Francis Kim

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline
    Francis Kim
    Department of Medicine, Box 359748, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Circulation 115:3064-70. 2007
  2. ncbi request reprint Adhesion to fibronectin enhances MKP-1 activation in human endothelial cells
    F Kim
    Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, 325 9th Avenue, Seattle, Washington 98104, USA
    Biochem Biophys Res Commun 273:539-45. 2000
  3. ncbi request reprint TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells
    F Kim
    Department of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Am J Physiol Cell Physiol 280:C1057-65. 2001
  4. ncbi request reprint Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta
    Francis Kim
    Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, Seattle, Wash 98104, USA
    Arterioscler Thromb Vasc Biol 25:989-94. 2005
  5. ncbi request reprint Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells
    Francis Kim
    Department of Medicine, Harborview Medical Center, University of Washington, Box 359748, Seattle, WA 98104, USA
    J Mol Cell Cardiol 39:327-34. 2005
  6. ncbi request reprint Pilot study of rapid infusion of 2 L of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest
    Francis Kim
    Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA, USA
    Circulation 112:715-9. 2005
  7. pmc The use of pre-hospital mild hypothermia after resuscitation from out-of-hospital cardiac arrest
    Francis Kim
    Department of Medicine and Neurology, University of Washington, Seattle, Washington 98104, USA
    J Neurotrauma 26:359-63. 2009
  8. ncbi request reprint Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    Francis Kim
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Circ Res 100:1589-96. 2007
  9. pmc Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance
    Francis Kim
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98104, USA
    Arterioscler Thromb Vasc Biol 28:1982-8. 2008
  10. pmc Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding
    Priya Handa
    Department of Medicine, 815 Mercer St, University of Washington, Seattle, WA 98109, USA
    Arterioscler Thromb Vasc Biol 31:2827-35. 2011

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline
    Francis Kim
    Department of Medicine, Box 359748, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Circulation 115:3064-70. 2007
    ..The aims of the present pilot study were to assess the feasibility, safety, and effectiveness of in-field cooling...
  2. ncbi request reprint Adhesion to fibronectin enhances MKP-1 activation in human endothelial cells
    F Kim
    Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, 325 9th Avenue, Seattle, Washington 98104, USA
    Biochem Biophys Res Commun 273:539-45. 2000
    ..Regulation of MKP-1 by MAPK likely represents an important negative-feedback mechanism...
  3. ncbi request reprint TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells
    F Kim
    Department of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Am J Physiol Cell Physiol 280:C1057-65. 2001
    ..This study suggests one potential mechanism for the development of endothelial dysfunction in disease states with alterations in insulin regulation and increased TNF-alpha levels...
  4. ncbi request reprint Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta
    Francis Kim
    Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, Seattle, Wash 98104, USA
    Arterioscler Thromb Vasc Biol 25:989-94. 2005
    ..Insulin receptor substrate-1 (IRS-1) regulation is critical for activation of endothelial nitric oxide synthase (eNOS) in response to stimulation by insulin or fluid shear stress...
  5. ncbi request reprint Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells
    Francis Kim
    Department of Medicine, Harborview Medical Center, University of Washington, Box 359748, Seattle, WA 98104, USA
    J Mol Cell Cardiol 39:327-34. 2005
    ..These data demonstrate that activation of IKKbeta plays a critical and novel role to mediate the deleterious effects of high glucose on endothelial cell function...
  6. ncbi request reprint Pilot study of rapid infusion of 2 L of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest
    Francis Kim
    Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA, USA
    Circulation 112:715-9. 2005
    ..Infusion of cold, intravenous fluid has been proposed as a safe, effective, and inexpensive technique to induce mild hypothermia after cardiac arrest...
  7. pmc The use of pre-hospital mild hypothermia after resuscitation from out-of-hospital cardiac arrest
    Francis Kim
    Department of Medicine and Neurology, University of Washington, Seattle, Washington 98104, USA
    J Neurotrauma 26:359-63. 2009
    ..Whether field cooling will improve survival and neurologic outcome remains an important unanswered clinical question...
  8. ncbi request reprint Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    Francis Kim
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Circ Res 100:1589-96. 2007
    ....
  9. pmc Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance
    Francis Kim
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98104, USA
    Arterioscler Thromb Vasc Biol 28:1982-8. 2008
    ....
  10. pmc Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding
    Priya Handa
    Department of Medicine, 815 Mercer St, University of Washington, Seattle, WA 98109, USA
    Arterioscler Thromb Vasc Biol 31:2827-35. 2011
    ....
