D W Kimberlin

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Pediatr 143:16-25. 2003
  2. ncbi request reprint Natural history of neonatal herpes simplex virus infections in the acyclovir era
    D W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Pediatrics 108:223-9. 2001
  3. ncbi request reprint Antiviral therapy for cytomegalovirus infections in pediatric patients
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
    Semin Pediatr Infect Dis 13:22-30. 2002
  4. ncbi request reprint Neonatal herpes: what have we learned
    David W Kimberlin
    Department of Pediatrics, The University of Alabama Birmingham, AL 35233, USA
    Semin Pediatr Infect Dis 16:7-16. 2005
  5. ncbi request reprint Herpes simplex virus infections of the newborn
    David W Kimberlin
    Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Semin Perinatol 31:19-25. 2007
  6. pmc Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, AL 35233, USA
    J Infect Dis 207:709-20. 2013
  7. pmc Oral acyclovir suppression and neurodevelopment after neonatal herpes
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    N Engl J Med 365:1284-92. 2011
  8. ncbi request reprint Current status of antiviral therapy for juvenile-onset recurrent respiratory papillomatosis
    David W Kimberlin
    Division of Pediatric Infectious Diseases, University of Alabama, 1600 Seventh Avenue South CHB 303, Birmingham, AL 35233, USA
    Antiviral Res 63:141-51. 2004
  9. ncbi request reprint Antiviral therapies in children: has their time arrived?
    David W Kimberlin
    Department of Pediatrics, Division of Pediatric Infectious Diseases, The University of Alabama, Birmingham, AL 35233, USA
    Pediatr Clin North Am 52:837-67, vii. 2005
  10. ncbi request reprint Diagnosis of herpes simplex virus infections of the CNS
    David W Kimberlin
    Division of Pediatric Infectious Diseases, The University of Alabama, 1600 Seventh Avenue South, CHB 303, Birmingham, AL 35233, USA
    Expert Rev Mol Diagn 5:537-47. 2005

Detail Information

Publications42

  1. ncbi request reprint Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Pediatr 143:16-25. 2003
    ..To evaluate the efficacy and safety of ganciclovir therapy in neonates with congenital cytomegalovirus (CMV) disease...
  2. ncbi request reprint Natural history of neonatal herpes simplex virus infections in the acyclovir era
    D W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Pediatrics 108:223-9. 2001
    ..The objective of this study was to provide an update of neonatal HSV disease to identify means by which future improvements in the management of HSV-infected neonates can be made...
  3. ncbi request reprint Antiviral therapy for cytomegalovirus infections in pediatric patients
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
    Semin Pediatr Infect Dis 13:22-30. 2002
    ..Ganciclovir is the first-line compound used, followed by foscarnet and cidofovir. This article summarizes those CMV infections that require antiviral therapy and outlines therapeutic options for each...
  4. ncbi request reprint Neonatal herpes: what have we learned
    David W Kimberlin
    Department of Pediatrics, The University of Alabama Birmingham, AL 35233, USA
    Semin Pediatr Infect Dis 16:7-16. 2005
    ..In the longer term, development of a bedside nucleic acid detection kit for real-time detection of HSV DNA in the maternal genital tract at the time of delivery could identify which babies are at risk of developing neonatal HSV disease...
  5. ncbi request reprint Herpes simplex virus infections of the newborn
    David W Kimberlin
    Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Semin Perinatol 31:19-25. 2007
    ..This article will summarize the current state of neonatal HSV disease presentation, diagnosis, and management...
  6. pmc Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, AL 35233, USA
    J Infect Dis 207:709-20. 2013
    ..Children <2 years of age are at high risk of influenza-related mortality and morbidity. However, the appropriate dose of oseltamivir for children <2 years of age is unknown...
  7. pmc Oral acyclovir suppression and neurodevelopment after neonatal herpes
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    N Engl J Med 365:1284-92. 2011
    ..Poor neurodevelopmental outcomes and recurrences of cutaneous lesions remain unacceptably frequent among survivors of neonatal herpes simplex virus (HSV) disease...
  8. ncbi request reprint Current status of antiviral therapy for juvenile-onset recurrent respiratory papillomatosis
    David W Kimberlin
    Division of Pediatric Infectious Diseases, University of Alabama, 1600 Seventh Avenue South CHB 303, Birmingham, AL 35233, USA
    Antiviral Res 63:141-51. 2004
    ..As with surgical management, viral persistence occurs following treatment with these adjuvant modalities, further contributing to the challenge of managing patients with this potentially devastating disease...
  9. ncbi request reprint Antiviral therapies in children: has their time arrived?
    David W Kimberlin
    Department of Pediatrics, Division of Pediatric Infectious Diseases, The University of Alabama, Birmingham, AL 35233, USA
    Pediatr Clin North Am 52:837-67, vii. 2005
    ..This article describes the clinical utilities, pharmacokinetics, and adverse effects of these new drugs to empower practitioners to use them appropriately...
