Soo Hyun Kim

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain
    S H Kim
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 166:148-54. 2001
  2. ncbi Identification of amino acid residues critical for biological activity in human interleukin-18
    Soo Hyun Kim
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:10998-1003. 2002
  3. ncbi Interleukin-32: a cytokine and inducer of TNFalpha
    Soo Hyun Kim
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Immunity 22:131-42. 2005
  4. pmc A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
    Philip Bufler
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 99:13723-8. 2002
  5. pmc Differences in signaling pathways by IL-1beta and IL-18
    Jae Kwon Lee
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:8815-20. 2004
  6. ncbi Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF
    Rogier J L Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Cytokine 21:65-73. 2003
  7. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
  8. pmc Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide
    Philip Bufler
    Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
    Biochem J 381:503-10. 2004
  9. pmc IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism
    Mihai G Netea
    Divisions of Infectious Diseases and Pulmonary Science and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:16309-14. 2005
  10. ncbi The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma
    Leonid L Reznikov
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Interferon Cytokine Res 22:593-601. 2002

Collaborators

Detail Information

Publications56

  1. ncbi Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain
    S H Kim
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 166:148-54. 2001
    ..The synergism of IL-18 plus IL-12 for IFN-gamma production is, in part, due to IL-12 up-regulation of both IL-18R alpha and IL-18R beta chains, although postreceptor events likely contribute to IFN-gamma production...
  2. ncbi Identification of amino acid residues critical for biological activity in human interleukin-18
    Soo Hyun Kim
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:10998-1003. 2002
    ..The present study reveals that Glu-42 and Lys-89 are critical amino acid residues for the integrity of IL-18 structure and are important for binding to cell surface receptors, for signal transduction, and for neutralization by IL-18BP...
  3. ncbi Interleukin-32: a cytokine and inducer of TNFalpha
    Soo Hyun Kim
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Immunity 22:131-42. 2005
    ....
  4. pmc A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
    Philip Bufler
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 99:13723-8. 2002
    ..We propose that after binding to IL-18BP, IL-1F7b forms a complex with IL-18Rbeta, depriving the beta-chain of forming a functional receptor complex with IL-18Ralpha and thus inhibiting IL-18 activity...
  5. pmc Differences in signaling pathways by IL-1beta and IL-18
    Jae Kwon Lee
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:8815-20. 2004
    ..We conclude that in epithelial cells, IL-18 signal transduction is primarily via the MAPK p38 pathway rather than NF-kappaB, which may explain the absence of COX-2 and the failure of IL-18 to cause fever...
  6. ncbi Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF
    Rogier J L Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Cytokine 21:65-73. 2003
    ..In conclusion, S. epidermidis stimulates IFN-gamma which is IL-18, IL-12 and TNF-dependent, but IL-1 independent...
  7. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
    ..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system...
  8. pmc Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide
    Philip Bufler
    Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
    Biochem J 381:503-10. 2004
    ..These results indicate that both IL-1F7b and IL-18 mRNA contain functional instability determinants within their coding region, which influence mRNA decay as a novel mechanism to regulate the expression of IL-1 family members...
  9. pmc IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism
    Mihai G Netea
    Divisions of Infectious Diseases and Pulmonary Science and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:16309-14. 2005
    ..The modulation of intracellular NOD2 pathways by IL-32, but not cell-surface TLRs, and the marked expression of IL-32 in colon mucosa suggest a role of IL-32 in the pathogenesis of Crohn's disease...
  10. ncbi The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma
    Leonid L Reznikov
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Interferon Cytokine Res 22:593-601. 2002
    ..These studies reveal that the combination of the ligand-binding and the nonligand-binding extracellular domains of IL-18R is needed to inhibit IL-18, whereas IL-18BP neutralizes at equimolar concentration...
  11. doi IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages
    Xiyuan Bai
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver at Anschutz Medical Center, Denver, CO 80045, USA
    J Immunol 184:3830-40. 2010
    ..tuberculosis bacteria, which was modestly but significantly abrogated with a caspase-3 inhibitor. We conclude that IL-32 plays a host defense role against M. tuberculosis in differentiated THP-1 human macrophages...
  12. ncbi The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures
    Mihai G Netea
    Department of Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 185:963-70. 2002
    ..Blocking the biologic activities of IL-18, IL-12, and IL-1beta in patients (e.g., for treatment of autoimmune diseases) may result in increased susceptibility to C. albicans infection...
  13. ncbi Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein
    Nirmal K Banda
    Division of Rheumatology, Health Sciences Center, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 170:2100-5. 2003
    ..The mechanisms of mIL-18BP inhibition of CIA include reductions in cell-mediated and humoral immunity to collagen as well as decreases in production of proinflammatory cytokines in the spleen and joints...
