Helen H Kim

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Promoter sequences targeting tissue-specific gene expression of hypothalamic and ovarian gonadotropin-releasing hormone in vivo
    Helen H Kim
    Section of Reproductive Endocrinology and Infertility, The Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 277:5194-202. 2002
  2. ncbi request reprint In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone
    Helen H Kim
    Section of Reproductive Endocrinology and Infertility, The University of Chicago, 5841 South Maryland Avenue, MC 2050, Chicago, Illinois 60637, USA
    Mol Endocrinol 21:457-71. 2007
  3. ncbi request reprint Regulation of gonadotropin-releasing hormone gene expression
    Helen H Kim
    In Vitro Fertilization Program, Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA
    Semin Reprod Med 25:313-25. 2007
  4. ncbi request reprint Regulation of gonadotropin-releasing hormone in nonhypothalamic tissues
    Helen H Kim
    In Vitro Fertilization Program, Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA
    Semin Reprod Med 25:326-36. 2007
  5. ncbi request reprint Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: a role for POU homeodomain transcription factors
    Andrew Wolfe
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    Mol Endocrinol 16:435-49. 2002
  6. ncbi request reprint The GnRH neuron: molecular aspects of migration, gene expression and regulation
    Andrew Wolfe
    University of Chicago, Department of Pediatrics, 5839 South Maryland Ave, MC5053, Chicago, IL 60637, USA
    Prog Brain Res 141:243-57. 2002
  7. ncbi request reprint Insulin regulation of GnRH gene expression through MAP kinase signaling pathways
    Helen H Kim
    University of Chicago, Department of Obstetrics and Gynecology, 5839 South Maryland Avenue MC5053, Chicago, IL 60637, USA
    Mol Cell Endocrinol 242:42-9. 2005
  8. ncbi request reprint Empty follicle syndrome in the setting of dramatic weight loss after bariatric surgery: case report and review of available literature
    Jennifer Hirshfeld-Cytron
    Department of Obstetrics and Gynecology, Section of Reproductive Endocrinology and Infertility, The University of Chicago, Chicago, Illinois 60637, USA
    Fertil Steril 90:1199.e21-3. 2008
  9. ncbi request reprint Induction of apoptosis and ovarian cyst formation in the mouse ovary by dehydroepiandrosterone (DHEA)
    Helen H Kim
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Med 34:101-12. 2003
  10. pmc Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice
    Iris L Romero
    Department of Obstetrics and Gynecology Center forIntegrative Science, University of Chicago, Chicago, IL 60637, USA
    Cancer Prev Res (Phila) 2:792-9. 2009

Research Grants

  1. Differential Regulation of GnRH Gene Expression
    Helen Kim; Fiscal Year: 2005
  2. GnRH Gene Expression in the Ovary
    Helen Kim; Fiscal Year: 2008

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Promoter sequences targeting tissue-specific gene expression of hypothalamic and ovarian gonadotropin-releasing hormone in vivo
    Helen H Kim
    Section of Reproductive Endocrinology and Infertility, The Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 277:5194-202. 2002
    ..Our results also suggest that DNA sequences distal to -2078 bp mediate the repression of ovarian GnRH...
  2. ncbi request reprint In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone
    Helen H Kim
    Section of Reproductive Endocrinology and Infertility, The University of Chicago, 5841 South Maryland Avenue, MC 2050, Chicago, Illinois 60637, USA
    Mol Endocrinol 21:457-71. 2007
    ..Luciferase activity was, however, still present in the ovary. Our findings provide evidence that Otx2 may have a critical role in directing tissue-specific expression of the mGnRH gene to the neuron, but not the ovary...
  3. ncbi request reprint Regulation of gonadotropin-releasing hormone gene expression
    Helen H Kim
    In Vitro Fertilization Program, Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA
    Semin Reprod Med 25:313-25. 2007
    ....
  4. ncbi request reprint Regulation of gonadotropin-releasing hormone in nonhypothalamic tissues
    Helen H Kim
    In Vitro Fertilization Program, Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA
    Semin Reprod Med 25:326-36. 2007
    ..Consequently, the factors that mediate GnRH gene expression in these tissues are only beginning to be identified...
  5. ncbi request reprint Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: a role for POU homeodomain transcription factors
    Andrew Wolfe
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    Mol Endocrinol 16:435-49. 2002
    ..Functional studies demonstrated that Brn-2 increased promoter activity of the human and mouse GnRH genes...
  6. ncbi request reprint The GnRH neuron: molecular aspects of migration, gene expression and regulation
    Andrew Wolfe
    University of Chicago, Department of Pediatrics, 5839 South Maryland Ave, MC5053, Chicago, IL 60637, USA
    Prog Brain Res 141:243-57. 2002
  7. ncbi request reprint Insulin regulation of GnRH gene expression through MAP kinase signaling pathways
    Helen H Kim
    University of Chicago, Department of Obstetrics and Gynecology, 5839 South Maryland Avenue MC5053, Chicago, IL 60637, USA
    Mol Cell Endocrinol 242:42-9. 2005
    ..Our studies suggest that insulin may regulate reproductive function by direct effects on the GnRH neurons and specifically by stimulating GnRH gene expression...
  8. ncbi request reprint Empty follicle syndrome in the setting of dramatic weight loss after bariatric surgery: case report and review of available literature
    Jennifer Hirshfeld-Cytron
    Department of Obstetrics and Gynecology, Section of Reproductive Endocrinology and Infertility, The University of Chicago, Chicago, Illinois 60637, USA
    Fertil Steril 90:1199.e21-3. 2008
    ..To describe empty follicle syndrome, potentially due to route of human chorionic gonadotropin (hCG) administration, in a patient who had previously undergone bariatric surgery...
  9. ncbi request reprint Induction of apoptosis and ovarian cyst formation in the mouse ovary by dehydroepiandrosterone (DHEA)
    Helen H Kim
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Med 34:101-12. 2003
    ..This may be the mechanism by which androgens cause ovarian cyst formation...
  10. pmc Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice
    Iris L Romero
    Department of Obstetrics and Gynecology Center forIntegrative Science, University of Chicago, Chicago, IL 60637, USA
    Cancer Prev Res (Phila) 2:792-9. 2009
    ..Our study results support further investigation of OC effects and mechanisms for OvCa prevention...

Research Grants2

  1. Differential Regulation of GnRH Gene Expression
    Helen Kim; Fiscal Year: 2005
    ..abstract_text> ..
  2. GnRH Gene Expression in the Ovary
    Helen Kim; Fiscal Year: 2008
    ..Elucidating the molecular mechanisms by which ovarian GnRH is regulated should lead to improved therapeutic regimens optimizing the differential use of GnRH agonists and antagonists. ..