Research Topics
Species | S E KimmelSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Trends in the use of percutaneous closure of patent foramen ovale and atrial septal defect in adults, 1998-2004Alexander R Opotowsky
JAMA 299:521-2. 2008- The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) StudyStephen E Kimmel
Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
Arch Intern Med 167:229-35. 2007..Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control... - Mortality and adverse events after protamine administration in patients undergoing cardiopulmonary bypassStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Anesth Analg 94:1402-8, table of contents. 2002..IMPLICATIONS: A retrospective cohort study demonstrated an association between adverse events after a protamine administration and increased in-hospital mortality... - Relationship between coronary angioplasty laboratory volume and outcomes after hospital dischargeStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
Am Heart J 143:833-40. 2002.... - Enhancement of medication recall using medication pictures and lists in telephone interviewsStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 12:1-8. 2003..To determine the effect of reading medication lists and providing medication pictures on recall of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) during telephone interviews in a case-control study... - Epidemiologic review of the calcium channel blocker drugs. An up-to-date perspective on the proposed hazardsJ R Kizer
MSc, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
Arch Intern Med 161:1145-58. 2001..Remaining questions await completion of ongoing trials to better define the indications for these agents... - Apolipoprotein E genotype and warfarin dosing among Caucasians and African AmericansS E Kimmel
Department of Medicine, School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
Pharmacogenomics J 8:53-60. 2008..APOE polymorphisms thus may be important determinants of warfarin maintenance dose and could explain at least some of the observed racial differences in dose requirements... - Risk of acute first myocardial infarction and use of nicotine patches in a general populationS E Kimmel
Center for Clinical Epidmiology and Biostatistics and Department of Biostatistics and Epidmiology, University Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
J Am Coll Cardiol 37:1297-302. 2001..To determine if nicotine patches, both as prescribed and used over-the-counter, increase the risk of first myocardial infarction (MI)... - The effects of contemporary use of coronary stents on in-hospital mortality. Registry Committee of the Society for Cardiac Angiography and InterventionsS E Kimmel
Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
J Am Coll Cardiol 37:499-504. 2001..This study was designed to determine the effect of coronary stents on in-hospital mortality... - Effects of coronary stents on cardiovascular outcomes in broad-based clinical practiceS E Kimmel
University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 717 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
Arch Intern Med 160:2593-9. 2000.... - The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirinStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
J Am Coll Cardiol 43:985-90. 2004.... - Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North DakotaS E Kimmel
Department of Medicine, Hospital of the University of Pennsylvania, and Center for Clinical Epidemiology, and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Am J Cardiol 84:304-8. 1999..Further study is needed to test these hypotheses... - Parenteral ketorolac and risk of myocardial infarctionStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Pharmacoepidemiol Drug Saf 11:113-9. 2002..To examine the effects of ketorolac, a non-aspirin non-steroidal anti-inflammatory drug (NANSAID) with antiplatelet properties, on the risk of in-hospital myocardial infarction (MI)... - Warfarin response and vitamin K epoxide reductase complex 1 in African Americans and CaucasiansH Schelleman
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, and Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
Clin Pharmacol Ther 81:742-7. 2007..However, these polymorphisms may not be as useful in predicting over-anticoagulation among African Americans... 
