LAURA KIESSLING

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc A defined glycosaminoglycan-binding substratum for human pluripotent stem cells
    Joseph R Klim
    Cell and Molecular Biology Program, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Methods 7:989-94. 2010
  2. pmc Glycopolymer probes of signal transduction
    Laura L Kiessling
    Department of Chemistry, University of Wisconsin Madison, 1101 University Ave, Madison, WI 53706, USA
    Chem Soc Rev 42:4476-91. 2013
  3. ncbi request reprint Symbiosis: Chemical biology at Wisconsin
    Laura L Kiessling
    Department of Biochemistry and Department of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA
    ACS Chem Biol 1:481-4. 2006
  4. pmc Synthetic multivalent ligands as probes of signal transduction
    Laura L Kiessling
    Department of Chemistry, University of Wisconsin Madison, 1101 University Ave, Madison, WI 53706, USA
    Angew Chem Int Ed Engl 45:2348-68. 2006
  5. ncbi request reprint A strategy for designing inhibitors of beta-amyloid toxicity
    J Ghanta
    Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 271:29525-8. 1996
  6. ncbi request reprint Chemical approaches to glycobiology
    Laura L Kiessling
    Department of Chemistry, University of Wisconsin Madison, Wisconsin 53706, USA
    Annu Rev Biochem 79:619-53. 2010
  7. ncbi request reprint Hitting the sweet spot
    Laura L Kiessling
    Department of Chemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Nat Biotechnol 20:234-5. 2002
  8. ncbi request reprint Synthetic multivalent ligands in the exploration of cell-surface interactions
    L L Kiessling
    Departments of Chemistry and Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Curr Opin Chem Biol 4:696-703. 2000
  9. ncbi request reprint Transforming the cell surface through proteolysis
    L L Kiessling
    Department of Chemistry, University of Wisconsin Madison 53706, USA
    Chem Biol 5:R49-62. 1998
  10. ncbi request reprint Bifunctional ligands that target cells displaying the alpha v beta3 integrin
    Robert M Owen
    Department of Chemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Chembiochem 8:68-82. 2007

Research Grants

  1. Synthetic Ligands for Modulating B-Cell Responses
    Laura L Kiessling; Fiscal Year: 2010
  2. The Chemistry and Biology of Galactofuranose Residues
    Laura L Kiessling; Fiscal Year: 2010
  3. Glycopeptides and Other Non-Natural Variants: Probes of Carbohydrate Function
    Laura L Kiessling; Fiscal Year: 2011
  4. The Chemistry and Biology of Galactofuranose Residues
    LAURA KIESSLING; Fiscal Year: 2006
  5. Multivalent Ligands as Effectors
    LAURA KIESSLING; Fiscal Year: 2001
  6. Synthetic Ligands for Modulating B-Cell Responses
    LAURA KIESSLING; Fiscal Year: 2009
  7. Synthetic Ligands for Modulating B-Cell Responses
    LAURA KIESSLING; Fiscal Year: 2006
  8. PROBES OF CARBOHYDRATE FUNCTION
    LAURA KIESSLING; Fiscal Year: 2006
  9. Mulitvalent Ligands as Effectors
    LAURA KIESSLING; Fiscal Year: 2006
  10. The Chemistry and Biology of Galactofuranose Residues
    LAURA KIESSLING; Fiscal Year: 2007

Collaborators

  • RONALD RAINES
  • JASON GESTWICKI
  • Christopher W Cairo
  • Ronen Alon
  • A C Rapraeger
  • P H Seeberger
  • S D Rosen
  • M Jack Borrok
  • Ratmir Derda
  • Zhi Qiang Yang
  • Robert M Owen
  • Erik B Puffer
  • Joseph R Klim
  • Rebecca A Splain
  • Lingyin Li
  • Katrina T Forest
  • John F May
  • Erin M Kolonko
  • Erin E Carlson
  • Jason K Pontrello
  • Patricia Mowery
  • Kathleen C A Garber
  • Chutima Jiarpinitnun
  • Emily C Dykhuizen
  • Adam H Courtney
  • Todd D Gruber
  • Brendan P Orner
  • Shane L Mangold
  • David Borrok
  • Byron R Griffith
  • Yi He
  • Olga D Genbacev
  • Allison C Lamanna
  • Paul J Wrighton
  • Samira Musah
  • Marian S Piekarczyk
  • Kittikhun Wangkanont
  • Christine Brotschi
  • William M Westler
  • Yimin Zhu
  • Rachael T Carpenter
  • Jinwang Xu
  • Elisabetta Fasella
  • Coby B Carlson
  • James A Thomson
  • John A Kink
  • Jessica J Hollenbeck
  • Rachel L Lewis
  • Jeremy B Fein
  • Oren Dwir
  • Benjamin L Allen
  • Ronald J Hinklin
  • Andrew G Spencer
  • Eva J Gordon
  • Jiyoung Chang
  • Russell A Foulk
  • Susan J Fisher
  • Dusko Ilic
  • Ana R Krtolica
  • Mark S Singer
  • Akraporn Prakobphol
  • Laura E Strong
  • Sara L Borchardt
  • J Ghanta
  • Travis Young
  • R M Murphy
  • C L Shen

Detail Information

Publications41

  1. pmc A defined glycosaminoglycan-binding substratum for human pluripotent stem cells
    Joseph R Klim
    Cell and Molecular Biology Program, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Methods 7:989-94. 2010
    ..The peptides supported growth of eight pluripotent cell lines on a variety of scaffolds. Our results indicate that synthetic substrates that recognize cell-surface glycans can facilitate the long-term culture of pluripotent stem cells...
