Research Topics
Genomes and Genes | Hyung Suk KimSummaryAffiliation: University of North Carolina Country: USA Publications
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Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cellsH S Kim
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
J Biol Chem 274:14210-7. 1999....
Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titrationHyung Suk Kim
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Proc Natl Acad Sci U S A 99:4602-7. 2002..06) than in males (P = 0.001). The marked gender differences in gene expression in wild-type mice and the changes induced by moderate alterations in Agt expression and BP emphasize the need to look for similar differences in humans...- Homeostatic responses in the adrenal cortex to the absence of aldosterone in miceGene Lee
Department of Pathology and Laboratory Medicine, University of North Carolina, 703 Brinkhous Bullitt Building, Chapel Hill, North Carolina 27599 7525, USA
Endocrinology 146:2650-6. 2005.... - Reduced alpha-lipoic acid synthase gene expression exacerbates atherosclerosis in diabetic apolipoprotein E-deficient miceXianwen Yi
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599 7525, USA
Atherosclerosis 223:137-43. 2012..To study the effects of reduced lipoic acid gene expression on diabetic atherosclerosis in apolipoprotein E null mice (Apoe(-/-))... - Kidney function in mice lacking aldosteroneNatalia Makhanova
Dept of Pathology and Laboratory Medicine, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
Am J Physiol Renal Physiol 290:F61-9. 2006..Our data show the substantial correction of these abnormalities, except the low blood pressure, by high dietary salt does not depend on aldosterone... - Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-typeNobuyuki Takahashi
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
J Am Soc Nephrol 16:125-32. 2005..These results demonstrate that renin is the only enzyme capable of maintaining plasma angiotensins and that renin expression in the kidney is very tightly regulated at the mRNA level... - Reduced expression of lipoic acid synthase accelerates diabetic nephropathyXianwen Yi
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
J Am Soc Nephrol 23:103-11. 2012..These results suggest that lipoic acid synthase deficiency increases oxidative stress and accelerates the development of diabetic nephropathy... - Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A geneToshio Nishikimi
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
Cardiovasc Res 66:94-103. 2005..Contribution of the natriuretic peptide system to the development of heart failure (HF) in vivo was examined using mice lacking or having decreased natriuretic peptide receptor-A (NPRA), a guanylyl cyclase-linked receptor... - A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathyChih Hong Wang
Department of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 108:2070-5. 2011..Our data demonstrate that a modest decrease in eNOS, comparable to that associated with human NOS3 variants, is sufficient to enhance diabetic nephropathy independently of its effects on BP... - Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic miceMasao Kakoki
Department of Pathology and Laboratory Medicine and Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 107:10190-5. 2010..The enhanced renal injury in diabetic mice caused by lack of B1R and B2R may be mediated by a combination of increases in oxidative stress, mitochondrial DNA damage and over expression of fibrogenic genes... - Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgammaYau Sheng Tsai
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Clin Invest 114:240-9. 2004..These results provide genetic evidence for a critical role for PPARgamma in blood pressure regulation that is not dependent on altered insulin sensitivity... - Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null miceAvani A Pendse
Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, 710 Brinkhous Bullitt Bldg, Chapel Hill, NC 27599 7525, USA
Arterioscler Thromb Vasc Biol 32:1436-44. 2012..We hypothesized that the equivalent mutation, PPARγ-P465L, in mice will worsen atherosclerosis... - Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptorsMasao Kakoki
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
J Clin Invest 116:1302-9. 2006..Thus, absence of the bradykinin B2 receptor increases the oxidative stress, mitochondrial DNA damage, and many senescence-associated phenotypes already present in untreated Akita diabetic mice... - Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgeneKathleen M I Caron
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 101:3106-11. 2004.... - Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in miceJeffrey B Hodgin
Department of Pathology and Laboratory Medicine, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 27599 7525, USA
J Clin Invest 109:541-8. 2002..Endogenous sex hormones, on the other hand, cause significant damage to the vasculature in the absence of eNOS, but these effects are overridden by interactions between eNOS and sex hormones... - Genetic reduction of lipoic acid synthase expression modestly increases atherosclerosis in male, but not in female, apolipoprotein E-deficient miceXianwen Yi
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC 27599 7525, USA
Atherosclerosis 211:424-30. 2010..To evaluate the effects of a genetic reduction of Lias gene expression on atherosclerosis development... - eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotypeFeng Li
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
J Am Soc Nephrol 23:652-60. 2012..In conclusion, reduced maternal eNOS/nitric oxide exacerbates the sFlt1-related pre-eclampsia-like phenotype through activation of the endothelin system... - Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in malesKathleen Caron
Department of Cell and Molecular Physiology and Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 104:3420-5. 2007..These observations suggest that the effect of gender on the role of AM in counteracting cardiovascular damage in humans merits careful evaluation... - Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking reninNobuyuki Takahashi
Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Cell Metab 6:506-12. 2007..Most of the metabolic changes in Ren1c(-/-) mice were reversed by angiotensin II administration. These results support a role for angiotensin II in the pathogenesis of diet-induced obesity and insulin resistance... - Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetiteRaymond Fox
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 108:8779-84. 2011..We conclude that reduced diabetic symptoms of aging Polg-Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis... - Minireview: computer simulations of blood pressure regulation by the renin-angiotensin systemNobuyuki Takahashi
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
Endocrinology 144:2184-90. 2003..This emphasizes that the value of these types of simulation lies in the thoughts that they provoke rather than in their ability to replicate experimental data... - Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptorLance A Johnson
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Diabetes 60:2285-94. 2011..We investigated the differential roles of apolipoprotein E (apoE) isoforms in modulating diabetic dyslipidemia-a potential cause of the increased cardiovascular disease risk of patients with diabetes... - Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammationLance A Johnson