Dosing algorithms to predict warfarin maintenance dose in Caucasians and African AmericansH Schelleman
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Clin Pharmacol Ther 84:332-9. 2008..The dosing algorithms explained <45% of the observed variability in Caucasians, and the algorithms performed only marginally better for African Americans when compared with giving 5 mg empirically...- Warfarin with fluoroquinolones, sulfonamides, or azole antifungals: interactions and the risk of hospitalization for gastrointestinal bleedingH Schelleman
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Clin Pharmacol Ther 84:581-8. 2008..Warfarin users who had received an anti-infective agent showed a substantially increased risk of GI bleeding. However, a drug-drug interaction with warfarin was evident only for co-trimoxazole and fluconazole... - Risk factors for clinically important adverse events after protamine administration following cardiopulmonary bypassS E Kimmel
Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
J Am Coll Cardiol 32:1916-22. 1998..The purpose of this study was to determine risk factors for adverse events following protamine administration after cardiopulmonary bypass... - A simplified lesion classification for predicting success and complications of coronary angioplasty. Registry Committee of the Society for Cardiac Angiography and InterventionR J Krone
Department of Medicine, Washington University, St Louis, Missouri 63110 1093, USA
Am J Cardiol 85:1179-84. 2000..659, 0.693, respectively). The SCAI classification was preferred for predicting major complications and in-hospital death and was similar to the ACC/AHA classification for predicting emergency bypass surgery... - Selective serotonin reuptake inhibitors and myocardial infarctionW H Sauer
Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Circulation 104:1894-8. 2001..This could be attributable to the inhibitory effect SSRIs have on serotonin-mediated platelet activation or possibly amelioration of other factors associated with increased risk for MI in depression... - Paying people to lose weight and stop smokingKevin G Volpp
LDI Center for Health Incentives University of Pennsylvania School of Medicine the Wharton School and Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA
LDI Issue Brief 14:1-4. 2009..This Issue Brief explores the use of financial incentives to motivate and sustain smoking cessation and weight loss... - Is thirty-day hospital mortality really lower for black veterans compared with white veterans?Kevin G Volpp
Philadelphia Veterans Affairs Medical Center, University and Woodland Avenue, Philadelphia, PA 19104, USA
Health Serv Res 42:1613-31. 2007.... 
Risk of myocardial infarction associated with chronic hepatitis C virus infection: a population-based cohort studyK A Forde
Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
J Viral Hepat 19:271-7. 2012..16; 95% CI, 0.77-1.74). In conclusion, HCV infection was not associated with an increased risk of incident MI...- Building physician work hour regulations from first principles and best evidenceKevin G Volpp
Center for Health Equity Research and Promotion, Veterans Administration Hospital, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
JAMA 300:1197-9. 2008 - Internal medicine and general surgery residents' attitudes about the ACGME duty hours regulations: a multicenter studyJennifer S Myers
Division of General Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Acad Med 81:1052-8. 2006..To assess internal medicine and general surgery residents' attitudes about the effects of the Accreditation Council for Graduate Medical Education duty hours regulations on medical errors, quality of patient care, and residency experiences... - Patient opinions regarding 'pay for performance for patients'Judith A Long
Philadelphia VA Center for Health Equity Research and Promotion, Philadelphia, PA, USA
J Gen Intern Med 23:1647-52. 2008..Many large employers and payers are turning to pay for performance for patients (P4P4P) to reduce health costs and improve the health of their covered populations. How these programs may be perceived by patients is unknown... - A randomized controlled trial of financial incentives for smoking cessationKevin G Volpp
CHERP, Philadelphia Veterans Affairs Medical Center, University and Woodland Ave, Philadelphia, PA 19104 6021, USA
Cancer Epidemiol Biomarkers Prev 15:12-8. 2006..The objective of this study was to determine whether modest financial incentives increase the rate of smoking cessation program enrollment, completion, and quit rates in a outpatient clinical setting... - Effect of cuts in Medicare reimbursement on process and outcome of care for acute myocardial infarction patientsKevin G Volpp
Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, PA, USA
Circulation 112:2268-75. 2005.... - Short- and long-term mortality after an acute illness for elderly whites and blacksDaniel Polsky
VA Center for Health Equity Research and Promotion, Department of General Internal Medicine, University of Pennsylvania School of Medicine, Wharton School, University of Pennsylvania, Philadelphia, PA 19104, USA
