Bryan R Kestenbaum

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Dietary phosphorus is associated with greater left ventricular mass
    Kalani T Yamamoto
    Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Kidney Int 83:707-14. 2013
  2. ncbi request reprint Survival following parathyroidectomy among United States dialysis patients
    Bryan Kestenbaum
    Division of Nephrology, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Kidney Int 66:2010-6. 2004
  3. ncbi request reprint Phosphate metabolism in the setting of chronic kidney disease: significance and recommendations for treatment
    Bryan Kestenbaum
    Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Semin Dial 20:286-94. 2007
  4. ncbi request reprint Mineral metabolism disturbances in patients with chronic kidney disease
    B Kestenbaum
    University of Washington, Seattle, WA 98104 2499, USA
    Eur J Clin Invest 37:607-22. 2007
  5. pmc Differences in kidney function and incident hypertension: the multi-ethnic study of atherosclerosis
    Bryan Kestenbaum
    University of Washington, Division of Nephrology, Harborview Medical Center, Seattle, Washington 98104 2499, USA
    Ann Intern Med 148:501-8. 2008
  6. pmc Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis
    Bryan R Kestenbaum
    Division of Nephrology, Department of Medicine, Harborview Medical Center, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Kidney Int 76:991-8. 2009
  7. pmc Common genetic variants associate with serum phosphorus concentration
    Bryan Kestenbaum
    Division of Nephrology, Department of Medicine, University of Washington, Kidney Research Institute, Seattle, Washington 98104 2499, USA
    J Am Soc Nephrol 21:1223-32. 2010
  8. ncbi request reprint Serum phosphate levels and mortality risk among people with chronic kidney disease
    Bryan Kestenbaum
    Veterans Affairs Puget Sound Health Care System, Division of Nephrology, Mail Stop 111A, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Am Soc Nephrol 16:520-8. 2005
  9. ncbi request reprint Kidney function, electrocardiographic findings, and cardiovascular events among older adults
    Bryan Kestenbaum
    Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    Clin J Am Soc Nephrol 2:501-8. 2007
  10. pmc Vitamin D, parathyroid hormone, and cardiovascular events among older adults
    Bryan Kestenbaum
    Kidney Research Institute, University of Washington, Seattle, WA, USA
    J Am Coll Cardiol 58:1433-41. 2011

Detail Information

Publications84

  1. pmc Dietary phosphorus is associated with greater left ventricular mass
    Kalani T Yamamoto
    Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Kidney Int 83:707-14. 2013
    ..1 g greater LVM compared with the lowest quintile. Higher dietary phosphorus intake was associated with greater odds of LVH among women, but not men. These associations require confirmation in other studies...
  2. ncbi request reprint Survival following parathyroidectomy among United States dialysis patients
    Bryan Kestenbaum
    Division of Nephrology, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Kidney Int 66:2010-6. 2004
    ..Parathyroidectomy (PTX) can dramatically reduce parathyroid hormone (PTH) and phosphate levels; however, the relationship between PTX and survival is not known...
  3. ncbi request reprint Phosphate metabolism in the setting of chronic kidney disease: significance and recommendations for treatment
    Bryan Kestenbaum
    Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Semin Dial 20:286-94. 2007
    ..This review discusses PO(4) metabolism in the context of CKD, examines associations of PO(4) levels with adverse outcomes in the CKD setting, and suggests treatment strategies for moderating serum PO(4) levels...
  4. ncbi request reprint Mineral metabolism disturbances in patients with chronic kidney disease
    B Kestenbaum
    University of Washington, Seattle, WA 98104 2499, USA
    Eur J Clin Invest 37:607-22. 2007
    ..Secondary hyperparathyroidism, a disorder characterized by elevated serum parathyroid hormone levels, and alteration of calcium and phosphorus homeostasis are common metabolic complications of CKD that may impact cardiovascular health...
  5. pmc Differences in kidney function and incident hypertension: the multi-ethnic study of atherosclerosis
    Bryan Kestenbaum
    University of Washington, Division of Nephrology, Harborview Medical Center, Seattle, Washington 98104 2499, USA
    Ann Intern Med 148:501-8. 2008
    ..Kidney disease and hypertension commonly coexist, yet the direction of their association is still debated...
