of angiotensin-converting enzyme inhibitors?
    Sean Hennessy
    Ann Intern Med 141:157-8. 2004

Research Grants13

  1. A randomized trial of interventions to improve warfarin adherence
    Kevin G Volpp; Fiscal Year: 2010
    ....
  2. A randomized trial of interventions to improve warfarin adherence
    Stephen Kimmel; Fiscal Year: 2009
    ....
  3. Patient Oriented Research in Anticoagulation
    Stephen Kimmel; Fiscal Year: 2006
    ..The ultimate goal is to improve the use of a highly efficacious, but underused, drug, and reduce morbidity and mortality in the large proportion of the population at risk for TE. ..
  4. Research:Genetics of complex traits(RMI)
    Stephen Kimmel; Fiscal Year: 2006
    ....
  5. PREDICTORS OF ANTICOAGULATION CONTROL ON WARFARIN
    Stephen Kimmel; Fiscal Year: 2005
    ..The ultimate goal is to improve the use of a highly efficacious, but underused, drug and reduce morbidity and mortality in the large proportion of the population at risk for TE. ..
  6. Prediction of warfarin dosing using clinical and genetic factors
    Stephen E Kimmel; Fiscal Year: 2010
    ....