Affiliation: University of Michigan
Kim B, McLean L, Philip S, Feldman E. Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons. Endocrinology. 2011;152:3638-47 pubmed publisher
..e. that, similar to insulin dependent tissues, neurons develop IR and, in turn, cannot respond to the neurotrophic properties of insulin, resulting in neuronal injury and the development of neuropathy. ..
Kim B, Figueroa Romero C, Pacut C, Backus C, Feldman E. Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485 Phosphorylation. J Biol Chem. 2015;290:19146-57 pubmed publisher
..Together, our results show for the first time a possible contribution of IR-induced AMPK(Ser-485) phosphorylation to the increased risk of AD in obesity and diabetes. ..
Kim B, Feldman E. Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis. Apoptosis. 2009;14:665-73 pubmed publisher
Kim B, Backus C, Oh S, Hayes J, Feldman E. Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinology. 2009;150:5294-301 pubmed publisher
Kim B, Backus C, Oh S, Feldman E. Hyperglycemia-induced tau cleavage in vitro and in vivo: a possible link between diabetes and Alzheimer's disease. J Alzheimers Dis. 2013;34:727-39 pubmed publisher
..We speculate that tau cleavage in diabetic conditions (especially in type 2 diabetes) may be a key link for the increased incidence of AD in diabetic patients. ..