CRAIG KIEN

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood
    C Lawrence Kien
    Departments of Pediatrics, University of Vermont, Burlington, VT, USA
    Am J Clin Nutr 97:689-97. 2013
  2. pmc A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults
    C Lawrence Kien
    Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
    Diabetes 62:1054-63. 2013
  3. pmc Lactulose feeding lowers cecal densities of clostridia in piglets
    C Lawrence Kien
    Department of Pediatrics, College of Medicine, University of Vermont, Burlington, Vermont, USA
    JPEN J Parenter Enteral Nutr 31:194-8. 2007
  4. pmc Effects of palmitate and oleate on the respiratory quotient during acute feeding
    C Lawrence Kien
    Department of Pediatrics and Medicine, E203 Given Building, 89 Beaumont Avenue, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Obesity (Silver Spring) 15:1640-2. 2007
  5. pmc Effects of the in vivo supply of butyrate on histone acetylation of cecum in piglets
    C Lawrence Kien
    Department of Pediatrics, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    JPEN J Parenter Enteral Nutr 32:51-6. 2008
  6. pmc Gender alters the effects of palmitate and oleate on fat oxidation and energy expenditure
    C Lawrence Kien
    Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
    Obesity (Silver Spring) 16:29-33. 2008
  7. pmc Cecal infusion of butyrate does not alter cecal concentration of butyrate in piglets fed inulin
    C Lawrence Kien
    Department of Pediatrics and Medicine, College of Medicine, and the Office of Animal Care Management, University of Vermont, Burlington, VT 05405 0068, USA
    JPEN J Parenter Enteral Nutr 32:439-42. 2008
  8. pmc Dietary interventions for metabolic syndrome: role of modifying dietary fats
    CRAIG LAWRENCE KIEN
    University of Vermont College of Medicine, Department of Pediatrics, E203 Given Building, 89 Beaumont Avenue, Burlington, VT 05405 0068, USA
    Curr Diab Rep 9:43-50. 2009
  9. pmc Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects
    C Lawrence Kien
    Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
    Obesity (Silver Spring) 19:305-11. 2011
  10. pmc Cecal infusion of butyrate increases intestinal cell proliferation in piglets
    C Lawrence Kien
    Department of Pediatrics, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Nutr 137:916-22. 2007

