Research Topics
Genomes and Genes
| Francis KimSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal salineFrancis Kim
Department of Medicine, Box 359748, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
Circulation 115:3064-70. 2007..The aims of the present pilot study were to assess the feasibility, safety, and effectiveness of in-field cooling...- Adhesion to fibronectin enhances MKP-1 activation in human endothelial cellsF Kim
Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, 325 9th Avenue, Seattle, Washington 98104, USA
Biochem Biophys Res Commun 273:539-45. 2000..Regulation of MKP-1 by MAPK likely represents an important negative-feedback mechanism... - TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cellsF Kim
Department of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
Am J Physiol Cell Physiol 280:C1057-65. 2001..This study suggests one potential mechanism for the development of endothelial dysfunction in disease states with alterations in insulin regulation and increased TNF-alpha levels... - Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbetaFrancis Kim
Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, Seattle, Wash 98104, USA
Arterioscler Thromb Vasc Biol 25:989-94. 2005..Insulin receptor substrate-1 (IRS-1) regulation is critical for activation of endothelial nitric oxide synthase (eNOS) in response to stimulation by insulin or fluid shear stress... - Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cellsFrancis Kim
Department of Medicine, Harborview Medical Center, University of Washington, Box 359748, Seattle, WA 98104, USA
J Mol Cell Cardiol 39:327-34. 2005..These data demonstrate that activation of IKKbeta plays a critical and novel role to mediate the deleterious effects of high glucose on endothelial cell function... - Pilot study of rapid infusion of 2 L of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrestFrancis Kim
Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA, USA
Circulation 112:715-9. 2005..Infusion of cold, intravenous fluid has been proposed as a safe, effective, and inexpensive technique to induce mild hypothermia after cardiac arrest... 
The use of pre-hospital mild hypothermia after resuscitation from out-of-hospital cardiac arrestFrancis Kim
Department of Medicine and Neurology, University of Washington, Seattle, Washington 98104, USA
J Neurotrauma 26:359-63. 2009..Whether field cooling will improve survival and neurologic outcome remains an important unanswered clinical question...- Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesityFrancis Kim
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Circ Res 100:1589-96. 2007.... - Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistanceFrancis Kim
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98104, USA
Arterioscler Thromb Vasc Biol 28:1982-8. 2008.... - Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feedingNorma O Rizzo
Department of Medicine, University of Washington, Seattle, WA 98109, USA
Arterioscler Thromb Vasc Biol 30:758-65. 2010..We sought to determine whether reduced NO-cGMP signaling contributes to the deleterious effects of DIO on the vasculature and, if so, whether these effects can be blocked by increased vascular NO-cGMP signaling... - Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feedingPriya Handa
Department of Medicine, 815 Mercer St, University of Washington, Seattle, WA 98109, USA
Arterioscler Thromb Vasc Biol 31:2827-35. 2011.... - Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feedingSanshiro Tateya
Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes 60:2792-801. 2011.... - Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activationEzekiel Maloney
Department of Medicine, University of Washington, Seattle, WA 98109, USA
Arterioscler Thromb Vasc Biol 29:1370-5. 2009..We investigated whether NADPH oxidase-dependent production of superoxide contributes to activation of NF-kappaB in endothelial cells by the saturated free fatty acid palmitate... - Physiology. An integrative view of obesityBrent E Wisse
Department of Medicine, Harborview Medical Center and University of Washington, Seattle, WA 98104, USA
Science 318:928-9. 2007 - A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrainDenis G Baskin
Office of Research and Development Medical Research Service, Veterans Affairs Puget Sound Health Care System, Department of Veterans Affairs Medical Center, Seattle, Washington 98108, USA
Endocrinology 151:4207-13. 2010.... - Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acidsSun Ju Choi
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine and Diabetes, University of Washington, Seattle, WA 98109 4714, USA
Am J Physiol Endocrinol Metab 298:E1122-30. 2010..Therefore, hypothalamic neuronal inflammation in the setting of DIO may involve an indirect mechanism mediated by saturated fatty acids on nonneuronal cells... - Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerveJonathan German
Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Box 358055, Seattle, Washington 98195
Endocrinology 150:4502-11. 2009..We conclude that hypothalamic leptin action increases peripheral insulin sensitivity primarily via effects on the liver and that the mechanism underlying this effect is dependent on the hepatic branch of the vagus nerve... - Apolipoprotein A-I attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid raftsAndrew M Cheng
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington, United States of America
PLoS ONE 7:e33917. 2012..Thus, apoA-I overexpression might be a useful therapeutic tool against vascular inflammation... - Active surface cooling protocol to induce mild therapeutic hypothermia after out-of-hospital cardiac arrest: a retrospective before-and-after comparison in a single hospitalCreighton W Don
Departments of Medicine, University of Washington, Seattle, WA, USA
Crit Care Med 37:3062-9. 2009.... - Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cellsNaomi G Iwata
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, Washington, USA
PLoS ONE 6:e29600. 2011.... - Comparison of role of early (less than six hours) to later (more than six hours) or no cardiac catheterization after resuscitation from out-of-hospital cardiac arrestJustin A Strote
Department of Medicine, University of Washington, Seattle, Washington, USA
Am J Cardiol 109:451-4. 2012..In conclusion, in this series of patients who sustained out-of-hospital cardiac arrest, acute catheterization (<6 hours of presentation) was associated with improved survival... 
Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in miceChad S Weldy
Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA 98195, USA
Free Radic Biol Med 53:1264-78. 2012....- The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signalingGregory J Morton
Department of Medicine, University of Washington at South Lake Union, 815 Mercer St, Box 358055, Seattle, WA 98195, USA
Am J Physiol Endocrinol Metab 297:E202-10. 2009.... - Helper-dependent adenoviral vectors are superior in vitro to first-generation vectors for endothelial cell-targeted gene therapyRowan Flynn
Department of Medicine, University of Washington, Seattle, Washington, USA
Mol Ther 18:2121-9. 2010..Expression of apoA-I by HDAd reduced EC VCAM-1 expression. HDAd is a promising vector and apoA-I is a promising gene for atheroprotective human gene therapy delivered via EC... - Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in miceNathalie Pamir
Department of Medicine, Div of Metabolism, Endocrinology, and Nutrition, Univ of Washington, Seattle, WA 98109 8050, USA
Am J Physiol Endocrinol Metab 302:E961-71. 2012..Thus, LT contributes to body weight and adiposity and is required to modulate the accumulation of immune cells in adipose tissue... - Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002B Gallis
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 274:30101-8. 1999..Finally, PKB phosphorylated eNOS in vitro at the same site phosphorylated in the cell and increased eNOS enzymatic activity by 15-20-fold... - Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respirationI R Sweet
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington at South Lake Union, Seattle, Washington 98195 8055, USA
Diabetologia 52:921-31. 2009..Since endothelial cells decrease their oxygen consumption rate (OCR) in response to glucose, we hypothesised that increased mitochondrial function would not mediate these cells' response to excess substrate... - Nitrite therapy is neuroprotective and safe in cardiac arrest survivorsCameron Dezfulian
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Nitric Oxide 26:241-50. 2012..Nitrite thus appears safe and effective for clinical translation as a promising therapy against cardiac arrest mediated heart and brain injury... - Reduced cytochrome C is an essential regulator of sustained insulin secretion by pancreatic isletsSeung Ryoung Jung
Department of Medicine, Diabetes and Obesity Center, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 286:17422-34. 2011..The data suggest that the metabolic factor essential for sustained calcium-stimulated insulin secretion to occur is linked to reduction and translocation of cytochrome c... - Overexpression of endothelial nitric oxide synthase improves endothelium-dependent vasodilation in arteries infused with helper-dependent adenovirusBo Jiang
Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98195
Hum Gene Ther 23:1166-75. 2012..Addition of an eNOS expression cassette improves the performance of HDAd, has no harmful effects, and may reduce atherosclerotic lesion growth... - Role of smooth muscle protein SM22α in glomerular epithelial cell injuryCaroline B Marshall
Div of Nephrology, Department of Medicine, Univ of Washington, Seattle, WA 98195, USA
Am J Physiol Renal Physiol 300:F1026-42. 2011..Furthermore, there was decreased activation of Erk1/2 in diseased SM22α +/+ mice. We conclude that the de novo expression of SM22α in glomerular epithelial cells affects the course of crescentic glomerulonephritis... - Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasisAaron W Pardini
Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
Brain Res 1112:169-78. 2006..An improved understanding of mechanisms underlying normal and abnormal energy homeostasis may be gained by analysis of the role played by signaling through IRS-2 in these brain areas...
Research Grants
- INSULIN RECEPTOR SUBSTRATE -1 AND FLUID SHEAR STRESSFrancis Kim; Fiscal Year: 2005..To further characterize this potential link between insulin and NO signaling. Specific Aim 3: Characterize FSS dependent signaling elements which associate with IRS-1...
- IKKBeta Mediated Impairment of Endothelial Nitric Oxide ProductionFrancis Kim; Fiscal Year: 2007..Aim 3. To determine whether the Toll Like Receptor pathway is necessary for endothelial activation of IKKbeta during the development of vascular insulin resistance. ..
- IKKBeta Mediated Impairment of Endothelial Nitric Oxide ProductionFrancis Kim; Fiscal Year: 2010..Aim 3. To determine whether the Toll Like Receptor pathway is necessary for endothelial activation of IKKbeta during the development of vascular insulin resistance. ..
- Mild Hypothermia for Resuscitated Out-of-Hospital Cardiac Arrest PatientsFrancis Kim; Fiscal Year: 2010....