Matcheri S Keshavan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychoses
    Matcheri S Keshavan
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Bull 29:757-69. 2003
  2. ncbi request reprint Can psychiatrists recognize mental illness in paintings?
    Anjali Rao
    UPMC Health System Western Psychiatric Institute and Clinic, Room 441, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 163:599. 2006
  3. pmc Social cognition deficits among individuals at familial high risk for schizophrenia
    Shaun M Eack
    School of Social Work, University of Pittsburgh, Pittsburgh, PA, USA
    Schizophr Bull 36:1081-8. 2010
  4. ncbi request reprint Decreased nonlinear complexity and chaos during sleep in first episode schizophrenia: a preliminary report
    Matcheri S Keshavan
    Department of Psychiatry, University of Pittsburgh School of Medicine, UPMC Health System Western Psychiatric Institute and Clinic, Room 441, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 71:263-72. 2004
  5. ncbi request reprint Personality dimensions in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 162:102-9. 2005
  6. pmc Neuroprotective effects of cognitive enhancement therapy against gray matter loss in early schizophrenia: results from a 2-year randomized controlled trial
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, USA
    Arch Gen Psychiatry 67:674-82. 2010
  7. ncbi request reprint Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
  8. ncbi request reprint Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder
    Simerjit Kaur
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Psychiatry 162:1637-43. 2005
  9. pmc Neuroanatomical substrates of foresight in schizophrenia
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    Schizophr Res 103:62-70. 2008
  10. ncbi request reprint Smaller cingulate volumes in unipolar depressed patients
    Sheila C Caetano
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Biol Psychiatry 59:702-6. 2006

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. ncbi request reprint Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychoses
    Matcheri S Keshavan
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Bull 29:757-69. 2003
    ..The latter, if true, would strongly support therapeutic intervention efforts in the prodromal and early psychotic phases of schizophrenia...
  2. ncbi request reprint Can psychiatrists recognize mental illness in paintings?
    Anjali Rao
    UPMC Health System Western Psychiatric Institute and Clinic, Room 441, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 163:599. 2006
  3. pmc Social cognition deficits among individuals at familial high risk for schizophrenia
    Shaun M Eack
    School of Social Work, University of Pittsburgh, Pittsburgh, PA, USA
    Schizophr Bull 36:1081-8. 2010
    ..These results suggest that impairments in social cognition may be unique endophenotypes for schizophrenia...
  4. ncbi request reprint Decreased nonlinear complexity and chaos during sleep in first episode schizophrenia: a preliminary report
    Matcheri S Keshavan
    Department of Psychiatry, University of Pittsburgh School of Medicine, UPMC Health System Western Psychiatric Institute and Clinic, Room 441, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 71:263-72. 2004
    ..Diminished complexity of EEG time series during awake and REM sleep in patients with schizophrenia may underlie the impaired ability to process information in psychotic disorders such as schizophrenia...
  5. ncbi request reprint Personality dimensions in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 162:102-9. 2005
    ..The authors compared the patterns and specificity of premorbid personality dimensions in first-episode schizophrenia patients with those in patients with first-episode nonschizophrenia psychoses and healthy comparison subjects...
  6. pmc Neuroprotective effects of cognitive enhancement therapy against gray matter loss in early schizophrenia: results from a 2-year randomized controlled trial
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, USA
    Arch Gen Psychiatry 67:674-82. 2010
    ..Cognitive rehabilitation has shown efficacy in improving cognition in patients with schizophrenia but the underlying neurobiologic changes that occur during these treatments and support cognitive improvement are not well known...
  7. ncbi request reprint Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
    ..This study examined the OFC and its subdivisions in patients with MDD and matched healthy control subjects...
  8. ncbi request reprint Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder
    Simerjit Kaur
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Psychiatry 162:1637-43. 2005
    ..This anatomical magnetic resonance imaging study examined the cingulate cortex in children and adolescents with bipolar disorder and matched healthy comparison subjects...
  9. pmc Neuroanatomical substrates of foresight in schizophrenia
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    Schizophr Res 103:62-70. 2008
    ..Implications and directions for future research are discussed...
  10. ncbi request reprint Smaller cingulate volumes in unipolar depressed patients
    Sheila C Caetano
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Biol Psychiatry 59:702-6. 2006
    ..This anatomical magnetic resonance imaging (MRI) study compared cingulate cortex volumes in unipolar depressed patients and age- and gender-matched healthy control subjects...
