Helen Kim

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Attenuation of neurodegeneration-relevant modifications of brain proteins by dietary soy
    H Kim
    Department of Pharmacology and Toxicology and the UAB Center for Aging, University of Alabama at Birmingham, 35294 0019, USA
    Biofactors 12:243-50. 2000
  2. ncbi request reprint Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent
    Helen Kim
    Departments of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Nutr 134:3445S-3452S. 2004
  3. ncbi request reprint Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta
    H Kim
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294 0019, U S A
    Biochem Soc Trans 29:216-22. 2001
  4. ncbi request reprint Proteomics analysis of the actions of grape seed extract in rat brain: technological and biological implications for the study of the actions of psychoactive compounds
    Helen Kim
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, AL 35294, USA
    Life Sci 78:2060-5. 2006
  5. doi request reprint 2D difference gel electrophoresis of prepubertal and pubertal rat mammary gland proteomes
    Helen Kim
    Departments of Pharmacology and Toxicology, the UAB Center for Nutrient Gene Interaction, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Proteome Res 7:4638-50. 2008
  6. ncbi request reprint Proteomics and mass spectrometry in nutrition research
    Helen Kim
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nutrition 20:155-65. 2004
  7. ncbi request reprint 2D gel proteomics: an approach to study age-related differences in protein abundance or isoform complexity in biological samples
    Helen Kim
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA
    Methods Mol Biol 371:349-91. 2007
  8. ncbi request reprint Proteomics analysis of rat brain protein modulations by grape seed extract
    Jessy Deshane
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama 35294, USA
    J Agric Food Chem 52:7872-83. 2004
  9. ncbi request reprint Simvastatin enhances learning and memory independent of amyloid load in mice
    Ling Li
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Ann Neurol 60:729-39. 2006
  10. doi request reprint Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract
    Jeevan K Prasain
    Department of Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phytomedicine 16:233-43. 2009

Research Grants

  1. Integrated Instrumentation for Proteomics
    Helen Kim; Fiscal Year: 2002

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Attenuation of neurodegeneration-relevant modifications of brain proteins by dietary soy
    H Kim
    Department of Pharmacology and Toxicology and the UAB Center for Aging, University of Alabama at Birmingham, 35294 0019, USA
    Biofactors 12:243-50. 2000
    ..The rationale is discussed for the use of soy-based foods for protection against postmenopausal neurodegeneration...
  2. ncbi request reprint Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent
    Helen Kim
    Departments of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Nutr 134:3445S-3452S. 2004
    ....
  3. ncbi request reprint Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta
    H Kim
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294 0019, U S A
    Biochem Soc Trans 29:216-22. 2001
    ..The results discussed here indicate that genistein, and probably other related phytoestrogens, have pleiotropic actions, some of which may involve TGFbeta activity...
  4. ncbi request reprint Proteomics analysis of the actions of grape seed extract in rat brain: technological and biological implications for the study of the actions of psychoactive compounds
    Helen Kim
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, AL 35294, USA
    Life Sci 78:2060-5. 2006
    ..The fact that GSE affects proteins implicated in cognitive disorders suggests moreover that GSE may have impact on the actions of psychoactive drugs by maintaining an overall viability of the nervous system...
  5. doi request reprint 2D difference gel electrophoresis of prepubertal and pubertal rat mammary gland proteomes
    Helen Kim
    Departments of Pharmacology and Toxicology, the UAB Center for Nutrient Gene Interaction, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Proteome Res 7:4638-50. 2008
    ..This is a first report of mammary gland proteome differences at these important breast cancer-relevant time-points...
  6. ncbi request reprint Proteomics and mass spectrometry in nutrition research
    Helen Kim
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nutrition 20:155-65. 2004
  7. ncbi request reprint 2D gel proteomics: an approach to study age-related differences in protein abundance or isoform complexity in biological samples
    Helen Kim
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA
    Methods Mol Biol 371:349-91. 2007
    ....
  8. ncbi request reprint Proteomics analysis of rat brain protein modulations by grape seed extract
    Jessy Deshane
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama 35294, USA
    J Agric Food Chem 52:7872-83. 2004
    ..This is the first identification and quantitation of specific proteins in mammalian tissues modulated by a dietary supplement, as well as the first to demonstrate links of such proteins with any disease...
  9. ncbi request reprint Simvastatin enhances learning and memory independent of amyloid load in mice
    Ling Li
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Ann Neurol 60:729-39. 2006
    ..Our objective was to determine whether administering a statin drug (simvastatin) would protect against the development of behavioral deficits in an established mouse model of Alzheimer's disease...