  11. pmc Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding
    Norma O Rizzo
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Arterioscler Thromb Vasc Biol 30:758-65. 2010
    ..We sought to determine whether reduced NO-cGMP signaling contributes to the deleterious effects of DIO on the vasculature and, if so, whether these effects can be blocked by increased vascular NO-cGMP signaling...
  12. pmc Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding
    Sanshiro Tateya
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 60:2792-801. 2011
    ....
  13. pmc VASP increases hepatic fatty acid oxidation by activating AMPK in mice
    Sanshiro Tateya
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 62:1913-22. 2013
    ..These studies identify a role of VASP to enhance hepatic fatty acid oxidation by activating AMPK and to promote VLDL-TG secretion from the liver...
  14. pmc Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment
    Xin Li
    Departments of Pathology, University of Washington, Seattle WA, USA
    Arterioscler Thromb Vasc Biol 33:232-40. 2013
    ....
  15. pmc Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation
    Ezekiel Maloney
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Arterioscler Thromb Vasc Biol 29:1370-5. 2009
    ..We investigated whether NADPH oxidase-dependent production of superoxide contributes to activation of NF-kappaB in endothelial cells by the saturated free fatty acid palmitate...
  16. pmc Overexpression of endothelial nitric oxide synthase improves endothelium-dependent vasodilation in arteries infused with helper-dependent adenovirus
    Bo Jiang
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, 98195, USA
    Hum Gene Ther 23:1166-75. 2012
    ..Addition of an eNOS expression cassette improves the performance of HDAd, has no harmful effects, and may reduce atherosclerotic lesion growth...
  17. doi request reprint Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial
    Francis Kim
    Department of Medicine, School of Medicine, University of Washington, Seattle
    JAMA 311:45-52. 2014
    ..Hospital cooling improves outcome after cardiac arrest, but prehospital cooling immediately after return of spontaneous circulation may result in better outcomes...
  18. ncbi request reprint Physiology. An integrative view of obesity
    Brent E Wisse
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, WA 98104, USA
    Science 318:928-9. 2007
  19. pmc A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain
    Denis G Baskin
    Office of Research and Development Medical Research Service, Veterans Affairs Puget Sound Health Care System, Department of Veterans Affairs Medical Center, Seattle, Washington 98108, USA
    Endocrinology 151:4207-13. 2010
    ....
  20. pmc Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids
    Sun Ju Choi
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine and Diabetes, University of Washington, Seattle, WA 98109 4714, USA
    Am J Physiol Endocrinol Metab 298:E1122-30. 2010
    ..Therefore, hypothalamic neuronal inflammation in the setting of DIO may involve an indirect mechanism mediated by saturated fatty acids on nonneuronal cells...
  21. pmc Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
    Jonathan German
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Box 358055, Seattle, Washington 98195
    Endocrinology 150:4502-11. 2009
    ..We conclude that hypothalamic leptin action increases peripheral insulin sensitivity primarily via effects on the liver and that the mechanism underlying this effect is dependent on the hepatic branch of the vagus nerve...
  22. pmc Apolipoprotein A-I attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid rafts
    Andrew M Cheng
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e33917. 2012
    ..Thus, apoA-I overexpression might be a useful therapeutic tool against vascular inflammation...
  23. pmc Active surface cooling protocol to induce mild therapeutic hypothermia after out-of-hospital cardiac arrest: a retrospective before-and-after comparison in a single hospital
    Creighton W Don
    Departments of Medicine, University of Washington, Seattle, WA, USA
    Crit Care Med 37:3062-9. 2009
    ....
  24. pmc Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells
    Naomi G Iwata
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington, USA
    PLoS ONE 6:e29600. 2011
    ....
  25. pmc Comparison of role of early (less than six hours) to later (more than six hours) or no cardiac catheterization after resuscitation from out-of-hospital cardiac arrest
    Justin A Strote
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 109:451-4. 2012
    ..In conclusion, in this series of patients who sustained out-of-hospital cardiac arrest, acute catheterization (<6 hours of presentation) was associated with improved survival...
  26. pmc Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice
    Chad S Weldy
    Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA 98195, USA
    Free Radic Biol Med 53:1264-78. 2012
    ....
  27. pmc The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling
    Gregory J Morton
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer St, Box 358055, Seattle, WA 98195, USA
    Am J Physiol Endocrinol Metab 297:E202-10. 2009
    ....
  28. pmc Helper-dependent adenoviral vectors are superior in vitro to first-generation vectors for endothelial cell-targeted gene therapy
    Rowan Flynn
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Mol Ther 18:2121-9. 2010
    ..Expression of apoA-I by HDAd reduced EC VCAM-1 expression. HDAd is a promising vector and apoA-I is a promising gene for atheroprotective human gene therapy delivered via EC...
