Hubert T Kim

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Chondrocyte apoptosis: implications for osteochondral allograft transplantation
    Hubert T Kim
    Orthopedic Surgery Section, San Francisco VA Medical Center, 4150 Clement Street 112, San Francisco, CA 94121, USA
    Clin Orthop Relat Res 466:1819-25. 2008
  2. doi request reprint mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats
    Sunil K Joshi
    San Francisco Veterans Affairs Medical Center, Department of Veterans Affairs, University of California, 1500 Owens Avenue, San Francisco, CA 94153, USA
    J Orthop Res 31:724-30. 2013
  3. doi request reprint MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears
    Sanjum P Samagh
    Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    J Orthop Res 31:421-6. 2013
  4. pmc Peripheral nerve repair in rats using composite hydrogel-filled aligned nanofiber conduits with incorporated nerve growth factor
    Jenny Jin
    Department of Orthopaedic Surgery, University of California San Francisco, CA 94121, USA
    Tissue Eng Part A 19:2138-46. 2013
  5. pmc Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury
    Sunil K Joshi
    Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California, 94153 Department of Orthopaedic Surgery, University of California, San Francisco, California, 94158
    J Orthop Res 32:138-44. 2014
  6. doi request reprint Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model
    Xuhui Liu
    Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, Califronia, USA
    J Orthop Res 30:1440-6. 2012
  7. doi request reprint A mouse model of massive rotator cuff tears
    Xuhui Liu
    San Francisco Veterans Affairs Medical Center, Building 2, Room 639, 4150 Clement Street, San Francisco, CA 94121, USA
    J Bone Joint Surg Am 94:e41. 2012
  8. pmc Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy
    Erik J Kramer
    Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA
    J Shoulder Elbow Surg 22:1702-9. 2013
  9. doi request reprint Cytotoxicity of local anesthetics on human mesenchymal stem cells
    Ruyan Rahnama
    Department of Orthopaedic Surgery, University of California San Francisco, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Bone Joint Surg Am 95:132-7. 2013
  10. pmc Chondrocyte apoptosis after simulated intraarticular fracture: a comparison of histologic detection methods
    Alexis C Dang
    Department of Orthopaedic Surgery, University of California, 500 Parnassus Avenue, MU320 W, Box 0728, San Francisco, CA 94143, USA
    Clin Orthop Relat Res 467:1877-84. 2009