  10. doi request reprint Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract
    Jeevan K Prasain
    Department of Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phytomedicine 16:233-43. 2009
    ..Using LC-MS/MS, (+)-catechin and (-)-epicatechin were identified in the brain conclusively. These data suggested that GSE catechins cross the blood brain barrier and may be responsible for the neuroprotective effects of GSE...
  11. ncbi request reprint Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice
    Dongfeng Cao
    Atherosclerosis Research Unit, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 658, Birmingham, AL 35294, USA
    Neurobiol Aging 27:1632-43. 2006
    ..Our results suggest that the LDLR plays a role in the development of Alzheimer-type learning impairment and amyloidosis and can be a novel therapeutic target for AD...
  12. pmc The case for well-conducted experiments to validate statistical protocols for 2D gels: different pre-processing = different lists of significant proteins
    Sreelatha Meleth
    Biostatistics and Bioinformatics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Biotechnol 5:7. 2005
    ..However, there is a dearth of systematic studies that have investigated appropriate statistical approaches to analyse the data from these experiments...
  13. ncbi request reprint New nutrition, proteomics, and how both can enhance studies in cancer prevention and therapy
    Helen Kim
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, 1918 University Blvd, Birmingham, AL 35294, USA
    J Nutr 135:2715-8. 2005
    ..This report illustrates how experimental approaches that combine proteomics technologies with a dietary intervention with specific phytochemicals in normal animals can enhance studies on cancer prevention and treatment...
  14. pmc High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function
    Stephen Barnes
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem Soc Trans 36:1037-44. 2008
    ..These results suggest that future in vivo studies should carefully assess the critical sites that are modified rather than using antibodies that do not distinguish between different modified sites...
  15. pmc 2D-difference gel electrophoretic proteomic analysis of a cell culture model of alveolar rhabdomyosarcoma
    Joseph G Pressey
    Department of Pediatrics, Division of Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Proteome Res 10:624-36. 2011
    ..Thus, the 2D-DIGE proteomics methodology described here provided an important discovery approach to the study of RMS biology and complements the findings of previous mRNA expression studies...
  16. ncbi request reprint Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity
    Aparna Venkatraman
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 279:22092-101. 2004
    ..These data also suggest that the response of mitochondria to stress may not involve non-discriminate changes in the proteome but is restricted to those metabolic pathways that have a direct role in a specific pathology...
  17. ncbi request reprint Immunization of Alzheimer model mice with adenovirus vectors encoding amyloid beta-protein and GM-CSF reduces amyloid load in the brain
    Hong Duck Kim
    Department of Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, KHGB 640B, 720 20th Street South, Birmingham, AL 35294 0024, USA
    Neurosci Lett 370:218-23. 2004
    ..Thus, intranasal administration of adenovirus vectors encoding Abeta and GM-CSF may be effective in prevention and treatment of AD...
  18. ncbi request reprint Nutriproteomics: identifying the molecular targets of nutritive and non-nutritive components of the diet
    Stephen Barnes
    Departments of Pharmacology and Toxicology, 452 McCallum Building, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
    J Biochem Mol Biol 37:59-74. 2004
    ..These are described, as are the pros and cons of each method in current use...
  19. ncbi request reprint Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats
    Ning Peng
    Dept of Cell Biology, University of Alabama at Birmingham, 1900 Univ Blvd THT 950, Birmingham, AL 35294 0006, USA
    Am J Physiol Regul Integr Comp Physiol 289:R771-5. 2005
    ..These results indicate that grape seed polyphenols decrease arterial pressure in SHR, probably via an antioxidant mechanism...
  20. ncbi request reprint active site modifications of the brain isoform of creatine kinase by 4-hydroxy-2-nonenal correlate with reduced enzyme activity: mapping of modified sites by Fourier transform-ion cyclotron resonance mass spectrometry
    Shannon M Eliuk
    Department of Pharmacology Toxicology, UAB Biomedical FT ICR MS Laboratory, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, LA 35294, USA
    Chem Res Toxicol 20:1260-8. 2007
    ....
  21. ncbi request reprint Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways
    H Kim
    Department of Pharmacology and Toxicology, Comprehensive Cancer Center, University of Alabama at Birmingham, 35294 0019, USA
    Am J Clin Nutr 68:1418S-1425S. 1998
    ..These preclinical studies in combination with our cell culture data suggest that the mechanism of genistein involves, if not requires, TGFbeta1-signaling...
  22. pmc In nutrition, can we "see" what is good for us?
    Stephen Barnes
    Department of Pharmacology and Toxicology, Targeted Metabolomics and Proteomics Laboratory, University of Alabama at Birmingham, Birmingham, AL, USA
    Adv Nutr 4:327S-34S. 2013
    ..Extensive metabolism by phase I/II enzymes and by the gut microbiome may also create compounds that the eye is never allowed to appreciate...