Health Serv Res 43:1388-402. 2008..To estimate racial differences in mortality at 30 days and up to 2 years following a hospital admission for the elderly with common medical conditions... - Mortality among hospitalized Medicare beneficiaries in the first 2 years following ACGME resident duty hour reformKevin G Volpp
Center for Health Equity Research and Promotion, Veterans Administration Hospital, Philadelphia, Pennsylvania 19104 6021, USA
JAMA 298:975-83. 2007..The association of duty hour reform with mortality among patients in teaching hospitals nationally has not been well established... - Financial incentive-based approaches for weight loss: a randomized trialKevin G Volpp
Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
JAMA 300:2631-7. 2008..Identifying effective obesity treatment is both a clinical challenge and a public health priority due to the health consequences of obesity... - The Hospital Compare mortality model and the volume-outcome relationshipJeffrey H Silber
Center for Outcomes Research, 3535 Market Street, Suite 1029, Philadelphia, PA 19104, USA
Health Serv Res 45:1148-67. 2010..We ask whether Medicare's Hospital Compare random effects model correctly assesses acute myocardial infarction (AMI) hospital mortality rates when there is a volume-outcome relationship... - Mortality among patients in VA hospitals in the first 2 years following ACGME resident duty hour reformKevin G Volpp
Center for Health Equity Research and Promotion, Veterans Administration Hospital, Philadelphia, Pennsylvania 19104 6021, USA
JAMA 298:984-92. 2007..The association of these changes with mortality among hospitalized patients has not been well established... - A test of financial incentives to improve warfarin adherenceKevin G Volpp
Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
BMC Health Serv Res 8:272. 2008..Novel methods are needed to improve adherence for warfarin. We conducted two pilot studies to determine whether a lottery-based daily financial incentive is feasible and improves warfarin adherence and anticoagulation control... - Prolonged hospital stay and the resident duty hour rules of 2003Jeffrey H Silber
Center for Outcomes Research, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Med Care 47:1191-200. 2009..Resident duty hour reforms of 2003 had the potential to create a major impact on the delivery of inpatient care... - Effect of work-hours regulations on intensive care unit mortality in United States teaching hospitalsMeeta Prasad
Division of Pulmonary, Allergy, and Critical Care Medicine MP, JDC, JMK, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Crit Care Med 37:2564-9. 2009..The United States instituted restrictions on resident work-hours in July 2003. The clinical impact of this reform on critically ill patients is unknown... - Did duty hour reform lead to better outcomes among the highest risk patients?Kevin G Volpp
Center for Health Equity Research and Promotion, Veterans Administration Hospital, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
J Gen Intern Med 24:1149-55. 2009..Earlier work demonstrated that ACGME duty hour reform did not adversely affect mortality, with slight improvement noted among specific subgroups... - Hospital teaching intensity, patient race, and surgical outcomesJeffrey H Silber
Center for Outcomes Research, The Children s Hospital of Philadelphia, 3535 Market St, Ste 1029, Philadelphia, PA 19104, USA
Arch Surg 144:113-20; discussion 121. 2009.... - A randomized, controlled trial of financial incentives for smoking cessationKevin G Volpp
Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, USA
N Engl J Med 360:699-709. 2009.... - Impact of a prescription copayment increase on lipid-lowering medication adherence in veteransJalpa A Doshi
Center for Health Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
Circulation 119:390-7. 2009..We examined the impact of the copayment increase on lipid-lowering medication adherence... - P4P4P: an agenda for research on pay-for-performance for patientsKevin G Volpp
Center for Health Incentives, Leonard Davis Institute of Health Economics, Wharton School, University of Pennsylvania, USA
Health Aff (Millwood) 28:206-14. 2009..Patient-targeted incentives have great potential, and systematic testing will help determine how they can best be used to improve population health... - An empirical comparison of several clustered data approaches under confounding due to cluster effects in the analysis of complications of coronary angioplastyJ A Berlin
Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
Biometrics 55:470-6. 1999..While conditional approaches provide estimates of the within-cluster effect, they do not provide information about among-center effects. We recommend using the decomposition approach, as it provides both types of estimates... - Adjustments for center in multicenter studies: an overviewA R Localio
