M S Keshavan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophrenia
    Matcheri S Keshavan
    Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room 984, Pittsburgh, PA 15213, USA
    Schizophr Res 58:173-83. 2002
  2. ncbi request reprint Prefrontal membrane phospholipid metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: an in vivo 31P MRS study
    M S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Mol Psychiatry 8:316-23, 251. 2003
  3. pmc Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia
    M S Keshavan
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Neurol Neurosurg Psychiatry 72:757-60. 2002
  4. ncbi request reprint Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic and University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
    Am J Psychiatry 160:1298-304. 2003
  5. ncbi request reprint Development of the corpus callosum in childhood, adolescence and early adulthood
    Matcheri S Keshavan
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Life Sci 70:1909-22. 2002
  6. ncbi request reprint Development, disease and degeneration in schizophrenia: a unitary pathophysiological model
    M S Keshavan
    University of Pittsburgh Medical Center, PA 15213, USA
    J Psychiatr Res 33:513-21. 1999
  7. ncbi request reprint Correlates of insight in first episode psychosis
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Res 70:187-94. 2004
  8. ncbi request reprint Efficacy and tolerability of olanzapine in the treatment of schizotypal personality disorder
    Matcheri Keshavan
    University of Pittsburgh Medical Center, Health System Western Psychiatric Institute and Clinic, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 71:97-101. 2004
  9. ncbi request reprint A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Room 984, University of Pittsburgh School of Medicine, 3811 0 Hara Street, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:1143-9. 2002
  10. ncbi request reprint Anatomical MRI study of basal ganglia in bipolar disorder patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Psychiatry Res 106:65-80. 2001

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophrenia
    Matcheri S Keshavan
    Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room 984, Pittsburgh, PA 15213, USA
    Schizophr Res 58:173-83. 2002
    ..Follow-up studies are needed to examine the predictive value of these measures for future emergence of schizophrenia in at-risk individuals...
  2. ncbi request reprint Prefrontal membrane phospholipid metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: an in vivo 31P MRS study
    M S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Mol Psychiatry 8:316-23, 251. 2003
    ..Follow-up studies are needed to examine the predictive value of these measures for future emergence of schizophrenia in at-risk individuals...
  3. pmc Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia
    M S Keshavan
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Neurol Neurosurg Psychiatry 72:757-60. 2002
    ..Areas of primary and association cortices have been topographically mapped in the CC...
  4. ncbi request reprint Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic and University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
    Am J Psychiatry 160:1298-304. 2003
    ..quot; This study examined the neuroanatomical correlates and diagnostic specificity of abnormal findings on the neurological examination in first-episode schizophrenia and other psychotic disorders...
  5. ncbi request reprint Development of the corpus callosum in childhood, adolescence and early adulthood
    Matcheri S Keshavan
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Life Sci 70:1909-22. 2002
    ..CC maturational changes appeared synchronous across sub-regions suggesting parallel maturation of diverse brain regions during childhood and adolescence...
  6. ncbi request reprint Development, disease and degeneration in schizophrenia: a unitary pathophysiological model
    M S Keshavan
    University of Pittsburgh Medical Center, PA 15213, USA
    J Psychiatr Res 33:513-21. 1999
    ..This 'three hit' model extends similar integrative conceptualization by other investigators and generates testable predictions of relevance to future pathophysiology and treatment research in schizophrenia...
  7. ncbi request reprint Correlates of insight in first episode psychosis
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Res 70:187-94. 2004
    ..These observations suggest that deficits in insight may be related to a generalized dysfunction of neural networks involved in memory, learning, and executive functions...
  8. ncbi request reprint Efficacy and tolerability of olanzapine in the treatment of schizotypal personality disorder
    Matcheri Keshavan
    University of Pittsburgh Medical Center, Health System Western Psychiatric Institute and Clinic, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 71:97-101. 2004
    ..This study examined the efficacy and tolerability of olanzapine, an atypical antipsychotic drug, in a series of patients with DSM-IV diagnosed schizotypal personality disorder...