  23. pmc 2D difference gel electrophoresis analysis of different time points during the course of neoplastic transformation of human mammary epithelial cells
    J Tyson DeAngelis
    Department of Biology, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 1170, USA
    J Proteome Res 10:447-58. 2011
    ....
  24. pmc Cautions and research needs identified at the equol, soy, and menopause research leadership conference
    Stephen Barnes
    Department of Pharmacology and Toxicology, and Center for Nutrient Gene Interaction, University of Alabama at Birmingham and Purdue University University of Alabama at Birmingham Botanicals Research Center for Age Related Disease, Birmingham, AL 35294, USA
    J Nutr 140:1390S-4S. 2010
    ....
  25. pmc Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochim Biophys Acta 1773:1116-23. 2007
    ..These data suggest that partial reversal of tumor exosome-mediated inhibition of NK cell tumor cytotoxicity may account for the anti-cancer properties of curcumin...
  26. ncbi request reprint The UAB Proteomics Database
    Aubrey Hill
    UAB Comprehensive Cancer Center, UAB Mass Spectrometry and Proteomics Shared Facility, University of Alabama at Birmingham, 1530 3rd Ave South, Kaul 602A, Birmingham, AL 35294, USA
    Bioinformatics 19:2149-51. 2003
    ..Images of the gels from which each of these proteins was isolated are accessed by hyperlinks embedded in the database...
  27. ncbi request reprint High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes
    Paul S Brookes
    Department of Pathology, University of Alabama at Birmingham, Biomedical Research Building 2, 901 19th Street South, Birmingham, AL 35294, USA
    Proteomics 2:969-77. 2002
    ..Applications of this functional mitochondrial proteomics method are discussed...
  28. pmc Proteomic analysis of mouse hypothalamus under simulated microgravity
    Poonam Sarkar
    Department of Pharmacology and Toxicology, University of Alabama, Birmingham, AL, 35294, USA
    Neurochem Res 33:2335-41. 2008
    ..Taken together the results reported here indicate that oxidative imbalance occurred in the hypothalamus in response to simulated microgravity...
  29. ncbi request reprint DING, a genistein target in human breast cancer: a protein without a gene
    Michael Belenky
    Department of Biochemistry and Molecular Genetics and Pharmacology and Toxicology, University of Alabama at Birmingham, AL 35294, USA
    J Nutr 133:2497S-2501S. 2003
    ..The DING protein (N-terminal amino acid sequence Asp-Ile-Asn-Gly) that binds to genistein with high affinity is one of these. Its biological role, however, remains to be defined...
  30. pmc Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease
    Ling Li
    Departments of Medicine, Pharmacology, and Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Pathol 163:2155-64. 2003
    ..Our results suggest that synergistic mechanisms may be involved in the pathogenesis of atherosclerosis and AD. These findings may have important implications in the prevention and treatment of cardiovascular diseases as well as AD...
  31. ncbi request reprint Prospective highlights of functional skin proteomics
    Chun Ming Huang
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mass Spectrom Rev 24:647-60. 2005
    ..This type of research into functional skin proteomics will provide a critical step toward understanding disease and developing successful therapeutic strategies...
  32. pmc VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator
    Rebecca F Goldstein
    Department of Cell Biology, Comprehensive Cancer Center, and Gregory Fleming James Cystic Fibrosis Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Am J Respir Cell Mol Biol 36:706-14. 2007
    ....
  33. ncbi request reprint Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis
    Hui Chen Hsu
    University of Alabama at Birmingham, 701 South 19th Street, Birmingham, AL 35294, USA
    Arthritis Rheum 54:343-55. 2006
    ..The goal of this study was to identify the antigenic target proteins and epitopes and to unravel the mechanisms by which the related conditions arise in BXD2 mice...
  34. ncbi request reprint Dr Helen Kim's story: the risk to blossom and glad to be exactly me
    Kim Helen
    University of Alabama at Birmingham, USA
    J Cancer Educ 22:202-3. 2007
  35. ncbi request reprint Soy isoflavonoids and cancer -- metabolism at the target site
    B J Boersma
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, VH G009, 1670 University Boulevard, Birmingham, AL 35294, USA
    Mutat Res 480:121-7. 2001
    ..Future investigations of GEN and other polyphenols must, therefore, take into account metabolism at the tissue site...
  36. ncbi request reprint Insulin resistance, dietary cholesterol, and cholesterol concentration in postmenopausal women
    G M Reaven
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Metabolism 50:594-7. 2001
    ....
  37. pmc Anti-Abeta single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease
    Ken Ichiro Fukuchi
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, PO Box 1649, Peoria, IL 61656, USA
    Neurobiol Dis 23:502-11. 2006
    ..Because the scFv lacks the Fc portion of the immunoglobulin molecule, this modality may be a feasible solution for AD without eliciting inflammation...