  6. pmc Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis
    Bryan R Kestenbaum
    Division of Nephrology, Department of Medicine, Harborview Medical Center, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Kidney Int 76:991-8. 2009
    ..Our study shows that coronary artery calcification is common in people with stage 3 disease, progresses rapidly, and may contribute to cardiovascular risk...
  7. pmc Common genetic variants associate with serum phosphorus concentration
    Bryan Kestenbaum
    Division of Nephrology, Department of Medicine, University of Washington, Kidney Research Institute, Seattle, Washington 98104 2499, USA
    J Am Soc Nephrol 21:1223-32. 2010
    ..05 for each). In conclusion, common genetic variants associate with serum phosphorus in the general population. Further study of the loci identified in this study may help elucidate mechanisms of phosphorus regulation...
  8. ncbi request reprint Serum phosphate levels and mortality risk among people with chronic kidney disease
    Bryan Kestenbaum
    Veterans Affairs Puget Sound Health Care System, Division of Nephrology, Mail Stop 111A, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Am Soc Nephrol 16:520-8. 2005
    ..Mortality risk increased linearly with each subsequent 0.5-mg/dl increase in serum phosphate levels. Elevated serum phosphate levels were independently associated with increased mortality risk among this population of patients with CKD...
  9. ncbi request reprint Kidney function, electrocardiographic findings, and cardiovascular events among older adults
    Bryan Kestenbaum
    Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    Clin J Am Soc Nephrol 2:501-8. 2007
    ..Associations seemed stronger for participants with CKD; however, no significant interactions were detected. Resting electrocardiographic abnormalities are common in CKD and independently predict future clinical CV events in this setting...
  10. pmc Vitamin D, parathyroid hormone, and cardiovascular events among older adults
    Bryan Kestenbaum
    Kidney Research Institute, University of Washington, Seattle, WA, USA
    J Am Coll Cardiol 58:1433-41. 2011
    ....
  11. ncbi request reprint Cardiovascular and thromboembolic events following hypertensive pregnancy
    Bryan Kestenbaum
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA, USA
    Am J Kidney Dis 42:982-9. 2003
    ..We conducted a population-based cohort study to estimate the risks for cardiovascular and thromboembolic events in women with pregnancy-related hypertension...
  12. pmc Racial differences in the association of serum 25-hydroxyvitamin D concentration with coronary heart disease events
    Cassianne Robinson-Cohen
    Department of Medicine, Kidney Research Institute, University of Washington, Seattle 98104, USA
    JAMA 310:179-88. 2013
    ..This association has not been rigorously evaluated in other races or ethnicities, in which the distributions of 25(OH)D concentration and possibly other aspects of 25(OH)D metabolism differ...
  13. pmc Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA
    Joachim H Ix
    Department of Medicine, Division of Nephrology and Hypertension, University of California San Diego, San Diego, CA 92161, USA
    Clin J Am Soc Nephrol 4:609-15. 2009
    ..Higher phosphorus levels are associated with cardiovascular disease (CVD) events and mortality. Whether vascular stiffness may be responsible is unknown...
  14. ncbi request reprint Risk factors for incident stroke among patients with end-stage renal disease
    Stephen L Seliger
    Division of Nephrology, University of Washington, Seattle, Washington 98102, USA
    J Am Soc Nephrol 14:2623-31. 2003
    ..The association between black race and stroke differs by cardiac disease status; the reasons for this differing effect of race deserve further investigation...
  15. pmc Association of serum phosphate with vascular and valvular calcification in moderate CKD
    Kathryn L Adeney
    University of Washington, Department of Epidemiology, Harborview Medical Center, Seattle, WA 98104, USA
    J Am Soc Nephrol 20:381-7. 2009
    ..It remains to be determined whether lowering phosphate concentrations will impact calcification risk in the setting of kidney disease...
