M S Keshavan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Decreased caudate volume in neuroleptic-naive psychotic patients
    M S Keshavan
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 155:774-8. 1998
  2. ncbi request reprint Research and treatment strategies in first-episode psychoses. The Pittsburgh experience
    M S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Br J Psychiatry Suppl 172:60-5. 1998
  3. ncbi request reprint Anatomical MRI study of basal ganglia in bipolar disorder patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Psychiatry Res 106:65-80. 2001
  4. ncbi request reprint Decreased pituitary volume in patients with bipolar disorder
    R B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 50:271-80. 2001
  5. ncbi request reprint Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 54:824-30. 1997
  6. ncbi request reprint MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals
    S C Caetano
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213-3282, USA
    Psychiatry Res 108:161-8. 2001
  7. ncbi request reprint Differential effects of age on brain gray matter in bipolar patients and healthy individuals
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychobiology 43:242-7. 2001
  8. ncbi request reprint Thalamic volumes in patients with first-episode schizophrenia
    A R Gilbert
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:618-24. 2001
  9. ncbi request reprint Brain lithium concentrations in bipolar disorder patients: preliminary (7)Li magnetic resonance studies at 3 T
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 49:437-43. 2001
  10. ncbi request reprint MRI study of posterior fossa structures and brain ventricles in bipolar patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:313-22. 2001

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Decreased caudate volume in neuroleptic-naive psychotic patients
    M S Keshavan
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 155:774-8. 1998
    ..Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients...
  2. ncbi request reprint Research and treatment strategies in first-episode psychoses. The Pittsburgh experience
    M S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Br J Psychiatry Suppl 172:60-5. 1998
    ..Prospective studies of this population can clarify the impact of illness course and treatment on neurobiology...
  3. ncbi request reprint Anatomical MRI study of basal ganglia in bipolar disorder patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Psychiatry Res 106:65-80. 2001
    ....
  4. ncbi request reprint Decreased pituitary volume in patients with bipolar disorder
    R B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 50:271-80. 2001
    ..Our findings suggest that detectable abnormalities in pituitary size are present in patients with bipolar disorder, which may reflect a dysfunctional HPA axis...
  5. ncbi request reprint Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 54:824-30. 1997
    ....
  6. ncbi request reprint MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals
    S C Caetano
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213-3282, USA
    Psychiatry Res 108:161-8. 2001
    ..Although functional abnormalities in the thalamus are likely to be implicated in the pathophysiology of mood disorders, no abnormalities in thalamic size appear present in bipolar or unipolar individuals...
  7. ncbi request reprint Differential effects of age on brain gray matter in bipolar patients and healthy individuals
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychobiology 43:242-7. 2001
    ....
  8. ncbi request reprint Thalamic volumes in patients with first-episode schizophrenia
    A R Gilbert
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:618-24. 2001
    ..Future analysis of individual thalamic nuclei may reveal important, specific relationships between thalamic abnormalities and schizophrenia...
  9. ncbi request reprint Brain lithium concentrations in bipolar disorder patients: preliminary (7)Li magnetic resonance studies at 3 T
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 49:437-43. 2001
    ..Future studies should examine a possible role for this methodology in investigations of lithium refractoriness and prediction of treatment outcome in bipolar patients...
  10. ncbi request reprint MRI study of posterior fossa structures and brain ventricles in bipolar patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:313-22. 2001
    ..However, there were suggestions that abnormalities in cerebellum, vermis, and lateral ventricle sizes may be present in familial cases of the disorder, which should be further examined in future studies with larger patient samples...
  11. ncbi request reprint N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD
    M D De Bellis
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 157:1175-7. 2000
    ..Anterior cingulate dysfunction has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). The authors hypothesized that integrity of the anterior cingulate may be affected in childhood PTSD...
  12. ncbi request reprint Hippocampal volume in adolescent-onset alcohol use disorders
    M D De Bellis
    University of Pittsburgh Medical Center, Developmental Traumatology Neuroimaging Laboratory, Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Am J Psychiatry 157:737-44. 2000
    ..This study compared the hippocampal volumes of adolescents and young adults with adolescent-onset alcohol use disorders to those of healthy matched comparison subjects...
  13. ncbi request reprint Brain lithium measurements with (7)Li magnetic resonance spectroscopy (MRS): a literature review
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Eur Neuropsychopharmacol 10:151-8. 2000
    ..In this paper we reviewed the accumulated literature in this area, and discuss possible directions for this research in the context of preliminary studies conducted by our group that demonstrated the feasibility of 7Li MRS at 3 T...
  14. ncbi request reprint Posterior fossa magnetic resonance imaging in autism
    A Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 40:666-72. 2001
    ..To determine whether the sizes and volumes of the posterior fossa structures are abnormal in non-mentally retarded autistic adolescents and adults...
