Genomes and Genes
Affiliation: University of Texas Southwestern Medical Center
- Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminusMikhail Khvotchev
Department of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 27:12147-55. 2007..Viewed together, our data indicate that binding of Munc18 to the syntaxin N terminus unites different modes of Munc18/SNARE interactions and is essential for exocytic membrane fusion...
- VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmissionJesica Raingo
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Nat Neurosci 15:738-45. 2012..These results provide molecular insight into how synapses diversify their release properties by taking advantage of distinct synaptic vesicle-associated SNAREs...
- Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmissionDenise M O Ramirez
Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9111, USA
Neuron 73:121-34. 2012..Taken together, these results support the premise that in its native form vti1a selectively maintains spontaneous neurotransmitter release...
- Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle primingFerenc Deak
Howard Hughes Medical Institute, Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Cell Biol 184:751-64. 2009....
- Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machineryFerenc Deak
Department of Neuroscience and Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Neurosci 29:8639-48. 2009....
- Munc18-1 binds directly to the neuronal SNARE complexIrina Dulubova
Department of Biochemistry and Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:2697-702. 2007....
- Spontaneous neurotransmission: an independent pathway for neuronal signaling?Ege T Kavalali
Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas, USA
Physiology (Bethesda) 26:45-53. 2011..This article will examine the role of spontaneous release events in neuronal signaling by focusing on aspects that distinguish this process from evoked neurotransmission, and evaluate the mechanisms that may underlie this segregation...
- Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transportMikhail Khvotchev
Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
J Biol Chem 279:47101-8. 2004..Our data suggest that, different from Notch, cleavage of APP is independent of cell surface regulation by extracellular ligands but may be controlled by intracellular signaling...
- N-terminal insertion and C-terminal ankyrin-like repeats of alpha-latrotoxin are critical for Ca2+-dependent exocytosisGang Li
Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
J Neurosci 25:10188-97. 2005....
- Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusionOliver M Schlüter
Max Planck Institut fur experimentelle Medizin, 37075 Gottingen, Germany
J Biol Chem 277:40919-29. 2002..These results offer an hypothesis that reconciles Rab3 transfection and knock-out studies by suggesting that Rab3 functions as a gatekeeper of a late stage in exocytosis...