Detail Information

Publications20

  1. pmc Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood
    C Lawrence Kien
    Departments of Pediatrics, University of Vermont, Burlington, VT, USA
    Am J Clin Nutr 97:689-97. 2013
    ..The Western diet increases risk of metabolic disease...
  2. pmc A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults
    C Lawrence Kien
    Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
    Diabetes 62:1054-63. 2013
    ..This study provides evidence that the dietary PA/OA ratio impacts diabetes risk in women...
  3. pmc Lactulose feeding lowers cecal densities of clostridia in piglets
    C Lawrence Kien
    Department of Pediatrics, College of Medicine, University of Vermont, Burlington, Vermont, USA
    JPEN J Parenter Enteral Nutr 31:194-8. 2007
    ..Because clostridia may be a major source of colonic butyrate production, we hypothesized that feeding piglets lactulose or inulin would increase cecal densities of clostridia...
  4. pmc Effects of palmitate and oleate on the respiratory quotient during acute feeding
    C Lawrence Kien
    Department of Pediatrics and Medicine, E203 Given Building, 89 Beaumont Avenue, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Obesity (Silver Spring) 15:1640-2. 2007
    ..Thus, we hypothesized that increasing PA vs. OA would decrease FA oxidation during the first day of feeding the diets...
  5. pmc Effects of the in vivo supply of butyrate on histone acetylation of cecum in piglets
    C Lawrence Kien
    Department of Pediatrics, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    JPEN J Parenter Enteral Nutr 32:51-6. 2008
    ..In vitro, butyrate inhibits histone deacetylase and down-regulates expression of cyclin D1. We hypothesized that an increased entry rate of butyrate into the cecal lumen would have similar effects in vivo...
  6. pmc Gender alters the effects of palmitate and oleate on fat oxidation and energy expenditure
    C Lawrence Kien
    Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
    Obesity (Silver Spring) 16:29-33. 2008
    ..oleic acid (OA) in subjects participating in a previously described trial...
  7. pmc Cecal infusion of butyrate does not alter cecal concentration of butyrate in piglets fed inulin
    C Lawrence Kien
    Department of Pediatrics and Medicine, College of Medicine, and the Office of Animal Care Management, University of Vermont, Burlington, VT 05405 0068, USA
    JPEN J Parenter Enteral Nutr 32:439-42. 2008
    ..As part of a larger study of the cellular effects of cecal infusions of butyrate, we sought to rule out the null hypothesis that cecal infusion of butyrate also would not alter butyrate concentration in the cecum...
  8. pmc Dietary interventions for metabolic syndrome: role of modifying dietary fats
    CRAIG LAWRENCE KIEN
    University of Vermont College of Medicine, Department of Pediatrics, E203 Given Building, 89 Beaumont Avenue, Burlington, VT 05405 0068, USA
    Curr Diab Rep 9:43-50. 2009
    ..A research challenge is to determine whether feeding humans diets with markedly different contents of PA and OA would alter insulin sensitivity and/or critical biochemical mechanisms impacting muscle insulin signaling...
  9. pmc Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects
    C Lawrence Kien
    Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
    Obesity (Silver Spring) 19:305-11. 2011
    ..11 ± 0.02 in the HI OA group (n = 4) (P = 0.067). The relative PA concentration in muscle DAG and TAG and the serum palmitoylcarnitine concentration was higher in those fed the high-PA diet...
  10. pmc Cecal infusion of butyrate increases intestinal cell proliferation in piglets
    C Lawrence Kien
    Department of Pediatrics, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Nutr 137:916-22. 2007
    ..Thus, intracolonic butyrate may enhance intestinal growth during infancy...
  11. pmc Increased colonic luminal synthesis of butyric acid is associated with lowered colonic cell proliferation in piglets
    C Lawrence Kien
    Department of Pediatrics, University of Texas Medical Branch, USA
    J Nutr 136:64-9. 2006
    ..026) and was higher in L + I than in L (P = 0.013) or I (P = 0.046). The increased supply of butyrate to the cecum was associated with decreased cell proliferation, but cecal butyrate concentration did not reflect synthesis...
  12. ncbi request reprint Effects of prefeeding a prebiotic on diarrhea and colonic cell proliferation in piglets fed lactulose
    C Lawrence Kien
    Children s Research Institute, Department of Pediatrics, The Ohio State University, Columbus, OH, USA
    JPEN J Parenter Enteral Nutr 28:22-6. 2004
    ..Severe lactulose malabsorption causes osmotic diarrhea and decreased cecal cell proliferation. We tested the hypothesis that prefeeding with inulin, a prebiotic, would attenuate these effects...
  13. pmc Prediction of daily energy expenditure during a feeding trial using measurements of resting energy expenditure, fat-free mass, or Harris-Benedict equations
    C Lawrence Kien
    Department of Pediatrics, University of Texas Medical Branch and the Shriners Hospital for Children, Galveston, TX, USA
    Am J Clin Nutr 80:876-80. 2004
    ..During feeding trials, it is useful to predict daily energy expenditure (DEE) to estimate energy requirements and to assess subject compliance...
  14. pmc Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure
    C Lawrence Kien
    Department of Pediatrics, University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX, USA
    Am J Clin Nutr 82:320-6. 2005
    ..Oleic acid (OA) is oxidized more rapidly than is palmitic acid (PA)...
  15. pmc Differential effects of dietary intake of palmitic acid and oleic acid on oxygen consumption during and after exercise
    Elisabet Børsheim
    Department of Surgery, University of Texas Medical Branch, Galveston, USA
    Metabolism 55:1215-21. 2006
    ..7% +/- 4.9% of preexercise V o(2) in OA, whereas there was no EPOC present in PA (P = .06 between diets). In conclusion, a high-PA diet appears to lower V o(2) during and after exercise compared with a high-OA diet...
  16. ncbi request reprint Short-chain fatty acids: ready for prime time?
    Claude C Roy
    Ste Justine Hospital, 3175 Ste Catherine Road, Montreal, Quebec H3T 1C5, Canada
    Nutr Clin Pract 21:351-66. 2006
    ..The future lies with the design of studies to further explore basic mechanisms, and gene expression in particular, but emphasis should be placed on human intervention trials...
  17. ncbi request reprint Moderate disaccharide malabsorption does not affect weight gain and cecal cell proliferation in piglets
    C Lawrence Kien
    Children s Research Institute, and the Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA
    JPEN J Parenter Enteral Nutr 27:323-6. 2003
    ..We addressed the hypothesis that normal weight gain and stool characteristics would occur during disaccharide malabsorption approximating 50% of intake...
  18. ncbi request reprint Quantitation of colonic luminal synthesis of butyric acid in piglets
    C Lawrence Kien
    Children s Research Institute, The Ohio State University, Columbus, Ohio, USA
    J Pediatr Gastroenterol Nutr 35:324-8. 2002
    ..The objective of this paper is to describe a newly developed stable isotope method for quantifying butyric acid synthesis in the colonic lumen and to demonstrate its application during cecal infusions of lactose and lactulose in piglets...
  19. ncbi request reprint Diarrhea in severely burned children
    Kalpesh Thakkar
    Shriners Burns Hospital, Texas, USA
    JPEN J Parenter Enteral Nutr 29:8-11. 2005
    ..Our patients are fed a high-carbohydrate enteral formula. We hypothesized that diarrhea in our patients may be related to the osmotic effects of unabsorbed carbohydrate in the small intestine and colon...
  20. ncbi request reprint Physical activity in middle school-aged children participating in a school-based recreation program
    C Lawrence Kien
    Children s Research Institute and The Department of Pediatrics, Ohio State University College of Medicine, Columbus, USA
    Arch Pediatr Adolesc Med 157:811-5. 2003
    ....