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 606 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Ann Intern Med 135:112-23. 2001..This paper uses examples from the recent biomedical literature to highlight the issues and analytic options... - Did postoperative mortality increase after the implementation of the Medicare Balanced Budget Act?Meena Seshamani
Philadelphia Veterans Affairs Medical Center, and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Med Care 44:527-33. 2006..The Balanced Budget Act (BBA) of 1997 was a cost-saving measure designed to reduce Medicare reimbursements by $116.4 billion from 1998 to 2002. Resulting financial strain could adversely affect the quality of patient care in hospitals... - Incidence and prognostic value of low plasma ionized calcium concentration in cats with acute pancreatitis: 46 cases (1996-1998)S E Kimmel
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA
J Am Vet Med Assoc 219:1105-9. 2001..A grave prognosis and aggressive medical treatment are warranted for cats with AP that have a plasma ionized calcium concentration < or = 1.00 mmol/L... - To leave or to lie? Are concerns about a shift-work mentality and eroding professionalism as a result of duty-hour rules justified?Julia E Szymczak
University of Pennsylvania, Philadelphia, PA 19104, USA
Milbank Q 88:350-81. 2010..In this qualitative study, we explore how medical and surgical residents perceive and respond to DHR by examining the "local" organizational culture in which their work is embedded... - A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertensionI M Robbins
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, and Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Eur Respir J 27:578-84. 2006..Further clinical trials of aspirin in patients with idiopathic pulmonary arterial hypertension should be performed... - Validity of The Health Improvement Network (THIN) for the study of psoriasisN M Seminara
Department of Dermatology, University of Pennsylvania, Philadelphia, 19104, USA
Br J Dermatol 164:602-9. 2011..Psoriasis is a common disease frequently studied in large databases. To date the validity of psoriasis information has not been established in The Health Improvement Network (THIN)... - Accuracy of initial stroke subtype diagnosis. a decision analysisS E Kasner
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cerebrovasc Dis 10:18-24. 2000..Several candidate diagnostic tests might be useful for early determination of subtype, but there is no consensus on what level of accuracy is required to be useful in the selection of patients for subtype-specific studies or therapies... - Failure-to-rescue: comparing definitions to measure quality of careJeffrey H Silber
Center for Outcomes Research, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Med Care 45:918-25. 2007..This study examines the reliability and validity of different FTR measures currently in use... - Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivityCarmel Kealey
University of Pennsylvania, Department of Pharmacology and Center for Pharmacogenetics, School of Medicine, Philadelphia, PA, USA
Pharmacogenomics 8:217-25. 2007..0 and 3.0 were genotyped. Warfarin sensitivity stratified by genotype was investigated using univariate and multivariate analyses... - Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE studyCatherine S Parker
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
J Gen Intern Med 22:1254-9. 2007..Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied... - ACCF/AHA/SCAI 2007 update of the Clinical Competence Statement on Cardiac Interventional Procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and Spencer B King
Circulation 116:98-124. 2007 - Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug eventsCharles E Leonard
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 61:561-71. 2008..We sought to examine the validity of specific hospital discharge codes in identifying drug toxicity precipitating hospitalization, among elderly users of high-risk medications... - Epidemiologic features of the presentation of critical congenital heart disease: implications for screeningAmy H Schultz
Department of, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Pediatrics 121:751-7. 2008..These descriptive parameters must be defined to evaluate the impact and feasibility of any proposed screening strategy... - Warfarin therapy: in need of improvement after all these yearsStephen E Kimmel
University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Expert Opin Pharmacother 9:677-86. 2008..As a result, warfarin is a leading cause of serious medication-related adverse events, and its efficacy is also suboptimal... - Single procedure efficacy of isolating all versus arrhythmogenic pulmonary veins on long-term control of atrial fibrillation: a prospective randomized studySanjay Dixit
Cardiovascular Division, Hospital of The University of Pennsylvania and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Heart Rhythm 5:174-81. 2008..Current atrial fibrillation (AF) ablation involves isolation of all pulmonary veins (PVs) with or without additional linear lesions. However, whether such extensive ablation is necessary is unclear... - Incidence and prevalence of abnormal liver associated enzymes in patients with atrial fibrillation in a routine clinical care populationGeorge A Makar
