Research Topics
| M P KilgardSummaryAffiliation: University of Texas at Dallas Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Harnessing plasticity to understand learning and treat diseaseMichael P Kilgard
The University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, TX 75080, USA
Trends Neurosci 35:715-22. 2012..Precisely targeted neural plasticity provides a new avenue for the treatment of neurological and psychiatric disorders and is a powerful tool to test the neural mechanisms of learning and memory...
Reorganization in processing of spectral and temporal input in the rat posterior auditory field induced by environmental enrichmentVikram Jakkamsetti
School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75083, USA
J Neurophysiol 107:1457-75. 2012..Along with other reports observing greater reorganization in nonprimary sensory cortex, our results in PAF suggest that nonprimary fields might have a greater capacity for reorganization compared with primary fields...
Sensory input directs spatial and temporal plasticity in primary auditory cortexM P Kilgard
Neuroscience Program, School of Human Development, University of Texas at Dallas, Richardson, Texas 75083 0688, USA
J Neurophysiol 86:326-38. 2001....- Spectral features control temporal plasticity in auditory cortexM P Kilgard
Cortical Plasticity Laboratory, Cognition and Neuroscience Program, University of Texas at Dallas, Richardson, TX 75083, USA
Audiol Neurootol 6:196-202. 2001..Additional experiments with more complex stimuli are needed to clarify how the cortex learns natural sounds such as speech... - Cortical network reorganization guided by sensory input featuresMichael P Kilgard
Neuroscience Program, School of Human Development, GR 41, University of Texas at Dallas, Richardson, TX 75083 0688, USA
Biol Cybern 87:333-43. 2002.... - Distributed representation of spectral and temporal information in rat primary auditory cortexM P Kilgard
Department of Otolaryngology, Keck Center for Integrative Neuroscience, University of California at San Francisco, 94143 0444, USA
Hear Res 134:16-28. 1999..No organized topography of these temporal filters could be determined... - Experience dependent plasticity alters cortical synchronizationM P Kilgard
University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, TX 75083, USA
Hear Res 229:171-9. 2007.... - Inverted-U function relating cortical plasticity and task difficultyN D Engineer
School of Behavioral and Brain Sciences, University of Texas at Dallas, 800 W Campbell Road Richardson, TX 75080, USA
Neuroscience 205:81-90. 2012..These results suggest an inverted-U function relating neural plasticity and task difficulty... - Vagus nerve stimulation modulates cortical synchrony and excitability through the activation of muscarinic receptorsJ A Nichols
School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
Neuroscience 189:207-14. 2011..These results are discussed with respect to their possible implications for sensory processing, neural plasticity, and epilepsy... - Asynchronous inputs alter excitability, spike timing, and topography in primary auditory cortexPritesh K Pandya
Neuroscience Program, School of Behavioral and Brain Sciences, PO Box 830688, GR 41, University of Texas at Dallas, Richardson, TX 75083-0688, USA
Hear Res 203:10-20. 2005..These results are consistent with earlier observations that sensory input statistics can shape cortical map organization and spike timing... - Background sounds contribute to spectrotemporal plasticity in primary auditory cortexRaluca Moucha
Neuroscience Program, School of Brain and Behavioral Sciences, GR41, University of Texas at Dallas, Richardson, TX 75083-0688, USA
Exp Brain Res 162:417-27. 2005..These results extend earlier observations that cortical neurons can develop stimulus specific plasticity and indicate that background conditions can strongly influence cortical plasticity... - Plasticity of temporal information processing in the primary auditory cortexM P Kilgard
Coleman Laboratory, Department of Otolaryngology, University of California at San Francisco 94143 0444, USA
Nat Neurosci 1:727-31. 1998..Thus this protocol elicits extensive cortical remodeling of temporal response properties and demonstrates that simple differences in spectral and temporal features of the sensory input can drive very different cortical reorganizations... - Cortical activity patterns predict speech discrimination abilityCrystal T Engineer
School of Behavioral and Brain Sciences, University of Texas at Dallas, 800 W Campbell Road, Richardson, Texas 75080, USA
Nat Neurosci 11:603-8. 2008..This result suggests that spike timing contributes to the auditory cortex representation of consonant sounds... - Plasticity in the rat posterior auditory field following nucleus basalis stimulationAmanda C Puckett
Neuroscience Program, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75083 0688, USA