  9. ncbi request reprint A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Room 984, University of Pittsburgh School of Medicine, 3811 0 Hara Street, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:1143-9. 2002
    ..These abnormalities need to be prospectively investigated in nonpsychotic individuals at risk for schizophrenia in order to determine their predictive value for eventual emergence of schizophrenia or related disorders...
  10. ncbi request reprint Anatomical MRI study of basal ganglia in bipolar disorder patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Psychiatry Res 106:65-80. 2001
    ....
  11. ncbi request reprint Thalamic volumes in patients with first-episode schizophrenia
    A R Gilbert
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:618-24. 2001
    ..Future analysis of individual thalamic nuclei may reveal important, specific relationships between thalamic abnormalities and schizophrenia...
  12. ncbi request reprint Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 54:824-30. 1997
    ....
  13. ncbi request reprint Decreased pituitary volume in patients with bipolar disorder
    R B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 50:271-80. 2001
    ..Our findings suggest that detectable abnormalities in pituitary size are present in patients with bipolar disorder, which may reflect a dysfunctional HPA axis...
  14. ncbi request reprint Hippocampal volume in adolescent-onset alcohol use disorders
    M D De Bellis
    University of Pittsburgh Medical Center, Developmental Traumatology Neuroimaging Laboratory, Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Am J Psychiatry 157:737-44. 2000
    ..This study compared the hippocampal volumes of adolescents and young adults with adolescent-onset alcohol use disorders to those of healthy matched comparison subjects...
  15. ncbi request reprint Differential effects of age on brain gray matter in bipolar patients and healthy individuals
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychobiology 43:242-7. 2001
    ....
  16. ncbi request reprint N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD
    M D De Bellis
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 157:1175-7. 2000
    ..Anterior cingulate dysfunction has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). The authors hypothesized that integrity of the anterior cingulate may be affected in childhood PTSD...
  17. ncbi request reprint MRI study of posterior fossa structures and brain ventricles in bipolar patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:313-22. 2001
    ..However, there were suggestions that abnormalities in cerebellum, vermis, and lateral ventricle sizes may be present in familial cases of the disorder, which should be further examined in future studies with larger patient samples...
  18. ncbi request reprint Brain lithium concentrations in bipolar disorder patients: preliminary (7)Li magnetic resonance studies at 3 T
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 49:437-43. 2001
    ..Future studies should examine a possible role for this methodology in investigations of lithium refractoriness and prediction of treatment outcome in bipolar patients...
  19. ncbi request reprint Decreased caudate volume in neuroleptic-naive psychotic patients
    M S Keshavan
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 155:774-8. 1998
    ..Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients...
  20. ncbi request reprint MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals
    S C Caetano
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213-3282, USA
    Psychiatry Res 108:161-8. 2001
    ..Although functional abnormalities in the thalamus are likely to be implicated in the pathophysiology of mood disorders, no abnormalities in thalamic size appear present in bipolar or unipolar individuals...
  21. ncbi request reprint Brain lithium measurements with (7)Li magnetic resonance spectroscopy (MRS): a literature review
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Eur Neuropsychopharmacol 10:151-8. 2000
    ..In this paper we reviewed the accumulated literature in this area, and discuss possible directions for this research in the context of preliminary studies conducted by our group that demonstrated the feasibility of 7Li MRS at 3 T...
  22. ncbi request reprint Posterior fossa magnetic resonance imaging in autism
    A Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 40:666-72. 2001
    ..To determine whether the sizes and volumes of the posterior fossa structures are abnormal in non-mentally retarded autistic adolescents and adults...
  23. ncbi request reprint Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism
    S Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 49:894-905. 2001
    ..Because the amygdala tends to increase in volume during childhood and adolescence, smaller volumes in high-risk children may indicate a developmental delay that parallels delays seen in visual P300 amplitude...
  24. ncbi request reprint Research and treatment strategies in first-episode psychoses. The Pittsburgh experience
    M S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Br J Psychiatry Suppl 172:60-5. 1998
    ..Prospective studies of this population can clarify the impact of illness course and treatment on neurobiology...