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Lipid Res 54:386-96. 2013.... - Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injuryMasao Kakoki
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Proc Natl Acad Sci U S A 104:7576-81. 2007..Thus, both the B1 and B2 bradykinin receptors play an important role in reducing DNA damage, apoptosis, morphological and functional kidney changes, and mortality during renal ischemia/reperfusion injury... - Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4Jose M Arbones-Mainar
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Bldg, Chapel Hill, NC 27599 7525, USA
FASEB J 24:3809-18. 2010..We conclude that the effects of TZDs are APOE isoform dependent, and that the metabolic damage observed in APOE4 mice is rooted in an impaired activation of the adipogenic program in the adipose tissues expressing APOE4... - Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivoKumar Pandya
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 103:16864-9. 2006..We conclude that beta-MHC gene expression in the normal aging adult and hypertrophic mouse heart is a marker of fibrosis rather than of cellular hypertrophy... - Salt-sensitive blood pressure in mice with increased expression of aldosterone synthaseNatalia Makhanova
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
Hypertension 51:134-40. 2008.... - Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injuryXianwen Yi
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Bldg, Chapel Hill, NC 27599 7525, USA
J Leukoc Biol 85:146-53. 2009..These data demonstrate the importance of endogenously produced LA for preventing leukocyte accumulation and tissue injury that result from LPS-induced inflammation... - A mouse strain where basal connective tissue growth factor gene expression can be switched from low to highHeather E Doherty
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
PLoS ONE 5:e12909. 2010.... - Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitroJeffrey H Fair
Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 102:2958-63. 2005..The PEP engraftment was not associated with detectable cell fusion, and the transplantation was accompanied with only a low incidence of teratoma formation... - Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivoKumar Pandya
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 105:13063-8. 2008.... - Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefactionCinzia Perrino
Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 116:1547-60. 2006..Thus stress-induced activation of pathogenic signaling pathways, not the duration of stress or the hypertrophic growth per se, is the molecular trigger of cardiac dysfunction... - A genetically clamped renin transgene for the induction of hypertensionKathleen M I Caron
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 99:8248-52. 2002.... - Physiological impact of increased expression of the AT1 angiotensin receptorThu H Le
Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
Hypertension 42:507-14. 2003..The impact of enhanced AT1 receptor expression on blood pressure may be blunted by systemic compensatory responses and altered signal-effector coupling in the vasculature... - Arterial stiffness and angiotensinogen gene in hypertensive patients and mutant miceErwan Bozec
Department of Pharmacology, Hôpital Européen Georges Pompidou and Institut National de la Santé et de la Recherche Médicale EMI 0107, Paris, France
J Hypertens 22:1299-307. 2004.... - Prostacyclin protects against elevated blood pressure and cardiac fibrosisHelene Francois
Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705
Cell Metab 2:201-7. 2005..Our data suggest that adjuvant therapy that blocks unrestrained Tx actions might protect against end-organ damage without affecting blood pressure in patients taking COX-2 inhibitors... - Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin systemSteven D Crowley
Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705, USA
J Clin Invest 115:1092-9. 2005..Thus, the regulation of blood pressure by the RAS is mediated by AT(1) receptors both within and outside the kidney... - Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruptionNatalia Makhanova
Department of Pathology and Laboratory Medicine, University of Virginia, Charlottesville, USA
Hypertension 48:1151-9. 2006.... - A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient miceThu H Le
Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham 27705, USA
Physiol Genomics 18:290-8. 2004.... - Lifelong genetic minipumpsKathleen M I Caron
Department of Cell and Molecular Physiology, University of North Carolina-CH
Physiol Genomics 20:203-9. 2005..The procedure and DNA constructs we describe can be used to generate genetic minipumps for controlling plasma levels of a wide variety of secreted protein products... - Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidneySteven D Crowley
Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 103:17985-90. 2006..Further, they suggest that the major mechanism of action of RAS inhibitors in hypertension is attenuation of angiotensin II effects in the kidney... - Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertensionSteven D Crowley
Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA
Am J Physiol Renal Physiol 295:F515-24. 2008..These proinflammatory actions of ANG II seem to have a proclivity for inducing kidney injury while having negligible actions in the pathogenesis of cardiac hypertrophy... - Lipocalin-type prostaglandin D synthase is up-regulated in oligodendrocytes in lysosomal storage diseases and binds gangliosidesIkuko Mohri
Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Neurochem 97:641-51. 2006..This suggests that L-PGDS may play a role in scavenging harmful lipophilic substrates in LSD... - Amino acids as modulators of endothelium-derived nitric oxideMasao Kakoki
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, USA
Am J Physiol Renal Physiol 291:F297-304. 2006..Thus the present experiments demonstrate that cationic and neutral amino acids can modulate NO production in endothelial cells by altering cellular l-arginine transport through y(+) and y(+)L transport mechanisms... - Altering the expression in mice of genes by modifying their 3' regionsMasao Kakoki
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Dev Cell 6:597-606. 2004..In mice having two functionally different native genes with modified 3'UTRs, the desired expression was obtained... - Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cellsBarbara J Muller Borer
Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
Proc Natl Acad Sci U S A 104:3877-82. 2007..We hypothesize that the WB F344 cell [Ca(2+)](nu) oscillations activate the expression of a cardiac specifying gene program, ushering in a cardiac phenotype... - Targeted disruption of hsp70.1 sensitizes to osmotic stressEun Hee Shim
Department of Biochemistry and ILCHUN Molecular Medicine Institute MRC, Seoul National University College of Medicine, Korea
EMBO Rep 3:857-61. 2002..Taken together, our results demonstrate that differential expression of hsp70 genes contributes to the stress response and that the hsp70.1 gene plays a critical role in osmotolerance...