M P Kilgard

Summary

Affiliation: University of Texas at Dallas
Country: USA

Publications

  1. pmc Harnessing plasticity to understand learning and treat disease
    Michael P Kilgard
    The University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, TX 75080, USA
    Trends Neurosci 35:715-22. 2012
  2. pmc Reorganization in processing of spectral and temporal input in the rat posterior auditory field induced by environmental enrichment
    Vikram Jakkamsetti
    School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75083, USA
    J Neurophysiol 107:1457-75. 2012
  3. pmc Experience dependent plasticity alters cortical synchronization
    M P Kilgard
    University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, TX 75083, USA
    Hear Res 229:171-9. 2007
  4. pmc Distributed representation of spectral and temporal information in rat primary auditory cortex
    M P Kilgard
    Department of Otolaryngology, Keck Center for Integrative Neuroscience, University of California at San Francisco, 94143 0444, USA
    Hear Res 134:16-28. 1999
  5. ncbi request reprint Sensory input directs spatial and temporal plasticity in primary auditory cortex
    M P Kilgard
    Neuroscience Program, School of Human Development, University of Texas at Dallas, Richardson, Texas 75083 0688, USA
    J Neurophysiol 86:326-38. 2001
  6. ncbi request reprint Spectral features control temporal plasticity in auditory cortex
    M P Kilgard
    Cortical Plasticity Laboratory, Cognition and Neuroscience Program, University of Texas at Dallas, Richardson, TX 75083, USA
    Audiol Neurootol 6:196-202. 2001
  7. ncbi request reprint Cortical network reorganization guided by sensory input features
    Michael P Kilgard
    Neuroscience Program, School of Human Development, GR 41, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Biol Cybern 87:333-43. 2002
  8. pmc Inverted-U function relating cortical plasticity and task difficulty
    N D Engineer
    School of Behavioral and Brain Sciences, University of Texas at Dallas, 800 W Campbell Road Richardson, TX 75080, USA
    Neuroscience 205:81-90. 2012
  9. doi request reprint Vagus nerve stimulation modulates cortical synchrony and excitability through the activation of muscarinic receptors
    J A Nichols
    School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
    Neuroscience 189:207-14. 2011
  10. pmc Asynchronous inputs alter excitability, spike timing, and topography in primary auditory cortex
    Pritesh K Pandya
    Neuroscience Program, School of Behavioral and Brain Sciences, PO Box 830688, GR 41, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Hear Res 203:10-20. 2005

Research Grants

  1. CORTICAL PLASTICITY AND PROCESSING OF COMPLEX STIMULI
    Michael Kilgard; Fiscal Year: 2002
  2. Cortical Plasticity and Processing of Speech Sounds
    Michael Kilgard; Fiscal Year: 2006
  3. Animal Model of Speech Sound Processing in Autism
    Michael P Kilgard; Fiscal Year: 2010

Collaborators

  • T M Centanni
  • Navzer D Engineer
  • Pritesh K Pandya
  • F Aboitiz
  • Marco Atzori
  • Amanda C Puckett
  • Vikram Jakkamsetti
  • Raluca Moucha
  • J A Nichols
  • Cherie R Percaccio
  • K G Ranasinghe
  • Kevin Q Chang
  • Mitali Bose
  • Crystal T Engineer
  • YeTing H Chen
  • Owen R Floody
  • Autumn L Pruette
  • Daniel L Rathbun
  • W A Vrana
  • C J Matney
  • S M Smirnakis
  • A R Nichols
  • Humberto Salgado
  • Justin A Nichols
  • Rajasekhar Byrapureddy
  • Benjamin Porter
  • Alexies Dagnino-Subiabre
  • Pablo Muñoz-Llancao
  • Swagata Roychowdhury
  • Claudia A Perez
  • Jai A Shetake
  • Ryan S Carraway
  • Amanda C Reed
  • L Dinh
  • Shilpa T Mistry
  • V P Jakkamsetti
  • H Salgado