  11. doi request reprint Striatal metabolic alterations in non-psychotic adolescent offspring at risk for schizophrenia: a (1)H spectroscopy study
    Matcheri S Keshavan
    Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Schizophr Res 115:88-93. 2009
    ....
  12. pmc Prefrontal cortical dysfunction during visual perspective-taking in schizophrenia
    Shaun M Eack
    School of Social Work, University of Pittsburgh, United States Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, United States Electronic address
    Schizophr Res 150:491-7. 2013
    ..These findings suggest that disruptions are present in the most fundamental aspects of perspective-taking in schizophrenia, and that these disruptions impact higher-order social information processing. ..
  13. pmc Commonalities in social and non-social cognitive impairments in adults with autism spectrum disorder and schizophrenia
    Shaun M Eack
    School of Social Work, University of Pittsburgh, United States
    Schizophr Res 148:24-8. 2013
    ....
  14. ncbi request reprint Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder
    Barbara K Chen
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 56:399-405. 2004
    ....
  15. ncbi request reprint Reduced left anterior cingulate volumes in untreated bipolar patients
    Roberto B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 56:467-75. 2004
    ....
  16. pmc An integrated psychobiological predictive model of emergent psychopathology among young relatives at risk for schizophrenia
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1873-8. 2008
    ..We tested the predictive power of an integrated psychobiological model of schizophrenia risk to subsequent psychopathology development among young relatives at risk for the disorder...
  17. pmc Response suppression deficits in treatment-naïve first-episode patients with schizophrenia, psychotic bipolar disorder and psychotic major depression
    Margret S H Harris
    Department of Psychiatry, University of Illinois, Chicago, IL, USA
    Psychiatry Res 170:150-6. 2009
    ..However, the distinct pattern of dysfunction in schizophrenia across oculomotor paradigms suggests possible unique causes of their observed oculomotor performance deficits...
  18. pmc Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:469-74. 2010
    ..Our results suggest an altered maturational trajectory of executive function during adolescence in individuals at familial risk for schizophrenia...
  19. ncbi request reprint Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study
    Marsal Sanches
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Curl Drive, San Antonio, TX 87229, USA
    Psychiatry Res 138:43-9. 2005
    ..55 +/- 73.67 mm(3), respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents...
  20. ncbi request reprint 1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Affect Disord 86:61-7. 2005
    ..Furthermore, recent MRS reports suggested possible lithium-induced increase in NAA levels in bipolar patients. We examined with in vivo (1)H MRS NAA levels in the DLPFC of adult bipolar patients...
  21. pmc Abnormal corpus callosum myelination in pediatric bipolar patients
    Sheila C Caetano
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Affect Disord 108:297-301. 2008
    ..Here we compared the callosal signal intensity of children and adolescents with bipolar disorder to that of matched healthy subjects, to investigate the hypothesis that callosal myelination is abnormal in pediatric bipolar patients...
  22. pmc Abnormalities of the corpus callosum in non-psychotic high-risk offspring of schizophrenia patients
    Alan N Francis
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Psychiatry Res 191:9-15. 2011
    ..The absence of an age-related volume increase suggests an abnormal developmental trajectory that may underlie susceptibility to schizophrenia...
  23. ncbi request reprint MRI investigation of temporal lobe structures in bipolar patients
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Psychiatr Res 37:287-95. 2003
    ..Longitudinal studies in high-risk offspring and first-episode patients will be needed to examine whether such abnormalities precede the appearance of symptoms, or whether they may appear subsequently as a result of illness course...
  24. pmc MRI study of the cerebellum in young bipolar patients
    E Serap Monkul
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:613-9. 2008
    ..Our results are preliminary, but consistent with the findings from studies in adult bipolar patients suggesting the involvement of structural changes in cerebellar vermis in the pathophysiology of bipolar disorder...
  25. ncbi request reprint Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression
    Sheila C Caetano
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Sciences Center at San Antonio, TX, USA
    Psychiatry Res 132:141-7. 2004
    ..A smaller hippocampal size may be more characteristic of the depressive state and not be present in remitted patients...
  26. pmc Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 118:62-8. 2010
    ..Gray-matter volumetric alterations may be related to these functional connectivity deficits. Also, gray-matter volume inter-regional correlations may reflect altered inter-regional functional connectivity...