Research Grants15

  1. Mechanisms for differential effects of dietary fatty acids on metabolism
    CRAIG LAWRENCE KIEN; Fiscal Year: 2010
    ..new information regarding how mitochondrial malfunction, modified by dietary FA, plays a central role in the development of obesity, the metabolic syndrome, type 2 diabetes, and both heritable and age-related metabolic diseases ..
  2. Mechanisms for differential effects of dietary fatty acids on metabolism
    CRAIG KIEN; Fiscal Year: 2007
    ..regarding how mitochondrial malfunction, modified by dietary FA, plays a central role in the development of obesity, the metabolic syndrome, type 2 diabetes, and both heritable and age-related metabolic diseases ..
  3. Mechanisms for differential effects of dietary fatty acids on metabolism
    CRAIG KIEN; Fiscal Year: 2007
    ..important new information regarding how mitochondrial malfunction, modified by dietary FA, plays a central role in the development of obesity, the metabolic syndrome, type 2 diabetes, and both heritable and age-related metabolic diseases ..
  4. DIFFERENTIAL METABOLISM OF DIETARY FATTY ACIDS
    CRAIG KIEN; Fiscal Year: 2003
    ..In specific aim 4, the PI will measure the thermic effect of feeding during both the solid food and formula diet periods. The PI hypothesizes that the high OA feeding will be associated with a higher thermic effect of feeding. ..
  5. Colonic Bacterial Synthesis of Butyric Acid
    CRAIG KIEN; Fiscal Year: 2004
    ....
  6. Palmitate Metabolism and Insulin Resistance
    CRAIG LAWRENCE KIEN; Fiscal Year: 2010
    ..The proposed study will examine biochemical and molecular mechanisms for how a high saturated fat diet versus a low saturated fat/high monounsaturated fat diet alters the action of the hormone, insulin, in skeletal muscle. ..