  25. pmc Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia
    J K Yao
    Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
    Mol Psychiatry 15:938-53. 2010
    ..Considering N-acetylserotonin as a potent antioxidant, such increases in N-acetylserotonin might be a compensatory response to increased oxidative stress, implicated in the pathogenesis of schizophrenia...
  26. ncbi request reprint Corpus callosum size in autism
    A Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Neurology 55:1033-6. 2000
    ..No differences were found in the other subregions. This observation is consistent with the frontal lobe dysfunction reported in autism...
  27. ncbi request reprint Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine
    D R Rosenberg
    Department of Psychiatry, Wayne State University, Detroit, USA
    J Am Acad Child Adolesc Psychiatry 39:1096-103. 2000
    ..To measure in vivo neurochemical changes in the caudate nucleus in pediatric obsessive-compulsive disorder (OCD) before and after treatment...
  28. ncbi request reprint Brain volume in autism
    A Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Child Neurol 16:421-4. 2001
    ..Additional longitudinal neuroimaging and, more importantly, neuropathologic studies are warranted to provide a better understanding of the complexities underlying increased brain size in autism...
  29. ncbi request reprint Maturation of widely distributed brain function subserves cognitive development
    B Luna
    Neurobehavioral Studies Program, MR Research Center, Pittsburgh, Pennsylvania, USA
    Neuroimage 13:786-93. 2001
    ....
  30. ncbi request reprint Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia
    K M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Psychiatry 12:105-13, 1. 2007
    ..This study provides suggestive evidence for a link between HSV1 exposure and some of the cerebral morphological changes often reported in schizophrenia...
  31. ncbi request reprint Sex differences in brain maturation during childhood and adolescence
    M D De Bellis
    University of Pittsburgh Medical Center and Developmental Traumatology Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cereb Cortex 11:552-7. 2001
    ..The study of age-related sex differences in cerebral pruning and myelination may aid in understanding the mechanism of several developmental neuropsychiatric disorders...
  32. ncbi request reprint Anterior cingulate N-acetylaspartate/creatine ratios during clonidine treatment in a maltreated child with posttraumatic stress disorder
    M D De Bellis
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA
    J Child Adolesc Psychopharmacol 11:311-6. 2001
    ..N-acetylaspartate/creatine ratios increased, and sleep measures improved upon symptom remission...
  33. ncbi request reprint Managing antipsychotic-induced parkinsonism
    D C Mamo
    Department of Psychiatry, University of Pittsburgh School of Medicine, Philadelphia, USA
    Drug Saf 20:269-75. 1999
    ..An individualised risk-benefit assessment is necessary for the younger patient in whom prophylactic use of anticholinergic drugs is considered...
  34. ncbi request reprint Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder
    E S Monkul
    MOOD CNS Program Mood Disorders Clinical Neurosciences Program, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mol Psychiatry 12:360-6. 2007
    ..Abnormalities in the orbitofrontal cortex and amygdala in suicidal patients may impair decision-making and predispose these patients to act more impulsively and to attempt suicide...
  35. ncbi request reprint Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients
    K M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:213-9. 2005
    ..The findings suggest that RGS4 polymorphisms may contribute to structural alterations in the DLPFC...
  36. pmc Corpus callosum signal intensity in patients with bipolar and unipolar disorder
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 75:221-5. 2004
    ..MRI signal intensity can be used as a putative index of corpus callosum myelination...
  37. pmc Foresight in schizophrenia: a potentially unique and relevant factor to functional disability
    Shaun M Eack
    School of Social Work, University of Pittsburgh, USA
    Psychiatr Serv 59:256-60. 2008
    ..This research sought to further elucidate the factors that conspire against functional recovery from schizophrenia by introducing the concept of foresight and exploring its unique contribution to functional outcome...