  10. ncbi request reprint Diagnosis of herpes simplex virus infections of the CNS
    David W Kimberlin
    Division of Pediatric Infectious Diseases, The University of Alabama, 1600 Seventh Avenue South, CHB 303, Birmingham, AL 35233, USA
    Expert Rev Mol Diagn 5:537-47. 2005
    ..This article will summarize the advances in the diagnosis of herpes simplex virus CNS disease within the context of how these advances can enhance the care of individual patients...
  11. ncbi request reprint Herpes simplex virus infections in neonates and early childhood
    David W Kimberlin
    Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Semin Pediatr Infect Dis 16:271-81. 2005
    ..This article will summarize the current state of neonatal HSV disease presentation, diagnosis, and management...
  12. ncbi request reprint Varicella-zoster vaccine for the prevention of herpes zoster
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    N Engl J Med 356:1338-43. 2007
  13. ncbi request reprint Management of HSV encephalitis in adults and neonates: diagnosis, prognosis and treatment
    David W Kimberlin
    Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Herpes 14:11-6. 2007
    ..Intravenous aciclovir remains the mainstay of antiviral management. Even with recent treatment advances and enhanced awareness, potentially devastating outcomes remain possible...
  14. doi request reprint Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Infect Dis 197:836-45. 2008
    ..Intravenous ganciclovir administered for 6 weeks improves hearing outcomes in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system...
  15. pmc Safety of oseltamivir compared with the adamantanes in children less than 12 months of age
    David W Kimberlin
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama, Birmingham, Birmingham, AL 35233, USA
    Pediatr Infect Dis J 29:195-8. 2010
    ..To assess potential neurologic adverse effects of oseltamivir use in infants, a retrospective chart review was performed in infants less than 12 months of age who received oseltamivir, amantadine, or rimantadine...
  16. doi request reprint Pharmacokinetics and safety of extemporaneously compounded valacyclovir oral suspension in pediatric patients from 1 month through 11 years of age
    David W Kimberlin
    Department of Pediatrics, University of Alabama, Birmingham, AL 35233, USA
    Clin Infect Dis 50:221-8. 2010
    ..Valacyclovir provides enhanced acyclovir bioavailability in adults, but limited data are available in children...
  17. doi request reprint Targeted antiviral prophylaxis with oseltamivir in a summer camp setting
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Arch Pediatr Adolesc Med 164:323-7. 2010
    ..To describe the effectiveness of containment of novel influenza A(H1N1) infection at a summer camp...
  18. ncbi request reprint Herpes simplex virus, meningitis and encephalitis in neonates
    David Kimberlin
    Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Herpes 11:65A-76A. 2004
    ..At the end of therapy in CNS and disseminated disease, PCR assessment of CSF should be used and treatment continued if the child remains PCR positive at this site...
  19. ncbi request reprint Advances in the treatment of neonatal herpes simplex infections
    D W Kimberlin
    Department of Pediatrics, The University of Alabama at Birmingham, 1600 Seventh Avenue South, Suite 616, Birmingham, AL 35233, USA
    Rev Med Virol 11:157-63. 2001
    ..Utilisation of suppressive oral acyclovir following acute neonatal disease is another therapeutic option under clinical investigation with the potential to improve morbidity outcomes of neonatal HSV disease survivors...
  20. ncbi request reprint Herpes simplex virus infections of the central nervous system
    David W Kimberlin
    Department of Pediatrics, The University of Alabama at Birmingham, AL 35233, USA
    Semin Pediatr Infect Dis 14:83-9. 2003
    ..Although advances have been achieved, morbidity and mortality rates from neonatal HSV disease and HSE remain unacceptably high...
  21. ncbi request reprint Pharmacotherapy of recurrent respiratory papillomatosis
    David W Kimberlin
    Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, 35233, USA
    Expert Opin Pharmacother 3:1091-9. 2002
    ..As with surgical management, viral persistence occurs following treatment with these adjuvant modalities, further contributing to the challenge of managing patients with this potentially devastating disease...
  22. ncbi request reprint Juvenile onset recurrent respiratory papillomatosis: possibilities for successful antiviral therapy
    D W Kimberlin
    Division of Infectious Diseases, The University of Alabama at Birmingham, 35233, USA
    Antiviral Res 45:83-93. 2000
    ..However, numerous antiviral therapies have also been evaluated, albeit primarily under uncontrolled settings. This article will review the biology, natural history and management of HPV infection, with particular emphasis on JO-RRP...
  23. ncbi request reprint Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections
    D W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Alabama 35233, USA
    Pediatrics 108:230-8. 2001
    ..In addition, an estimate of therapeutic efficacy was sought, both with respect to mortality and to morbidity. Virologic efficacy of HD acyclovir was also assessed...
