Sepideh Khorasanizadeh

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi The nucleosome: from genomic organization to genomic regulation
    Sepideh Khorasanizadeh
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA
    Cell 116:259-72. 2004
  2. ncbi Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain
    Daesung Kim
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
    Nat Struct Mol Biol 17:1027-9. 2010
  3. ncbi Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
    Wolfgang Fischle
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908 0733, USA
    Genes Dev 17:1870-81. 2003
  4. ncbi Double chromodomains cooperate to recognize the methylated histone H3 tail
    John F Flanagan
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Nature 438:1181-5. 2005
  5. ncbi Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs
    Wolfgang Fischle
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908 0733, USA
    J Biol Chem 283:19626-35. 2008
  6. ncbi Assays for the determination of structure and dynamics of the interaction of the chromodomain with histone peptides
    Steven A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville 22908, USA
    Methods Enzymol 376:131-48. 2004
  7. ncbi Molecular implications of evolutionary differences in CHD double chromodomains
    John F Flanagan
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Mol Biol 369:334-42. 2007
  8. ncbi Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
    Srilatha Raghuram
    Department of Pharmacology and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0733, USA
    Nat Struct Mol Biol 14:1207-13. 2007
  9. ncbi Structural basis for bile acid binding and activation of the nuclear receptor FXR
    Li Zhi Mi
    Department of Pharmacology, University of Virginia Health System, Charlottesville 22908, USA
    Mol Cell 11:1093-100. 2003
  10. ncbi The active site of the SET domain is constructed on a knot
    Steven A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Nat Struct Biol 9:833-8. 2002

Research Grants

  1. Structural basis of histone tail recognition
    Sepideh Khorasanizadeh; Fiscal Year: 2006
  2. Structural Determinants of Chromodomain Function
    Sepideh Khorasanizadeh; Fiscal Year: 2007

Collaborators

Detail Information

Publications17

  1. ncbi The nucleosome: from genomic organization to genomic regulation
    Sepideh Khorasanizadeh
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA
    Cell 116:259-72. 2004
    ..These events directly impact DNA transcription, replication, recombination, and repair...
  2. ncbi Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain
    Daesung Kim
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
    Nat Struct Mol Biol 17:1027-9. 2010
    ..H4K16 acetylation antagonizes MSL3 binding, suggesting that MSL function is regulated by a combination of post-translational modifications...
  3. ncbi Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
    Wolfgang Fischle
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908 0733, USA
    Genes Dev 17:1870-81. 2003
    ..The Pc chromodomain distinguishes its methylation target on the H3 tail via an extended recognition groove that binds five additional residues preceding the ARKS motif...
  4. ncbi Double chromodomains cooperate to recognize the methylated histone H3 tail
    John F Flanagan
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Nature 438:1181-5. 2005
    ..Furthermore, unique inserts within chromodomain 1 of CHD1 block the expected site of H3 tail binding seen in HP1 and Polycomb, instead directing H3 binding to a groove at the inter-chromodomain junction...
  5. ncbi Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs
    Wolfgang Fischle
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908 0733, USA
    J Biol Chem 283:19626-35. 2008
    ..Our studies underscore the significance of subtle sequence differences in a conserved signaling module for diverse epigenetic regulatory pathways...
  6. ncbi Assays for the determination of structure and dynamics of the interaction of the chromodomain with histone peptides
    Steven A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville 22908, USA
    Methods Enzymol 376:131-48. 2004
  7. ncbi Molecular implications of evolutionary differences in CHD double chromodomains
    John F Flanagan
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Mol Biol 369:334-42. 2007
    ..By using the available structural and biochemical data we highlight the evolutionary specialization of CHD double chromodomains, and provide insights about their targeting capacities...
  8. ncbi Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
    Srilatha Raghuram
    Department of Pharmacology and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0733, USA
    Nat Struct Mol Biol 14:1207-13. 2007
    ..Our results further indicate that heme regulation of REV-ERBs may link the control of metabolism and the mammalian clock...
  9. ncbi Structural basis for bile acid binding and activation of the nuclear receptor FXR
    Li Zhi Mi
    Department of Pharmacology, University of Virginia Health System, Charlottesville 22908, USA
    Mol Cell 11:1093-100. 2003
    ..These FXR complexes provide direct insights into the design of therapeutic bile acids for treatment of hyperlipidemia and cholestasis...
  10. ncbi The active site of the SET domain is constructed on a knot
    Steven A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Nat Struct Biol 9:833-8. 2002
    ..A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain...
  11. ncbi Implications of a histone code mimic in epigenetic signaling
    Christopher H Henkels
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908 0733, USA
    Mol Cell 27:521-2. 2007
    ..2007). Two lysines are found to be automethylated in G9a, and one is H3K9-like and can establish a docking site for HP1 chromodomain...
  12. ncbi Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail
    Steven A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908 0733, USA
    Science 295:2080-3. 2002
    ..Comparison of dimethyl- and trimethyllysine-containing complexes suggests a role for cation-pi and van der Waals interactions, with trimethylation slightly improving the binding affinity...
  13. ncbi Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation
    Sara E Rosasco-Nitcher
    Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, VA 22908, USA
    Science 319:469-72. 2008
    ..These regulatory mechanisms suggest models for phosphorylation by Aurora-B of centromeric substrates at unaligned chromosomes and merotelic attachments...
  14. ncbi Recognition of trimethyllysine by a chromodomain is not driven by the hydrophobic effect
    Robert M Hughes
    Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 104:11184-8. 2007
    ..This article presents an excellent example of synergy between model systems and in vitro studies that allows for the investigation of the key forces that control biomolecular recognition...
  15. ncbi The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation
    Xiaoyu Zhang
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
    Nat Struct Mol Biol 14:869-71. 2007
    ..The LHP1 chromodomain also binds H3K27me3 with high affinity, suggesting that LHP1 has functions similar to those of Polycomb...
  16. ncbi Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3
    Anders M Lindroth
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095 1606, USA
    EMBO J 23:4286-96. 2004
    ..Our results suggest a model in which H3K9 methylation by KYP, and H3K27 methylation by an unknown enzyme provide a combinatorial histone code for the recruitment of CMT3 to silent loci...
  17. ncbi Beyond the double helix: writing and reading the histone code
    Yanming Wang
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Novartis Found Symp 259:3-17; discussion 17-21, 163-9. 2004
    ..As this modification is not found during mitotic chromosome condensation, these findings suggest the intriguing possibility that a unique 'death' mark exists for chromatin condensation during apoptosis...

Research Grants9

  1. Structural basis of histone tail recognition
    Sepideh Khorasanizadeh; Fiscal Year: 2006
    ..Through these studies we hope to reveal the mechanism of histone tail recognition within the family of chromo domain containing proteins. ..
  2. Structural Determinants of Chromodomain Function
    Sepideh Khorasanizadeh; Fiscal Year: 2007
    ....