  38. pmc Effects of second-generation antipsychotic medication on smooth pursuit performance in antipsychotic-naive schizophrenia
    Rebekka Lencer
    Department of Psychiatry, University of Lubeck, Lubeck, Germany
    Arch Gen Psychiatry 65:1146-54. 2008
    ..Although pursuit eye tracking deficits have been widely reported in schizophrenia, the integrity of discrete components of pursuit responses and the effect of second-generation antipsychotic medication on them are not well established...
  39. ncbi request reprint Can psychiatrists recognize mental illness in paintings?
    Anjali Rao
    UPMC Health System Western Psychiatric Institute and Clinic, Room 441, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 163:599. 2006
  40. ncbi request reprint Dorsolateral prefrontal cortex morphology and short-term outcome in first-episode schizophrenia
    Konasale M R Prasad
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Psychiatry Res 140:147-55. 2005
    ..Volume of the left DLPFC at baseline predicted functional outcome in schizophrenia at 1 but not at 2 years. Specific cognitive functions regulated by the left DLPFC may be critical for functional outcome...
  41. ncbi request reprint Adverse effects of risperidone on spatial working memory in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, IL 60612, USA
    Arch Gen Psychiatry 63:1189-97. 2006
    ..The oculomotor delayed response task is a translational spatial working memory paradigm used to characterize the neurophysiologic and neurochemical aspects of working memory in the primate brain...
  42. ncbi request reprint Genetically predisposed offspring with schizotypal features: an ultra high-risk group for schizophrenia?
    Vaibhav A Diwadkar
    Depatment of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:230-8. 2006
    ..We propose that schizotypy may define a hyper vulnerable sub-sample among individuals genetically predisposed to schizophrenia and that future studies that attempt to assess risk may benefit from such a convergent approach...
  43. pmc Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 63:776-83. 2008
    ..This suggests that dysregulation of automatic attentional processes may contribute to disturbances in prefrontally mediated control of voluntary behavior...
  44. ncbi request reprint Premorbid indicators and risk for schizophrenia: a selective review and update
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine, Suite 9B, Detroit, MI 48201, USA
    Schizophr Res 79:45-57. 2005
    ..Collectively, such data may help us to predict the eventual emergence of schizophrenia, and schizophrenia spectrum or non-spectrum psychopathology...
  45. ncbi request reprint Reduced red blood cell membrane essential polyunsaturated fatty acids in first episode schizophrenia at neuroleptic-naive baseline
    Ravinder D Reddy
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Schizophr Bull 30:901-11. 2004
    ..The findings also suggest that membrane fatty acid losses are quite specific to the highly unsaturated fatty acids...
  46. ncbi request reprint Early treatment-induced improvement of negative symptoms predicts cognitive functioning in treatment-naive first episode schizophrenia: a 2-year followup
    Daniel Schuepbach
    Psychiatric University Hospital Zurich, PO Box 68, CH 8029 Zurich, Switzerland
    Schizophr Bull 30:837-48. 2004
    ..These findings suggest an important relationship between treatment efficacy of antipsychotic medication and the longer term course of cognitive deficits in schizophrenia...
  47. ncbi request reprint Investigation of corpus callosum in schizophrenia with diffusion imaging
    Paolo Brambilla
    Department of Pathology and Clinical and Experimental Medicine, Section of Psychiatry, University of Udine, Udine, Italy
    Schizophr Res 79:201-10. 2005
    ..We here further investigated CC organization with diffusion imaging (DWI) in a sample of schizophrenia patients recruited from the epidemiologically defined catchment area of South Verona, Italy...
  48. ncbi request reprint Abnormal brain size effect on the thalamus in autism
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 147:145-51. 2006
    ....
  49. pmc Neuroanatomical substrates of foresight in schizophrenia
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    Schizophr Res 103:62-70. 2008
    ..Implications and directions for future research are discussed...
  50. pmc Cognitive enhancement therapy improves emotional intelligence in early course schizophrenia: preliminary effects
    Shaun M Eack
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, United States
    Schizophr Res 89:308-11. 2007
    ..These findings lend preliminary support to the previously documented benefits of CET on social cognition in schizophrenia, and suggest that such benefits can be extended to patients in the early course of the illness...
