Nicholas K H Khoo

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels
    Nicholas K H Khoo
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Free Radic Biol Med 49:339-47. 2010
  2. pmc Electrophilic nitro-fatty acids: anti-inflammatory mediators in the vascular compartment
    Nicholas K H Khoo
    Department of Pharmacology and Chemical Biology, E1314 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Curr Opin Pharmacol 10:179-84. 2010
  3. pmc Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids
    Nicholas K H Khoo
    Department of Pharmacology and Chemical Biology, E1314 BST, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Free Radic Biol Med 48:230-9. 2010
  4. pmc Electrophilic fatty acids regulate matrix metalloproteinase activity and expression
    Gustavo Bonacci
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:16074-81. 2011
  5. pmc Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury
    Marsha P Cole
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, PA, USA
    Circ Res 105:965-72. 2009
  6. pmc Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions
    Francisco J Schopfer
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:12321-33. 2010
  7. pmc Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice
    Tanja K Rudolph
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Arterioscler Thromb Vasc Biol 30:938-45. 2010
  8. pmc Conjugated linoleic acid is a preferential substrate for fatty acid nitration
    Gustavo Bonacci
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 287:44071-82. 2012
  9. pmc Nitro-fatty acid metabolome: saturation, desaturation, beta-oxidation, and protein adduction
    Volker Rudolph
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:1461-73. 2009
  10. pmc Hydrogen peroxide is the major oxidant product of xanthine oxidase
    Eric E Kelley
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Free Radic Biol Med 48:493-8. 2010

Collaborators

Detail Information

Publications15

  1. pmc Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels
    Nicholas K H Khoo
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Free Radic Biol Med 49:339-47. 2010
    ....
  2. pmc Electrophilic nitro-fatty acids: anti-inflammatory mediators in the vascular compartment
    Nicholas K H Khoo
    Department of Pharmacology and Chemical Biology, E1314 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Curr Opin Pharmacol 10:179-84. 2010
    ..NO(2)-FAs represent a novel therapeutic strategy to treat vascular disorders by improving endothelial dysfunction through enhancing NO signaling and blocking vascular smooth muscle proliferation, inflammation, and maladaptive remodeling...
  3. pmc Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids
    Nicholas K H Khoo
    Department of Pharmacology and Chemical Biology, E1314 BST, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Free Radic Biol Med 48:230-9. 2010
    ..In aggregate, OA-NO(2)-induced eNOS and HO-1 expression by vascular cells can induce beneficial effects on endothelial function and provide a new strategy for treating various vascular inflammatory and hypertensive disorders...
  4. pmc Electrophilic fatty acids regulate matrix metalloproteinase activity and expression
    Gustavo Bonacci
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:16074-81. 2011
    ....
  5. pmc Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury
    Marsha P Cole
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, PA, USA
    Circ Res 105:965-72. 2009
    ..Existing evidence indicates nitroalkenes support posttranslational protein modifications and transcriptional activation that promote the resolution of inflammation...
  6. pmc Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions
    Francisco J Schopfer
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:12321-33. 2010
    ..Administration of this class of signaling mediators to ob/ob mice revealed that NO(2)-FA lower insulin and glucose levels without inducing adverse side effects such as the increased weight gain induced by TZDs...
  7. pmc Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice
    Tanja K Rudolph
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Arterioscler Thromb Vasc Biol 30:938-45. 2010
    ..The in vivo action of nitro-fatty acids in chronic inflammatory processes such as atherosclerosis remains to be elucidated...
  8. pmc Conjugated linoleic acid is a preferential substrate for fatty acid nitration
    Gustavo Bonacci
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 287:44071-82. 2012
    ..These results affirm that metabolic and inflammatory reactions yield electrophilic products that can modulate adaptive cell signaling mechanisms...
  9. pmc Nitro-fatty acid metabolome: saturation, desaturation, beta-oxidation, and protein adduction
    Volker Rudolph
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:1461-73. 2009
    ....
  10. pmc Hydrogen peroxide is the major oxidant product of xanthine oxidase
    Eric E Kelley
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Free Radic Biol Med 48:493-8. 2010
    ....
  11. doi request reprint Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity
    Eric E Kelley
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
    Cardiovasc Res 101:352-63. 2014
    ..In this regard, electrophilic nitro-fatty acids display pleiotropic anti-inflammatory signalling actions...
  12. pmc Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling
    Imad Al Ghouleh
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Free Radic Biol Med 51:1271-88. 2011
    ....
  13. pmc Obesity-induced tissue free radical generation: an in vivo immuno-spin trapping study
    Nicholas K H Khoo
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    Free Radic Biol Med 52:2312-9. 2012
    ..Combined, these data affirm the utility of immuno-spin trapping as a tool for in vivo assessment of altered extents of macromolecule oxidation to radical intermediates under chronic inflammatory conditions...
  14. ncbi request reprint Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells
    Eric E Kelley
    Department of Anesthesiology, University of Alabama at Birmingham, AL 35233, USA
    Free Radic Biol Med 40:952-9. 2006
    ..These effects appear to be mediated in part via adenosine-dependent processes...
  15. ncbi request reprint Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARgamma
    Balu K Chacko
    Department of Pathology, Purdue UAB Botanical Center, University of Alabama, Birmingham, AL 35294, USA
    J Nutr 137:351-6. 2007
    ....