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:43-51. 2008..The aim of this study was to estimate the prevalence and incidence of alanine aminotransferase (ALT) elevations in a cohort with AF... - Acetaminophen for altering body temperature in acute stroke: a randomized clinical trialScott E Kasner
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Stroke 33:130-4. 2002..Elevated core body temperature (CBT), even if mild, may exacerbate neuronal injury and worsen outcome, whereas hypothermia is potentially neuroprotective. The antipyretic effects of acetaminophen were hypothesized to reduce CBT... - Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicityJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:328-35. 2008..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity... - ACCF/AHA/SCAI 2007 update of the clinical competence statement on cardiac interventional procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and Spencer B King
J Am Coll Cardiol 50:82-108. 2007 - Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitusRoshanak Bagheri
Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, and Department of Medicine, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
Am J Cardiol 99:951-5. 2007.... - Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trialSean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Pharmacotherapy 26:1342-7. 2006..To measure the effectiveness of a multifaceted educational intervention to improve ambulatory hypertension control... - Class effect of angiotensin-converting enzyme inhibitors on prevention of myocardial infarctionWilliam H Sauer
Cardiovascular Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Am J Cardiol 94:1171-3. 2004..The present study examined this question and found no correlation between tissue ACE affinity and risk of first nonfatal myocardial infarction in patients who have hypertension... - Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetesMuredach P Reilly
Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
J Clin Endocrinol Metab 89:3872-8. 2004..Whether leptin signaling promotes atherosclerosis directly or represents a therapeutic target for the prevention of atherosclerotic cardiovascular disease remains to be explored... - Comparative cardiac safety of low-dose thioridazine and low-dose haloperidolSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Br J Clin Pharmacol 58:81-7. 2004..To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol... - Association between pulmonary fibrosis and coronary artery diseaseJorge R Kizer
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
Arch Intern Med 164:551-6. 2004..Further research is necessary to confirm this relationship and to explore the pathologic processes underlying, and potentially linking, these 2 conditions... - Giving aspirin and ibuprofen after myocardial infarctionStephen E Kimmel
BMJ 327:1298-9. 2003 - Clinical risk factors for primary graft failure following lung transplantationJason D Christie
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelhia, 19104, USA
Chest 124:1232-41. 2003..s: Primary graft failure (PGF) is a devastating acute lung injury syndrome following lung transplantation. We sought to identify donor, recipient, and operative risk factors for its development... - One-year clinical outcomes of protected and unprotected left main coronary artery stentingMichael P Kelley
Hospital of the University of Pennsylvania, University Health System, 9 Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
Eur Heart J 24:1554-9. 2003..Stenting for unprotected LMCA disease in a high-risk population should only be considered in the absence of other revascularization options. Further studies are needed to evaluate the role of stenting for unprotected LMCA disease... - Adverse events after protamine administration following cardiopulmonary bypass in infants and childrenHarry A Seifert
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Anesth Analg 97:383-9, table of contents. 2003..Female sex, larger protamine dose, and smaller heparin dose were each associated with increased risk. The development of protamine alternatives or prophylactic therapies may be useful for reducing the frequency of these events... - Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarctionWilliam H Sauer
Cardiovascular Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
Circulation 108:32-6. 2003..There was no association detected between non-SSRI antidepressant use and MI. CONCLUSIONS: Increasing serotonin transporter affinity correlates with greater MI protection with SSRI but not other antidepressant exposure... - Bleeding risk of platelet glycoprotein IIb/IIIa receptor antagonists in broad-based practice (results from the Society for Cardiac Angiography and Interventions Registry)Phillip A Horwitz
Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Cardiol 91:803-6. 2003..Assuming these agents are as effective as shown in these trials, the risk-benefit ratio of GP IIb/IIIa inhibitors in broad-based PCI practice should be favorable... - Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative dataSean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
BMJ 325:1070. 2002..To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls... - Usefulness of the TIMI risk score in predicting both short- and long-term outcomes in the Veterans Affairs Non-Q-Wave Myocardial Infarction Strategies In-Hospital (VANQWISH) TrialFrederick F Samaha
Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Cardiol 90:922-6. 2002..76). No significant difference in outcomes between strategies was detected for a score > or =3. The TIMI risk score provides moderate incremental prognostic information in high-risk patients, during both short- and long-term follow-up... - Racial differences in the prevalence of cardiac sources of embolism in subjects with unexplained stroke or transient ischemic attack evaluated by transesophageal echocardiographyJorge R Kizer
Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA
Am J Cardiol 90:395-400. 2002.... - Stress test criteria used in the conservative arm of the FRISC-II trial underdetects surgical coronary artery disease when applied to patients in the VANQWISH trialAbhinav Goyal
University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, Pennsylvania 19104, USA
J Am Coll Cardiol 39:1601-7. 2002..A lower threshold for catheterization in the FRISC-II conservative patients might have improved their outcomes and therefore diminished the putative benefit of an invasive strategy... - Cigarette yield and the risk of myocardial infarction in smokersWilliam H Sauer
Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Arch Intern Med 162:300-6. 2002..001 for the trend). CONCLUSIONS: Smoking higher-yield cigarettes is associated with an increased risk of MI, and there is a dose-response relationship between total tar consumption per day and MI... - Impact of primary graft failure on outcomes following lung transplantationJason D Christie
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Chest 127:161-5. 2005..Primary graft failure (PGF) is a severe acute lung injury syndrome that occurs following lung transplantation. We compared the clinical outcomes of patients who developed PGF with those who did not... - Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarctionStephen E Kimmel
University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Ann Intern Med 142:157-64. 2005..Cardiovascular effects among the COX-2 inhibitors seem different, but further studies, preferably randomized trials, are needed to fully understand the spectrum of effects of COX-2 inhibitors and potential differences among them... - Comparison of cool tip versus 8-mm tip catheter in achieving electrical isolation of pulmonary veins for long-term control of atrial fibrillation: a prospective randomized pilot studySanjay Dixit
Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Cardiovasc Electrophysiol 17:1074-9. 2006..To compare safety and efficacy of 8-mm versus cooled tip catheter in achieving electrical isolation (EI) of pulmonary veins (PV) for long-term control of atrial fibrillation (AF)... - Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitusWilliam H Sauer
Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Am J Cardiol 97:651-4. 2006.... - Can atorvastatin improve the response to sildenafil in men with erectile dysfunction not initially responsive to sildenafil? Hypothesis and pilot trial resultsHoward C Herrmann
Hospital of the University of Pennsylvania, Philadelphia, 19104, USA
J Sex Med 3:303-8. 2006..Erectile dysfunction (ED) may be one manifestation of a generalized vascular disorder characterized by endothelial dysfunction. Statin drugs may improve endothelial function, even before altering the lipid profile... - The role of risk stratification in the decision to provide upstream versus selective glycoprotein IIb/IIIa inhibitors for acute coronary syndromes: a cost-effectiveness analysisRuchira Glaser
Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Am Coll Cardiol 47:529-37. 2006.... - Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugsJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Gastroenterology 129:1865-74. 2005..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs... - Comparison of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the primary prevention of myocardial infarction in hypertensive patientsJefferson T Baer
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Cardiol 94:479-81. 2004..In the present case-control study, we found no difference between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the primary prevention of nonfatal myocardial infarction among patients with hypertension... - Comparing the standard rating scale and the magnifier scale for assessing risk perceptionsAndrea D Gurmankin
Department of Society, Human Development and Health, Harvard School of Public Health, Boston, Massachusetts, USA
