Hyung Suk Kim

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells
    H S Kim
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    J Biol Chem 274:14210-7. 1999
  2. pmc Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration
    Hyung Suk Kim
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 99:4602-7. 2002
  3. ncbi request reprint Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice
    Gene Lee
    Department of Pathology and Laboratory Medicine, University of North Carolina, 703 Brinkhous Bullitt Building, Chapel Hill, North Carolina 27599 7525, USA
    Endocrinology 146:2650-6. 2005
  4. pmc Reduced alpha-lipoic acid synthase gene expression exacerbates atherosclerosis in diabetic apolipoprotein E-deficient mice
    Xianwen Yi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599 7525, USA
    Atherosclerosis 223:137-43. 2012
  5. ncbi request reprint Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    J Am Soc Nephrol 16:125-32. 2005
  6. pmc A genetically clamped renin transgene for the induction of hypertension
    Kathleen M I Caron
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 99:8248-52. 2002
  7. ncbi request reprint Kidney function in mice lacking aldosterone
    Natalia Makhanova
    Dept of Pathology and Laboratory Medicine, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Am J Physiol Renal Physiol 290:F61-9. 2006
  8. pmc Reduced expression of lipoic acid synthase accelerates diabetic nephropathy
    Xianwen Yi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    J Am Soc Nephrol 23:103-11. 2012
  9. pmc Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 110:5600-5. 2013
  10. pmc Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation
    Lance A Johnson
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Lipid Res 54:386-96. 2013

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells
    H S Kim
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    J Biol Chem 274:14210-7. 1999
    ....
  2. pmc Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration
    Hyung Suk Kim
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 99:4602-7. 2002
    ..06) than in males (P = 0.001). The marked gender differences in gene expression in wild-type mice and the changes induced by moderate alterations in Agt expression and BP emphasize the need to look for similar differences in humans...
  3. ncbi request reprint Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice
    Gene Lee
    Department of Pathology and Laboratory Medicine, University of North Carolina, 703 Brinkhous Bullitt Building, Chapel Hill, North Carolina 27599 7525, USA
    Endocrinology 146:2650-6. 2005
    ....
  4. pmc Reduced alpha-lipoic acid synthase gene expression exacerbates atherosclerosis in diabetic apolipoprotein E-deficient mice
    Xianwen Yi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599 7525, USA
    Atherosclerosis 223:137-43. 2012
    ..To study the effects of reduced lipoic acid gene expression on diabetic atherosclerosis in apolipoprotein E null mice (Apoe(-/-))...
  5. ncbi request reprint Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    J Am Soc Nephrol 16:125-32. 2005
    ..These results demonstrate that renin is the only enzyme capable of maintaining plasma angiotensins and that renin expression in the kidney is very tightly regulated at the mRNA level...
  6. pmc A genetically clamped renin transgene for the induction of hypertension
    Kathleen M I Caron
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 99:8248-52. 2002
    ....
  7. ncbi request reprint Kidney function in mice lacking aldosterone
    Natalia Makhanova
    Dept of Pathology and Laboratory Medicine, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Am J Physiol Renal Physiol 290:F61-9. 2006
    ..Our data show the substantial correction of these abnormalities, except the low blood pressure, by high dietary salt does not depend on aldosterone...
  8. pmc Reduced expression of lipoic acid synthase accelerates diabetic nephropathy
    Xianwen Yi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    J Am Soc Nephrol 23:103-11. 2012
    ..These results suggest that lipoic acid synthase deficiency increases oxidative stress and accelerates the development of diabetic nephropathy...
  9. pmc Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 110:5600-5. 2013
    ..Thus, changes in Tgfb1 expression cause marked progressive changes in multiple systems that regulate blood pressure and fluid homeostasis, with the major effects being mediated by changes in adrenocortical function...
  10. pmc Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation
    Lance A Johnson
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Lipid Res 54:386-96. 2013
    ....
  11. pmc A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy
    Chih Hong Wang
    Department of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 108:2070-5. 2011
    ..Our data demonstrate that a modest decrease in eNOS, comparable to that associated with human NOS3 variants, is sufficient to enhance diabetic nephropathy independently of its effects on BP...
  12. ncbi request reprint Altering the expression in mice of genes by modifying their 3' regions
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Cell 6:597-606. 2004
    ..In mice having two functionally different native genes with modified 3'UTRs, the desired expression was obtained...
  13. ncbi request reprint Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene
    Toshio Nishikimi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Cardiovasc Res 66:94-103. 2005
    ..Contribution of the natriuretic peptide system to the development of heart failure (HF) in vivo was examined using mice lacking or having decreased natriuretic peptide receptor-A (NPRA), a guanylyl cyclase-linked receptor...
  14. pmc Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice
    Masao Kakoki
    Department of Pathology and Laboratory Medicine and Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 107:10190-5. 2010
    ..The enhanced renal injury in diabetic mice caused by lack of B1R and B2R may be mediated by a combination of increases in oxidative stress, mitochondrial DNA damage and over expression of fibrogenic genes...
