Genomes and Genes
Helmut W Kessels
Affiliation: University of California
- Synaptic AMPA receptor plasticity and behaviorHelmut W Kessels
Department of Neuroscience, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
Neuron 61:340-50. 2009..We argue that monitoring and manipulating synaptic AMPAR trafficking represents an attractive means to study cognitive function and dysfunction in animal models...
- Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depressionHelmut W Kessels
Center for Neural Circuits and Behavior, Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 110:4033-8. 2013..This Aβ-induced signaling mediated by alterations in GluN2B conformation may be a target for therapeutic intervention of Alzheimer's disease...
- Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depressionSadegh Nabavi
Center for Neural Circuits and Behavior, Division of Biology, Department of Neuroscience and Section of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 110:4027-32. 2013..Our findings indicate that metabotropic actions of NMDARs can weaken active synapses without raising postsynaptic calcium, thereby revising and expanding the mechanisms controlling synaptic plasticity...
- The prion protein as a receptor for amyloid-betaHelmut W Kessels
Center for Neural Circuits and Behavior, 9500 Gilman Drive 0634, University of California at San Diego, La Jolla, California 92093, USA
Nature 466:E3-4; discussion E4-5. 2010..Here we show that PrP(C) is not required for amyloid-beta-induced synaptic depression, reduction in spine density, or blockade of LTP; our results indicate that amyloid-beta-mediated synaptic defects do not require PrP(c)...
- Synapto-depressive effects of amyloid beta require PICK1Stephanie Alfonso
Center for Neural Circuits and Behavior, Departments of Neuroscience and Biology, University of California at San Diego, La Jolla, CA, 92093, USA
Eur J Neurosci 39:1225-33. 2014..We concluded that GluA2-PICK1 interactions are a key component of the effects of Aβ on synapses. ..