  2. pmc Glycopolymer probes of signal transduction
    Laura L Kiessling
    Department of Chemistry, University of Wisconsin Madison, 1101 University Ave, Madison, WI 53706, USA
    Chem Soc Rev 42:4476-91. 2013
    ..Our objective is to illustrate how these powerful tools can reveal the molecular mechanisms that underlie carbohydrate-mediated signal transduction...
  3. ncbi request reprint Symbiosis: Chemical biology at Wisconsin
    Laura L Kiessling
    Department of Biochemistry and Department of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA
    ACS Chem Biol 1:481-4. 2006
  4. pmc Synthetic multivalent ligands as probes of signal transduction
    Laura L Kiessling
    Department of Chemistry, University of Wisconsin Madison, 1101 University Ave, Madison, WI 53706, USA
    Angew Chem Int Ed Engl 45:2348-68. 2006
    ..Multivalent ligands can be generated that possess a variety of sizes, shapes, valencies, orientations, and densities of binding elements. This Review focuses on the use of synthetic multivalent ligands to characterize receptor function...
  5. ncbi request reprint A strategy for designing inhibitors of beta-amyloid toxicity
    J Ghanta
    Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 271:29525-8. 1996
    ..Significantly, these results demonstrate that complete disruption of amyloid fibril formation is not necessary for abrogation of toxicity...
  6. ncbi request reprint Chemical approaches to glycobiology
    Laura L Kiessling
    Department of Chemistry, University of Wisconsin Madison, Wisconsin 53706, USA
    Annu Rev Biochem 79:619-53. 2010
    ..These examples illustrate how chemical glycobiology is providing new insight into the functional roles of glycans and new opportunities to interfere with or exploit these roles...
  7. ncbi request reprint Hitting the sweet spot
    Laura L Kiessling
    Department of Chemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Nat Biotechnol 20:234-5. 2002
  8. ncbi request reprint Synthetic multivalent ligands in the exploration of cell-surface interactions
    L L Kiessling
    Departments of Chemistry and Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Curr Opin Chem Biol 4:696-703. 2000
    ....
  9. ncbi request reprint Transforming the cell surface through proteolysis
    L L Kiessling
    Department of Chemistry, University of Wisconsin Madison 53706, USA
    Chem Biol 5:R49-62. 1998
    ..Growing evidence suggesting that protein shedding and protein function are closely linked may lead to new strategies for the treatment of a wide range of diseases...
  10. ncbi request reprint Bifunctional ligands that target cells displaying the alpha v beta3 integrin
    Robert M Owen
    Department of Chemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Chembiochem 8:68-82. 2007
    ..We anticipate that our modifiable alpha v beta3-binding ligands will be valuable in a variety of applications, including drug delivery and tumor targeting...
  11. doi request reprint Chemical probes of bacterial signal transduction reveal that repellents stabilize and attractants destabilize the chemoreceptor array
    M Jack Borrok
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    ACS Chem Biol 3:101-9. 2008
    ..Moreover, our data demonstrate that repellents can be transformed into attractants merely by their multivalent display. These results have implications for designing agonists and antagonists for other signaling systems...