  16. ncbi request reprint Cystatin C and subclinical brain infarction
    Stephen L Seliger
    Division of Nephrology, University of Maryland, Baltimore, MD 21201, USA
    J Am Soc Nephrol 16:3721-7. 2005
    ..Compared with creatinine, CysC, a novel marker of renal function, has a stronger and more direct association with SBI in the elderly...
  17. pmc Serum phosphorus levels and the spectrum of ankle-brachial index in older men: the Osteoporotic Fractures in Men (MrOS) study
    Jerry Meng
    Division of Nephrology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Am J Epidemiol 171:909-16. 2010
    ..These associations may explain the link between serum phosphorus levels and CVD events...
  18. pmc Effects of a high-protein diet on regulation of phosphorus homeostasis
    Robin A Kremsdorf
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA
    J Clin Endocrinol Metab 98:1207-13. 2013
    ..High-protein diets, which are popular for weight loss, contain large quantities of phosphorus. Phosphorus excess and consequent changes in phosphorus regulatory hormones are implicated in vascular calcification and cardiovascular disease...
  19. ncbi request reprint Risk factors for upper gastrointestinal bleeding among end-stage renal disease patients
    Haimanot Wasse
    University of Washington, Division of Nephrology, Seattle, Washington, USA
    Kidney Int 64:1455-61. 2003
    ..However, correlates of UGIB among ESRD patients remain unknown. We conducted a cohort study of dialysis patients to ascertain risk factors for UGIB...
  20. ncbi request reprint Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis
    Ronit Katz
    University of Washington, Seattle, WA, USA
    Circulation 113:2113-9. 2006
    ....
  21. pmc Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels
    Conall M O'Seaghdha
    Division of Nephrology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 19:4296-303. 2010
    ..We conclude that common genetic variation in the CASR gene is associated with similar but milder features in the general population...
  22. pmc Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)
    Christopher Keller
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    BMC Nephrol 9:9. 2008
    ..Using eGFR and cystatin C, a novel marker of kidney function, the authors investigated the association of kidney function with multiple biomarkers in a diverse cohort...
  23. ncbi request reprint Interaction of age with lipoproteins as predictors of aortic valve calcification in the multi-ethnic study of atherosclerosis
    David S Owens
    Division of Cardiology, Department of Internal Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195 6422, USA
    Arch Intern Med 168:1200-7. 2008
    ....
  24. ncbi request reprint Fracture risk after parathyroidectomy among chronic hemodialysis patients
    Kyle D Rudser
    Division of Biostatistics, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    J Am Soc Nephrol 18:2401-7. 2007
    ..Surgical amelioration of secondary hyperparathyroidism may outweigh the risk of parathyroid hormone oversuppression in terms of bone health...
  25. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  26. pmc Cystatin C concentration as a predictor of systolic and diastolic heart failure
    Andrew Moran
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Card Fail 14:19-26. 2008
    ..We hypothesized that kidney dysfunction would predict diastolic HF (DHF) better than systolic HF (SHF) in the Cardiovascular Health Study...
  27. pmc Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study)
    Joachim H Ix
    Department of Medicine, University of California San Diego, USA
    J Am Coll Cardiol 54:1176-84. 2009
    ..This study sought to determine the association of chronic kidney disease (CKD) with high ankle brachial index (ABI) measurement and to compare its strength with that of CKD with a low ABI...
  28. ncbi request reprint HMG-CoA reductase inhibitors are associated with reduced mortality in ESRD patients
    Stephen L Seliger
    Division of Nephrology, University of Washington Medical Center, Seattle, Washington, USA
    Kidney Int 61:297-304. 2002
    ..We determined whether the use of statins is associated with a reduction in cardiovascular-specific death and total mortality in ESRD patients...
  29. pmc Assessment of physical activity in chronic kidney disease
    Cassianne Robinson-Cohen
    Department of Epidemiology, University of Washington, Seattle, USA
    J Ren Nutr 23:123-31. 2013
    ..Physical inactivity plays an important role in the development of kidney disease and its complications; however, the validity of standard tools for measuring physical activity (PA) is not well understood...