  51. ncbi request reprint Caudate volume in offspring of patients with schizophrenia
    Rajaprabhakaran Rajarethinam
    Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Street UHC 9B, Detroit, Michigan 48201, USA
    Br J Psychiatry 191:258-9. 2007
    ..1% respectively in 50 offspring without psychosis of patients with schizophrenia compared with 53 age- and gender-matched controls, providing new evidence that caudate volume reduction may be a trait-related abnormality in schizophrenia...
  52. pmc Reduced N-acetyl-aspartate levels in schizophrenia patients with a younger onset age: a single-voxel 1H spectroscopy study
    Jeffrey A Stanley
    Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, United States
    Schizophr Res 93:23-32. 2007
    ....
  53. ncbi request reprint Sex difference in cognitive response to antipsychotic treatment in first episode schizophrenia
    Leah H Rubin
    Department of Psychiatry and Psychology, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 33:290-7. 2008
    ..Future studies of the neurocognitive effects of antipsychotic treatment may need to take potential sex differences in cognitive response into account...
  54. doi request reprint Brain structure and symptom dimension relationships in obsessive-compulsive disorder: a voxel-based morphometry study
    Andrew R Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
    J Affect Disord 109:117-26. 2008
    ..Past inconsistent results from structural neuroimaging studies of OCD may have resulted from the effects of these specific symptom dimensions as well as other socio-demographic and clinical variables upon gray matter (GM) volume...
  55. ncbi request reprint Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Biol Psychiatry 62:818-21. 2007
    ....
  56. ncbi request reprint Morphology of the orbitofrontal cortex in first-episode schizophrenia: relationship with negative symptomatology
    Acioly L T Lacerda
    Interdisciplinary Lab of Neuroimaging and Cognition LiNC, Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 31:510-6. 2007
    ..Future follow-up studies examining high-risk individuals who subsequently develop schizophrenia at different stages of disease could be especially instructive...
  57. ncbi request reprint Pituitary volume in neuroleptic-naïve schizophrenia: a structural MRI study
    Ameet R Upadhyaya
    Brain Research and Imaging Neuroscience, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48201, USA
    Schizophr Res 90:266-73. 2007
    ..Similar volume reductions have been seen in other neuropsychiatric populations and may cut across diagnostic boundaries...
  58. ncbi request reprint Emotional words induce enhanced brain activity in schizophrenic patients with auditory hallucinations
    Julio Sanjuan
    Psychiatric Unit, University of Valencia School of Medicine, Valencia, Spain
    Psychiatry Res 154:21-9. 2007
    ..Our findings are consistent with other studies suggesting a relevant role for emotional response in the pathogenesis and treatment of auditory hallucinations...
  59. ncbi request reprint Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy study
    Jeffrey A Stanley
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, University Health Center 9B 28, 4201 St Antoine Street, Detroit, MI 48201, USA
    Psychiatry Res 148:217-21. 2006
    ..No differences were noted in the ST. These deficits in membrane phospholipid (MPL) precursor levels suggest reduced mass of cellular MPLs due to a possible underdevelopment of neuronal processes and synapses in ADHD...
  60. pmc An MRI and proton spectroscopy study of the thalamus in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Psychiatry Res 163:97-105. 2008
    ..Further investigations of this structure are warranted, since it plays an important role in information processing as part of the cortico-thalamo-cortical pathways...
  61. ncbi request reprint Reduced cortical folding in individuals at high risk for schizophrenia: a pilot study
    Roger J Jou
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Schizophr Res 75:309-13. 2005
    ..The left GI was lower in HR when compared to controls, but no difference in the right GI was observed. These results are consistent with studies of affected individuals, supporting genetic and neurodevelopmental models of schizophrenia...
