Reuben H Kim

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes
    Reuben H Kim
    School of Dentistry at UCLA, Los Angeles, CA 90095, USA
    Exp Cell Res 313:462-72. 2007
  2. pmc Camphorquinone inhibits odontogenic differentiation of dental pulp cells and triggers release of inflammatory cytokines
    Reuben H Kim
    UCLA School of Dentistry, Los Angeles, California, USA
    J Endod 39:57-61. 2013
  3. pmc Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling
    Reuben H Kim
    UCLA School of Dentistry, Center for the Health Sciences, Room 43 091, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    Exp Cell Res 316:2600-8. 2010
  4. pmc Bisphosphonates induce senescence in normal human oral keratinocytes
    R H Kim
    UCLA School of Dentistry, Center for the Health Sciences, Room 43 091, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    J Dent Res 90:810-6. 2011
  5. pmc Impaired odontogenic differentiation of senescent dental mesenchymal stem cells is associated with loss of Bmi-1 expression
    Shebli Mehrazarin
    UCLA School of Dentistry, Los Angeles, CA, USA
    J Endod 37:662-6. 2011
  6. doi request reprint Radioprotective effects of Bmi-1 involve epigenetic silencing of oxidase genes and enhanced DNA repair in normal human keratinocytes
    Qinghua Dong
    UCLA School of Dentistry, Center for the Health Sciences, Los Angeles, California 90095, USA
    J Invest Dermatol 131:1216-25. 2011
  7. pmc Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells
    Reuben H Kim
    University of California, Los Angeles School of Dentistry, Center for the Health Sciences, Los Angeles, CA 90095, USA
    Carcinogenesis 29:2425-31. 2008
  8. pmc p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G
    Ki Hyuk Shin
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    DNA Repair (Amst) 6:830-40. 2007
  9. pmc Efavirenz induces autophagy and aberrant differentiation in normal human keratinocytes
    Qinghua Dong
    School of Dentistry, University of California, Los Angeles, CA, USA
    Int J Mol Med 31:1305-12. 2013
  10. pmc hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip
    Ki Hyuk Shin
    School of Dentistry, University of California, CHS 43 033, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 372:880-5. 2008

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes
    Reuben H Kim
    School of Dentistry at UCLA, Los Angeles, CA 90095, USA
    Exp Cell Res 313:462-72. 2007
    ..Our results provide new information on the roles of Bmi-1 and HPV-16 E6 in the multi-step process of oral epithelial carcinogenesis...
  2. pmc Camphorquinone inhibits odontogenic differentiation of dental pulp cells and triggers release of inflammatory cytokines
    Reuben H Kim
    UCLA School of Dentistry, Los Angeles, California, USA
    J Endod 39:57-61. 2013
    ..In order to understand the mechanisms of CQ-induced side effects, we investigated the effect of CQ on cell viability, cytokine secretion, and odontogenic differentiation of dental pulp stem cells in vitro...
  3. pmc Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling
    Reuben H Kim
    UCLA School of Dentistry, Center for the Health Sciences, Room 43 091, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    Exp Cell Res 316:2600-8. 2010
    ..Taken together, these data suggest that Bmi-1 suppresses senescence of cells by inhibiting the TGF-beta signaling pathway in NHOK...
  4. pmc Bisphosphonates induce senescence in normal human oral keratinocytes
    R H Kim
    UCLA School of Dentistry, Center for the Health Sciences, Room 43 091, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    J Dent Res 90:810-6. 2011
    ..Analysis of these data indicates that premature senescence of oral mucosal cells and subsequent defective soft-tissue wound healing might be partly responsible for the development of BRONJ in individuals receiving PAM or other BPs...
  5. pmc Impaired odontogenic differentiation of senescent dental mesenchymal stem cells is associated with loss of Bmi-1 expression
    Shebli Mehrazarin
    UCLA School of Dentistry, Los Angeles, CA, USA
    J Endod 37:662-6. 2011
    ..Dental mesenchymal stem cells (dMSCs) might differentiate into odontoblast-like cells and form mineralized nodules. In the current study, we investigated the effects of senescence on odontogenic differentiation of dMSCs...
  6. doi request reprint Radioprotective effects of Bmi-1 involve epigenetic silencing of oxidase genes and enhanced DNA repair in normal human keratinocytes
    Qinghua Dong
    UCLA School of Dentistry, Center for the Health Sciences, Los Angeles, California 90095, USA
    J Invest Dermatol 131:1216-25. 2011
    ..These results indicate that Bmi-1 elicits radioprotective effects on NHK by mitigating the genotoxicity of IR through epigenetic mechanisms...
  7. pmc Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells
    Reuben H Kim
    University of California, Los Angeles School of Dentistry, Center for the Health Sciences, Los Angeles, CA 90095, USA
    Carcinogenesis 29:2425-31. 2008
    ....
  8. pmc p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G
    Ki Hyuk Shin
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    DNA Repair (Amst) 6:830-40. 2007
    ..Our results suggest that wt p53 modulates DNA DSB repair by, in part, inducing hnRNP G, and the ability of hnRNP G to bind and protect DNA ends may contribute its ability to promote the fidelity of DNA EJ...
  9. pmc Efavirenz induces autophagy and aberrant differentiation in normal human keratinocytes
    Qinghua Dong
    School of Dentistry, University of California, Los Angeles, CA, USA
    Int J Mol Med 31:1305-12. 2013
    ..Our data indicate that EFV elicits cytotoxic effects on NHKs in part through induction of autophagy and aberrant differentiation of cells...