  14. ncbi Endogenous IL-32 controls cytokine and HIV-1 production
    Marcel F Nold
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 181:557-65. 2008
    ..In summary, depletion of endogenous IL-32 reduced the levels of Th1 and proinflammatory cytokines but paradoxically increased p24, proposing IL-32 as a natural inhibitor of HIV-1...
  15. ncbi Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex
    Tania Azam
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 171:6574-80. 2003
    ....
  16. ncbi Generation and characterization of mice transgenic for human IL-18-binding protein isoform a
    Giamila Fantuzzi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 74:889-96. 2003
    ..These results indicate that high endogenous levels of IL-18BP in trangenic mice effectively neutralize IL-18 and are protective in response to different inflammatory stimuli...
  17. pmc Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 284:25900-11. 2009
    ....
  18. pmc IL-32-dependent effects of IL-1beta on endothelial cell functions
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 106:3883-8. 2009
    ..This study introduces IL-32 as a critical regulator of endothelial function, expanding the properties of this cytokine relevant to coagulation, endothelial inflammation, and atherosclerosis...
  19. ncbi Differential gene regulation by specific gain-of-function JNK1 proteins expressed in Swiss 3T3 fibroblasts
    Sun young Han
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:47167-74. 2002
    ..These findings reveal evidence for JNK isoform-selective gene regulation and support a role for distinct JNK isoforms in specific cellular responses...
  20. ncbi Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors
    Mihai G Netea
    Division of Infectious Diseases, B168 University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Leukoc Biol 80:1454-61. 2006
    ..This latter finding supports the concept that TREM-1 provides optimal amplification of cytokine-induced inflammation during the initiation of host defense...
  21. pmc Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
    Mihai G Netea
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:3515-20. 2008
    ..Thus, IL-32 not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells...
  22. ncbi Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, 80262, USA
    J Immunol 176:7753-60. 2006
    ..049 for TNFRII. These results demonstrate that stable patterns in the response of peripheral blood neutrophils to LPS exist in the human population and correlate with inflammatory response following direct exposure to LPS in the lung...
  23. ncbi Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone
    Jung Won Park
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 30:830-6. 2004
    ..In summary, acute exposure to O(3) induces AHR, neutrophilic inflammation, epithelial damage, and IL-1. An IL-1Ra effectively prevents the development of altered airway function, inflammation, and structural damage...
  24. pmc IL-32, a proinflammatory cytokine in rheumatoid arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
    Proc Natl Acad Sci U S A 103:3298-303. 2006
    ..IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases...
  25. doi Interleukin-32 monoclonal antibodies for immunohistochemistry, Western blotting, and ELISA
    Ki Hong Kim
    Department of Bioscience and Biotechnology, Konkuk University, Seoul 143 701, South Korea
    J Immunol Methods 333:38-50. 2008
    ..Our newly established mAbs, KU32-07, KU32-09, KU32-52, KU32-56, have different and useful properties for the detection of IL-32 by immunohistochemistry, ELISA, and Western blotting...
  26. pmc Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function
    A Mario Marcondes
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Department of Pathology, and Division of Oncology, University of Washington, Seattle, WA 98195
    Proc Natl Acad Sci U S A 105:2865-70. 2008
    ..We propose that IL-32 is a marrow stromal marker that distinguishes patients with MDS and CMML. Furthermore, IL-32 appears to contribute to the pathophysiology of MDS and may be a therapeutic target...
  27. doi Unique expression of a small IL-32 protein in the Jurkat leukemic T cell line
    Na Young Ko
    Department of Immunology, College of Medicine, Konkuk University, Chungju 380 701, Republic of Korea
    Cytokine 42:121-7. 2008
    ..Thus, the constitutive expression of IL-32 mRNA as well as the predominant production of a smaller sized IL-32 isoform in Jurkat cells may implicate a role for IL-32 in human T cell leukemia...
  28. ncbi Effects of a tetramethoxyhydroxyflavone p7f on the expression of inflammatory mediators in LPS-treated human synovial fibroblast and macrophage cells
    Do Young Yoon
    Division of Bioscience and Biotechnology, Konkuk University, Hwayang Dong 1, Kwangjin gu, Seoul 143 701, Korea
    J Microbiol Biotechnol 18:686-94. 2008
    ....
  29. ncbi The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines
    Sheetal Sharma
    Children s Hospital, Ludwig Maximilians University, Munich, Germany
    J Immunol 180:5477-82. 2008
    ....