  30. pmc Race, gender, and mortality in adults > or =65 years of age with incident heart failure (from the Cardiovascular Health Study)
    Susmita Parashar
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Cardiol 103:1120-7. 2009
    ..In conclusion, in older adults with HF, women had significantly better survival than men irrespective of race, suggesting that gender-based survival differences may be more important than race-based differences...
  31. pmc Metabolic syndrome, inflammation, and incident heart failure in the elderly: the cardiovascular health study
    Takeki Suzuki
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    Circ Heart Fail 1:242-8. 2008
    ..We evaluated whether combining inflammation markers and MetS provided additive information for incident CHF and if incorporating inflammation markers to the MetS definition added prognostic information...
  32. pmc Obesity and change in estimated GFR among older adults
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Am J Kidney Dis 54:1043-51. 2009
    ..Obesity assessed in midlife has been associated with chronic kidney disease...
  33. pmc Sugar-sweetened beverage consumption and the progression of chronic kidney disease in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Andrew S Bomback
    Department of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY 10032, USA
    Am J Clin Nutr 90:1172-8. 2009
    ....
  34. pmc Inflammatory biomarkers and decline in kidney function in the elderly: the Cardiovascular Health Study
    Christopher Keller
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Nephrol Dial Transplant 25:119-24. 2010
    ..The objective of this study was to determine whether elevated markers of inflammation are independently associated with longitudinal kidney function decline...
  35. pmc Cystatin C, albuminuria, and mortality among older adults with diabetes
    Ian H De Boer
    University of Washington, Seattle, Washington, USA
    Diabetes Care 32:1833-8. 2009
    ..Joint associations of albuminuria and impaired GFR with mortality have not been comprehensively evaluated in this population...
  36. ncbi request reprint African ancestry, socioeconomic status, and kidney function in elderly African Americans: a genetic admixture analysis
    Carmen A Peralta
    Department of Medicine, University of California at San Francisco, San Francisco, California 94124, USA
    J Am Soc Nephrol 17:3491-6. 2006
    ..Rather, kidney dysfunction in elderly African Americans seems more attributable to differences in environmental and social factors...
  37. pmc Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Ronit Katz
    University of Washington, Seattle, Washington, USA
    Diabetes 58:813-9. 2009
    ..The purpose of this study was to determine whether MetS is associated with increased risks for the development of new ("incident") AVC or for progression of established AVC as assessed by CT...
  38. pmc Physical activity and rapid decline in kidney function among older adults
    Cassianne Robinson-Cohen
    Department of Epidemiology, University of Washington, Seattle, 98195, USA
    Arch Intern Med 169:2116-23. 2009
    ..We tested the hypothesis that higher levels of PA are associated with a lower risk of kidney function decline using longitudinal data from a large cohort of older adults...
  39. pmc Age-modification of lipoprotein, lipid, and lipoprotein ratio-associated risk for coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA])
    Pathmaja Paramsothy
    Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
    Am J Cardiol 105:352-8. 2010
    ..However, these associations were markedly attenuated by age. In conclusion, abnormal lipoprotein levels in middle age are a powerful risk factor for early atherosclerosis, as manifested by prevalent CAC...
  40. pmc Incidence and progression of aortic valve calcium in the Multi-ethnic Study of Atherosclerosis (MESA)
    David S Owens
    University of Washington, Seattle, Washington, USA
    Am J Cardiol 105:701-8. 2010
    ..AVC progression risk was associated with male gender and the baseline Agatston score. Additional research is needed to determine whether age- and stage-specific mechanisms underlie the risk of AVC progression...
  41. pmc Cystatin C and aging success
    Mark J Sarnak
    Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Arch Intern Med 168:147-53. 2008
    ..To our knowledge, the effect of kidney function on successful aging has not been examined...
  42. pmc Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study
    Jason P Linefsky
    Health Services Research and Development Northwest Center for Excellence, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98195 6422, USA
    J Am Coll Cardiol 58:291-7. 2011
    ..This study was conducted to evaluate mineral metabolism markers as potential risk factors for calcific aortic valve disease...