Detail Information

Publications28

  1. pmc Harnessing plasticity to understand learning and treat disease
    Michael P Kilgard
    The University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, TX 75080, USA
    Trends Neurosci 35:715-22. 2012
    ..Precisely targeted neural plasticity provides a new avenue for the treatment of neurological and psychiatric disorders and is a powerful tool to test the neural mechanisms of learning and memory...
  2. pmc Reorganization in processing of spectral and temporal input in the rat posterior auditory field induced by environmental enrichment
    Vikram Jakkamsetti
    School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75083, USA
    J Neurophysiol 107:1457-75. 2012
    ..Along with other reports observing greater reorganization in nonprimary sensory cortex, our results in PAF suggest that nonprimary fields might have a greater capacity for reorganization compared with primary fields...
  3. pmc Experience dependent plasticity alters cortical synchronization
    M P Kilgard
    University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, TX 75083, USA
    Hear Res 229:171-9. 2007
    ....
  4. pmc Distributed representation of spectral and temporal information in rat primary auditory cortex
    M P Kilgard
    Department of Otolaryngology, Keck Center for Integrative Neuroscience, University of California at San Francisco, 94143 0444, USA
    Hear Res 134:16-28. 1999
    ..No organized topography of these temporal filters could be determined...
  5. ncbi request reprint Sensory input directs spatial and temporal plasticity in primary auditory cortex
    M P Kilgard
    Neuroscience Program, School of Human Development, University of Texas at Dallas, Richardson, Texas 75083 0688, USA
    J Neurophysiol 86:326-38. 2001
    ....
  6. ncbi request reprint Spectral features control temporal plasticity in auditory cortex
    M P Kilgard
    Cortical Plasticity Laboratory, Cognition and Neuroscience Program, University of Texas at Dallas, Richardson, TX 75083, USA
    Audiol Neurootol 6:196-202. 2001
    ..Additional experiments with more complex stimuli are needed to clarify how the cortex learns natural sounds such as speech...
  7. ncbi request reprint Cortical network reorganization guided by sensory input features
    Michael P Kilgard
    Neuroscience Program, School of Human Development, GR 41, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Biol Cybern 87:333-43. 2002
    ....
  8. pmc Inverted-U function relating cortical plasticity and task difficulty
    N D Engineer
    School of Behavioral and Brain Sciences, University of Texas at Dallas, 800 W Campbell Road Richardson, TX 75080, USA
    Neuroscience 205:81-90. 2012
    ..These results suggest an inverted-U function relating neural plasticity and task difficulty...
  9. doi request reprint Vagus nerve stimulation modulates cortical synchrony and excitability through the activation of muscarinic receptors
    J A Nichols
    School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
    Neuroscience 189:207-14. 2011
    ..These results are discussed with respect to their possible implications for sensory processing, neural plasticity, and epilepsy...
  10. pmc Asynchronous inputs alter excitability, spike timing, and topography in primary auditory cortex
    Pritesh K Pandya
    Neuroscience Program, School of Behavioral and Brain Sciences, PO Box 830688, GR 41, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Hear Res 203:10-20. 2005
    ..These results are consistent with earlier observations that sensory input statistics can shape cortical map organization and spike timing...
  11. pmc Background sounds contribute to spectrotemporal plasticity in primary auditory cortex
    Raluca Moucha
    Neuroscience Program, School of Brain and Behavioral Sciences, GR41, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Exp Brain Res 162:417-27. 2005
    ..These results extend earlier observations that cortical neurons can develop stimulus specific plasticity and indicate that background conditions can strongly influence cortical plasticity...
  12. pmc Plasticity of temporal information processing in the primary auditory cortex
    M P Kilgard
    Coleman Laboratory, Department of Otolaryngology, University of California at San Francisco 94143 0444, USA
    Nat Neurosci 1:727-31. 1998
    ..Thus this protocol elicits extensive cortical remodeling of temporal response properties and demonstrates that simple differences in spectral and temporal features of the sensory input can drive very different cortical reorganizations...
  13. pmc Reversing pathological neural activity using targeted plasticity
    Navzer D Engineer
    Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, USA
    Nature 470:101-4. 2011
    ..These improvements persisted for weeks after the end of therapy. This method for restoring neural activity to normal may be applicable to a variety of neurological disorders...
  14. pmc Cortical activity patterns predict speech discrimination ability
    Crystal T Engineer
    School of Behavioral and Brain Sciences, University of Texas at Dallas, 800 W Campbell Road, Richardson, Texas 75080, USA
    Nat Neurosci 11:603-8. 2008
    ..This result suggests that spike timing contributes to the auditory cortex representation of consonant sounds...
  15. ncbi request reprint Plasticity in the rat posterior auditory field following nucleus basalis stimulation
    Amanda C Puckett
    Neuroscience Program, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    J Neurophysiol 98:253-65. 2007
    ..These results demonstrate that experience-dependent plasticity can take different forms in both A1 and secondary auditory cortex...
  16. pmc Increasing diversity of neural responses to speech sounds across the central auditory pathway
    K G Ranasinghe
    The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41, Richardson, TX 75080 3021, United States Electronic address