  27. ncbi request reprint 1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients
    Paolo Brambilla
    Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA
    Psychiatry Res 138:131-9. 2005
    ..Future 1H MRS investigations should longitudinally examine the role of illness chronicity on DLPFC abnormalities and their relationship with the symptoms of unipolar disorder...
  28. ncbi request reprint Anatomical MRI study of corpus callosum in unipolar depression
    Acioly L T Lacerda
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA
    J Psychiatr Res 39:347-54. 2005
    ..The possible role of callosal abnormalities in the pathogenesis of mood disorders should be further examined...
  29. ncbi request reprint Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 27:792-9. 2002
    ..05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial...
  30. pmc Assessing social-cognitive deficits in schizophrenia with the Mayer-Salovey-Caruso Emotional Intelligence Test
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Schizophr Bull 36:370-80. 2010
    ..Further investigation is warranted to examine the instrument's latent factor structure and convergence with other measures of social cognition...
  31. ncbi request reprint Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic and University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
    Am J Psychiatry 160:1298-304. 2003
    ..This study examined the neuroanatomical correlates and diagnostic specificity of abnormal findings on the neurological examination in first-episode schizophrenia and other psychotic disorders...
  32. pmc Gray matter loss in young relatives at risk for schizophrenia: relation with prodromal psychopathology
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    Neuroimage 54:S272-9. 2011
    ....
  33. pmc Progressive alterations of the auditory association areas in young non-psychotic offspring of schizophrenia patients
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 45:205-12. 2011
    ..These alterations may be greater in male patients. It is unclear if these deficits are state-dependent or whether they predate illness onset and reflect familial diathesis...
  34. pmc Negative symptom improvement during cognitive rehabilitation: results from a 2-year trial of Cognitive Enhancement Therapy
    Shaun M Eack
    School of Social Work, University of Pittsburgh, 2117 Cathedral of Learning, Pittsburgh, PA 15260, USA
    Psychiatry Res 209:21-6. 2013
    ..Future studies specifically designed to examine negative symptoms during the course of cognitive rehabilitation are needed. ..
  35. pmc 3-Hydroxykynurenine and clinical symptoms in first-episode neuroleptic-naive patients with schizophrenia
    Ruth Condray
    VA Pittsburgh Healthcare System, Medical Research Service, Pittsburgh, PA, USA
    Int J Neuropsychopharmacol 14:756-67. 2011
    ..Baseline level of 3-OHKY may also predict the degree of clinical improvement following brief treatment with antipsychotics...
  36. ncbi request reprint Adverse effects of risperidone on spatial working memory in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, IL 60612, USA
    Arch Gen Psychiatry 63:1189-97. 2006
    ..The oculomotor delayed response task is a translational spatial working memory paradigm used to characterize the neurophysiologic and neurochemical aspects of working memory in the primate brain...
  37. ncbi request reprint Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 54:1294-7. 2003
    ..This study was conducted to further examine the hypothesis of abnormalities in size of corpus callosum in subjects with bipolar disorder...
  38. ncbi request reprint Orbitofrontal cortex gray matter volumes in bipolar disorder patients: a region-of-interest MRI study
    Fabiano G Nery
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Bipolar Disord 11:145-53. 2009
    ..This anatomical magnetic resonance imaging (MRI) study examined whether BD patients have smaller OFC gray matter volumes compared to healthy comparison subjects (HC)...
  39. pmc Effects of risperidone on procedural learning in antipsychotic-naive first-episode schizophrenia
    Margret S H Harris
    Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 34:468-76. 2009
    ....
  40. ncbi request reprint Developmental abnormalities in striatum in young bipolar patients: a preliminary study
    Marsal Sanches
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Bipolar Disord 7:153-8. 2005
    ..To investigate whether these abnormalities are present early in illness course, we compared the volume of striatal structures in young bipolar patients and healthy controls...
  41. ncbi request reprint White matter hyperintensities in bipolar and unipolar patients with relatively mild-to-moderate illness severity
    Roberto B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 77:237-45. 2003
    ..We examined the rates of hyperintense lesions in adult, non-elderly bipolar and unipolar patients, with a relatively mild-to-moderate illness severity, and in matched healthy controls...
  42. ncbi request reprint Relationships between cognitive and neurological performance in neuroleptic-naïve psychosis
    Richard D Sanders
    Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 16:480-7. 2004
    ..Customarily, frontal neuropsychological tasks also relate more strongly to CogPer than to RepMot. Approximately one-half of the variability in these cognitive and neurological assessments is shared...