Med Decis Making 25:560-70. 2005..The authors tested whether the magnifier scale lowers risk perceptions for low-probability (in 0%-1% magnifying glass section of scale) but not high-probability (>1%) events compared to a standard rating scale (SRS)... - Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposureJames D Lewis
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 15:39-45. 2006..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse... - Hemodynamics and survival of patients with portopulmonary hypertensionSteven M Kawut
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Liver Transpl 11:1107-11. 2005..Future studies of the specific mechanisms of and therapy for pulmonary arterial hypertension should focus on the distinctions between the different forms of this disease... - Role of computerized physician order entry systems in facilitating medication errorsRoss Koppel
Department of Sociology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 USA
JAMA 293:1197-203. 2005..Published studies report that CPOE reduces medication errors up to 81%. Few researchers, however, have focused on the existence or types of medication errors facilitated by CPOE... - The effect of primary graft dysfunction on survival after lung transplantationJason D Christie
Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 719 Blockley Hall, Philadelphia, PA 19104, USA
Am J Respir Crit Care Med 171:1312-6. 2005..Primary graft dysfunction is a severe acute lung injury syndrome after lung transplantation. Long-term outcomes of subjects with primary graft dysfunction have not been studied... - Medication safety in older adults: home-based practice patternsJoshua P Metlay
Penn Program for the Reduction in Medication Errors, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania 19104, USA
J Am Geriatr Soc 53:976-82. 2005..To identify the current state of medication-taking practices of community-dwelling older adults on high-risk medications... - Potential limitations of electronic database studies of prescription non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and risk of myocardial infarction (MI)Leonard Ilkhanoff
Department of Medicine, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:513-22. 2005..Further studies-preferably randomized trials-are needed to address the risk-benefit ratio of NANSAID use... - The effect of cardiac troponin testing on clinical care in a veterans population: a randomized controlled trialMichael Berkwits
Philadelphia VA Medical Center and the Division of General Internal Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA
J Gen Intern Med 20:584-92. 2005..Cardiac troponin is more accurate than creatine kinase (CK) testing for detecting myocardial injury in patients with acute coronary syndromes (ACS), but its effects on clinical care compared with CK testing alone is open to question... - Evaluation of the Society for Coronary Angiography and Interventions' lesion classification system in 14,133 patients with percutaneous coronary interventions in the current stent eraRonald J Krone
Department of Medicine, Washington University, St Louis, Missouri, USA
Catheter Cardiovasc Interv 55:1-7. 2002..In the current PCI device era, the simpler SCAI classification using 7 variables predicted interventional success and complications as well as or better than the ACC/AHA system requiring 26... - Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosisSteven M Kawut
Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, USA
Chest 123:344-50. 2003..The goal of this study was to determine whether the survival of patients with pulmonary hypertension related to systemic sclerosis (SScPH) was different from that of patients with other forms of pulmonary arterial hypertension... - Limitations of current risk-adjustment models in the era of coronary stentingJorge R Kizer
Division of Cardiology, Department of Medicine, Weill Medical College, Cornell University, New York, NY, USA
Am Heart J 145:683-92. 2003..Yet the accuracy of these models in contemporary interventional practice--characterized by the widespread use of stents and novel adjuvant pharmacotherapies--has not been sufficiently studied... - Is improved survival a class effect of angiotensin-converting enzyme inhibitors?Sean Hennessy
Ann Intern Med 141:157-8. 2004
Research Grants
- A randomized trial of interventions to improve warfarin adherenceKevin G Volpp; Fiscal Year: 2010....
- A randomized trial of interventions to improve warfarin adherenceStephen Kimmel; Fiscal Year: 2009....
- Patient Oriented Research in AnticoagulationStephen Kimmel; Fiscal Year: 2006..The ultimate goal is to improve the use of a highly efficacious, but underused, drug, and reduce morbidity and mortality in the large proportion of the population at risk for TE. ..
- Research:Genetics of complex traits(RMI)Stephen Kimmel; Fiscal Year: 2006....
- PREDICTORS OF ANTICOAGULATION CONTROL ON WARFARINStephen Kimmel; Fiscal Year: 2005..The ultimate goal is to improve the use of a highly efficacious, but underused, drug and reduce morbidity and mortality in the large proportion of the population at risk for TE. ..
- Prediction of warfarin dosing using clinical and genetic factorsStephen E Kimmel; Fiscal Year: 2010....