Collaborators

Detail Information

Publications25

  1. pmc Chondrocyte apoptosis: implications for osteochondral allograft transplantation
    Hubert T Kim
    Orthopedic Surgery Section, San Francisco VA Medical Center, 4150 Clement Street 112, San Francisco, CA 94121, USA
    Clin Orthop Relat Res 466:1819-25. 2008
    ..These data suggest that key contributors to the apoptotic process can be manipulated to enhance chondrocyte survival. This knowledge may lead to better surgical outcomes for osteochondral transplantation...
  2. doi request reprint mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats
    Sunil K Joshi
    San Francisco Veterans Affairs Medical Center, Department of Veterans Affairs, University of California, 1500 Owens Avenue, San Francisco, CA 94153, USA
    J Orthop Res 31:724-30. 2013
    ..Therefore, our study suggests that mTOR signaling mediates rotator cuff fatty infiltration via SREBP-1 and PPARγ. Clinically, our finding may alter current treatment methods to address rotator cuff fatty infiltration...
  3. doi request reprint MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears
    Sanjum P Samagh
    Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    J Orthop Res 31:421-6. 2013
    ..This suggests that MRI is a reliable modality in evaluating the progression of fatty infiltration and muscle atrophy following rotator cuff tears in a small animal model...
  4. pmc Peripheral nerve repair in rats using composite hydrogel-filled aligned nanofiber conduits with incorporated nerve growth factor
    Jenny Jin
    Department of Orthopaedic Surgery, University of California San Francisco, CA 94121, USA
    Tissue Eng Part A 19:2138-46. 2013
    ..The use of such hydrogels as luminal fillers for tubular nerve conduits may therefore be useful in assisting restoration of protective sensation following peripheral nerve injury. ..
  5. pmc Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury
    Sunil K Joshi
    Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California, 94153 Department of Orthopaedic Surgery, University of California, San Francisco, California, 94158
    J Orthop Res 32:138-44. 2014
    ..The findings of this study suggest that protein degradation is the primary factor contributing to atrophy following rotator cuff injury. However, different proteolytic pathways are activated if SSN injury is involved...
  6. doi request reprint Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model
    Xuhui Liu
    Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, Califronia, USA
    J Orthop Res 30:1440-6. 2012
    ....
  7. doi request reprint A mouse model of massive rotator cuff tears
    Xuhui Liu
    San Francisco Veterans Affairs Medical Center, Building 2, Room 639, 4150 Clement Street, San Francisco, CA 94121, USA
    J Bone Joint Surg Am 94:e41. 2012
    ..The goal of this study was to develop a mouse model of muscle atrophy and fatty infiltration after a rotator cuff tear. We also sought to study the role of denervation on muscle atrophy and fatty infiltration after a rotator cuff tear...
  8. pmc Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy
    Erik J Kramer
    Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA
    J Shoulder Elbow Surg 22:1702-9. 2013
    ..The goal of this study was to assess the utility of this model in investigating cuff tear arthropathy...
  9. doi request reprint Cytotoxicity of local anesthetics on human mesenchymal stem cells
    Ruyan Rahnama
    Department of Orthopaedic Surgery, University of California San Francisco, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Bone Joint Surg Am 95:132-7. 2013
    ..The present study was conducted to determine whether the toxic effects of local anesthetics on human chondrocytes also extend to human mesenchymal stem cells...
  10. pmc Chondrocyte apoptosis after simulated intraarticular fracture: a comparison of histologic detection methods
    Alexis C Dang
    Department of Orthopaedic Surgery, University of California, 500 Parnassus Avenue, MU320 W, Box 0728, San Francisco, CA 94143, USA
    Clin Orthop Relat Res 467:1877-84. 2009
    ..Using the protocols described in this article, investigators may have additional tools to identify and quantify chondrocytes undergoing programmed cell death after experimental cartilage injury...
  11. doi request reprint Inducible immortality in hTERT-human mesenchymal stem cells
    Samantha L Piper
    Department of Orthopaedic Surgery, University of California San Francisco, 500 Parnassus Avenue, San Francisco, California 94143, USA
    J Orthop Res 30:1879-85. 2012
    ..Thanks to their extended lifespan, preserved multipotentiality and controlled growth, i-hTERT hMSCs may prove to be a useful tool for the development and testing of novel stem cell therapies...
  12. doi request reprint Thermal stress potentiates bupivacaine chondrotoxicity
    Samantha L Piper
    Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, U S A
    Arthroscopy 28:1246-1254.e1. 2012
    ..The primary objective of this study was to determine whether thermal stress potentiates the chondrotoxic effect of bupivacaine, resulting in decreased articular chondrocyte viability compared with exposure to bupivacaine alone...
  13. doi request reprint Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes
    Samantha L Piper
    J Bone Joint Surg Am 90:986-91. 2008
    ..We compared the in vitro viability of human articular chondrocytes after exposure to bupivacaine, ropivacaine, and saline solution control...
  14. ncbi request reprint Admitting service and morbidity and mortality in elderly patients after hip fracture: finding a threshold for medical versus orthopedic admission
    James M Mok
    Department of Orthopaedic Surgery, University of California, San Francisco, 94143 0728, USA
    Am J Orthop (Belle Mead NJ) 39:80-7. 2010
    ..Addition of American Society of Anesthesiologists grade 4 and men 85 or older to existing criteria would increase the percentage of patients with adverse events admitted to a medical service (72% vs 28%; P<.005)...
  15. doi request reprint Minocycline reduces articular cartilage damage following osteochondral injury
    Akira Yamamoto
    Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA
    Knee 19:680-3. 2012
    ..The primary objective of this study was to test the potential chondroprotective effects of intra-articular minocycline following osteochondral injury...
  16. doi request reprint Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model
    Jenny Jin
    San Francisco VA Medical Center, 4150 Clement Street Box 112, San Francisco, CA 94121, USA
    Regen Med 7:799-806. 2012
    ..We examined motor outcomes with the use of longitudinally aligned poly (L-lactide-co-caprolactone) nanofiber conduits for repair of nerve gap injury in a rat model...
  17. doi request reprint Effects of local anesthetics on articular cartilage
    Samantha L Piper
    Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA
    Am J Sports Med 39:2245-53. 2011
    ..Clinically, chondrolysis associated with the use of intra-articular local anesthetic pain pumps has been described by several groups. This has raised concern regarding the clinical use of intra-articular local anesthetics...
  18. pmc Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis
    James R Pinney
    UC Berkeley UCSF Graduate Program in Bioengineering, San Francisco, CA 94158 2330, USA
    Magn Reson Imaging 30:271-82. 2012
    ....
  19. doi request reprint Muscle degeneration in rotator cuff tears
    Dominique Laron
    Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA 94158, USA
    J Shoulder Elbow Surg 21:164-74. 2012
    ..Understanding these molecular pathways will help guide further research and treatment options that can aim to alter expression of these pathways and improve outcomes after surgical repair of massive rotator cuff tears...
  20. ncbi request reprint A peek into the possible future of management of articular cartilage injuries: gene therapy and scaffolds for cartilage repair
    Hubert T Kim
    Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143 0728, USA
    J Orthop Sports Phys Ther 36:765-73. 2006
    ..The resulting "neo-cartilage implant" matures within the bioreactor, and can then be used to fill cartilage defects...
  21. ncbi request reprint Chondrocyte apoptosis induced by hydrogen peroxide requires caspase activation but not mitochondrial pore transition
    Marvin Y Lo
    Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA
    J Orthop Res 22:1120-5. 2004
    ..These results show that H2O2 triggers chondrocyte apoptosis through caspase activation, independent of mitochondrial membrane permeability transition...
  22. ncbi request reprint Comparison of chondrocyte apoptosis in vivo and in vitro following acute osteochondral injury
    John G Costouros
    Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA
    J Orthop Res 22:678-83. 2004
    ....
  23. ncbi request reprint Chondrocyte apoptosis induced by collagen degradation: inhibition by caspase inhibitors and IGF-1
    Marvin Y Lo
    Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA
    J Orthop Res 22:140-4. 2004
    ..Furthermore, these findings suggest that multiple pathways involving both the initiation and execution of programmed cell death are potential targets for chondrocyte apoptosis inhibition therapy...
  24. pmc Enhancing osteochondral allograft viability: effects of storage media composition
    Margie S Teng
    Stanford University School of Medicine, Stanford, CA, USA
    Clin Orthop Relat Res 466:1804-9. 2008
    ..These results confirm the hypotheses that media composition greatly influences chondrocyte viability during cold storage and that insulin growth factor-1 and ZVAD improve the storage properties of DMEM...
  25. ncbi request reprint Preventing chondrocyte programmed cell death caused by iatrogenic injury
    John G Costouros
    Department of Orthopaedic Surgery, University of California Medical Center, San Francisco, CA 95119, United States
    Knee 14:107-11. 2007
    ..1+/-2.4%; controls=26.5+/-3.6%; (p=0.0013)]. These results provide proof of concept for the use of PCD inhibitors to enhance the results of cartilage repair surgeries...