Jae-Sung Kim

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy
    John J Lemasters
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599 7090, USA
    Antioxid Redox Signal 4:769-81. 2002
  2. ncbi request reprint Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes
    Jae Sung Kim
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill, 27599, USA
    Gastroenterology 124:494-503. 2003
  3. doi request reprint Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes
    Jae Sung Kim
    Department of Surgery, University of Florida, Gainesville, FL, USA
    Hepatology 47:1725-36. 2008
  4. pmc Carbamazepine suppresses calpain-mediated autophagy impairment after ischemia/reperfusion in mouse livers
    Jae Sung Kim
    Department of Surgery, University of Florida, Gainesville, FL 32610, USA Electronic address
    Toxicol Appl Pharmacol 273:600-10. 2013
  5. pmc Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells
    Bonggoo Park
    College of Pharmacy, Gachon University, Incheon, Korea
    BMC Complement Altern Med 13:194. 2013
  6. pmc Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species
    Jae Sung Kim
    Univ of Florida, Dept of Surgery, Gainesville, FL 32610, USA
    Am J Physiol Gastrointest Liver Physiol 302:G723-31. 2012
  7. doi request reprint Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
    Takashi Nitta
    Department of Surgery, Division of General and Gastrointestinal GI Surgery, University of Florida, Gainesville, FL, USA
    Hepatology 48:909-19. 2008
  8. pmc Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species
    Dalliah Black
    Department of Surgery, 4024 Burnett Womack Building, CB 7050, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Biochimie 89:1464-73. 2007
  9. pmc Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes
    Jay Raval
    Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
    Free Radic Biol Med 41:1645-54. 2006
  10. pmc Opioid receptor-independent protection of ischemic rat hepatocytes by morphine
    Jae Sung Kim
    Department of Surgery, University of Florida, Gainesville, FL 32610, USA
    Biochem Biophys Res Commun 351:958-64. 2006

Research Grants

  1. Autophagy in liver injury
    Jae Sung Kim; Fiscal Year: 2010

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy
    John J Lemasters
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599 7090, USA
    Antioxid Redox Signal 4:769-81. 2002
    ....
  2. ncbi request reprint Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes
    Jae Sung Kim
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill, 27599, USA
    Gastroenterology 124:494-503. 2003
    ..Here, we investigated factors regulating how cell death switches from necrosis to apoptosis after ischemia/reperfusion injury...
  3. doi request reprint Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes
    Jae Sung Kim
    Department of Surgery, University of Florida, Gainesville, FL, USA
    Hepatology 47:1725-36. 2008
    ..Conclusion: Calpain 2-mediated degradation of Atg7 and Beclin-1 impairs mitochondrial autophagy, and this subsequently leads to MPT-dependent hepatocyte death after A/R...
  4. pmc Carbamazepine suppresses calpain-mediated autophagy impairment after ischemia/reperfusion in mouse livers
    Jae Sung Kim
    Department of Surgery, University of Florida, Gainesville, FL 32610, USA Electronic address
    Toxicol Appl Pharmacol 273:600-10. 2013
    ..In conclusion, CBZ prevents calcium overloading and calpain activation, which, in turn, suppresses Atg7 and Beclin-1 depletion, defective autophagy, onset of the MPT and cell death after I/R...
  5. pmc Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells
    Bonggoo Park
    College of Pharmacy, Gachon University, Incheon, Korea
    BMC Complement Altern Med 13:194. 2013
    ..Protopanaxadiol (PPD) exhibits the highest cytotoxic effect among 8 ginsenosides which we evaluated for anti-cancer activity. We investigated if PPD disrupts lipid rafts in its cytotoxic effects and also the possible mechanisms...
  6. pmc Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species
    Jae Sung Kim
    Univ of Florida, Dept of Surgery, Gainesville, FL 32610, USA
    Am J Physiol Gastrointest Liver Physiol 302:G723-31. 2012
    ..In conclusion, Ca(2+)-dependent mitochondrial ROS formation is the molecular signal culminating in onset of the MPT after reoxygenation of anoxic hepatocytes, leading to cell death...
  7. doi request reprint Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
    Takashi Nitta
    Department of Surgery, Division of General and Gastrointestinal GI Surgery, University of Florida, Gainesville, FL, USA
    Hepatology 48:909-19. 2008
    ..CLDH demonstrated increased basal p-extracellular signal-regulated kinase expression that was independent of Smad and PI3K/Akt signaling. Inhibition of the MAPK pathway produced a marked increase in CLDH apoptosis...
  8. pmc Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species
    Dalliah Black
    Department of Surgery, 4024 Burnett Womack Building, CB 7050, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Biochimie 89:1464-73. 2007
    ..In conclusion, TGFbeta-induced hepatocyte apoptosis occurs through Smad3 dependent activation of ROS with subsequent activation of the MPT and caspases...
  9. pmc Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes
    Jay Raval
    Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
    Free Radic Biol Med 41:1645-54. 2006
    ..In conclusion, cirrhotic hepatocytes have a nonfocal distribution of ROS. However, normal and cirrhotic hepatocytes exhibit mitochondrial localization of ROS that is necessary for apoptosis...
  10. pmc Opioid receptor-independent protection of ischemic rat hepatocytes by morphine
    Jae Sung Kim
    Department of Surgery, University of Florida, Gainesville, FL 32610, USA
    Biochem Biophys Res Commun 351:958-64. 2006
    ..These results indicate that morphine prevents anoxia/reoxygenation injury to hepatocytes. Protective mechanisms are associated with the potassium channels and NO, but are independent of opioid receptor-mediated signaling...
  11. ncbi request reprint Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition
    Jae Sung Kim
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Hepatology 39:1533-43. 2004
    ....
  12. ncbi request reprint Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes
    Kazuyoshi Kon
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, 27599 7090, USA
    Hepatology 40:1170-9. 2004
    ..The MPT then induces ATP depletion-dependent necrosis or caspase-dependent apoptosis as determined, in part, by ATP availability from glycolysis...
  13. pmc Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury
    Akira Uchiyama
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Hepatology 48:1644-54. 2008
    ....
  14. ncbi request reprint Mitochondrial permeability transition: a common pathway to necrosis and apoptosis
    Jae Sung Kim
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, CB 7090, 236 Taylor Hall, Chapel Hill, NC 27599 7090, USA
    Biochem Biophys Res Commun 304:463-70. 2003
    ..Thus, the MPT is a common pathway leading to both necrotic and apoptotic cell death after ischemia/reperfusion...

Research Grants2

  1. Autophagy in liver injury
    Jae Sung Kim; Fiscal Year: 2010
    ..Better understanding of the mechanisms underlying ischemia/reperfusion injury would establish novel therapeutic approaches for improving liver function after liver surgery. ..