Kyung Mee Kim

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid
    Kyung Mee Kim
    Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2032-8. 2009
  2. pmc Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress
    Christine Gersch
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
    Nucleosides Nucleotides Nucleic Acids 28:118-49. 2009
  3. pmc Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry
    Witcha Imaram
    Department of Chemistry, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 49:275-81. 2010
  4. pmc Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry
    Kyung Mee Kim
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, FL 32610 0226, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:65-70. 2009
  5. pmc Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 20:545-53. 2009
  6. pmc Inactivation of nitric oxide by uric acid
    Christine Gersch
    Department of Medicine, Division of Nephrology and Hypertension, University of Florida, Gainesville, Florida 32610, USA
    Nucleosides Nucleotides Nucleic Acids 27:967-78. 2008
  7. ncbi request reprint Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease
    Carlos Roncal
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1391-6. 2007

Collaborators

Detail Information

Publications7

  1. pmc A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid
    Kyung Mee Kim
    Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2032-8. 2009
    ..10 to 103.59% and 98.74 to 106.12% for in vivo and in vitro analyses, respectively. This study demonstrates that intracellular levels of UA can be measured using LC-MS/MS with isotope labeled UA as an internal standard...
  2. pmc Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress
    Christine Gersch
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
    Nucleosides Nucleotides Nucleic Acids 28:118-49. 2009
    ..These reactive intermediates could possibly explain how uric acid contributes to the pathogenesis of diseases such as the metabolic syndrome and hypertension...
  3. pmc Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry
    Witcha Imaram
    Department of Chemistry, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 49:275-81. 2010
    ..The ions of m/z 352 were characterized as the PBN-triuretcarbonyl radical adduct and the m/z 223 ion was identified as the PBN-aminocarbonyl radical adduct. Their mechanism of formation is discussed...
  4. pmc Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry
    Kyung Mee Kim
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, FL 32610 0226, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:65-70. 2009
    ..The new method was used to show that smoking, which can induce oxidative stress, is associated with elevated triuret levels in urine. Thus, the method may be helpful in identifying pathways of oxidative stress in biological samples...
  5. pmc Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 20:545-53. 2009
    ..Fructose increased intracellular uric acid, and uric acid induced production of MCP-1 as well. In summary, postprandial concentrations of fructose stimulate redox- and urate-dependent inflammatory mediators in proximal tubular cells...
  6. pmc Inactivation of nitric oxide by uric acid
    Christine Gersch
    Department of Medicine, Division of Nephrology and Hypertension, University of Florida, Gainesville, Florida 32610, USA
    Nucleosides Nucleotides Nucleic Acids 27:967-78. 2008
    ..This study shows a potential mechanism by which UA may deplete NO and cause endothelial dysfunction, particularly under conditions of oxidative stress in which UA is elevated and intracellular glutathione is depleted...
  7. ncbi request reprint Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease
    Carlos Roncal
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1391-6. 2007
    ..In conclusion, lead accelerates chronic renal disease, primarily by raising blood pressure and accelerating microvascular and tubulointerstitial injury...