  62. ncbi request reprint The effects of antipsychotic medication on factor and cluster structure of neurologic examination abnormalities in schizophrenia
    Gerald Goldstein
    VA Pittsburgh HCS, 7180 Highland Drive, Pittsburgh, PA 15206, USA
    Schizophr Res 75:55-64. 2005
    ..As is the case with other domains of symptoms and performance in schizophrenia, relationships among neurologic exam variables are altered by the presence of antipsychotic medication...
  63. ncbi request reprint 1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients
    Paolo Brambilla
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Affect Disord 86:61-7. 2005
    ..Furthermore, recent MRS reports suggested possible lithium-induced increase in NAA levels in bipolar patients. We examined with in vivo (1)H MRS NAA levels in the DLPFC of adult bipolar patients...
  64. ncbi request reprint Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychoses
    Matcheri S Keshavan
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Bull 29:757-69. 2003
    ..The latter, if true, would strongly support therapeutic intervention efforts in the prodromal and early psychotic phases of schizophrenia...
  65. ncbi request reprint Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia
    Vaibhav A Diwadkar
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Schizophr Res 67:277-82. 2004
    ....
  66. ncbi request reprint Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
    ..This study examined the OFC and its subdivisions in patients with MDD and matched healthy control subjects...
  67. ncbi request reprint Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 54:1294-7. 2003
    ..This study was conducted to further examine the hypothesis of abnormalities in size of corpus callosum in subjects with bipolar disorder...
  68. ncbi request reprint Phosphorus magnetic resonance spectroscopy: its utility in examining the membrane hypothesis of schizophrenia
    Ravinder Reddy
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Prostaglandins Leukot Essent Fatty Acids 69:401-5. 2003
    ..Because of it is relatively benign, repeated measures are possible. It has been used extensively in investigating brain biochemistry in schizophrenia...
  69. ncbi request reprint Membrane phospholipid abnormalities of basal ganglia in never-treated schizophrenia: a 31P magnetic resonance spectroscopy study
    Perumbava N Jayakumar
    Department of Neuroimaging and Interventional Neuroradiology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Biol Psychiatry 54:491-4. 2003
    ..We examined membrane phospholipid abnormality in the basal ganglia using (31)P MRS in neuroleptic-naive schizophrenia patients...
  70. ncbi request reprint Measurement of the orbitofrontal cortex: a validation study of a new method
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 19:665-73. 2003
    ..996 and 0.998. This method appears to be a valid method for measuring the OFC with excellent reliability. This uncomplicated approach is easy to apply and has the potential to be a valuable alternative to the previously published methods...
  71. ncbi request reprint Neuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:657-65. 2003
    ..They also extend the existing research, showing associations between deficits in cortical-subcortical circuitry and performance on neuropsychological tests of controlled attention and visuospatial functions...
  72. ncbi request reprint MRI investigation of temporal lobe structures in bipolar patients
    Paolo Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Psychiatr Res 37:287-95. 2003
    ..Longitudinal studies in high-risk offspring and first-episode patients will be needed to examine whether such abnormalities precede the appearance of symptoms, or whether they may appear subsequently as a result of illness course...
  73. ncbi request reprint Psychosis proneness and ADHD in young relatives of schizophrenia patients
    Matcheri S Keshavan
    Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 59:85-92. 2003
    ..Longitudinal studies can clarify whether an "ADHD subgroup" within HR subjects predict an increased risk for future emergence of schizophrenia...
  74. ncbi request reprint Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites
    Jeffrey K Yao
    Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA
    Biol Psychiatry 52:823-30. 2002
    ..To address this question we examined the relations between red blood cell polyunsaturated fatty acids and brain phospholipid metabolites from different regions of interest in schizophrenia and healthy subjects...
  75. ncbi request reprint Superior temporal gyrus volumes in pediatric generalized anxiety disorder
    Michael D De Bellis
    University of Pittsburgh Medical Center, Developmental Traumatology Program Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Biol Psychiatry 51:553-62. 2002
    ..Larger amygdala volumes were previously reported in pediatric GAD; however, the brain regions involved in social intelligence were not examined in this pilot study...
