Helen Kim

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Evaluating performance of the spetzler-martin supplemented model in selecting patients with brain arteriovenous malformation for surgery
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA
    Stroke 43:2497-9. 2012
  2. pmc Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations
    Bahar Mikhak
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
    Cerebrovasc Dis 31:338-45. 2011
  3. pmc Population stratification in a case-control study of brain arteriovenous malformation in Latinos
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94110, USA
    Neuroepidemiology 31:224-8. 2008
  4. pmc Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Cerebrovasc Dis 27:176-82. 2009
  5. pmc EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations
    Shantel Weinsheimer
    Center for Cerebrovascular Research, University of California, San Francisco, Calif 94110, USA
    Circ Cardiovasc Genet 2:476-82. 2009
  6. pmc Brain-derived neurotrophic factor Val66Met polymorphism predicts worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation
    Erick M Westbroek
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Stroke 43:2255-7. 2012
  7. pmc Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation rupture
    Helen Kim
    Department of Anesthesia and Perioperative Care, School of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Epidemiol 171:1317-22. 2010
  8. pmc Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis
    Hua Su
    Center of Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Pathol 176:1018-27. 2010
  9. pmc A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery
    Michael T Lawton
    Department of Neurological Surgery, and Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 66:702-13; discussion 713. 2010
  10. pmc Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture
    Yi Guo
    University of California, San Francisco, CA 94110, USA
    Stroke 43:1240-6. 2012

