Valerie Kickhoefer

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle
    Michael J Poderycki
    Department of Biological Chemistry and the Jonsson Comprehensive Cancer Center, The David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1737, USA
    Nucleic Acids Res 33:893-902. 2005
  2. pmc The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase
    V A Kickhoefer
    Department of Biological Chemistry, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    J Cell Biol 146:917-28. 1999
  3. pmc The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins
    Alex Bateman
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Bioinformatics 4:49. 2003
  4. ncbi request reprint Vaults and telomerase share a common subunit, TEP1
    V A Kickhoefer
    Department of Biological Chemistry, UCLA School of Medicine and Jonsson Comprehensive Cancer Center, Los Angeles, California 90095, USA
    J Biol Chem 274:32712-7. 1999
  5. pmc The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle
    V A Kickhoefer
    Department of Biological Chemistry, University of California at Los Angeles, School of Medicine, Los Angeles, California 90095, USA
    J Cell Biol 152:157-64. 2001
  6. ncbi request reprint The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein
    Valerie A Kickhoefer
    Department of Biological Chemistry, The David Geffen School of Medicine, University of California Los Angeles, 33 131 CHS mail code 173717, 10833 Le Conte Avenue, Los Angeles, CA 90095 1737, USA
    J Biol Chem 277:41282-6. 2002
  7. ncbi request reprint Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene
    Valerie A Kickhoefer
    Department of Biological Chemistry and the Jonsson Comprehensive Cancer Center, 33 131 CHS mail code 173717, The David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1737, USA
    Gene 309:65-70. 2003
  8. ncbi request reprint Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP
    Nil Emre
    The Department of Biological Chemistry and the Jonsson Comprehensive Cancer Center, The David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1737, USA
    Biochim Biophys Acta 1678:33-46. 2004
  9. ncbi request reprint A simpler way of comparing the labelling densities of cellular compartments illustrated using data from VPARP and LAMP-1 immunogold labelling experiments
    Terry Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, E Floor, University of Nottingham, Nottingham, NG7 2UH, UK
    Histochem Cell Biol 119:333-41. 2003

Collaborators

Detail Information

Publications9

  1. pmc The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle
    Michael J Poderycki
    Department of Biological Chemistry and the Jonsson Comprehensive Cancer Center, The David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1737, USA
    Nucleic Acids Res 33:893-902. 2005
    ..Antisense oligonucleotide-directed RNase H digestion of endogenous VR indicates that this region is largely single stranded, suggesting that TEP1 may require access to the VR central loop for efficient binding...
  2. pmc The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase
    V A Kickhoefer
    Department of Biological Chemistry, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    J Cell Biol 146:917-28. 1999
    ..A portion of p193 is nuclear and localizes to the mitotic spindle...
  3. pmc The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins
    Alex Bateman
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Bioinformatics 4:49. 2003
    ..Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding...
  4. ncbi request reprint Vaults and telomerase share a common subunit, TEP1
    V A Kickhoefer
    Department of Biological Chemistry, UCLA School of Medicine and Jonsson Comprehensive Cancer Center, Los Angeles, California 90095, USA
    J Biol Chem 274:32712-7. 1999
    ..The sharing of the TEP1 protein between vaults and telomerase suggests that TEP1 may play a common role in some aspect of ribonucleoprotein structure, function, or assembly...
  5. pmc The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle
    V A Kickhoefer
    Department of Biological Chemistry, University of California at Los Angeles, School of Medicine, Los Angeles, California 90095, USA
    J Cell Biol 152:157-64. 2001
    ..Therefore, we have uncovered a novel role for TEP1 in vivo as an integral vault protein important for the stabilization and recruitment of the vault RNA to the vault particle...
  6. ncbi request reprint The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein
    Valerie A Kickhoefer
    Department of Biological Chemistry, The David Geffen School of Medicine, University of California Los Angeles, 33 131 CHS mail code 173717, 10833 Le Conte Avenue, Los Angeles, CA 90095 1737, USA
    J Biol Chem 277:41282-6. 2002
    ..Moreover, we also demonstrate that the La autoantigen is the 50-kDa protein that we have previously reported as a protein that co-purifies with vaults...
  7. ncbi request reprint Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene
    Valerie A Kickhoefer
    Department of Biological Chemistry and the Jonsson Comprehensive Cancer Center, 33 131 CHS mail code 173717, The David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1737, USA
    Gene 309:65-70. 2003
    ..Furthermore, the unique arrangement of the internal promoter boxes (one A and two B boxes) is conserved in the expressed human vRNA genes even though a new RNA polymerase III termination sequence has evolved between the two B boxes...
  8. ncbi request reprint Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP
    Nil Emre
    The Department of Biological Chemistry and the Jonsson Comprehensive Cancer Center, The David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1737, USA
    Biochim Biophys Acta 1678:33-46. 2004
    ..These results suggest that up-regulation of MVP in multi-drug resistance (MDR) may involve chromatin remodeling...
  9. ncbi request reprint A simpler way of comparing the labelling densities of cellular compartments illustrated using data from VPARP and LAMP-1 immunogold labelling experiments
    Terry Mayhew
    School of Biomedical Sciences, Queen s Medical Centre, E Floor, University of Nottingham, Nottingham, NG7 2UH, UK
    Histochem Cell Biol 119:333-41. 2003
    ..This approach provides a simple and efficient way of comparing LDs in different compartments. Its utility is illustrated using data from VPARP and LAMP-1 labelling experiments...