  12. pmc Non-carbohydrate inhibitors of the lectin DC-SIGN
    M Jack Borrok
    Department of Biochemistry and Chemistry, University of Wisconsin, Madison, WI 53706, USA
    J Am Chem Soc 129:12780-5. 2007
    ..Thus, we anticipate that these non-carbohydrate inhibitors can be used to illuminate the role of DC-SIGN in pathogenesis and immune function...
  13. ncbi request reprint Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding
    Patricia Mowery
    Department of Biochemistry, 433 Babcock Drive, University of Wisconsin Madison, Madison, WI 53706 USA
    Chem Biol 11:725-32. 2004
    ..Thus, their inhibitory potency may arise from their ability to induce shedding. Our data indicate that screening for compounds that promote L-selectin release can identify ligands that inhibit rolling...
  14. ncbi request reprint Inter-receptor communication through arrays of bacterial chemoreceptors
    Jason E Gestwicki
    Department of Chemistry, University of Wisconsin Madison, 53706, USA
    Nature 415:81-4. 2002
    ..These results demonstrate that the entire array is involved in sensing. This mode of information exchange has general implications for the processing of signals by cellular receptors...
  15. pmc Conserved amplification of chemotactic responses through chemoreceptor interactions
    Allison C Lamanna
    Department of Biochemistry, University of Wisconsin at Madison, Madison, Wisconsin 53706, USA
    J Bacteriol 184:4981-7. 2002
    ..coli, signaling information is transferred among chemoreceptors in B. subtilis. These results suggest that interreceptor communication may be a general mechanism for modulating chemotactic responses in bacteria...
  16. ncbi request reprint Influencing receptor-ligand binding mechanisms with multivalent ligand architecture
    Jason E Gestwicki
    Departments of Biochemistry and Chemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    J Am Chem Soc 124:14922-33. 2002
    ..Diversity-oriented syntheses of multivalent ligands coupled with effective assays that can be used to compare the contributions of different binding parameters may afford ligands that function by specific mechanisms...
  17. ncbi request reprint A polymer scaffold for protein oligomerization
    Byron R Griffith
    Department of Chemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    J Am Chem Soc 126:1608-9. 2004
    ..We demonstrate that they can oligomerize fibroblast growth factor-8b (FGF-8b) and promote FGF-8b-mediated cell proliferation in the absence of heparin...
  18. pmc Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite
    Emily C Dykhuizen
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Org Lett 11:193-6. 2009
    ..The potency of these compounds stems from their ability to access both the substrate binding pocket and an adjacent site...
  19. ncbi request reprint Synthesis and applications of end-labeled neoglycopolymers
    Robert M Owen
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Org Lett 4:2293-6. 2002
    ..The data reveal that these multivalent ligands interact with multiple copies of L-selectin...
  20. pmc Structure-based design of a periplasmic binding protein antagonist that prevents domain closure
    M Jack Borrok
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    ACS Chem Biol 4:447-56. 2009
    ..These findings provide a blueprint for the design of new bacterial PBP inhibitors. Given the key role of PBPs in microbial physiology, we anticipate that PBP antagonists will have widespread uses as probes and antimicrobial agents...
  21. pmc Ligand binding and substrate discrimination by UDP-galactopyranose mutase
    Todd D Gruber
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1544, USA
    J Mol Biol 391:327-40. 2009
    ..To understand the consequences of these differences, we derived a model for the productive UGM-substrate complex that highlights interactions that can contribute to catalysis and substrate discrimination...
  22. pmc A tethering mechanism for length control in a processive carbohydrate polymerization
    John F May
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:11851-6. 2009
    ..The strength of interaction of that tether with the polymerase influences the length of the resultant polymer. Thus, our data identify a mechanism for length control by a template-independent polymerase...
  23. pmc High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells
    Ratmir Derda
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Am Chem Soc 132:1289-95. 2010
    ..Our results indicate that this screening strategy is a productive avenue for the generation of materials that control the growth and differentiation of cells...
  24. ncbi request reprint Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy
    Jason E Gestwicki
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Anal Biochem 305:149-55. 2002
    ..Together, our results indicate that synthetic surfaces can be created by selective immobilization of multivalent ligands and that these surfaces are capable of binding soluble and cell-surface-associated receptors with high affinity...
  25. pmc Synthesis of galactofuranose-based acceptor substrates for the study of the carbohydrate polymerase GlfT2
    Rebecca A Splain
    Department of Chemistry, University of Wisconsin, Madison, WI 53706, USA
    Bioorg Med Chem 18:3753-9. 2010
    ..Moreover, our investigations indicate that lipids possessing but a single galactofuranose residue can act as substrates for GlfT2...
