Ashwani Khanna

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis
    Ashwani K Khanna
    Department of Medicine Cardiology, University of Maryland, Baltimore, USA
    J Biomed Sci 16:66. 2009
  2. pmc Targeted in vitro and in vivo gene transfer into T lymphocytes: potential of direct inhibition of allo-immune activation
    Ashwani K Khanna
    Department of Medicine, Division of Cardiology, University of Maryland, Baltimore, MD 21201, USA
    BMC Immunol 7:26. 2006
  3. ncbi NADPH oxidase subunits (NOX-1, p22phox, Rac-1) and tacrolimus-induced nephrotoxicity in a rat renal transplant model
    Ashwani K Khanna
    Division of Cardiology, University of Maryland, 22 S Greene Street S 3B08, Baltimore, MD 21201, USA
    Nephrol Dial Transplant 22:376-85. 2007
  4. ncbi Expression of TGF-beta and fibrogenic genes in transplant recipients with tacrolimus and cyclosporine nephrotoxicity
    Ashwani Khanna
    Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 62:2257-63. 2002
  5. ncbi Wideband high-frequency echocardiography to evaluate myocardial infarct size
    Jianping Xu
    Division of Cardiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    J Ultrasound Med 28:1527-34. 2009
  6. pmc Reciprocal role of cyclins and cyclin kinase inhibitor p21WAF1/CIP1 on lymphocyte proliferation, allo-immune activation and inflammation
    Ashwani K Khanna
    Department of Medicine Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Immunol 6:22. 2005
  7. ncbi Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase
    Vani Nilakantan
    Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Heart Lung Transplant 24:1591-9. 2005
  8. ncbi Antagonizing reactive oxygen by treatment with a manganese (III) metalloporphyrin-based superoxide dismutase mimetic in cardiac transplants
    Vani Nilakantan
    Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    J Thorac Cardiovasc Surg 131:898-906. 2006
  9. ncbi Beneficial effect of alpha-tocopheryl succinate in rat cardiac transplants
    Thanh K Nguyen
    Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Heart Lung Transplant 25:707-15. 2006
  10. pmc Nitric oxide formation in acutely rejecting cardiac allografts correlates with GTP cyclohydrolase I activity
    Galen M Pieper
    Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    Biochem J 391:541-7. 2005