  43. pmc Untreated illness duration correlates with gray matter loss in first-episode psychoses
    Srihari S Bangalore
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Neuroreport 20:729-34. 2009
    ..The observed inverse relationship between DUI and temporal gray matter density is consistent with a progressive process during the early course of schizophrenia...
  44. pmc Antiherpes virus-specific treatment and cognition in schizophrenia: a test-of-concept randomized double-blind placebo-controlled trial
    Konasale M Prasad
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Schizophr Bull 39:857-66. 2013
    ....
  45. pmc Are structural brain abnormalities associated with suicidal behavior in patients with psychotic disorders?
    Christoforos I Giakoumatos
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Psychiatr Res 47:1389-95. 2013
    ..Regions in which differences were observed are part of neural circuitries that mediate inhibition, impulsivity and emotion, visceral, visual and auditory perception. ..
  46. doi request reprint Brain metabolite alterations in young adults at familial high risk for schizophrenia using proton magnetic resonance spectroscopy
    Neeraj Tandon
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    Schizophr Res 148:59-66. 2013
    ..While individuals at high familial risk for schizophrenia (HR) exhibit some neurobiological findings observed in the disorder, (1)H MRS findings and their clinical correlates are not well characterized in this population...
  47. pmc Grey matter changes associated with host genetic variation and exposure to Herpes Simplex Virus 1 (HSV1) in first episode schizophrenia
    Konasale M Prasad
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    Schizophr Res 118:232-9. 2010
    ..In this study, we examined whether PFC grey matter changes associated with HSV1 exposure varied against the background of MICB genotypes...
  48. pmc Gray matter differences between pediatric obsessive-compulsive disorder patients and high-risk siblings: a preliminary voxel-based morphometry study
    Andrew R Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Psychiatry 9B, 4201 St Antoine Boulevard, Pittsburgh, PA, United States
    Neurosci Lett 435:45-50. 2008
    ....
  49. ncbi request reprint Brief report: abnormal association between the thalamus and brain size in Asperger's disorder
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Autism Dev Disord 38:390-4. 2008
    ....
  50. pmc One-year durability of the effects of cognitive enhancement therapy on functional outcome in early schizophrenia
    Shaun M Eack
    School of Social Work, University of Pittsburgh, PA, USA
    Schizophr Res 120:210-6. 2010
    ..These findings support the durability of CET effects on functional outcome in the early course of schizophrenia, and point to the potential of cognitive rehabilitation to have a lasting impact on the early trajectory of the disorder...
  51. pmc Cognitive enhancement therapy for early-course schizophrenia: effects of a two-year randomized controlled trial
    Shaun M Eack
    School of Social Work, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Psychiatr Serv 60:1468-76. 2009
    ..This study examined the two-year effects of an integrated neurocognitive and social-cognitive rehabilitation program, cognitive enhancement therapy (CET), on cognitive and functional outcomes in early-course schizophrenia...
  52. pmc Decreased BDNF in patients with antipsychotic naïve first episode schizophrenia
    Ripu D Jindal
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Res 119:47-51. 2010
    ..Herein we report on serum BDNF levels in a series of patients with first-episode treatment naïve psychoses in comparison to age matched healthy controls...
  53. pmc Prefrontal gray matter morphology mediates the association between serum anticholinergicity and cognitive functioning in early course schizophrenia
    Jessica A Wojtalik
    School of Social Work, University of Pittsburgh, Pittsburgh, PA, USA
    Psychiatry Res 204:61-7. 2012
    ..Disease- and/or medication-related cholinergic dysfunction may be associated with brain volume abnormalities in early course schizophrenia, which may account for the association between SAA and cognitive dysfunction in the disorder...
  54. pmc Associations between purine metabolites and clinical symptoms in schizophrenia
    Jeffrey K Yao
    Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
    PLoS ONE 7:e42165. 2012
    ..Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology of schizophrenia...
  55. ncbi request reprint Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia
    Vaibhav A Diwadkar
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Schizophr Res 67:277-82. 2004
    ....
  56. pmc Evidence of factorial variance of the Mayer-Salovey-Caruso Emotional Intelligence Test across schizophrenia and normative samples
    Shaun M Eack
    School of Social Work, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Schizophr Res 114:105-9. 2009
    ..Results indicated that the factor structure of the MSCEIT was significantly different between the schizophrenia and normative samples. Implications for future research are discussed...