  30. doi Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM
    Kyung Jin Kim
    Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang 790 784, Korea
    J Biol Chem 283:14032-40. 2008
    ..Thus, this work identified the two potential molecular interaction sites of AIMP3 and determined the residues critical for its tumor-suppressive activity through the interaction with ATM...
  31. pmc Absence of p16INK4a and truncation of ARF tumor suppressors in chickens
    Soo Hyun Kim
    Molecular Oncology, Cancer Research UK
    Proc Natl Acad Sci U S A 100:211-6. 2003
    ..As well as indicating that the locus has been subject to dynamic evolutionary pressures, these unexpected findings suggest that in chickens, the tumor-suppressor functions of INK4a have been compensated for by other genes...
  32. pmc The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
    Flavio Leoni
    Italfarmaco, SPA, 20092 Cinisello Balsamo, Italy
    Proc Natl Acad Sci U S A 99:2995-3000. 2002
    ..Because SAHA exhibits antiinflammatory properties in vivo and in vitro, inhibitors of histone deacetylase may stimulate the expression of genes that control the synthesis of cytokines and nitric oxide or hyperacetylate other targets...
  33. ncbi IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease
    Anne Corbaz
    Department of Experimental Biology and Pharmacology, Serono Pharmaceutical Research Institute, Geneva, Switzerland
    J Immunol 168:3608-16. 2002
    ..These results demonstrate that the appropriate neutralizing isoforms are present in the intestinal tissue of patients with active CD and highlights the complexity of IL-18/IL-18BP biology...
  34. ncbi Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
    ..In addition, rIL-18 reversed hyperglycemia in Il18-/- mice through activation of STAT3 phosphorylation. These findings indicate a new role of IL-18 in the homeostasis of energy intake and insulin sensitivity...
  35. ncbi Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor
    Do Young Yoon-
    Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Clin Chem Lab Med 42:499-506. 2004
    ..Our results thus suggest that IL-18 and IL-18 receptor, together, may play a role in immunoregulation or in inflammation by augmenting the levels of IL-18 and reactive oxygen species in C33A cells...
  36. ncbi Rat interleukin-18 binding protein: cloning, expression, and characterization
    Sin Hyeog Im
    Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    J Interferon Cytokine Res 22:321-8. 2002
    ..Thus, rat IL-18BP can be employed to antagonize the proinflammatory responses induced by endogenous IL-18 in rat models of autoimmune diseases...
  37. ncbi Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene
    Runa L Nolsøe
    Steno Diabetes Center, Gentofte, Denmark
    Ann N Y Acad Sci 1005:332-9. 2003
    ..However, none of these were frequent enough to permit association studies in T1DM and we conclude that IL18BP does not contribute to the overall genetic susceptibility to type 1 diabetes...
  38. ncbi Metallothionein-III prevents gamma-ray-induced 8-oxoguanine accumulation in normal and hOGG1-depleted cells
    Hye Gwang Jeong
    Research Center for Proteineous Materials, Chosun University, 375 Seosuk dong, Gwangju 501 759, Korea
    J Biol Chem 279:34138-49. 2004
    ....
  39. ncbi Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment
    Mi Rha Lee
    Research Center for Proteineous Materials, Chosun University, 375 Seosuk dong, Gwangju 501 759, Korea
    J Biol Chem 279:9857-66. 2004
    ....
  40. pmc A surface amebic cysteine proteinase inactivates interleukin-18
    Xuchu Que
    Department of Pathology, University of California, San Diego, California 92103, USA
    Infect Immun 71:1274-80. 2003
    ..E. histolytica may block the host inflammatory response by a novel mechanism, inactivation of IL-18...
  41. pmc Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability
    In Youb Chang
    Research Center for Proteinous Materials, Chosun University, 375 Seusuk dong, Gwangju 501 759, Korea
    Nucleic Acids Res 33:5073-81. 2005
    ..The APE-mediated decrease in MMR activity described here demonstrates the presence of a new and highly effective APE-mediated mechanism for MSI...
  42. pmc Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites
    Soong Lee
    Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea
    World J Gastroenterol 14:3884-90. 2008
    ..To determine intestinal permeability, the serum tumor necrosis factor (TNF)-alpha level and urine nitric oxide (NO) metabolites are altered in liver cirrhosis (LC) with or without ascites...
  43. pmc Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator
    Youli Hu
    Centre for Neuroendocrinology, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
    Biochem J 384:495-505. 2004
    ..91 nM) was demonstrated by SPR. We thus propose that anosmin-1 may modulate the catalytic activity of uPA and its signalling pathway, whereas HS determines cell surface localization of the anosmin-1-uPA complex...