  43. pmc Intravenous tissue plasminogen activator and stroke in the elderly
    W T Longstreth
    Department of Neurology, University of Washington, Seattle, 98195, USA
    Am J Emerg Med 28:359-63. 2010
    ....
  44. pmc Mineral metabolism markers and the long-term risk of hip fracture: the cardiovascular health study
    Cassianne Robinson-Cohen
    Kidney Research Institute, Division of Nephrology, University of Washington, Seattle, Washington 98104, USA
    J Clin Endocrinol Metab 96:2186-93. 2011
    ..Disturbances in mineral metabolism are associated with lower bone mineral density and fracture; however, previous human studies have assessed individual mineral metabolism markers in isolation...
  45. pmc Serum 25-hydroxyvitamin D and change in estimated glomerular filtration rate
    Ian H De Boer
    Department of Medicine, University of Washington, Seattle, WA 98195, USA Tele
    Clin J Am Soc Nephrol 6:2141-9. 2011
    ..Mounting evidence suggests that 1,25-dihydroxyvitamin D prevents the progression of chronic kidney disease (CKD). It is not clear whether "nutritional" forms of vitamin D affect GFR...
  46. ncbi request reprint Elevated risk of stroke among patients with end-stage renal disease
    Stephen L Seliger
    Division of Nephrology, University of Washington, Seattle, Washington, USA
    Kidney Int 64:603-9. 2003
    ....
  47. pmc Vitamin D in chronic kidney disease: is the jury in?
    Ian H De Boer
    University of Washington, Division of Nephrology, Seattle, Washington 98195, USA
    Kidney Int 74:985-7. 2008
    ..However, such studies are limited by the potential for confounding by indication. A large randomized controlled trial is now needed to test the hypothesis that vitamin D therapy improves clinical outcomes in patients with kidney disease...
  48. pmc 25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification
    Ian H De Boer
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    J Am Soc Nephrol 20:1805-12. 2009
    ..Accelerated development of atherosclerosis may underlie, in part, the increased cardiovascular risk associated with vitamin D deficiency...
  49. ncbi request reprint 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98117, USA
    Am J Kidney Dis 50:69-77. 2007
    ..Albuminuria is a risk factor for chronic kidney disease progression, end-stage renal disease, cardiovascular events, and mortality. Animal studies suggested that vitamin D insufficiency may contribute to the pathogenesis of albuminuria...
  50. ncbi request reprint Calcium channel blocker use and mortality among patients with end-stage renal disease
    Bryan Kestenbaum
    Division of Nephrology, School of Public Health and Community Medicine, University of Washington, Seattle 98108, USA
    Kidney Int 61:2157-64. 2002
    ..We sought to determine the association between CCB use and mortality among a cohort of ESRD patients...
  51. pmc Central obesity, incident microalbuminuria, and change in creatinine clearance in the epidemiology of diabetes interventions and complications study
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    J Am Soc Nephrol 18:235-43. 2007
    ..In conclusion, waist circumference predicts the subsequent development of microalbuminuria in type 1 diabetes. In contrast, no association of waist circumference with decline in creatinine clearance was observed...
  52. pmc Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative
    Ian H De Boer
    Division of Nephrology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Diabetes Care 31:701-7. 2008
    ..We examined the effect of calcium plus vitamin D supplementation on the incidence of drug-treated diabetes in postmenopausal women...
  53. pmc Lipoprotein abnormalities associated with mild impairment of kidney function in the multi-ethnic study of atherosclerosis
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    Clin J Am Soc Nephrol 3:125-32. 2008
    ..Abnormal lipoprotein metabolism has been implicated as a possible cause of these complications, but lipoproteins have not been described at the earliest stages of kidney disease...
  54. pmc Insulin therapy, hyperglycemia, and hypertension in type 1 diabetes mellitus
    Ian H De Boer
    Division of Nephrology, University of Washington, Box 356521, 1959 NE Pacific St, Seattle, WA 98117, USA
    Arch Intern Med 168:1867-73. 2008
    ..Diabetes mellitus and hypertension are closely linked, but the long-term blood pressure effects of glucose-lowering therapy and hyperglycemia are not clear...