  57. pmc Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?
    Konasale M Prasad
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Schizophr Bull 34:774-90. 2008
    ..Further work is needed to examine how specific genes and their interactions with the environment may produce alterations in brain structure and function that accompany psychotic disorders...
  58. ncbi request reprint Anatomical MRI study of basal ganglia in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 124:129-40. 2003
    ..These findings suggest that abnormalities in lateralization and possibly neurodegenerative changes in basal ganglia structures participate in the pathophysiology of major depressive disorder...
  59. ncbi request reprint Anatomical MRI study of borderline personality disorder patients
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Psychiatry Res 131:125-33. 2004
    ..Early traumatic experiences may play a role in hippocampal atrophy, whereas substance use disorders may contribute to putamen enlargement...
  60. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  61. ncbi request reprint 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administration
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Neuropsychopharmacology 29:1918-24. 2004
    ....
  62. pmc Cortical surface characteristics among offspring of schizophrenia subjects
    Konasale M Prasad
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Schizophr Res 116:143-51. 2010
    ..We examined these measures obtained on structural magnetic resonance imaging (MRI) scans at baseline and one year on a series of offspring of schizophrenia parents and healthy subjects...
  63. doi request reprint Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 115:202-8. 2009
    ..Volumetric deficits and altered asymmetry in inferior parietal and Heschl's gyrii may accompany genetic liability to schizophrenia...
  64. ncbi request reprint Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of Schizophrenia
    Henry A Nasrallah
    Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 70:4-46. 2009
    ..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research...
  65. pmc Structural neurobiological correlates of Mayer-Salovery-Caruso Emotional Intelligence Test performance in early course schizophrenia
    Jessica A Wojtalik
    School of Social Work, University of Pittsburgh, Pittsburgh, PA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 40:207-12. 2013
    ..As a way to further investigate the validity of the MSCEIT, this study sought to examine the neurobiological correlates of MSCEIT performance in patients with early course schizophrenia...
  66. ncbi request reprint Dorsolateral prefrontal cortex morphology and short-term outcome in first-episode schizophrenia
    Konasale M R Prasad
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Psychiatry Res 140:147-55. 2005
    ..Volume of the left DLPFC at baseline predicted functional outcome in schizophrenia at 1 but not at 2 years. Specific cognitive functions regulated by the left DLPFC may be critical for functional outcome...
  67. pmc Sleep correlates of cognition in early course psychotic disorders
    Matcheri S Keshavan
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Res 131:231-4. 2011
    ..Cognitive impairments, seen early in the course of psychotic disorders, may be related to alterations in these oscillations, but few studies have examined this relationship...
  68. pmc Grey matter and cognitive deficits in young relatives of schizophrenia patients
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    Neuroimage 54:S287-92. 2011
    ..Overlapping structural and cognitive deficits may define a hyper vulnerable sub-sample among individuals at familial predisposition to schizophrenia...
  69. pmc Dorsolateral prefrontal cortex magnetic resonance imaging measurements and cognitive performance in autism
    Jessica Griebling
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Child Neurol 25:856-63. 2010
    ..The absence of correlations suggests that executive dysfunction is not the result of focal brain alterations but, rather, is the result of a distributed neural network dysfunction...
  70. ncbi request reprint The effects of antipsychotic medication on factor and cluster structure of neurologic examination abnormalities in schizophrenia
    Gerald Goldstein
    VA Pittsburgh HCS, 7180 Highland Drive, Pittsburgh, PA 15206, USA
    Schizophr Res 75:55-64. 2005
    ..As is the case with other domains of symptoms and performance in schizophrenia, relationships among neurologic exam variables are altered by the presence of antipsychotic medication...
  71. pmc Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Biol Psychiatry 65:129-36. 2009
    ..The role of the orbitofrontal cortex (OFC) in regulating emotional processing is increasingly being recognized along with its association with impulsive behavior...
  72. ncbi request reprint Neuropsychological dysfunction in antipsychotic-naive first-episode unipolar psychotic depression
    S Kristian Hill
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Psychiatry 161:996-1003. 2004
    ....
  73. ncbi request reprint Measurement of the orbitofrontal cortex: a validation study of a new method
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 19:665-73. 2003
    ..996 and 0.998. This method appears to be a valid method for measuring the OFC with excellent reliability. This uncomplicated approach is easy to apply and has the potential to be a valuable alternative to the previously published methods...