  15. ncbi request reprint Maturation of widely distributed brain function subserves cognitive development
    B Luna
    Neurobehavioral Studies Program, MR Research Center, Pittsburgh, Pennsylvania, USA
    Neuroimage 13:786-93. 2001
    ....
  16. ncbi request reprint Prefrontal membrane phospholipid metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: an in vivo 31P MRS study
    M S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Mol Psychiatry 8:316-23, 251. 2003
    ..Follow-up studies are needed to examine the predictive value of these measures for future emergence of schizophrenia in at-risk individuals...
  17. ncbi request reprint Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder
    E S Monkul
    MOOD CNS Program Mood Disorders Clinical Neurosciences Program, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mol Psychiatry 12:360-6. 2007
    ..Abnormalities in the orbitofrontal cortex and amygdala in suicidal patients may impair decision-making and predispose these patients to act more impulsively and to attempt suicide...
  18. ncbi request reprint Brain volume in autism
    A Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Child Neurol 16:421-4. 2001
    ..Additional longitudinal neuroimaging and, more importantly, neuropathologic studies are warranted to provide a better understanding of the complexities underlying increased brain size in autism...
  19. pmc Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia
    J K Yao
    Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
    Mol Psychiatry 15:938-53. 2010
    ..Considering N-acetylserotonin as a potent antioxidant, such increases in N-acetylserotonin might be a compensatory response to increased oxidative stress, implicated in the pathogenesis of schizophrenia...
  20. ncbi request reprint Corpus callosum size in autism
    A Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Neurology 55:1033-6. 2000
    ..No differences were found in the other subregions. This observation is consistent with the frontal lobe dysfunction reported in autism...
  21. pmc Mechanisms of functional improvement in a 2-year trial of cognitive enhancement therapy for early schizophrenia
    S M Eack
    School of Social Work, University of Pittsburgh, Pittsburgh, PA, USA
    Psychol Med 41:1253-61. 2011
    ..This research sought to identify the neurocognitive and social-cognitive mechanisms of functional improvement during a 2-year trial of cognitive enhancement therapy (CET) for early-course schizophrenia...
  22. ncbi request reprint Sex differences in brain maturation during childhood and adolescence
    M D De Bellis
    University of Pittsburgh Medical Center and Developmental Traumatology Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cereb Cortex 11:552-7. 2001
    ..The study of age-related sex differences in cerebral pruning and myelination may aid in understanding the mechanism of several developmental neuropsychiatric disorders...
  23. ncbi request reprint Development, disease and degeneration in schizophrenia: a unitary pathophysiological model
    M S Keshavan
    University of Pittsburgh Medical Center, PA 15213, USA
    J Psychiatr Res 33:513-21. 1999
    ..This 'three hit' model extends similar integrative conceptualization by other investigators and generates testable predictions of relevance to future pathophysiology and treatment research in schizophrenia...
  24. ncbi request reprint Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine
    D R Rosenberg
    Department of Psychiatry, Wayne State University, Detroit, USA
    J Am Acad Child Adolesc Psychiatry 39:1096-103. 2000
    ..To measure in vivo neurochemical changes in the caudate nucleus in pediatric obsessive-compulsive disorder (OCD) before and after treatment...
  25. ncbi request reprint Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia
    K M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Psychiatry 12:105-13, 1. 2007
    ..This study provides suggestive evidence for a link between HSV1 exposure and some of the cerebral morphological changes often reported in schizophrenia...
  26. ncbi request reprint Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients
    K M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:213-9. 2005
    ..The findings suggest that RGS4 polymorphisms may contribute to structural alterations in the DLPFC...
  27. pmc Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia
    M S Keshavan
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Neurol Neurosurg Psychiatry 72:757-60. 2002
    ..Areas of primary and association cortices have been topographically mapped in the CC...
  28. pmc Corpus callosum signal intensity in patients with bipolar and unipolar disorder
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 75:221-5. 2004
    ..MRI signal intensity can be used as a putative index of corpus callosum myelination...
  29. ncbi request reprint Managing antipsychotic-induced parkinsonism
    D C Mamo
    Department of Psychiatry, University of Pittsburgh School of Medicine, Philadelphia, USA
    Drug Saf 20:269-75. 1999
    ..An individualised risk-benefit assessment is necessary for the younger patient in whom prophylactic use of anticholinergic drugs is considered...
  30. ncbi request reprint Anterior cingulate N-acetylaspartate/creatine ratios during clonidine treatment in a maltreated child with posttraumatic stress disorder
    M D De Bellis
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA
    J Child Adolesc Psychopharmacol 11:311-6. 2001
    ..N-acetylaspartate/creatine ratios increased, and sleep measures improved upon symptom remission...