Helmut W Kessels

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Synaptic AMPA receptor plasticity and behavior
    Helmut W Kessels
    Department of Neuroscience, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    Neuron 61:340-50. 2009
  2. pmc Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression
    Helmut W Kessels
    Center for Neural Circuits and Behavior, Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 110:4033-8. 2013
  3. pmc Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression
    Sadegh Nabavi
    Center for Neural Circuits and Behavior, Division of Biology, Department of Neuroscience and Section of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 110:4027-32. 2013
  4. pmc The prion protein as a receptor for amyloid-beta
    Helmut W Kessels
    Center for Neural Circuits and Behavior, 9500 Gilman Drive 0634, University of California at San Diego, La Jolla, California 92093, USA
    Nature 466:E3-4; discussion E4-5. 2010

Collaborators

Detail Information

Publications4

  1. doi request reprint Synaptic AMPA receptor plasticity and behavior
    Helmut W Kessels
    Department of Neuroscience, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    Neuron 61:340-50. 2009
    ..We argue that monitoring and manipulating synaptic AMPAR trafficking represents an attractive means to study cognitive function and dysfunction in animal models...
  2. pmc Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression
    Helmut W Kessels
    Center for Neural Circuits and Behavior, Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 110:4033-8. 2013
    ..This Aβ-induced signaling mediated by alterations in GluN2B conformation may be a target for therapeutic intervention of Alzheimer's disease...
  3. pmc Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression
    Sadegh Nabavi
    Center for Neural Circuits and Behavior, Division of Biology, Department of Neuroscience and Section of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 110:4027-32. 2013
    ..Our findings indicate that metabotropic actions of NMDARs can weaken active synapses without raising postsynaptic calcium, thereby revising and expanding the mechanisms controlling synaptic plasticity...
  4. pmc The prion protein as a receptor for amyloid-beta
    Helmut W Kessels
    Center for Neural Circuits and Behavior, 9500 Gilman Drive 0634, University of California at San Diego, La Jolla, California 92093, USA
    Nature 466:E3-4; discussion E4-5. 2010
    ..Here we show that PrP(C) is not required for amyloid-beta-induced synaptic depression, reduction in spine density, or blockade of LTP; our results indicate that amyloid-beta-mediated synaptic defects do not require PrP(c)...