  29. pmc Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice
    Nathalie Pamir
    Department of Medicine, Div of Metabolism, Endocrinology, and Nutrition, Univ of Washington, Seattle, WA 98109 8050, USA
    Am J Physiol Endocrinol Metab 302:E961-71. 2012
    ..Thus, LT contributes to body weight and adiposity and is required to modulate the accumulation of immune cells in adipose tissue...
  30. pmc Glutathione (GSH) and the GSH synthesis gene Gclm modulate plasma redox and vascular responses to acute diesel exhaust inhalation in mice
    Chad S Weldy
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 354695, Seattle, WA 98195, USA
    Inhal Toxicol 25:444-54. 2013
    ..The rate-limiting enzyme in GSH synthesis is glutamate cysteine ligase and polymorphisms in its catalytic and modifier subunits (GCLC and GCLM) have been shown to influence vascular function and risk of myocardial infarction in humans...
  31. pmc Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration
    I R Sweet
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington at South Lake Union, Seattle, Washington 98195 8055, USA
    Diabetologia 52:921-31. 2009
    ..Since endothelial cells decrease their oxygen consumption rate (OCR) in response to glucose, we hypothesised that increased mitochondrial function would not mediate these cells' response to excess substrate...
  32. ncbi request reprint Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
    B Gallis
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 274:30101-8. 1999
    ..Finally, PKB phosphorylated eNOS in vitro at the same site phosphorylated in the cell and increased eNOS enzymatic activity by 15-20-fold...
  33. doi request reprint Nitrite therapy is neuroprotective and safe in cardiac arrest survivors
    Cameron Dezfulian
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Nitric Oxide 26:241-50. 2012
    ..Nitrite thus appears safe and effective for clinical translation as a promising therapy against cardiac arrest mediated heart and brain injury...
  34. pmc Reduced cytochrome C is an essential regulator of sustained insulin secretion by pancreatic islets
    Seung Ryoung Jung
    Department of Medicine, Diabetes and Obesity Center, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 286:17422-34. 2011
    ..The data suggest that the metabolic factor essential for sustained calcium-stimulated insulin secretion to occur is linked to reduction and translocation of cytochrome c...
  35. doi request reprint Does induction of hypothermia improve outcomes after in-hospital cardiac arrest?
    Graham Nichol
    University of Washington Harborview Center for Prehospital Emergency Care, USA
    Resuscitation 84:620-5. 2013
    ..Therefore, we evaluated the effect of induced hypothermia in a large cohort of patients with in-hospital cardiac arrest...
  36. pmc Role of smooth muscle protein SM22α in glomerular epithelial cell injury
    Caroline B Marshall
    Div of Nephrology, Department of Medicine, Univ of Washington, Seattle, WA 98195, USA
    Am J Physiol Renal Physiol 300:F1026-42. 2011
    ..Furthermore, there was decreased activation of Erk1/2 in diseased SM22α +/+ mice. We conclude that the de novo expression of SM22α in glomerular epithelial cells affects the course of crescentic glomerulonephritis...
  37. ncbi request reprint Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis
    Aaron W Pardini
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    Brain Res 1112:169-78. 2006
    ..An improved understanding of mechanisms underlying normal and abnormal energy homeostasis may be gained by analysis of the role played by signaling through IRS-2 in these brain areas...

Research Grants9

  1. INSULIN RECEPTOR SUBSTRATE -1 AND FLUID SHEAR STRESS
    Francis Kim; Fiscal Year: 2005
    ..To further characterize this potential link between insulin and NO signaling. Specific Aim 3: Characterize FSS dependent signaling elements which associate with IRS-1...
  2. IKKBeta Mediated Impairment of Endothelial Nitric Oxide Production
    Francis Kim; Fiscal Year: 2007
    ..Aim 3. To determine whether the Toll Like Receptor pathway is necessary for endothelial activation of IKKbeta during the development of vascular insulin resistance. ..
  3. IKKBeta Mediated Impairment of Endothelial Nitric Oxide Production
    Francis Kim; Fiscal Year: 2010
    ..Aim 3. To determine whether the Toll Like Receptor pathway is necessary for endothelial activation of IKKbeta during the development of vascular insulin resistance. ..
  4. Mild Hypothermia for Resuscitated Out-of-Hospital Cardiac Arrest Patients
    Francis Kim; Fiscal Year: 2010
    ....