Mikhail Khvotchev

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus
    Mikhail Khvotchev
    Department of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:12147-55. 2007
  2. pmc VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission
    Jesica Raingo
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 15:738-45. 2012
  3. pmc Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmission
    Denise M O Ramirez
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 73:121-34. 2012
  4. pmc Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
    Ferenc Deak
    Howard Hughes Medical Institute, Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 184:751-64. 2009
  5. pmc Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery
    Ferenc Deak
    Department of Neuroscience and Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 29:8639-48. 2009
  6. pmc Munc18-1 binds directly to the neuronal SNARE complex
    Irina Dulubova
    Department of Biochemistry and Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:2697-702. 2007
  7. doi request reprint Spontaneous neurotransmission: an independent pathway for neuronal signaling?
    Ege T Kavalali
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas, USA
    Physiology (Bethesda) 26:45-53. 2011
  8. ncbi request reprint Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport
    Mikhail Khvotchev
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 279:47101-8. 2004
  9. ncbi request reprint N-terminal insertion and C-terminal ankyrin-like repeats of alpha-latrotoxin are critical for Ca2+-dependent exocytosis
    Gang Li
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:10188-97. 2005
  10. ncbi request reprint Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion
    Oliver M Schlüter
    Max Planck Institut fur experimentelle Medizin, 37075 Gottingen, Germany
    J Biol Chem 277:40919-29. 2002

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus
    Mikhail Khvotchev
    Department of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:12147-55. 2007
    ..Viewed together, our data indicate that binding of Munc18 to the syntaxin N terminus unites different modes of Munc18/SNARE interactions and is essential for exocytic membrane fusion...
  2. pmc VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission
    Jesica Raingo
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 15:738-45. 2012
    ..These results provide molecular insight into how synapses diversify their release properties by taking advantage of distinct synaptic vesicle-associated SNAREs...
  3. pmc Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmission
    Denise M O Ramirez
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 73:121-34. 2012
    ..Taken together, these results support the premise that in its native form vti1a selectively maintains spontaneous neurotransmitter release...
  4. pmc Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
    Ferenc Deak
    Howard Hughes Medical Institute, Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 184:751-64. 2009
    ....
  5. pmc Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery
    Ferenc Deak
    Department of Neuroscience and Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 29:8639-48. 2009
    ....
  6. pmc Munc18-1 binds directly to the neuronal SNARE complex
    Irina Dulubova
    Department of Biochemistry and Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:2697-702. 2007
    ....
  7. doi request reprint Spontaneous neurotransmission: an independent pathway for neuronal signaling?
    Ege T Kavalali
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas, USA
    Physiology (Bethesda) 26:45-53. 2011
    ..This article will examine the role of spontaneous release events in neuronal signaling by focusing on aspects that distinguish this process from evoked neurotransmission, and evaluate the mechanisms that may underlie this segregation...
  8. ncbi request reprint Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport
    Mikhail Khvotchev
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 279:47101-8. 2004
    ..Our data suggest that, different from Notch, cleavage of APP is independent of cell surface regulation by extracellular ligands but may be controlled by intracellular signaling...
  9. ncbi request reprint N-terminal insertion and C-terminal ankyrin-like repeats of alpha-latrotoxin are critical for Ca2+-dependent exocytosis
    Gang Li
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:10188-97. 2005
    ....
  10. ncbi request reprint Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion
    Oliver M Schlüter
    Max Planck Institut fur experimentelle Medizin, 37075 Gottingen, Germany
    J Biol Chem 277:40919-29. 2002
    ..These results offer an hypothesis that reconciles Rab3 transfection and knock-out studies by suggesting that Rab3 functions as a gatekeeper of a late stage in exocytosis...