    Neuroscience 252:80-97. 2013
    ....
  17. pmc Cortical speech-evoked response patterns in multiple auditory fields are correlated with behavioral discrimination ability
    T M Centanni
    School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, USA
    J Neurophysiol 110:177-89. 2013
    ..Earlier observations in the visual and somatosensory systems that cortical neurons do not rely on spike timing should be reevaluated with more complex natural stimuli to determine whether spike timing contributes to sensory encoding. ..
  18. ncbi request reprint Environmental enrichment improves response strength, threshold, selectivity, and latency of auditory cortex neurons
    Navzer D Engineer
    Neuroscience Program, School of Behavioral and Brain Sciences, GR 41, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    J Neurophysiol 92:73-82. 2004
    ..These experiments provide the first evidence of physiologic changes in auditory cortex processing resulting from generalized environmental enrichment...
  19. ncbi request reprint Environmental enrichment increases paired-pulse depression in rat auditory cortex
    Cherie R Percaccio
    Neuroscience Program, School of Behavioral and Brain Sciences, GR 41, University of Texas at Dallas, Richardson, Texas 75083 0688, USA
    J Neurophysiol 94:3590-600. 2005
    ..These results are relevant to several clinical disorders characterized by abnormal gating of sensory information, including autism, schizophrenia, and dyslexia...
  20. ncbi request reprint Cortical map reorganization without cholinergic modulation
    Michael P Kilgard
    Cognition and Neuroscience Program, University of Texas, Dallas, School of Behavioral and Brain Sciences, GR41, Richardson, Texas 75083, USA
    Neuron 48:529-30. 2005
    ..This finding suggests that acetylcholine may act less as a gate and more as a gain control on cortical plasticity...
  21. pmc Environmental enrichment selectively increases glutamatergic responses in layer II/III of the auditory cortex of the rat
    J A Nichols
    School for Behavioral and Brain Sciences, The University of Texas at Dallas, 2601 North Floyd Road, GR41, Richardson, TX 75080, USA
    Neuroscience 145:832-40. 2007
    ..Our data suggest that auditory EE selectively enhances excitatory glutamatergic synaptic transmission in layer II/III without greatly altering inhibitory GABAergic transmission...
  22. ncbi request reprint Cortical plasticity and rehabilitation
    Raluca Moucha
    Neuroscience Program, School of Brain and Behavioral Sciences, University of Texas at Dallas, Dallas, TX, USA
    Prog Brain Res 157:111-122. 2006
    ....
  23. pmc Effect of the environment on the dendritic morphology of the rat auditory cortex
    Mitali Bose
    Laboratory of Cell and Synaptic Physiology, School for Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas, USA
    Synapse 64:97-110. 2010
    ....
  24. ncbi request reprint Sensory experience determines enrichment-induced plasticity in rat auditory cortex
    Cherie R Percaccio
    Neuroscience Program, School of Behavioral and Brain Sciences, GR 41, University of Texas at Dallas, 2601 N Floyd Road, Richardson, TX 75083 0688, USA
    Brain Res 1174:76-91. 2007
    ..This conclusion may be beneficial to clinical populations with sensory gating and cholinergic abnormalities, including individuals with autism, schizophrenia, and Alzheimer's disease...
  25. ncbi request reprint Knockdown of the dyslexia-associated gene kiaa0319 impairs temporal responses to speech stimuli in rat primary auditory cortex
    T M Centanni
    School of Behavioral and Brain Sciences, University of Texas at Dallas
    Cereb Cortex 24:1753-66. 2014
    ..These results provide the first evidence that decreased expression of the dyslexia-associated gene Kiaa0319 can alter cortical responses and impair phoneme processing in auditory cortex. ..
  26. pmc Order-sensitive plasticity in adult primary auditory cortex
    Michael P Kilgard
    Cognition and Neuroscience, School of Human Development, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Proc Natl Acad Sci U S A 99:3205-9. 2002
    ..These results indicate that context-dependent facilitation and response synchronization can be substantially altered in an experience-dependent fashion and provide a potential mechanism for learning spectrotemporal patterns...
  27. pmc Spectral and temporal processing in rat posterior auditory cortex
    Pritesh K Pandya
    Department of Speech and Hearing Science, College of Applied Health Sciences, University of Illinois at Urbana Champaign, 901 South Sixth Street, Champaign, IL 61820, USA
    Cereb Cortex 18:301-14. 2008
    ..These results indicate that PAF, like nonprimary visual fields, processes sensory information on larger spectral and longer temporal scales than primary cortex...
  28. pmc Differential reductions in acoustic startle document the discrimination of speech sounds in rats
    Owen R Floody
    Department of Psychology, Bucknell University, Lewisburg, Pennsylvania 17837, USA
    J Acoust Soc Am 122:1884-7. 2007
    ....

Research Grants3

  1. CORTICAL PLASTICITY AND PROCESSING OF COMPLEX STIMULI
    Michael Kilgard; Fiscal Year: 2002
    ..Our continuing studies will examine several other acoustic stimuli to determine precisely what stimulus features are required to generate each element of representational plasticity observed in our preliminary results. ..
  2. Cortical Plasticity and Processing of Speech Sounds
    Michael Kilgard; Fiscal Year: 2006
    ..Insights derived from these studies will influence the use and development of behavioral and sensory rehabilitation of language impairments. ..
  3. Animal Model of Speech Sound Processing in Autism
    Michael P Kilgard; Fiscal Year: 2010
    ..A better understanding of these mechanisms may aid the design of improved behavioral and sensory therapies to reduce communication impairments in autism. ..