  74. ncbi request reprint Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites
    Jeffrey K Yao
    Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA
    Biol Psychiatry 52:823-30. 2002
    ..To address this question we examined the relations between red blood cell polyunsaturated fatty acids and brain phospholipid metabolites from different regions of interest in schizophrenia and healthy subjects...
  75. ncbi request reprint Superior temporal gyrus volumes in pediatric generalized anxiety disorder
    Michael D De Bellis
    University of Pittsburgh Medical Center, Developmental Traumatology Program Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Biol Psychiatry 51:553-62. 2002
    ..Larger amygdala volumes were previously reported in pediatric GAD; however, the brain regions involved in social intelligence were not examined in this pilot study...
  76. pmc Corpus callosum volume and neurocognition in autism
    Christopher J Keary
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Autism Dev Disord 39:834-41. 2009
    ..These findings provide further evidence for anatomical alterations in the corpus callosum in autism, but warrant additional studies examining the relationship of this structure and specific measures of interhemispheric connectivity...
  77. ncbi request reprint Insight and prefrontal cortex in first-episode Schizophrenia
    Mujeeb U Shad
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 22:1315-20. 2004
    ....
  78. pmc Beat-to-beat heart rate and QT interval variability in first episode neuroleptic-naive psychosis
    Ripu D Jindal
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Res 113:176-80. 2009
    ..However, these studies did not control for the effects of medication. Herein, we report the results of our study comparing RRV and QTV in first episode neuroleptic-naive psychosis patients with healthy matched controls...
  79. ncbi request reprint Reduced red blood cell membrane essential polyunsaturated fatty acids in first episode schizophrenia at neuroleptic-naive baseline
    Ravinder D Reddy
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Schizophr Bull 30:901-11. 2004
    ..The findings also suggest that membrane fatty acid losses are quite specific to the highly unsaturated fatty acids...
  80. doi request reprint Effects of word frequency on semantic memory in schizophrenia: electrophysiological evidence for a deficit in linguistic access
    Ruth Condray
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Psychophysiol 75:141-56. 2010
    ..g., cholinergic system). Electrophysiological responding may be informative regarding the storage-access distinction for schizophrenia...
  81. ncbi request reprint Obstetric complications correlate with neurobehavioral and brain structural alterations in young relatives at risk for schizophrenia
    Andrew R Gilbert
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1008:269-75. 2003
    ....
  82. ncbi request reprint Correlates of insight in first episode psychosis
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Res 70:187-94. 2004
    ..These observations suggest that deficits in insight may be related to a generalized dysfunction of neural networks involved in memory, learning, and executive functions...
  83. ncbi request reprint Phosphorus magnetic resonance spectroscopy: its utility in examining the membrane hypothesis of schizophrenia
    Ravinder Reddy
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Prostaglandins Leukot Essent Fatty Acids 69:401-5. 2003
    ..Because of it is relatively benign, repeated measures are possible. It has been used extensively in investigating brain biochemistry in schizophrenia...
  84. ncbi request reprint Abnormal brain size effect on the thalamus in autism
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 147:145-51. 2006
    ....
  85. ncbi request reprint Psychosis proneness and ADHD in young relatives of schizophrenia patients
    Matcheri S Keshavan
    Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 59:85-92. 2003
    ..Longitudinal studies can clarify whether an "ADHD subgroup" within HR subjects predict an increased risk for future emergence of schizophrenia...
  86. ncbi request reprint Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophrenia
    Matcheri S Keshavan
    Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room 984, Pittsburgh, PA 15213, USA
    Schizophr Res 58:173-83. 2002
    ..Follow-up studies are needed to examine the predictive value of these measures for future emergence of schizophrenia in at-risk individuals...
  87. ncbi request reprint Negative symptom resolution and improvements in specific cognitive deficits after acute treatment in first-episode schizophrenia
    Daniel Schuepbach
    Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Schizophr Res 53:249-61. 2002
    ..Reduction in positive symptoms was not associated with change in cognitive abilities. These findings suggest a linkage between early, treatment-induced improvements in negative symptoms and reductions in distinct cognitive deficits...
  88. ncbi request reprint A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Room 984, University of Pittsburgh School of Medicine, 3811 0 Hara Street, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:1143-9. 2002
    ..These abnormalities need to be prospectively investigated in nonpsychotic individuals at risk for schizophrenia in order to determine their predictive value for eventual emergence of schizophrenia or related disorders...