  15. pmc Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma
    Yau Sheng Tsai
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 114:240-9. 2004
    ..These results provide genetic evidence for a critical role for PPARgamma in blood pressure regulation that is not dependent on altered insulin sensitivity...
  16. pmc Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice
    Avani A Pendse
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, 710 Brinkhous Bullitt Bldg, Chapel Hill, NC 27599 7525, USA
    Arterioscler Thromb Vasc Biol 32:1436-44. 2012
    ..We hypothesized that the equivalent mutation, PPARγ-P465L, in mice will worsen atherosclerosis...
  17. ncbi request reprint Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption
    Natalia Makhanova
    Department of Pathology and Laboratory Medicine, University of Virginia, Charlottesville, USA
    Hypertension 48:1151-9. 2006
    ....
  18. ncbi request reprint Amino acids as modulators of endothelium-derived nitric oxide
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, USA
    Am J Physiol Renal Physiol 291:F297-304. 2006
    ..Thus the present experiments demonstrate that cationic and neutral amino acids can modulate NO production in endothelial cells by altering cellular l-arginine transport through y(+) and y(+)L transport mechanisms...
  19. pmc Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    J Clin Invest 116:1302-9. 2006
    ..Thus, absence of the bradykinin B2 receptor increases the oxidative stress, mitochondrial DNA damage, and many senescence-associated phenotypes already present in untreated Akita diabetic mice...
  20. pmc Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
    Kathleen M I Caron
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 101:3106-11. 2004
    ....
  21. pmc Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
    Jeffrey B Hodgin
    Department of Pathology and Laboratory Medicine, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 27599 7525, USA
    J Clin Invest 109:541-8. 2002
    ..Endogenous sex hormones, on the other hand, cause significant damage to the vasculature in the absence of eNOS, but these effects are overridden by interactions between eNOS and sex hormones...
  22. pmc eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype
    Feng Li
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Am Soc Nephrol 23:652-60. 2012
    ..In conclusion, reduced maternal eNOS/nitric oxide exacerbates the sFlt1-related pre-eclampsia-like phenotype through activation of the endothelin system...
  23. pmc Genetic reduction of lipoic acid synthase expression modestly increases atherosclerosis in male, but not in female, apolipoprotein E-deficient mice
    Xianwen Yi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC 27599 7525, USA
    Atherosclerosis 211:424-30. 2010
    ..To evaluate the effects of a genetic reduction of Lias gene expression on atherosclerosis development...
  24. pmc Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor
    Lance A Johnson
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 60:2285-94. 2011
    ..We investigated the differential roles of apolipoprotein E (apoE) isoforms in modulating diabetic dyslipidemia-a potential cause of the increased cardiovascular disease risk of patients with diabetes...
  25. pmc Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite
    Raymond Fox
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 108:8779-84. 2011
    ..We conclude that reduced diabetic symptoms of aging Polg-Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis...
  26. pmc Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell Metab 6:506-12. 2007
    ..Most of the metabolic changes in Ren1c(-/-) mice were reversed by angiotensin II administration. These results support a role for angiotensin II in the pathogenesis of diet-induced obesity and insulin resistance...
  27. pmc Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males
    Kathleen Caron
    Department of Cell and Molecular Physiology and Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 104:3420-5. 2007
    ..These observations suggest that the effect of gender on the role of AM in counteracting cardiovascular damage in humans merits careful evaluation...
  28. ncbi request reprint Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system
    Nobuyuki Takahashi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    Endocrinology 144:2184-90. 2003
    ..This emphasizes that the value of these types of simulation lies in the thoughts that they provoke rather than in their ability to replicate experimental data...
  29. ncbi request reprint Lipocalin-type prostaglandin D synthase is up-regulated in oligodendrocytes in lysosomal storage diseases and binds gangliosides
    Ikuko Mohri
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurochem 97:641-51. 2006
    ..This suggests that L-PGDS may play a role in scavenging harmful lipophilic substrates in LSD...
  30. pmc Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4
    Jose M Arbones-Mainar
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Bldg, Chapel Hill, NC 27599 7525, USA
    FASEB J 24:3809-18. 2010
    ..We conclude that the effects of TZDs are APOE isoform dependent, and that the metabolic damage observed in APOE4 mice is rooted in an impaired activation of the adipogenic program in the adipose tissues expressing APOE4...
  31. pmc Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injury
    Xianwen Yi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Bldg, Chapel Hill, NC 27599 7525, USA
    J Leukoc Biol 85:146-53. 2009
    ..These data demonstrate the importance of endogenously produced LA for preventing leukocyte accumulation and tissue injury that result from LPS-induced inflammation...