  26. pmc Unexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituent
    Chutima Jiarpinitnun
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Am Chem Soc 132:8844-5. 2010
    ....
  27. pmc A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN
    Kathleen C A Garber
    Department of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, WI 53706, USA
    Chem Commun (Camb) 46:6747-9. 2010
    ..Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission...
  28. pmc Synthesis of fluorogenic polymers for visualizing cellular internalization
    Shane L Mangold
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Org Lett 10:2997-3000. 2008
    ..The utility of ligands of this type is highlighted by visualizing multivalent antigen internalization in live B cells...
  29. pmc A polymeric domain that promotes cellular internalization
    Erin M Kolonko
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Am Chem Soc 130:5626-7. 2008
    ..Because the synthesis of such materials is modular, we anticipate that compounds of this type can be fashioned that facilitate the delivery of cargo via end-cap derivatization or block copolymer synthesis...
  30. ncbi request reprint Stereoselective N-glycosylation by Staudinger ligation
    Yi He
    Departments of Chemistry and Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Org Lett 6:4479-82. 2004
    ..Our results provide precedence for the use of this powerful amide-bond-forming reaction for N-glycopeptide synthesis. [reaction: see text]..
  31. ncbi request reprint Visualization and characterization of receptor clusters by transmission electron microscopy
    Jason E Gestwicki
    Departments of Chemistry and Biochemistry, University of Wisconsin, 1101 University Avenue, Madison, Wisconsin 53706, USA
    Methods Enzymol 362:301-12. 2003
  32. ncbi request reprint Chemical probes of UDP-galactopyranose mutase
    Erin E Carlson
    Department of Chemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Chem Biol 13:825-37. 2006
    ..Our studies offer a blueprint for identifying inhibitors of the growing family of UGM homologs and provide insight into UGM inhibition...
  33. ncbi request reprint Synthesis of a multivalent display of a CD22-binding trisaccharide
    Zhi Qiang Yang
    Department of Chemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Carbohydr Res 337:1605-13. 2002
    ..3. A fluorescein-labeled version of the multivalent ligand binds to cells expressing CD22...
  34. ncbi request reprint Activating B cell signaling with defined multivalent ligands
    Erik B Puffer
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    ACS Chem Biol 2:252-62. 2007
    ..Our data suggest a link between the mechanisms underlying signal initiation by receptors that must respond with high sensitivity...
  35. pmc Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures
    M Jack Borrok
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Protein Sci 16:1032-41. 2007
    ..Together, these structures provide insight into how the hinge-bending movement of GGBP facilitates ligand binding, transport, and signaling...
  36. ncbi request reprint Defined substrates for human embryonic stem cell growth identified from surface arrays
    Ratmir Derda
    Department of Chemistry, 1101 University Avenue, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    ACS Chem Biol 2:347-55. 2007
    ..Our results demonstrate that synthetic substrates for promoting and probing human ES cell self-renewal can be discovered through SAM surface arrays...
  37. pmc Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation
    Adam H Courtney
    Departments of Biochemistry and Chemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:2500-5. 2009
    ..The ability of sialylated antigens to inhibit BCR signaling through trans CD22 interactions reveals a previously unrecognized role for the Siglec-family of receptors as modulators of immune signaling...
  38. ncbi request reprint Fostering major breakthroughs
    Laura L Kiessling
    ACS Chem Biol 1:1-2. 2006
  39. ncbi request reprint A higher degree of difficulty
    Laura L Kiessling
    ACS Chem Biol 2:197-9. 2007
  40. ncbi request reprint Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface
    Olga D Genbacev
    Departments of Stomatology, Anatomy, and Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA
    Science 299:405-8. 2003
    ..These results suggest that trophoblast L-selectin mediates interactions with the uterus and that this adhesion mechanism may be critical to establishing human pregnancy...
  41. ncbi request reprint Link between chemotactic response to Ni2+ and its adsorption onto the Escherichia coli cell surface
    David Borrok
    Department of Civil Engineering and Geological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Environ Sci Technol 39:5227-33. 2005
    ..Our data suggest that specified changes in environmental conditions can be used to tune chemotactic responses in natural biological and geological settings...

Research Grants38

  1. Synthetic Ligands for Modulating B-Cell Responses
    Laura L Kiessling; Fiscal Year: 2010
    ..g., for treating autoimmune diseases). The goal of this proposal is to synthesize new compounds that can be used to control B cell responses. ..