  89. ncbi request reprint Neuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:657-65. 2003
    ..They also extend the existing research, showing associations between deficits in cortical-subcortical circuitry and performance on neuropsychological tests of controlled attention and visuospatial functions...
  90. ncbi request reprint Caudate volume in offspring of patients with schizophrenia
    Rajaprabhakaran Rajarethinam
    Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Street UHC 9B, Detroit, Michigan 48201, USA
    Br J Psychiatry 191:258-9. 2007
    ..1% respectively in 50 offspring without psychosis of patients with schizophrenia compared with 53 age- and gender-matched controls, providing new evidence that caudate volume reduction may be a trait-related abnormality in schizophrenia...
  91. pmc Foresight in schizophrenia: a potentially unique and relevant factor to functional disability
    Shaun M Eack
    School of Social Work, University of Pittsburgh, USA
    Psychiatr Serv 59:256-60. 2008
    ..This research sought to further elucidate the factors that conspire against functional recovery from schizophrenia by introducing the concept of foresight and exploring its unique contribution to functional outcome...
  92. ncbi request reprint Increased frontal cortical folding in autism: a preliminary MRI study
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 131:263-8. 2004
    ..These preliminary findings suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder...
  93. doi request reprint Brain structure and symptom dimension relationships in obsessive-compulsive disorder: a voxel-based morphometry study
    Andrew R Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
    J Affect Disord 109:117-26. 2008
    ..Past inconsistent results from structural neuroimaging studies of OCD may have resulted from the effects of these specific symptom dimensions as well as other socio-demographic and clinical variables upon gray matter (GM) volume...
  94. ncbi request reprint Insular volumes in first-episode schizophrenia: gender effect
    Harpreet S Duggal
    Room 441, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 73:113-20. 2005
    ..Thus its role as a substrate of neurodevelopmental hypothesis in schizophrenia and the interplay with gender deserves more attention...
  95. ncbi request reprint Development of the corpus callosum in childhood, adolescence and early adulthood
    Matcheri S Keshavan
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Life Sci 70:1909-22. 2002
    ..CC maturational changes appeared synchronous across sub-regions suggesting parallel maturation of diverse brain regions during childhood and adolescence...
  96. pmc Cognitive enhancement therapy improves emotional intelligence in early course schizophrenia: preliminary effects
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, United States
    Schizophr Res 89:308-11. 2007
    ..These findings lend preliminary support to the previously documented benefits of CET on social cognition in schizophrenia, and suggest that such benefits can be extended to patients in the early course of the illness...
  97. ncbi request reprint Prefrontal subregions and dimensions of insight in first-episode schizophrenia--a pilot study
    Mujeeb U Shad
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
    Psychiatry Res 146:35-42. 2006
    ..DLPFC deficits may have resulted in illness unawareness by interfering with self-monitoring, while OFC abnormalities may have mediated symptom misattribution by conferring aberrant salience to perceived symptomatology...
  98. ncbi request reprint Membrane phospholipid abnormalities of basal ganglia in never-treated schizophrenia: a 31P magnetic resonance spectroscopy study
    Perumbava N Jayakumar
    Department of Neuroimaging and Interventional Neuroradiology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Biol Psychiatry 54:491-4. 2003
    ..We examined membrane phospholipid abnormality in the basal ganglia using (31)P MRS in neuroleptic-naive schizophrenia patients...
  99. ncbi request reprint Investigation of corpus callosum in schizophrenia with diffusion imaging
    Paolo Brambilla
    Department of Pathology and Clinical and Experimental Medicine, Section of Psychiatry, University of Udine, Udine, Italy
    Schizophr Res 79:201-10. 2005
    ..We here further investigated CC organization with diffusion imaging (DWI) in a sample of schizophrenia patients recruited from the epidemiologically defined catchment area of South Verona, Italy...
  100. ncbi request reprint Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naïve patients with schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:49-63. 2004
    ..Relatively static and generalized neuropsychological dysfunction, evident from illness onset, is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia...
  101. ncbi request reprint Morphology of the orbitofrontal cortex in first-episode schizophrenia: relationship with negative symptomatology
    Acioly L T Lacerda
    Interdisciplinary Lab of Neuroimaging and Cognition LiNC, Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 31:510-6. 2007
    ..Future follow-up studies examining high-risk individuals who subsequently develop schizophrenia at different stages of disease could be especially instructive...