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis
    Ashwani K Khanna
    Department of Medicine Cardiology, University of Maryland, Baltimore, USA
    J Biomed Sci 16:66. 2009
    ..This opens the possibility of p21 protein as a therapeutic tool to control progression of atherosclerosis...
  2. pmc Targeted in vitro and in vivo gene transfer into T lymphocytes: potential of direct inhibition of allo-immune activation
    Ashwani K Khanna
    Department of Medicine, Division of Cardiology, University of Maryland, Baltimore, MD 21201, USA
    BMC Immunol 7:26. 2006
    ..Lymphocyte proliferation was quantified by 3H-thymidine uptake assay; IL-2 mRNA expression was studied by RT-PCR and using Real Time PCR assay, we monitored the CD3, p21, TNF-alpha and IFN-gamma mRNA expression...
  3. ncbi NADPH oxidase subunits (NOX-1, p22phox, Rac-1) and tacrolimus-induced nephrotoxicity in a rat renal transplant model
    Ashwani K Khanna
    Division of Cardiology, University of Maryland, 22 S Greene Street S 3B08, Baltimore, MD 21201, USA
    Nephrol Dial Transplant 22:376-85. 2007
    ..We examined whether anti-TGF-beta antibody limits nephrotoxicity produced by tacrolimus (TAC) and whether this altered genes that regulate oxidative stress...
  4. ncbi Expression of TGF-beta and fibrogenic genes in transplant recipients with tacrolimus and cyclosporine nephrotoxicity
    Ashwani Khanna
    Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 62:2257-63. 2002
    ....
  5. ncbi Wideband high-frequency echocardiography to evaluate myocardial infarct size
    Jianping Xu
    Division of Cardiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    J Ultrasound Med 28:1527-34. 2009
    ..This study was designed to validate the feasibility of wideband high-frequency ultrasound imaging to resolve in vivo the degree, location, and morphologic changes of myocardial infarction (MI) in a rat model...
  6. pmc Reciprocal role of cyclins and cyclin kinase inhibitor p21WAF1/CIP1 on lymphocyte proliferation, allo-immune activation and inflammation
    Ashwani K Khanna
    Department of Medicine Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Immunol 6:22. 2005
    ..We hypothesize that the cell cycle control and inflammation are parallel events, inhibition of cellular proliferation by cyclin kinase inhibitor specifically p21 will limit inflammation and prevent allograft rejection...
  7. ncbi Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase
    Vani Nilakantan
    Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Heart Lung Transplant 24:1591-9. 2005
    ..In this study, we examined the effect of inducible nitric oxide synthase (iNOS) on MnSOD expression, activity and nitration in acutely rejecting cardiac transplants...
  8. ncbi Antagonizing reactive oxygen by treatment with a manganese (III) metalloporphyrin-based superoxide dismutase mimetic in cardiac transplants
    Vani Nilakantan
    Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    J Thorac Cardiovasc Surg 131:898-906. 2006
    ....
  9. ncbi Beneficial effect of alpha-tocopheryl succinate in rat cardiac transplants
    Thanh K Nguyen
    Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Heart Lung Transplant 25:707-15. 2006
    ..In this study we examined the effects of a novel vitamin E analog, alpha-tocopheryl polyethylene glycol-100 succinate (alpha-TPGS), and low-dose cyclosporine (CsA) in the treatment of acute and delayed cardiac rejection...
  10. pmc Nitric oxide formation in acutely rejecting cardiac allografts correlates with GTP cyclohydrolase I activity
    Galen M Pieper
    Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    Biochem J 391:541-7. 2005
    ..These findings provide insight into a potential pathway regulating NO bioactivity in graft rejection. Such knowledge may potentially assist in the design of newer strategies to prevent acute graft rejection...
  11. ncbi Recombinant p21 protein inhibits lymphocyte proliferation and transcription factors
    Ashwani K Khanna
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 174:7610-7. 2005
    ....
  12. ncbi Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplants
    Galen M Pieper
    Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, Wisconsin 53226, USA
    J Pharmacol Exp Ther 314:53-60. 2005
    ..Rather, effects seem to be downstream on decreased protein nitration, decreased lipid peroxidation, and decreased PARP activation...
  13. ncbi Anti-transforming growth factor antibody at low but not high doses limits cyclosporine-mediated nephrotoxicity without altering rat cardiac allograft survival: potential of therapeutic applications
    Ashwani K Khanna
    Division of Nephrology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circulation 110:3822-9. 2004
    ..Transforming growth factor-beta (TGF-beta) is one of the most potent mediators of the fibrogenic effects of cyclosporine...
  14. ncbi Treatment with {alpha}-phenyl-N-tert-butylnitrone, a free radical-trapping agent, abrogates inflammatory cytokine gene expression during alloimmune activation in rat cardiac allografts
    Galen M Pieper
    Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 312:774-9. 2005
    ..Thus, PBN retains significant anti-inflammatory properties through its action to down-regulate cytokine gene expression that contribute to protection against acute alloimmune activation in cardiac allografts...
  15. ncbi Mechanisms of the protective action of diethyldithiocarbamate-iron complex on acute cardiac allograft rejection
    Galen M Pieper
    Division of Transplant Surgery, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 284:H1542-51. 2003
    ..Gene expression for the proinflammatory cytokine interferon-gamma was also decreased by DETC-Fe. Thus DETC-Fe limits NF-kappaB-dependent gene expression and possesses significant immunosuppressive properties...
  16. ncbi The immunosuppressive agent tacrolimus induces p21WAF/CIP1WAF1/CIP1 via TGF-beta secretion
    Ashwani K Khanna
    Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochem Biophys Res Commun 303:266-72. 2003
    ..Strategies involving p21WAF/CIP1 induction should be considered a viable alternative strategy to achieve immunosuppression possibly with reduced toxicity associated with current immunosuppression...
  17. ncbi Analysis of transforming growth factor-beta and profibrogenic molecules in a rat cardiac allograft model treated with cyclosporine
    Ashwani K Khanna
    Department of Medicine Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
    Transplantation 73:1543-9. 2002
    ....
  18. ncbi TGF-beta1, FGF-2, and receptor mRNA expression in suture mesenchyme and dura versus underlying brain in fusing and nonfusing mouse cranial sutures
    Arun K Gosain
    Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Plast Reconstr Surg 113:1675-84. 2004
    ..Understanding these differences may eventually help to identify possible targets and time windows by which to most effectively modulate cranial suture fusion...
  19. ncbi Inhibition of nitrosylation, nitration, lymphocyte proliferation, and gene expression in acute and delayed cardiac allograft rejection by an orally active dithiocarbamate
    Galen M Pieper
    Department of Surgery Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 43:522-30. 2004
    ..These studies suggest that NOX-700 is protective in cardiac rejection, in part, by scavenging of NO and by limiting lymphocyte activation infiltration...
  20. ncbi Variable efficacy of N6-(1-iminoethyl)-L-lysine in acute cardiac transplant rejection
    Galen M Pieper
    Division of Transplant Surgery, Department of Surgery, Cardiovascular Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 286:H525-34. 2004
    ..These studies have important implications in understanding the dual role of NO in acute rejection and help to reconcile discrepancies in the literature...

Research Grants4

  1. TGF-BETA AND IMMUNOSUPPRESSION IN ORGAN TRANSPLANTATION
    Ashwani Khanna; Fiscal Year: 2002
    ..These studies will directly determine the role (if any) of the TGF-B and/or p21 pathways in the efficacy, and TGF-B in the toxicity, induced by CsA and tacrolimus. ..