  38. pmc Botanicals for age-related diseases: from field to practice
    Connie M Weaver
    Foods and Nutrition, Rutgers University, New Brunswick, NJ, USA
    Am J Clin Nutr 87:493S-7S. 2008
    ..Botanicals and their relation to bone antiresorptive capacity, cognitive function, vascular effects, and cancer are principal themes in our center...
  39. pmc Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse model
    Ken Ichiro Fukuchi
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Box 1649, Peoria, IL 61656, USA
    Biochem Biophys Res Commun 344:79-86. 2006
    ..Because scFvs lack the Fc portion of the immunoglobulin molecule, human scFvs against Abeta may be useful to treat AD patients without eliciting brain inflammation...
  40. pmc Proteomic analysis of mice hippocampus in simulated microgravity environment
    Poonam Sarkar
    Molecular Neurotoxicology Laboratory and Proteomics Core, Department of Biology, Texas Southern University, Houston, Texas 77004, USA
    J Proteome Res 5:548-53. 2006
    ..This preliminary investigation leads to an understanding of the alteration of proteins in the hippocampus in response to the microgravity environment...
  41. ncbi request reprint Increasing incidence of late second malignancies after conditioning with cyclophosphamide and total-body irradiation and autologous bone marrow transplantation for non-Hodgkin's lymphoma
    Jennifer R Brown
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 23:2208-14. 2005
    ..We report the incidence and outcome of solid tumors at 10-year follow-up in a large cohort of uniformly treated patients who underwent ABMT for non-Hodgkin's lymphoma (NHL)...
  42. ncbi request reprint The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension
    Albert W Dreisbach
    Divisions of Nephrology and Clinical Pharmacology, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Am J Hypertens 18:1276-81. 2005
    ..We performed a case-control study to determine the prevalence of epoxygenase-related SNP in African American individuals and to evaluate whether these SNP are associated with increased risk of hypertension...
  43. ncbi request reprint Comparison of sargramostim and filgrastim in the treatment of chemotherapy-induced neutropenia
    Dawn Marie Stull
    Department of Pharmacy, New York Presbyterian Hospital New York Weill Cornell Center, New York, NY 10128, USA
    Am J Health Syst Pharm 62:83-7. 2005
  44. ncbi request reprint Generation and characterization of monoclonal antibodies to human keratinocyte growth factor receptor
    Ping Wei
    Department of Hematology, Amgen Inc, Thousand Oaks, California 91320 1789, USA
    Hybridoma (Larchmt) 25:115-24. 2006
    ..Antagonistic MAbs were identified using a cell-based functional assay. These KGFR MAbs will be important reagents for studying the biological function and tissue distribution of this receptor in normal and pathological conditions...
  45. pmc Exploiting the apoptotic actions of oestrogen to reverse antihormonal drug resistance in oestrogen receptor positive breast cancer patients
    V Craig Jordan
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Breast 16:S105-13. 2007
    ..Once our program is complete, the new knowledge will be available to translate to clinical care for the long-term maintenance of patients on antihormone therapy...
  46. ncbi request reprint Weight, diet, and physical activity-related beliefs and practices among pregnant and postpartum Latino women: the role of social support
    Pamela L Thornton
    Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48106, USA
    Matern Child Health J 10:95-104. 2006
    ..The objective of this study was to investigate the influence of social support on weight, diet, and physical activity-related beliefs and behaviors among pregnant and postpartum Latinas...
  47. doi request reprint Genome-wide linkage scan for the metabolic syndrome: the GENNID study
    Karen L Edwards
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Obesity (Silver Spring) 16:1596-601. 2008
    ..1-2q13) in the white sample and on chromosome 3 (3q26.1-3q29) in the Mexican-American sample. In conclusion, the results suggest that several regions harbor MetS susceptibility genes and that heterogeneity may exist across groups...
  48. ncbi request reprint Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity
    Jonathan W Friedberg
    James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Blood 105:489-95. 2005
    ..CpG treatment resulted in no significant toxicity, providing rationale for further testing of this exciting combination immunotherapy approach to NHL...
  49. pmc Guanosine triphosphate acts as a cofactor to promote assembly of initial P-element transposase-DNA synaptic complexes
    Mei Tang
    Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California, Berkeley, California 94720, USA
    Genes Dev 19:1422-5. 2005
    ..This initial complex then randomly and independently cleaves each P-element end. These data show that GTP acts to promote protein-DNA assembly, and may explain why P-element excision often leads to unidirectional deletions...

Research Grants1

  1. Integrated Instrumentation for Proteomics
    Helen Kim; Fiscal Year: 2002
    ....