  2. The Chemistry and Biology of Galactofuranose Residues
    Laura L Kiessling; Fiscal Year: 2010
    ..The goal of this project is to understand key steps in mycobacterial cell wall biosynthesis that are not targeted by any current drugs and find inhibitors from which new types of drugs could be developed. ..
  3. Glycopeptides and Other Non-Natural Variants: Probes of Carbohydrate Function
    Laura L Kiessling; Fiscal Year: 2011
    ..This project is aimed at identifying DC-SIGN inhibitors and using compounds that bind to DC-SIGN to study its function. ..
  4. The Chemistry and Biology of Galactofuranose Residues
    LAURA KIESSLING; Fiscal Year: 2006
    ..Moreover, we hope that by pursuing the proposed investigations, new leads for the treatment of tuberculosis may emerge. ..
  5. Multivalent Ligands as Effectors
    LAURA KIESSLING; Fiscal Year: 2001
    ..Our studies of leukocyte chemotaxis may lead to new strategies for the control of inflammation and a deeper understanding of the role of receptor clustering in GPCR-mediated signal amplification and integration. ..
  6. Synthetic Ligands for Modulating B-Cell Responses
    LAURA KIESSLING; Fiscal Year: 2009
    ..g., for treating autoimmune diseases). The goal of this proposal is to synthesize new compounds that can be used to control B cell responses. ..
  7. Synthetic Ligands for Modulating B-Cell Responses
    LAURA KIESSLING; Fiscal Year: 2006
    ..We anticipate that our studies will provide insight into the signaling processes and may lead to new strategies for the generation of vaccines and/or compounds that inhibit autoimmune responses. ..
  8. PROBES OF CARBOHYDRATE FUNCTION
    LAURA KIESSLING; Fiscal Year: 2006
    ..We anticipate that the results from our studies will provide new tools for the investigation of DC-SIGN and DC-SIGNR function in particular and for probing C-type lectin function in general. ..
  9. Mulitvalent Ligands as Effectors
    LAURA KIESSLING; Fiscal Year: 2006
    ..Moreover, neutrophil chemotaxis occurs in the inflammatory/immune response. Thus, conclusions from our studies will be broadly applicable to understanding other signaling pathways involved in human disease. ..
  10. The Chemistry and Biology of Galactofuranose Residues
    LAURA KIESSLING; Fiscal Year: 2007
    ..Moreover, we hope that by pursuing the proposed investigations, new leads for the treatment of tuberculosis may emerge. ..
  11. Glycopeptides and Other Non-Natural Variants: Probes of Carbohydrate Function
    Laura L Kiessling; Fiscal Year: 2010
    ..This project is aimed at identifying DC-SIGN inhibitors and using compounds that bind to DC-SIGN to study its function. ..
  12. Glycopeptides and Other Non-Natural Variants: Probes of Carbohydrate Function
    LAURA KIESSLING; Fiscal Year: 2009
    ..This project is aimed at identifying DC-SIGN inhibitors and using compounds that bind to DC-SIGN to study its function. ..
  13. PROBES OF CARBOHYDRATE FUNCTION
    LAURA KIESSLING; Fiscal Year: 2005
    ..We anticipate that the results from our studies will provide new tools for the investigation of DC-SIGN and DC-SIGNR function in particular and for probing C-type lectin function in general. ..
  14. Synthetic Ligands for Modulating B-Cell Responses
    LAURA KIESSLING; Fiscal Year: 2005
    ..We anticipate that our studies will provide insight into the signaling processes and may lead to new strategies for the generation of vaccines and/or compounds that inhibit autoimmune responses. ..
  15. MULTIVALENT PROTEIN CARBOHYDRATE INTERACTIONS
    LAURA KIESSLING; Fiscal Year: 1999
    ..The tools and information gained from investigating multidentate interactions with the mannose-binding proteins will be applied to the study of the selectins. ..
  16. PROBES OF CARBOHYDRATE FUNCTION
    LAURA KIESSLING; Fiscal Year: 2001
    ..It is anticipated that these studies will lead to the development of new methodologies for the modulation of cell-cell and carbohydrate-receptor interactions. ..
  17. Multivalent Ligands as Effectors
    LAURA KIESSLING; Fiscal Year: 2002
    ..Our studies of leukocyte chemotaxis may lead to new strategies for the control of inflammation and a deeper understanding of the role of receptor clustering in GPCR-mediated signal amplification and integration. ..