  32. pmc Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice
    Yukako Kayashima
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 9:e88274. 2014
    ..SNPs in or near Fmo3, Sele and Selp for Ath44, and Lbp and Pkig for Ath45 were suggested for further investigation as potential candidates underlying the atherosclerosis susceptibility...
  33. ncbi request reprint L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1478-85. 2004
    ..These results suggest that L-arginine transport by cationic amino acid transport mechanisms is important in the production of NO and maintenance of blood flow in the renal medulla...
  34. pmc Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
    Kumar Pandya
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 103:16864-9. 2006
    ..We conclude that beta-MHC gene expression in the normal aging adult and hypertrophic mouse heart is a marker of fibrosis rather than of cellular hypertrophy...
  35. ncbi request reprint Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase
    Natalia Makhanova
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Hypertension 51:134-40. 2008
    ....
  36. pmc Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 104:7576-81. 2007
    ..Thus, both the B1 and B2 bradykinin receptors play an important role in reducing DNA damage, apoptosis, morphological and functional kidney changes, and mortality during renal ischemia/reperfusion injury...
  37. pmc A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high
    Heather E Doherty
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS ONE 5:e12909. 2010
    ....
  38. pmc Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro
    Jeffrey H Fair
    Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 102:2958-63. 2005
    ..The PEP engraftment was not associated with detectable cell fusion, and the transplantation was accompanied with only a low incidence of teratoma formation...
  39. pmc Mefloquine exposure induces cell cycle delay and reveals stage-specific expression of the pfmdr1 gene
    Elaine B Bohórquez
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Antimicrob Agents Chemother 57:833-9. 2013
    ..These results suggest that MFQ-induced increases in pfmdr1 expression are the direct result of the maturation delay at the ring stage but that this change in expression does not affect the antimalarial activity of artemisinin...
  40. pmc Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo
    Kumar Pandya
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:13063-8. 2008
    ....
  41. ncbi request reprint Arterial stiffness and angiotensinogen gene in hypertensive patients and mutant mice
    Erwan Bozec
    Department of Pharmacology, Hôpital Européen Georges Pompidou and Institut National de la Santé et de la Recherche Médicale EMI 0107, Paris, France
    J Hypertens 22:1299-307. 2004
    ....
  42. ncbi request reprint A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice
    Thu H Le
    Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham 27705, USA
    Physiol Genomics 18:290-8. 2004
    ....
  43. ncbi request reprint Physiological impact of increased expression of the AT1 angiotensin receptor
    Thu H Le
    Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
    Hypertension 42:507-14. 2003
    ..The impact of enhanced AT1 receptor expression on blood pressure may be blunted by systemic compensatory responses and altered signal-effector coupling in the vasculature...
  44. ncbi request reprint Lifelong genetic minipumps
    Kathleen M I Caron
    Department of Cell and Molecular Physiology, University of North Carolina CH
    Physiol Genomics 20:203-9. 2005
    ..The procedure and DNA constructs we describe can be used to generate genetic minipumps for controlling plasma levels of a wide variety of secreted protein products...
  45. pmc Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA
    Am J Physiol Renal Physiol 295:F515-24. 2008
    ..These proinflammatory actions of ANG II seem to have a proclivity for inducing kidney injury while having negligible actions in the pathogenesis of cardiac hypertrophy...
  46. pmc Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705, USA
    J Clin Invest 115:1092-9. 2005
    ..Thus, the regulation of blood pressure by the RAS is mediated by AT(1) receptors both within and outside the kidney...
  47. ncbi request reprint Prostacyclin protects against elevated blood pressure and cardiac fibrosis
    Helene Francois
    Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705
    Cell Metab 2:201-7. 2005
    ..Our data suggest that adjuvant therapy that blocks unrestrained Tx actions might protect against end-organ damage without affecting blood pressure in patients taking COX-2 inhibitors...
  48. pmc Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction
    Cinzia Perrino
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 116:1547-60. 2006
    ..Thus stress-induced activation of pathogenic signaling pathways, not the duration of stress or the hypertrophic growth per se, is the molecular trigger of cardiac dysfunction...
  49. pmc Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
    Steven D Crowley
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:17985-90. 2006
    ..Further, they suggest that the major mechanism of action of RAS inhibitors in hypertension is attenuation of angiotensin II effects in the kidney...
  50. pmc Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells
    Barbara J Muller-Borer
    Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Proc Natl Acad Sci U S A 104:3877-82. 2007
    ..We hypothesize that the WB F344 cell [Ca(2+)](nu) oscillations activate the expression of a cardiac specifying gene program, ushering in a cardiac phenotype...
  51. pmc Targeted disruption of hsp70.1 sensitizes to osmotic stress
    Eun Hee Shim
    Department of Biochemistry and ILCHUN Molecular Medicine Institute MRC, Seoul National University College of Medicine, Korea
    EMBO Rep 3:857-61. 2002
    ..Taken together, our results demonstrate that differential expression of hsp70 genes contributes to the stress response and that the hsp70.1 gene plays a critical role in osmotolerance...