J Neurophysiol 98:253-65. 2007..These results demonstrate that experience-dependent plasticity can take different forms in both A1 and secondary auditory cortex... - Reversing pathological neural activity using targeted plasticityNavzer D Engineer
Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, USA
Nature 470:101-4. 2011..These improvements persisted for weeks after the end of therapy. This method for restoring neural activity to normal may be applicable to a variety of neurological disorders... - Cortical map reorganization without cholinergic modulationMichael P Kilgard
Cognition and Neuroscience Program, University of Texas, Dallas, School of Behavioral and Brain Sciences, GR41, Richardson, Texas 75083, USA
Neuron 48:529-30. 2005..This finding suggests that acetylcholine may act less as a gate and more as a gain control on cortical plasticity... - Environmental enrichment improves response strength, threshold, selectivity, and latency of auditory cortex neuronsNavzer D Engineer
Neuroscience Program, School of Behavioral and Brain Sciences, GR 41, University of Texas at Dallas, Richardson, TX 75083-0688, USA
J Neurophysiol 92:73-82. 2004..These experiments provide the first evidence of physiologic changes in auditory cortex processing resulting from generalized environmental enrichment... - Environmental enrichment increases paired-pulse depression in rat auditory cortexCherie R Percaccio
Neuroscience Program, School of Behavioral and Brain Sciences, GR 41, University of Texas at Dallas, Richardson, Texas 75083-0688, USA
J Neurophysiol 94:3590-600. 2005..These results are relevant to several clinical disorders characterized by abnormal gating of sensory information, including autism, schizophrenia, and dyslexia... - Environmental enrichment selectively increases glutamatergic responses in layer II/III of the auditory cortex of the ratJ A Nichols
School for Behavioral and Brain Sciences, The University of Texas at Dallas, 2601 North Floyd Road, GR41, Richardson, TX 75080, USA
Neuroscience 145:832-40. 2007..Our data suggest that auditory EE selectively enhances excitatory glutamatergic synaptic transmission in layer II/III without greatly altering inhibitory GABAergic transmission... - Effect of the environment on the dendritic morphology of the rat auditory cortexMitali Bose
Laboratory of Cell and Synaptic Physiology, School for Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas, USA
Synapse 64:97-110. 2010.... - Sensory experience determines enrichment-induced plasticity in rat auditory cortexCherie R Percaccio
Neuroscience Program, School of Behavioral and Brain Sciences, GR 41, University of Texas at Dallas, 2601 N Floyd Road, Richardson, TX 75083 0688, USA
Brain Res 1174:76-91. 2007..This conclusion may be beneficial to clinical populations with sensory gating and cholinergic abnormalities, including individuals with autism, schizophrenia, and Alzheimer's disease... - Cortical plasticity and rehabilitationRaluca Moucha
Neuroscience Program, School of Brain and Behavioral Sciences, University of Texas at Dallas, Dallas, TX, USA
Prog Brain Res 157:111-122. 2006.... - Order-sensitive plasticity in adult primary auditory cortexMichael P Kilgard
Cognition and Neuroscience, School of Human Development, University of Texas at Dallas, Richardson, TX 75083-0688, USA
Proc Natl Acad Sci U S A 99:3205-9. 2002..These results indicate that context-dependent facilitation and response synchronization can be substantially altered in an experience-dependent fashion and provide a potential mechanism for learning spectrotemporal patterns... - Spectral and temporal processing in rat posterior auditory cortexPritesh K Pandya
Department of Speech and Hearing Science, College of Applied Health Sciences, University of Illinois at Urbana Champaign, 901 South Sixth Street, Champaign, IL 61820, USA
Cereb Cortex 18:301-14. 2008..These results indicate that PAF, like nonprimary visual fields, processes sensory information on larger spectral and longer temporal scales than primary cortex... - Differential reductions in acoustic startle document the discrimination of speech sounds in ratsOwen R Floody
Department of Psychology, Bucknell University, Lewisburg, Pennsylvania 17837, USA
J Acoust Soc Am 122:1884-7. 2007....
Research Grants
- CORTICAL PLASTICITY AND PROCESSING OF COMPLEX STIMULIMichael Kilgard; Fiscal Year: 2002..Our continuing studies will examine several other acoustic stimuli to determine precisely what stimulus features are required to generate each element of representational plasticity observed in our preliminary results. ..
- Cortical Plasticity and Processing of Speech SoundsMichael Kilgard; Fiscal Year: 2006..Insights derived from these studies will influence the use and development of behavioral and sensory rehabilitation of language impairments. ..
- Animal Model of Speech Sound Processing in AutismMichael P Kilgard; Fiscal Year: 2010..A better understanding of these mechanisms may aid the design of improved behavioral and sensory therapies to reduce communication impairments in autism. ..