  76. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  77. ncbi request reprint Obstetric complications correlate with neurobehavioral and brain structural alterations in young relatives at risk for schizophrenia
    Andrew R Gilbert
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1008:269-75. 2003
    ....
  78. ncbi request reprint Confirmatory factor analysis of the Neurological Evaluation Scale in unmedicated schizophrenia
    Richard D Sanders
    Dayton VA Hospital, 4100 W Third Street, Dayton, OH 45428, USA
    Psychiatry Res 133:65-71. 2005
    ..The current results contribute to the development of empirical subscales for neurological assessment procedures to be used in psychiatric conditions...
  79. ncbi request reprint Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 57:145-54. 2005
    ..Previous studies have reported intact visually guided saccades in schizophrenia, but these are limited by potential acute and long-term pharmacological treatment effects, small sample sizes, and a failure to follow patients over time...
  80. ncbi request reprint Personality dimensions in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 162:102-9. 2005
    ..The authors compared the patterns and specificity of premorbid personality dimensions in first-episode schizophrenia patients with those in patients with first-episode nonschizophrenia psychoses and healthy comparison subjects...
  81. ncbi request reprint Relationships between cognitive and neurological performance in neuroleptic-naïve psychosis
    Richard D Sanders
    Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 16:480-7. 2004
    ..Customarily, frontal neuropsychological tasks also relate more strongly to CogPer than to RepMot. Approximately one-half of the variability in these cognitive and neurological assessments is shared...
  82. ncbi request reprint Decreased nonlinear complexity and chaos during sleep in first episode schizophrenia: a preliminary report
    Matcheri S Keshavan
    Department of Psychiatry, University of Pittsburgh School of Medicine, UPMC Health System Western Psychiatric Institute and Clinic, Room 441, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 71:263-72. 2004
    ..Diminished complexity of EEG time series during awake and REM sleep in patients with schizophrenia may underlie the impaired ability to process information in psychotic disorders such as schizophrenia...
  83. ncbi request reprint Increased frontal cortical folding in autism: a preliminary MRI study
    Antonio Y Hardan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 131:263-8. 2004
    ..These preliminary findings suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder...
  84. ncbi request reprint The entorhinal cortex in first-episode psychotic disorders: a structural magnetic resonance imaging study
    Konasale M R Prasad
    University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:1612-9. 2004
    ..The authors used structural magnetic resonance imaging to examine the entorhinal cortex volumes of healthy subjects and medication-naive patients experiencing their first episode of psychotic illness...
  85. ncbi request reprint Insight and prefrontal cortex in first-episode Schizophrenia
    Mujeeb U Shad
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 22:1315-20. 2004
    ....
  86. ncbi request reprint Neuropsychological dysfunction in antipsychotic-naive first-episode unipolar psychotic depression
    S Kristian Hill
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Psychiatry 161:996-1003. 2004
    ....
  87. ncbi request reprint Impairment of verbal memory and learning in antipsychotic-naïve patients with first-episode schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:127-36. 2004
    ..The goal of this study was to characterize the nature of verbal memory impairments in antipsychotic-naïve schizophrenic patients early in the course of illness...
  88. ncbi request reprint Abnormalities of the corpus callosum in nonpsychotic children with chromosome 22q11 deletion syndrome
    Vandana Shashi
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuroimage 21:1399-406. 2004
    ..Further longitudinal studies on these children will help determine which of these structural abnormalities is/are pertinent to the development of psychosis...
  89. ncbi request reprint Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naïve patients with schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:49-63. 2004
    ..Relatively static and generalized neuropsychological dysfunction, evident from illness onset, is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia...
  90. ncbi request reprint Negative symptom resolution and improvements in specific cognitive deficits after acute treatment in first-episode schizophrenia
    Daniel Schuepbach
    Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Schizophr Res 53:249-61. 2002
    ..Reduction in positive symptoms was not associated with change in cognitive abilities. These findings suggest a linkage between early, treatment-induced improvements in negative symptoms and reductions in distinct cognitive deficits...