  18. The Chemistry and Biology of Galactofuranose Residues
    LAURA KIESSLING; Fiscal Year: 2005
    ..Moreover, we hope that by pursuing the proposed investigations, new leads for the treatment of tuberculosis may emerge. ..
  19. Synthetic Ligands for Modulating B-Cell Responses
    Laura L Kiessling; Fiscal Year: 2011
    ..g., for vaccine development), and those that block B cell activation could lead to tolerance (e.g., for treating autoimmune diseases). The goal of this proposal is to synthesize new compounds that can be used to control B cell responses. ..
  20. PROBES OF CARBOHYDRATE FUNCTION
    LAURA KIESSLING; Fiscal Year: 2000
    ..It is anticipated that these studies will lead to the development of new methodologies for the modulation of cell-cell and carbohydrate-receptor interactions. ..
  21. PROBES OF CARBOHYDRATE FUNCTION
    LAURA KIESSLING; Fiscal Year: 2002
    ..It is anticipated that these studies will lead to the development of new methodologies for the modulation of cell-cell and carbohydrate-receptor interactions. ..
  22. Multivalent Ligands as Effectors
    LAURA KIESSLING; Fiscal Year: 2003
    ..Our studies of leukocyte chemotaxis may lead to new strategies for the control of inflammation and a deeper understanding of the role of receptor clustering in GPCR-mediated signal amplification and integration. ..
  23. Chemical Biology Interface Training Grant
    LAURA KIESSLING; Fiscal Year: 2007
    ..This program will continue to provide CBI trainees with unique opportunities that will prepare them for leadership roles in academia and industry. ..
  24. Synthetic Ligands for Modulating B-Cell Responses
    LAURA KIESSLING; Fiscal Year: 2003
    ..We anticipate that our studies will provide insight into the signaling processes and may lead to new strategies for the generation of vaccines and/or compounds that inhibit autoimmune responses. ..
  25. PROBES OF CARBOHYDRATE FUNCTION
    LAURA KIESSLING; Fiscal Year: 2003
    ..We anticipate that the results from our studies will provide new tools for the investigation of DC-SIGN and DC-SIGNR function in particular and for probing C-type lectin function in general. ..
  26. Synthetic Ligands for Modulating B-Cell Responses
    LAURA KIESSLING; Fiscal Year: 2004
    ..We anticipate that our studies will provide insight into the signaling processes and may lead to new strategies for the generation of vaccines and/or compounds that inhibit autoimmune responses. ..
  27. Glycopeptides and Other Non-Natural Variants: Probes of Carbohydrate Function
    LAURA KIESSLING; Fiscal Year: 2009
    ..This project is aimed at identifying DC-SIGN inhibitors and using compounds that bind to DC-SIGN to study its function. ..
  28. PROBES OF CARBOHYDRATE FUNCTION
    LAURA KIESSLING; Fiscal Year: 2004
    ..We anticipate that the results from our studies will provide new tools for the investigation of DC-SIGN and DC-SIGNR function in particular and for probing C-type lectin function in general. ..
  29. PROBES OF CARBOHYDRATE FUNCTION
    LAURA KIESSLING; Fiscal Year: 1999
    ..It is anticipated that these studies will lead to the development of new methodologies for the modulation of cell-cell and carbohydrate-receptor interactions. ..
  30. Multivalent Ligands as Effectors
    LAURA KIESSLING; Fiscal Year: 2004
    ..Our studies of leukocyte chemotaxis may lead to new strategies for the control of inflammation and a deeper understanding of the role of receptor clustering in GPCR-mediated signal amplification and integration. ..
  31. Mulitvalent Ligands as Effectors
    LAURA KIESSLING; Fiscal Year: 2009
    ..Moreover, neutrophil chemotaxis occurs in the inflammatory/immune response. Thus, conclusions from our studies will be broadly applicable to understanding other signaling pathways involved in human disease. ..
  32. MULTIVALENT PROTEIN CARBOHYDRATE INTERACTIONS
    LAURA KIESSLING; Fiscal Year: 2000
    ..The tools and information gained from investigating multidentate interactions with the mannose-binding proteins will be applied to the study of the selectins. ..
  33. Mulitvalent Ligands as Effectors
    LAURA KIESSLING; Fiscal Year: 2007
    ..Moreover, neutrophil chemotaxis occurs in the inflammatory/immune response. Thus, conclusions from our studies will be broadly applicable to understanding other signaling pathways involved in human disease. ..