  24. pmc Neonatal herpes simplex infection
    David W Kimberlin
    Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Clin Microbiol Rev 17:1-13. 2004
    ..A thorough understanding of the biology and natural history of HSV in the gravid woman and the neonate provides the basis for such an index of suspicion and is provided in this article...
  25. ncbi request reprint Clinical practice. Genital herpes
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    N Engl J Med 350:1970-7. 2004
  26. ncbi request reprint Ganciclovir population pharmacokinetics in neonates following intravenous administration of ganciclovir and oral administration of a liquid valganciclovir formulation
    E P Acosta
    Division of Clinical Pharmacology, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Clin Pharmacol Ther 81:867-72. 2007
    ....
  27. ncbi request reprint Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous system
    Russell D Bradford
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Infect Dis 191:227-33. 2005
    ....
  28. ncbi request reprint Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis
    Mark J Abzug
    Pediatric Infectious Disease, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, 1056 E Nineteenth Avenue, Denver, CO 80218, USA
    Pediatr Infect Dis J 22:335-41. 2003
    ..Treatment of older children and adults with pleconaril has been associated with reduced severity and duration of symptoms. This study evaluated the pharmacokinetics, safety and efficacy of pleconaril in infants with EV meningitis...
  29. pmc Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system
    Sara E Oliver
    Department of Pediatrics, University of Alabama at Birmingham, United States
    J Clin Virol 46:S22-6. 2009
    ..Ganciclovir protects against hearing deterioration in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system (CNS)...
  30. pmc Oseltamivir dosing for influenza infection in premature neonates
    Edward P Acosta
    Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    J Infect Dis 202:563-6. 2010
    ..0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population...
  31. ncbi request reprint Herpes simplex encephalitis: children and adolescents
    Richard J Whitley
    Department of Pediatrics, The University of Alabama at Birmingham, AL, USA
    Semin Pediatr Infect Dis 16:17-23. 2005
    ..Recent investigative efforts are assessing the value of PCR detection of viral DNA at the completion of therapy and the value of prolonged antiviral therapy...
  32. pmc Determination of appropriate dosing of influenza drugs in pediatric patients
    E P Acosta
    Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA
    Clin Pharmacol Ther 88:704-7. 2010
    ..The evaluation of influenza antiviral agents in premature infants adds even more complexity. Recent advances in exposure-targeted study designs and modeling and simulations have aided in addressing some of these challenges...
  33. ncbi request reprint Antiretroviral pharmacokinetics in the paediatric population: a review
    Jennifer R King
    Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Clin Pharmacokinet 41:1115-33. 2002
    ..If prevention of treatment failure continues to be the goal of antiretroviral therapy, the pharmacokinetics of antiretrovirals in children need to be assessed early in the drug development process...
  34. ncbi request reprint Evaluation of multiple drug therapy in human immunodeficiency virus-infected pediatric patients
    Jennifer R King
    Division of Clinical Pharmacology, University of Alabama at Birmingham, 35294, USA
    Pediatr Infect Dis J 22:239-44. 2003
    ..The clinical benefits of this regimen are often accompanied by increased toxicities. We report the safety and tolerance of multiple drug therapy in HIV-infected children...
  35. pmc Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infection
    Scott H James
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1711, United States
    Antiviral Res 83:207-13. 2009
    ..Although advances in antiviral agents have led to improved outcomes, there is still a need for more effective treatments...
  36. ncbi request reprint Diagnosis of herpes simplex virus in the era of polymerase chain reaction
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
    Pediatr Infect Dis J 25:841-2. 2006
  37. ncbi request reprint Molecular diagnosis of viral infections of the central nervous system
    Jose R Romero
    Combined Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Nebraska Medical Center and Creighton University, 982165 Nebraska Medical Center, Omaha, NE 68198, USA
    Clin Lab Med 23:843-65, vi. 2003
    ..This article summarizes the current understanding with regard to the available, molecularly based, diagnostic assays for the detection of EVs, herpes viruses, and JCV...
  38. ncbi request reprint Impact of the rapid diagnosis of influenza on physician decision-making and patient management in the pediatric emergency department: results of a randomized, prospective, controlled trial
    Aleta B Bonner
    Division of Pediatric Emergency Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatrics 112:363-7. 2003
    ....
  39. ncbi request reprint When should you initiate acyclovir therapy in a neonate?
    David W Kimberlin
    J Pediatr 153:155-6. 2008
  40. ncbi request reprint Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants
    John P DeVincenzo
    University of Tennessee, LeBonheur Children s Medical Center, Memphis 38103, USA
    J Infect Dis 190:975-8. 2004
    ..Palivizumab bound to all 371 RSV isolates able to be evaluated, including 25 from active-palivizumab recipients. The palivizumab epitope appears to be highly conserved, even in infants receiving prophylaxis with palivizumab...
  41. ncbi request reprint Neonatal HSV infections: the global picture
    David W Kimberlin
    Herpes 11:31-2. 2004