Research Topics
| D W KimberlinSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Antiviral therapy for cytomegalovirus infections in pediatric patientsDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
Semin Pediatr Infect Dis 13:22-30. 2002..Ganciclovir is the first-line compound used, followed by foscarnet and cidofovir. This article summarizes those CMV infections that require antiviral therapy and outlines therapeutic options for each...- Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trialDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
J Pediatr 143:16-25. 2003..To evaluate the efficacy and safety of ganciclovir therapy in neonates with congenital cytomegalovirus (CMV) disease... - Natural history of neonatal herpes simplex virus infections in the acyclovir eraD W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Pediatrics 108:223-9. 2001..The objective of this study was to provide an update of neonatal HSV disease to identify means by which future improvements in the management of HSV-infected neonates can be made... - Neonatal herpes: what have we learnedDavid W Kimberlin
Department of Pediatrics, The University of Alabama Birmingham, AL 35233, USA
Semin Pediatr Infect Dis 16:7-16. 2005..In the longer term, development of a bedside nucleic acid detection kit for real-time detection of HSV DNA in the maternal genital tract at the time of delivery could identify which babies are at risk of developing neonatal HSV disease... - Herpes simplex virus infections of the newbornDavid W Kimberlin
Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35233, USA
Semin Perinatol 31:19-25. 2007..This article will summarize the current state of neonatal HSV disease presentation, diagnosis, and management... 
Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenzaDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, AL 35233, USA
J Infect Dis 207:709-20. 2013..Children <2 years of age are at high risk of influenza-related mortality and morbidity. However, the appropriate dose of oseltamivir for children <2 years of age is unknown...- Oral acyclovir suppression and neurodevelopment after neonatal herpesDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
N Engl J Med 365:1284-92. 2011..Poor neurodevelopmental outcomes and recurrences of cutaneous lesions remain unacceptably frequent among survivors of neonatal herpes simplex virus (HSV) disease... - Current status of antiviral therapy for juvenile-onset recurrent respiratory papillomatosisDavid W Kimberlin
Division of Pediatric Infectious Diseases, University of Alabama, 1600 Seventh Avenue South CHB 303, Birmingham, AL 35233, USA
Antiviral Res 63:141-51. 2004..As with surgical management, viral persistence occurs following treatment with these adjuvant modalities, further contributing to the challenge of managing patients with this potentially devastating disease... - Antiviral therapies in children: has their time arrived?David W Kimberlin
Department of Pediatrics, Division of Pediatric Infectious Diseases, The University of Alabama, Birmingham, AL 35233, USA
Pediatr Clin North Am 52:837-67, vii. 2005..This article describes the clinical utilities, pharmacokinetics, and adverse effects of these new drugs to empower practitioners to use them appropriately... - Diagnosis of herpes simplex virus infections of the CNSDavid W Kimberlin
Division of Pediatric Infectious Diseases, The University of Alabama, 1600 Seventh Avenue South, CHB 303, Birmingham, AL 35233, USA
Expert Rev Mol Diagn 5:537-47. 2005..This article will summarize the advances in the diagnosis of herpes simplex virus CNS disease within the context of how these advances can enhance the care of individual patients... - Herpes simplex virus infections in neonates and early childhoodDavid W Kimberlin
Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35233, USA
Semin Pediatr Infect Dis 16:271-81. 2005..This article will summarize the current state of neonatal HSV disease presentation, diagnosis, and management... - Varicella-zoster vaccine for the prevention of herpes zosterDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
N Engl J Med 356:1338-43. 2007 - Management of HSV encephalitis in adults and neonates: diagnosis, prognosis and treatmentDavid W Kimberlin
Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Herpes 14:11-6. 2007..Intravenous aciclovir remains the mainstay of antiviral management. Even with recent treatment advances and enhanced awareness, potentially devastating outcomes remain possible... 
Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus diseaseDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Infect Dis 197:836-45. 2008..Intravenous ganciclovir administered for 6 weeks improves hearing outcomes in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system...- Safety of oseltamivir compared with the adamantanes in children less than 12 months of ageDavid W Kimberlin
Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama, Birmingham, Birmingham, AL 35233, USA
Pediatr Infect Dis J 29:195-8. 2010..To assess potential neurologic adverse effects of oseltamivir use in infants, a retrospective chart review was performed in infants less than 12 months of age who received oseltamivir, amantadine, or rimantadine... - Pharmacokinetics and safety of extemporaneously compounded valacyclovir oral suspension in pediatric patients from 1 month through 11 years of ageDavid W Kimberlin
Department of Pediatrics, University of Alabama, Birmingham, AL 35233, USA
Clin Infect Dis 50:221-8. 2010..Valacyclovir provides enhanced acyclovir bioavailability in adults, but limited data are available in children... - Targeted antiviral prophylaxis with oseltamivir in a summer camp settingDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Arch Pediatr Adolesc Med 164:323-7. 2010..To describe the effectiveness of containment of novel influenza A(H1N1) infection at a summer camp... - Herpes simplex virus, meningitis and encephalitis in neonatesDavid Kimberlin
Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Herpes 11:65A-76A. 2004..At the end of therapy in CNS and disseminated disease, PCR assessment of CSF should be used and treatment continued if the child remains PCR positive at this site... - Advances in the treatment of neonatal herpes simplex infectionsD W Kimberlin
Department of Pediatrics, The University of Alabama at Birmingham, 1600 Seventh Avenue South, Suite 616, Birmingham, AL 35233, USA
Rev Med Virol 11:157-63. 2001..Utilisation of suppressive oral acyclovir following acute neonatal disease is another therapeutic option under clinical investigation with the potential to improve morbidity outcomes of neonatal HSV disease survivors... - Herpes simplex virus infections of the central nervous systemDavid W Kimberlin
Department of Pediatrics, The University of Alabama at Birmingham, AL 35233, USA
Semin Pediatr Infect Dis 14:83-9. 2003..Although advances have been achieved, morbidity and mortality rates from neonatal HSV disease and HSE remain unacceptably high... - Pharmacotherapy of recurrent respiratory papillomatosisDavid W Kimberlin
Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, 35233, USA
Expert Opin Pharmacother 3:1091-9. 2002..As with surgical management, viral persistence occurs following treatment with these adjuvant modalities, further contributing to the challenge of managing patients with this potentially devastating disease... - Juvenile onset recurrent respiratory papillomatosis: possibilities for successful antiviral therapyD W Kimberlin
Division of Infectious Diseases, The University of Alabama at Birmingham, 35233, USA
Antiviral Res 45:83-93. 2000..However, numerous antiviral therapies have also been evaluated, albeit primarily under uncontrolled settings. This article will review the biology, natural history and management of HPV infection, with particular emphasis on JO-RRP... - Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infectionsD W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Alabama 35233, USA
Pediatrics 108:230-8. 2001..In addition, an estimate of therapeutic efficacy was sought, both with respect to mortality and to morbidity. Virologic efficacy of HD acyclovir was also assessed... - Neonatal herpes simplex infectionDavid W Kimberlin
Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Clin Microbiol Rev 17:1-13. 2004..A thorough understanding of the biology and natural history of HSV in the gravid woman and the neonate provides the basis for such an index of suspicion and is provided in this article... - Clinical practice. Genital herpesDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
N Engl J Med 350:1970-7. 2004 - Ganciclovir population pharmacokinetics in neonates following intravenous administration of ganciclovir and oral administration of a liquid valganciclovir formulationE P Acosta
Division of Clinical Pharmacology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
Clin Pharmacol Ther 81:867-72. 2007.... - Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous systemRussell D Bradford
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Infect Dis 191:227-33. 2005..CONCLUSION: In children with symptomatic congenital CMV infection involving the CNS, viremia during early infancy is associated with hearing loss and systemic CMV disease... - Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitisMark J Abzug