Collaborators

Detail Information

Publications27

  1. pmc Evaluating performance of the spetzler-martin supplemented model in selecting patients with brain arteriovenous malformation for surgery
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA
    Stroke 43:2497-9. 2012
    ....
  2. pmc Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations
    Bahar Mikhak
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
    Cerebrovasc Dis 31:338-45. 2011
    ..We investigated whether common single nucleotide polymorphisms (SNPs) in ANGPTL4 were associated with risk of BAVM or ICH...
  3. pmc Population stratification in a case-control study of brain arteriovenous malformation in Latinos
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94110, USA
    Neuroepidemiology 31:224-8. 2008
    ..The purpose of this pilot study was to determine the presence and effect of population stratification in a case-control study of brain arteriovenous malformation (BAVM)...
  4. pmc Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Cerebrovasc Dis 27:176-82. 2009
    ..The aim of this study was to investigate associations between single nucleotide polymorphisms (SNPs) in IL-1beta and intracranial hemorrhage (ICH) in the natural course of brain arteriovenous malformation (BAVM) patients...
  5. pmc EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations
    Shantel Weinsheimer
    Center for Cerebrovascular Research, University of California, San Francisco, Calif 94110, USA
    Circ Cardiovasc Genet 2:476-82. 2009
    ..We investigated the association of single-nucleotide polymorphisms (SNPs) and haplotypes in EPHB4 with risk of ICH at clinical presentation in patients with BAVM...
  6. pmc Brain-derived neurotrophic factor Val66Met polymorphism predicts worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation
    Erick M Westbroek
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Stroke 43:2255-7. 2012
    ..We hypothesized that the Met allele is associated with worsening of functional outcome after brain arteriovenous malformation resection...
  7. pmc Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation rupture
    Helen Kim
    Department of Anesthesia and Perioperative Care, School of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Epidemiol 171:1317-22. 2010
    ..The data also suggest a biologic change around age 10 years influencing ICH rate...
  8. pmc Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis
    Hua Su
    Center of Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Pathol 176:1018-27. 2010
    ..These three lines of evidence from human studies and a mouse model suggest that reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic BAVMs...
  9. pmc A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery
    Michael T Lawton
    Department of Neurological Surgery, and Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 66:702-13; discussion 713. 2010
    ..Patient age, hemorrhagic presentation, nidal diffuseness, and deep perforating artery supply are important factors when selecting patients with brain arteriovenous malformations (AVMs) for surgery...
  10. pmc Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture
    Yi Guo
    University of California, San Francisco, CA 94110, USA
    Stroke 43:1240-6. 2012
    ....
  11. pmc Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development
    Helen Kim
    Center for Cerebrovascular Research, University of California, San Francisco, Calif, USA
    Stroke 40:S95-7. 2009
    ....
  12. pmc A genome-wide investigation of copy number variation in patients with sporadic brain arteriovenous malformation
    Nasrine Bendjilali
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e71434. 2013
    ..Most BAVMs are sporadic, but also occur in patients with Hereditary Hemorrhagic Telangiectasia, a Mendelian disorder caused by mutations in genes in the transforming growth factor beta (TGFβ) signaling pathway...
  13. pmc Cerebellar arteriovenous malformations: anatomic subtypes, surgical results, and increased predictive accuracy of the supplementary grading system
    Ana Rodríguez-Hernández
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 71:1111-24. 2012
    ..Selection tools like the Spetzler-Martin grading system are designed to work best with cerebral AVMs but have shortcomings with cerebellar AVMs...
  14. pmc Radiosurgery facilitates resection of brain arteriovenous malformations and reduces surgical morbidity
    Rene O Sanchez-Mejia
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 02114, USA
    Neurosurgery 64:231-8; discussion 238-40. 2009
    ..To better characterize these effects, we compared results of microsurgical resection of radiated (RS) and nonradiated (RS) AVMs to demonstrate that previous radiosurgery facilitates surgery and decreases operative morbidity...
  15. doi An admission bioclinical score to predict 1-year outcomes in patients undergoing aneurysm coiling
    Vincent Degos
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Stroke 43:1253-9. 2012
    ..Our goal was to develop, compare, and validate a predictive score for 1-year outcomes in patients with coiled subarachnoid hemorrhage...
  16. pmc Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Acta Neurochir Suppl 111:83-92. 2011
    ..Based on the various lines of evidence reviewed in this paper, we propose a "response-to-injury" model of brain AVM pathogenesis...
  17. ncbi Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment
    Achal S Achrol
    Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
    Neurosurgery 61:731-9; discussion 740. 2007
    ..We hypothesized that the risk of posttreatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes...
  18. pmc Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue
    Michael P Kahle
    Department of Neuroscience and Experimental Therapeutics, Texas A and M College of Medicine, College Station, Texas 77843, USA
    Neuroreport 23:627-30. 2012
    ..Furthermore, increases in all components were strongly correlated. Excessive generation of proangiogenic DV in BAVM suggests that DV may participate in its pathology and may represent a future therapeutic target...
  19. pmc Arteriovenous malformation in the adult mouse brain resembling the human disease
    Espen J Walker
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Ann Neurol 69:954-62. 2011
    ..We tested the hypothesis that vascular endothelial growth factor (VEGF) stimulation with regional homozygous deletion of Alk1 induces severe dysplasia in the adult mouse brain, akin to human bAVM...
  20. pmc Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage
    Nerissa U Ko
    Department of Neurology, University of California, San Francisco, USA
    Stroke 39:1103-8. 2008
    ..Decreased availability of nitric oxide (NO) may be crucial in its pathogenesis. We hypothesized that endothelial NO synthase (eNOS) polymorphisms may determine susceptibility to vasospasm in SAH patients...
  21. pmc G Protein-Coupled Receptor 124 (GPR124) Gene Polymorphisms and Risk of Brain Arteriovenous Malformation
    Shantel Weinsheimer
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA
    Transl Stroke Res 3:418-27. 2012
    ..SNP rs7015566 mapping to intron 1 of GPR124 was associated with BAVM susceptibility among Caucasians. Future work is focused on investigating this gene region. ..
  22. doi Cardiovascular predictors of long-term outcomes after non-traumatic subarachnoid hemorrhage
    Jonathan G Zaroff
    Kaiser Northern California Division of Research, San Francisco, CA, USA
    Neurocrit Care 17:374-81. 2012
    ..The second aim was to quantify the effects of cardiac injury on the outcome rates...
  23. pmc Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance
    Tim Frenzel
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Cerebrovasc Dis 25:157-63. 2008
    ..Tetracyclines may be useful in preventing pathological vascular remodeling, thus decreasing the risk of spontaneous hemorrhage from brain vascular malformations...
  24. pmc Soluble endoglin modulates aberrant cerebral vascular remodeling
    Yongmei Chen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco, CA, USA
    Ann Neurol 66:19-27. 2009
    ....
  25. pmc Association of cardiovascular risk factors with disease severity in cerebral cavernous malformation type 1 subjects with the common Hispanic mutation
    Helene Choquet
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, Calif, USA
    Cerebrovasc Dis 37:57-63. 2014
    ..The purpose of this study was to investigate whether cardiovascular (CV) risk factors influence potential markers of familial CCM1 disease severity, such as lesion count and history of intracerebral hemorrhage...
  26. doi Race\ethnicity and outcome after traumatic brain injury at a single, diverse center
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco, California 94110, USA
    J Trauma 67:75-80. 2009
    ..However, the role of race\ethnicity has typically been studied tangentially or in homogeneous settings. We investigated whether race\ethnicity was associated with medical outcomes at a single, diverse center...
  27. ncbi Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94115, USA
    Stroke 38:2430-7. 2007
    ..We evaluated whether race/ethnicity was a risk factor for ICH in the natural course in a large, multiethnic cohort of patients with brain arteriovenous malformation followed longitudinally...