  10. pmc hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip
    Ki Hyuk Shin
    School of Dentistry, University of California, CHS 43 033, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 372:880-5. 2008
    ..These studies indicate that hnRNP G promotes the expression of Txnip and mediates its tumor-suppressive effect...
  11. pmc Identification of senescence-inducing microRNAs in normal human keratinocytes
    Ki Hyuk Shin
    School of Dentistry, UCLA, Los Angeles, CA 90024, USA
    Int J Oncol 39:1205-11. 2011
    ..Since senescence would be viewed as a potent tumor suppressive pathway, the newly identified senescence-inducing miRNAs deserve to be further investigated for their therapeutic application in cancer treatment...
  12. pmc DeltaNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes
    Ju Eun Oh
    School of Dentistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 286:38757-67. 2011
    ..Furthermore, these cells expressed enhanced levels of Nanog and Lin28, which are transcription factors associated with pluripotency. These data indicate that EMT required ΔNp63α transduction and intact TGF-β signaling in NHEK...
  13. pmc Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes
    Wei Chen
    School of Dentistry, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 285:40852-63. 2010
    ..Also, knockdown of endogenous GRHL2 led to hypermethylation of the promoter. These results indicate that GRHL2 regulates the hTERT expression through an epigenetic mechanism and controls the cellular life span...
  14. ncbi request reprint HIV-1 Tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome
    Reuben H Kim
    UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    Int J Oncol 33:777-82. 2008
    ..Our results indicate that HIV could play a role in the HPV-associated pathogenesis by exerting oncogenic stimulus via Tat protein...
  15. pmc Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer
    Ki Hyuk Shin
    School of Dentistry, University of California, Los Angeles, CA, USA
    Oral Oncol 47:1011-6. 2011
    ..e., point mutation and exonic deletion. This study suggest that genetic alterations and aberrant expression of hnRNP G occurring during oral carcinogenesis might be useful markers for the early detection of human oral cancer...
  16. ncbi request reprint Abnormal DNA end-joining activity in human head and neck cancer
    Ki Hyuk Shin
    UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    Int J Mol Med 17:917-24. 2006
    ..These data indicated that aberrant DNA EJ activity may be partly responsible for genetic instability and oncogenic transformation...
  17. ncbi request reprint Heterogeneous nuclear ribonucleoprotein G shows tumor suppressive effect against oral squamous cell carcinoma cells
    Ki Hyuk Shin
    School of Dentistry, University of California, Los Angeles, California 90095 1668, USA
    Clin Cancer Res 12:3222-8. 2006
    ..The current study was designed to test the hypothesis that hnRNP G is a tumor suppressor...
  18. ncbi request reprint Senescence-associated decline in the intranuclear accumulation of hOGG1-alpha and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo
    Mo K Kang
    UCLA School of Dentistry, CHS 43 009, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, USA
    Exp Cell Res 310:186-95. 2005
    ..These results indicated that senescing NHOK accumulated oxidative DNA lesions in part due to increased level of endogenous ROS and impaired intranuclear translocation of hOGG1 enzyme upon exposure to oxidative stress...
  19. ncbi request reprint Development of oral osteomucosal tissue constructs in vitro and localization of fluorescently-labeled bisphosphonates to hard and soft tissue
    Susan Bae
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Int J Mol Med 34:559-63. 2014
    ..Collectively, the data from the present study suggest that N-BPs localize to epithelial tissue and that such a localization and subsequent toxicity of N-BPs may be associated, at least in part, with soft tissue-related side-effects. ..
  20. pmc 2-Hydroxyethyl methacrylate inhibits migration of dental pulp stem cells
    Drake W Williams
    UCLA School of Dentistry, Los Angeles, California 90095, USA
    J Endod 39:1156-60. 2013
    ..Here, we investigated the effects of 2-hydroxyethyl methacrylate (HEMA) on the migration of dental pulp stem cells (DPSC) in vitro...
  21. pmc TNFα enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells
    Sung Hee Lee
    School of Dentistry, University of California, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 424:58-64. 2012
    ..In conclusion, inflammatory cytokine exposure may enhance CSC phenotype of OSCC, in part by activating the Notch-Hes1 pathway...
  22. ncbi request reprint miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras
    Ki Hyuk Shin
    School of Dentistry, University of California, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 404:896-902. 2011
    ..In conclusion, miR-181a may function as an OSCC suppressor by targeting on K-ras oncogene. Thus, miR-181a should be considered for therapeutic application for OSCC...
  23. ncbi request reprint The telomeric length and heterogeneity decrease with age in normal human oral keratinocytes
    Mo K Kang
    Dental Research Institute, University of California, 73 017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, USA
    Mech Ageing Dev 123:585-92. 2002
    ..The short telomere length and decreased telomeric length heterogeneity in immortalized cells suggested that there is a critical minimum for cell survival...
  24. pmc Therapeutic potential of mesenchymal stem cells for oral and systemic diseases
    Reuben H Kim
    Division of Restorative Dentistry, University of California Los Angeles School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Dent Clin North Am 56:651-75. 2012
    ..It also addresses challenges to MSC-mediated therapeutics arising from tissue and MSC aging and host immune response against allogenic MSC transplantation, and discusses alternative sources of MSCs aimed at overcoming these limitations...