  55. pmc Association of oral calcitriol with improved survival in nondialyzed CKD
    Abigail B Shoben
    Department of Biostatistics, Puget Sound Veterans Affairs Medical Center, Seattle, WA, USA
    J Am Soc Nephrol 19:1613-9. 2008
    ..Calcitriol use was associated with a greater risk for hypercalcemia. In conclusion, oral calcitriol use is associated with lower mortality in nondialysis patients with CKD...
  56. ncbi request reprint Hepatitis C virus infection and the prevalence of renal insufficiency
    Lorien S Dalrymple
    Health Services Research and Development Northwest Center of Excellence, Seattle, WA 98108, USA
    Clin J Am Soc Nephrol 2:715-21. 2007
    ..Hepatitis C virus (HCV) is associated with pathologic changes in the kidney. However, the association between HCV and renal dysfunction is not well defined...
  57. pmc Mild elevations of urine albumin excretion are associated with atherogenic lipoprotein abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Atherosclerosis 197:407-14. 2008
    ....
  58. ncbi request reprint Amprenavir and didanosine are associated with declining kidney function among patients receiving tenofovir
    Heidi M Crane
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS 21:1431-9. 2007
    ..To examine the effect of antiretroviral agents and clinical factors on the development of tenofovir-associated kidney dysfunction...
  59. ncbi request reprint Risk of hip fracture among dialysis and renal transplant recipients
    Adrianne M Ball
    Division of Nephrology, School of Medicine, University of Washington, Seattle, Wash, USA
    JAMA 288:3014-8. 2002
    ..Renal failure places people at particularly high risk of hip fracture. However, the possible differential impact of dialysis and renal transplantation on this risk is not well understood...
  60. ncbi request reprint Factors associated with incidence and persistence of symptoms of disturbed sleep in an elderly cohort: the Cardiovascular Health Study
    Stuart F Quan
    Department of Medicine, Sleep and Arizona Respiratory Centers, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Am J Med Sci 329:163-72. 2005
    ..Factors influencing these rates were assessed as well...
  61. pmc Albuminuria, impaired kidney function and cardiovascular outcomes or mortality in the elderly
    Dena E Rifkin
    Tufts Medical Center and Tufts University School of Medicine, University of Washington, Seattle, USA
    Nephrol Dial Transplant 25:1560-7. 2010
    ..Kidney disease is a risk factor for mortality and cardiovascular disease in older adults, but the separate and combined effects of albuminuria and cystatin C, a novel marker of glomerular filtration, are not known...
  62. pmc Rapid kidney function decline and mortality risk in older adults
    Dena E Rifkin
    Division of Nephrology, Tufts Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Arch Intern Med 168:2212-8. 2008
    ..It remains unknown, however, whether longitudinal declines in kidney function are independently associated with increased cardiovascular and all-cause mortality in older adults...
  63. pmc Association of mild to moderate kidney dysfunction and coronary calcification
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and San Diego VA Healthcare System, 3350 La Jolla Village Drive, Mail Code 111 H, San Diego, CA 92161, USA
    J Am Soc Nephrol 19:579-85. 2008
    ..These results suggest that a higher burden of CAC is unlikely to explain the association between mild to moderate kidney dysfunction and cardiovascular mortality...
  64. ncbi request reprint Kidney function and aortic valve and mitral annular calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Am J Kidney Dis 50:412-20. 2007
    ..Whether less severe kidney dysfunction is associated with AVC and MAC is uncertain...
  65. ncbi request reprint Parathyroidectomy rates among United States dialysis patients: 1990-1999
    Bryan Kestenbaum
    University of Washington Department of Medicine, Division of Nephrology, Seattle, Washington 98195, USA
    Kidney Int 65:282-8. 2004
    ..We report PTX rates in the United States from 1990 to 1999 among persons with end-stage renal disease, accounting for changes in patient characteristics...
