Mohamed K Khan
Affiliation: University of Michigan
- In vivo biodistribution of dendrimers and dendrimer nanocomposites -- implications for cancer imaging and therapyMohamed K Khan
NanoBiotechnology Center at RPCI, Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Technol Cancer Res Treat 4:603-13. 2005..We also discuss major issues confronting the use of nanoparticles in the near future, with consideration of toxicity analysis and whether biodegradable devices are needed or even desirable...
- Significant effect of size on the in vivo biodistribution of gold composite nanodevices in mouse tumor modelsLajos Balogh
The NanoBiotechnology Center at Roswell Park Cancer Institute NBC at RPCI, Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Nanomedicine 3:281-96. 2007..These findings have significance for the design of all particle-based nanodevices for medical uses. The observed organ selectivity may make these nanodevices exciting for several targeted medical applications...
- Radiotherapy and antiangiogenic TM in lung cancerMohamed K Khan
Department of Radiation Oncology, The University of Michigan Medical Center, Ann Arbor, MI 48109 0936, USA
Neoplasia 4:164-70. 2002..We also show that their therapeutic effects are additive, with no additional toxicity. We show that TM has no significant cytotoxicity in vitro against LLHM tumor cells, further supporting the antiangiogenic mechanism for its action...
- Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancerJolanta F Kukowska-Latallo
University of Michigan Center for Biologic Nanotechnology, Ann Arbor, Michigan, USA
Cancer Res 65:5317-24. 2005..Targeting methotrexate increased its antitumor activity and markedly decreased its toxicity, allowing therapeutic responses not possible with a free drug...
- Tetrathiomolybdate blocks bFGF- but not VEGF-induced incipient angiogenesis in vitroFatema Mamou
Department of Radiation Oncology, Comprehensive Cancer and Geriatrics Center, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Anticancer Res 26:1753-8. 2006..These inhibitory effects of TM are attributed to its potent copper level-reducing property. Copper is needed for activation of various angiogenic pathways at the transcriptional and protein levels...
- Combination tetrathiomolybdate and radiation therapy in a mouse model of head and neck squamous cell carcinomaMohamed K Khan
Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Arch Otolaryngol Head Neck Surg 132:333-8. 2006..To assess the effect of combining tetrathiomolybdate therapy and radiation treatment (RT) on tumor growth in the mouse head and neck squamous cell carcinoma (HNSCC) model...
- E-selectin is required for the antiangiogenic activity of endostatinYing Yu
Vascular Biology Program, Department of Surgery, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:8005-10. 2004..E-selectin may be a useful predictor and modulator of endostatin efficacy in antiangiogenic therapy...
- Synthesis and characterization of PAMAM dendrimer-based multifunctional nanodevices for targeting alphavbeta3 integrinsWojciech G Lesniak
NanoBiotechnology Center at RPCI, Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Bioconjug Chem 18:1148-54. 2007..The PAMAM_E5.(NHAc)72(NHBT)8(NHSAH)35(NHSA-cR GD)4 nanodevice is nontoxic within physiologic concentration ranges and specifically binds to the alphavbeta3 integrins, apparently much stronger than the cyclic cRGD peptide itself...