Mehmet Kesimer

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii
    Mehmet Kesimer
    Department of Biochemistry, Faculty of Medicine, University of Gazi, 06510 Besevler, Ankara, Turkey
    BMC Microbiol 9:163. 2009
  2. ncbi Mass spectrometric analysis of mucin core proteins
    Mehmet Kesimer
    Department of Biochemistry and Biophysics Cystic Fibrosis Pulmonary Research Center, University of North Carolina, 4021 Thurston Bowles Bldg CB 7248, Chapel Hill, NC, USA
    Methods Mol Biol 842:67-79. 2012
  3. ncbi Unpacking a gel-forming mucin: a view of MUC5B organization after granular release
    Mehmet Kesimer
    1Department of Biochemistry and Biophysics and Cystic Fibrosis Pulmonary Research and Treatment Center, Chapel Hill, NC, USA
    Am J Physiol Lung Cell Mol Physiol 298:L15-22. 2010
  4. ncbi Analyzing the functions of large glycoconjugates through the dissipative properties of their absorbed layers using the gel-forming mucin MUC5B as an example
    Mehmet Kesimer
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Glycobiology 18:463-72. 2008
  5. ncbi Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?
    Mehmet Kesimer
    Dept of Biochemistry and Biophysics, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 296:L92-L100. 2009
  6. ncbi Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense
    Mehmet Kesimer
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    FASEB J 23:1858-68. 2009
  7. ncbi A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia
    Brian Button
    Cystic Fibrosis Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Science 337:937-41. 2012
  8. ncbi Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways
    Carey A Hobbs
    Cystic Fibrosis Pulmonary Research and Treatment Center, Department of Prosthodontics, University of North Carolina, Chapel Hill, 7125 Thurston Bowles Bldg, Chapel Hill, NC 27599 7248, USA
    FASEB J 26:4348-59. 2012
  9. ncbi Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study
    Rui Cao
    Cystic Fibrosis and Pulmonary Research Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, North Carolina, United States
    J Proteome Res 11:4013-23. 2012
  10. ncbi The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A
    William R Thelin
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 280:41512-20. 2005

Research Grants

  1. The role of mucin-protein interactions in the innate defense of the lung
    Mehmet Kesimer; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. ncbi Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii
    Mehmet Kesimer
    Department of Biochemistry, Faculty of Medicine, University of Gazi, 06510 Besevler, Ankara, Turkey
    BMC Microbiol 9:163. 2009
    ..Identification and characterization of the specific interacting proteins on the bacterial cell surface, termed adhesins, are crucial to further understand host-pathogen interactions...
  2. ncbi Mass spectrometric analysis of mucin core proteins
    Mehmet Kesimer
    Department of Biochemistry and Biophysics Cystic Fibrosis Pulmonary Research Center, University of North Carolina, 4021 Thurston Bowles Bldg CB 7248, Chapel Hill, NC, USA
    Methods Mol Biol 842:67-79. 2012
    ..In this chapter, we present our current protocol employing a modified shotgun proteomic approach to identify these complex glycoproteins...
  3. ncbi Unpacking a gel-forming mucin: a view of MUC5B organization after granular release
    Mehmet Kesimer
    1Department of Biochemistry and Biophysics and Cystic Fibrosis Pulmonary Research and Treatment Center, Chapel Hill, NC, USA
    Am J Physiol Lung Cell Mol Physiol 298:L15-22. 2010
    ....
  4. ncbi Analyzing the functions of large glycoconjugates through the dissipative properties of their absorbed layers using the gel-forming mucin MUC5B as an example
    Mehmet Kesimer
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Glycobiology 18:463-72. 2008
    ..g. binding viruses, but could also be informative to the surfaces (often ciliated) onto which such mucus films are attached...
  5. ncbi Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?
    Mehmet Kesimer
    Dept of Biochemistry and Biophysics, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 296:L92-L100. 2009
    ..This shows that the primary cell culture system is an important model for study of aspects of innate defense of the upper airways related specifically to mucus consisting solely of airway cell products...
  6. ncbi Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense
    Mehmet Kesimer
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    FASEB J 23:1858-68. 2009
    ..Taken together, these findings suggest that airway epithelial cells release exosome-like vesicles and that these structures may be involved in diverse physiological processes in airway biology, including innate mucosal defense...
  7. ncbi A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia
    Brian Button
    Cystic Fibrosis Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Science 337:937-41. 2012
    ..The relative osmotic moduli of the mucus and periciliary brush layers explain both the stability of mucus clearance in health and its failure in airway disease...
  8. ncbi Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways
    Carey A Hobbs
    Cystic Fibrosis Pulmonary Research and Treatment Center, Department of Prosthodontics, University of North Carolina, Chapel Hill, 7125 Thurston Bowles Bldg, Chapel Hill, NC 27599 7248, USA
    FASEB J 26:4348-59. 2012
    ..Furthermore, the robust inhibition of ENaC by the G22-A39 peptide suggests that this peptide may be suitable for treating CF lung disease...
  9. ncbi Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study
    Rui Cao
    Cystic Fibrosis and Pulmonary Research Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, North Carolina, United States
    J Proteome Res 11:4013-23. 2012
    ....
  10. ncbi The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A
    William R Thelin
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 280:41512-20. 2005
    ..Furthermore, PP2A may be a clinically relevant drug target for CF, which should be considered in future studies...
  11. ncbi Studying mucin secretion from human bronchial epithelial cell primary cultures
    Lubna H Abdullah
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Biol 842:259-77. 2012
    ..These results indicate that the more nonspecific assays are suitable to assess overall secretory responses by goblet cells, but are likely unsuited for specific measurements of polymeric mucins, per se...
  12. ncbi Innate immunity and mucus structure and function
    John K Sheehan
    Cystic Fibrosis Center, Campus Box 7248, 4019a Thurston Bowles, University of North Carolina at Chapel Hill, NC 27599, USA
    Novartis Found Symp 279:155-66; discussion 167-9, 216-9. 2006
    ....
  13. ncbi Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces
    Hirotoshi Matsui
    Cystic Fibrosis Pulmonary Research and Treatment Center and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 175:1090-9. 2005
    ..We conclude that concentrated ("thick") mucus inhibits neutrophil migration and killing and is a key component in the failure of defense against chronic airways infection in CF...
  14. ncbi Hemoglobin Raleigh results in factitiously low hemoglobin A1c when evaluated via immunoassay analyzer
    Nina Jain
    Division of Pediatric Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Diabetes Complications 25:14-8. 2011
    ..Glycosylated hemoglobin (HbA1c) is commonly used to assess long-term blood glucose control in patients with diabetes mellitus. Numerous conditions including hemoglobinopathies can alter HbA1c measurements and cause misleading results...
  15. ncbi Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model
    Long P Nguyen
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, 4800 Calhoun, Houston, TX 77204 5037, USA
    Am J Respir Cell Mol Biol 38:256-62. 2008
    ..Similar to heart failure, our results provide a second disease model in which beta-blockers producing an acutely detrimental effect may provide a therapeutically beneficial effect with chronic administration...

Research Grants1

  1. The role of mucin-protein interactions in the innate defense of the lung
    Mehmet Kesimer; Fiscal Year: 2010
    ....