  66. pmc Serum phosphorus concentrations in the third National Health and Nutrition Examination Survey (NHANES III)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98104 2499, USA
    Am J Kidney Dis 53:399-407. 2009
    ..Reasons for interindividual variation in steady-state serum phosphorus concentrations are largely unknown...
  67. ncbi request reprint Increased risk of hip fracture among men with CKD
    Annemarie C Dooley
    Northwest Health Services Research and Development Program, Veterans Administration Puget Sound, University of Washington, Seattle, WA 98104 2499, USA
    Am J Kidney Dis 51:38-44. 2008
    ..Those requiring dialysis therapy are at substantially increased risk of fracture. However, fracture risk in patients with CKD not requiring dialysis has not been well studied...
  68. ncbi request reprint Estimation of 24-hour urine phosphate excretion from spot urine collection: development of a predictive equation
    Cassianne Robinson-Cohen
    Kidney Research Institute, University of Washington, Seattle, Washington Electronic address
    J Ren Nutr 24:194-9. 2014
    ..We investigated the precision and accuracy of spot urine phosphate measurements, compared to 24-hour urine phosphate (24hUrP) collection...
  69. doi request reprint Allopurinol and mortality in hyperuricaemic patients
    Andrew J Luk
    Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA, USA
    Rheumatology (Oxford) 48:804-6. 2009
    ..We examined the impact of allopurinol, the most commonly used urate-lowering drug, on the risk of mortality in hyperuricaemic patients...
  70. pmc Left ventricular hypertrophy in mild and moderate reduction in kidney function determined using cardiac magnetic resonance imaging and cystatin C: the multi-ethnic study of atherosclerosis (MESA)
    Andrew Moran
    Division of General Internal Medicine, Department of Medicine, Columbia University, New York, NY, USA
    Am J Kidney Dis 52:839-48. 2008
    ..We hypothesized that mild and moderate decreases in kidney function, reflected in greater serum cystatin C concentrations, would be linearly associated with a greater prevalence of LVH...
  71. ncbi request reprint A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study
    Neil A Zakai
    Department of Medicine, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, USA
    Arch Intern Med 165:2214-20. 2005
    ..Anemia is viewed as a negative prognostic factor in the elderly population; its independent impact on survival is unclear...
  72. ncbi request reprint Cystatin C and incident peripheral arterial disease events in the elderly: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, and General Internal Medicine Section, Veterans Affairs Medical Center San Francisco, 4150 Clement Street, San Faancisco, CA 94121, USA
    Arch Intern Med 165:2666-70. 2005
    ..The association of cystatin C, a novel marker of renal function, with risk for developing complications related to peripheral arterial disease (PAD) has not been examined...
  73. ncbi request reprint Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, VA Medical Center San Francisco, University of California, San Francisco, CA, USA
    Circulation 113:388-93. 2006
    ..A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population...
  74. doi request reprint Repeatability limits for measurement of coronary artery calcified plaque with cardiac CT in the Multi-Ethnic Study of Atherosclerosis
    Hyoju Chung
    Department of Biostatistics, Collaborative Health Studies Coordinating Center, University of Washington, 6200 NE 74th St, Building 29, Suite 310, Seattle, WA 98115, USA
    AJR Am J Roentgenol 190:W87-92. 2008
    ....
  75. pmc Cystatin C and carotid intima-media thickness in asymptomatic adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Anh L Bui
    Department of Medicine, University of California, San Francisco, CA, USA
    Am J Kidney Dis 53:389-98. 2009
    ..We therefore explored whether serum cystatin C level is associated with carotid intima-media thickness (IMT) in ambulatory adults without clinical heart disease...
  76. ncbi request reprint Increased risk for cardiovascular mortality among malnourished end-stage renal disease patients
    Frank Fung
    Division of Nephrology, University of Washington, Seattle, WA, USA
    Am J Kidney Dis 40:307-14. 2002
    ....
  77. ncbi request reprint Risk of lymphoma after renal transplantation varies with time: an analysis of the United States Renal Data System
    Jodi M Smith
    Department of Pediatrics, Division of Nephrology, Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA 98105, USA
    Transplantation 81:175-80. 2006
    ..We analyzed the United States Renal Data System to describe the occurrence of lymphoma following renal transplantation...