Pediatric Infectious Disease, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, 1056 E Nineteenth Avenue, Denver, CO 80218, USA
Pediatr Infect Dis J 22:335-41. 2003..Treatment of older children and adults with pleconaril has been associated with reduced severity and duration of symptoms. This study evaluated the pharmacokinetics, safety and efficacy of pleconaril in infants with EV meningitis... - Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous systemSara E Oliver
Department of Pediatrics, University of Alabama at Birmingham, United States
J Clin Virol 46:S22-6. 2009..Ganciclovir protects against hearing deterioration in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system (CNS)... - Oseltamivir dosing for influenza infection in premature neonatesEdward P Acosta
Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
J Infect Dis 202:563-6. 2010..0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population... - Herpes simplex encephalitis: children and adolescentsRichard J Whitley
Department of Pediatrics, The University of Alabama at Birmingham, AL, USA
Semin Pediatr Infect Dis 16:17-23. 2005..Recent investigative efforts are assessing the value of PCR detection of viral DNA at the completion of therapy and the value of prolonged antiviral therapy... - Determination of appropriate dosing of influenza drugs in pediatric patientsE P Acosta
Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA
Clin Pharmacol Ther 88:704-7. 2010..The evaluation of influenza antiviral agents in premature infants adds even more complexity. Recent advances in exposure-targeted study designs and modeling and simulations have aided in addressing some of these challenges... - Antiretroviral pharmacokinetics in the paediatric population: a reviewJennifer R King
Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA
Clin Pharmacokinet 41:1115-33. 2002..If prevention of treatment failure continues to be the goal of antiretroviral therapy, the pharmacokinetics of antiretrovirals in children need to be assessed early in the drug development process... - Evaluation of multiple drug therapy in human immunodeficiency virus-infected pediatric patientsJennifer R King
Division of Clinical Pharmacology, University of Alabama at Birmingham, 35294, USA
Pediatr Infect Dis J 22:239-44. 2003..Larger controlled clinical trials in this patient population are necessary to determine whether the benefit of this therapeutic approach outweighs potential risks... - Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infectionScott H James
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1711, United States
Antiviral Res 83:207-13. 2009..Although advances in antiviral agents have led to improved outcomes, there is still a need for more effective treatments... - Diagnosis of herpes simplex virus in the era of polymerase chain reactionDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
Pediatr Infect Dis J 25:841-2. 2006 - Molecular diagnosis of viral infections of the central nervous systemJose R Romero
Combined Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Nebraska Medical Center and Creighton University, 982165 Nebraska Medical Center, Omaha, NE 68198, USA
Clin Lab Med 23:843-65, vi. 2003..This article summarizes the current understanding with regard to the available, molecularly based, diagnostic assays for the detection of EVs, herpes viruses, and JCV... - Impact of the rapid diagnosis of influenza on physician decision-making and patient management in the pediatric emergency department: results of a randomized, prospective, controlled trialAleta B Bonner
Division of Pediatric Emergency Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pediatrics 112:363-7. 2003.... - When should you initiate acyclovir therapy in a neonate?David W Kimberlin
J Pediatr 153:155-6. 2008 - Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutantsJohn P DeVincenzo
University of Tennessee, LeBonheur Children s Medical Center, Memphis 38103, USA
J Infect Dis 190:975-8. 2004..Palivizumab bound to all 371 RSV isolates able to be evaluated, including 25 from active-palivizumab recipients. The palivizumab epitope appears to be highly conserved, even in infants receiving prophylaxis with palivizumab... - Neonatal HSV infections: the global pictureDavid W Kimberlin
Herpes 11:31-2. 2004 - Prevention of influenza: recommendations for influenza immunization of children, 2007-2008Joseph A Bocchini
Pediatrics 121:e1016-31. 2008..However, oseltamivir and zanamivir can be prescribed for treatment or chemoprophylaxis, because influenza A and B strains remain susceptible...