  44. doi A novel adipokine CTRP1 stimulates aldosterone production
    Jun Ho Jeon
    Department of Life Science, Sookmyung Women s University, Seoul 140 742, Korea
    FASEB J 22:1502-11. 2008
    ..As CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension...
  45. ncbi Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level
    Jun Jaekal
    Laboratory of Cytokine Immunology, Institute of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Korea
    J Microbiol Biotechnol 17:1862-7. 2007
    ..The present study therefore suggests that the constitutive expression levels of TLR2 and TLR4 may contribute to the individual response to LPS...
  46. ncbi IL-18 E42A mutant is resistant to the inhibitory effects of HPV-16 E6 and E7 oncogenes on the IL-18-mediated immune response
    Kyung Ae Lee
    Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology, Yuseong, P O Box 115, Daejeon 305 600, South Korea
    Cancer Lett 229:261-70. 2005
    ..Thus, it is suggested that E42A could be used in immunotherapy for patients with cervical cancer...
  47. pmc Proteinase 3 is an IL-32 binding protein
    Daniela Novick
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 103:3316-21. 2006
    ..Therefore, specific inhibition of PR3 activity to process IL-32 or neutralization of IL-32 by inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases...
  48. ncbi Upregulation of chicken p15INK4b at senescence and in the developing brain
    Soo Hyun Kim
    Molecular Oncology, Cancer Research UK London Research Institute, Lincoln s Inn Fields, London, WC2A 3PX, UK
    J Cell Sci 119:2435-43. 2006
    ..Although ARF RNA is not detectable in early chicken embryos, the INK4b transcript is expressed in the roof-plate of the developing hind-brain, consistent with a role in limiting cell proliferation...
  49. ncbi Induction of thymocyte apoptosis by systemic administration of concanavalin A in mice: role of TNF-alpha, IFN-gamma and glucocorticoids
    Raja Fayad
    Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Eur J Immunol 35:2304-12. 2005
    ..These data demonstrate that the thymus is a critical target organ of Con A-induced inflammation; the effects of Con A on the thymus are mediated by extrathymic production of TNF-alpha and IFN-gamma, but not by glucocorticoids...
  50. ncbi E7-expressing HaCaT keratinocyte cells are resistant to oxidative stress-induced cell death via the induction of catalase
    Jung Hyun Shim
    Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology, Daejeon
    Proteomics 5:2112-22. 2005
    ..These results suggest that the HPV 16 E7 oncogene induces higher resistance to ROS-induced cell injury in the E7-infected cells, probably via the modulation of several anti-oxidant enzymes, including catalase...
  51. ncbi Small interfering RNA-induced suppression of ERCC1 enhances sensitivity of human cancer cells to cisplatin
    In Youb Chang
    Research Center for Proteineous Materials, Chosun University, 375 Seosuk dong, Gwangju 501 759, Republic of Korea
    Biochem Biophys Res Commun 327:225-33. 2005
    ....
  52. ncbi A simple method to screen ligands of peroxisome proliferator-activated receptor delta
    Min Chul Cho
    Department of Bioscience and Biotechnology, Konkuk University, Seoul 143 701, Republic of Korea
    Eur J Pharm Sci 29:355-60. 2006
    ..We optimized and developed a novel and useful ELISA system for the mass screening of PPARdelta ligands. This screening system may be useful in the development of drugs for metabolic disorders and skin disorders...
  53. ncbi Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity
    Cha Kyung Youn
    Department of Pharmacology, School of Medicine, Chosun University, 375 Seusuk dong, Gwangju 501 759, South Korea
    Nat Cell Biol 7:137-47. 2005
    ..MMR has a key role in protection against deleterious mutation accumulation and in maintaining genomic stability. Therefore, the decreased MMR activity by Bcl-2 may be an underlying mechanism for Bcl-2-promoted oncogenesis...
  54. ncbi The apoptotic effect of intercalating agents on HPV-negative cervical cancer C-33A cells
    Yun Hee Kang
    Department of Bioscience and Biotechnology, Konkuk University, Seoul, South Korea
    Amino Acids 33:105-12. 2007
    ....
  55. ncbi Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism
    David González-Martínez
    Centre for Neuroendocrinology, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    J Neurosci 24:10384-92. 2004
    ....
  56. ncbi Cytotoxic effect of buckwheat (Fagopyrum esculentum Moench) hull against cancer cells
    Soo Hyun Kim
    School of Food Bioscience and Biotechnology, Kangwon National University, Republic of Korea
    J Med Food 10:232-8. 2007
    ..From these results, it is suggested that buckwheat hull possesses anticancer properties against a variety of different cancer cell lines...