  78. pmc Cardiovascular risk factors and incident acute renal failure in older adults: the cardiovascular health study
    Anuja Mittalhenkle
    Division of Nephrology and Hypertension, Department of Medicine, Mail Code MQ360, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Clin J Am Soc Nephrol 3:450-6. 2008
    ..Although the elderly are at increased risk for acute renal failure, few prospective studies have identified risk factors for acute renal failure in the elderly...
  79. ncbi request reprint Plasma total homocysteine levels and cranial magnetic resonance imaging findings in elderly persons: the Cardiovascular Health Study
    W T Longstreth
    Department of Neurology, University of Washington, Box 359775, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104 2420, USA
    Arch Neurol 61:67-72. 2004
    ..An elevated plasma total homocysteine (tHcy) level is associated with an increased risk of vascular disease. Some studies have shown associations between tHcy level and small-vessel disease of the brain on magnetic resonance imaging (MRI)...
  80. pmc Chronic kidney disease prevalence estimates among racial/ethnic groups: the Multi-Ethnic Study of Atherosclerosis
    Holly Kramer
    Department of Preventive Medicine and Epidemiology, Loyola Medical Center, 2160 First Avenue, Maywood, IL 60153, USA
    Clin J Am Soc Nephrol 3:1391-7. 2008
    ..Muscle mass is not a major determinant of serum cystatin C levels, and its use to estimate GFR may lead to more congruent estimates of chronic kidney disease (CKD) across gender and racial/ethnic groups...
  81. ncbi request reprint Relationship of uric acid with progression of kidney disease
    Michel Chonchol
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 50:239-47. 2007
    ..Uric acid levels are increased in patients with kidney dysfunction. We tested the hypothesis that uric acid may be associated with kidney disease progression...
  82. ncbi request reprint Association of kidney function with incident hip fracture in older adults
    Linda F Fried
    VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    J Am Soc Nephrol 18:282-6. 2007
    ..Further studies are needed to evaluate potential mediators of this relationship and to assess whether interventions can decrease this risk...
  83. doi request reprint Tenofovir-associated decline in renal function
    Heidi M Crane
    J Infect Dis 198:937; author reply 937-8. 2008
  84. doi request reprint Calcification in CKD: no closer to the cure
    Bryan Kestenbaum
    Am J Kidney Dis 51:877-9. 2008

Research Grants6

  1. Cardiac Outcomes Associated with Renal Osteodystrophy
    Bryan Kestenbaum; Fiscal Year: 2007
    ..The proposed study aims to shed light on the relationship between a common renal related metabolic disorder and the epidemic burden of CVD found among this patient population. ..
  2. Mineral Metabolism and Cardiovascular Risk among Older Adults
    Bryan Kestenbaum; Fiscal Year: 2007
    ..Proposed analyses aim to clarify the roles of individual mineral markers with respect to CV health among older adults and to pave the way for future trials that target these markers as a means to improve CV outcomes. ..
  3. Mineral Metabolism and Cardiovascular Risk among Older Adults
    Bryan Kestenbaum; Fiscal Year: 2009
    ..Proposed analyses aim to clarify the roles of individual mineral markers with respect to CV health among older adults and to pave the way for future trials that target these markers as a means to improve CV outcomes. ..
  4. Mineral Metabolism and Cardiovascular Risk among Older Adults
    Bryan Kestenbaum; Fiscal Year: 2009
    ..Proposed analyses aim to clarify the roles of individual mineral markers with respect to CV health among older adults and to pave the way for future trials that target these markers as a means to improve CV outcomes. ..
  5. Phosphorus and Vitamin D Metabolism and Cardiovascular Outcomes: The multi-ethni
    BRYAN R contact KESTENBAUM; Fiscal Year: 2010
    ..Findings will help clarify optimal serum concentrations of phosphorous and vitamin D biomarkers with respect to cardiovascular health and inform clinical trials which target mineral metabolism to prevent and reduce CVD. ..