Phillip A Kern

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi request reprint Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    P A Kern
    Division of Endocrinology, Department of Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    Am J Physiol Endocrinol Metab 280:E745-51. 2001
  2. ncbi request reprint Perilipin expression in human adipose tissue is elevated with obesity
    Philip A Kern
    Central Arkansas Veterans Healthcare System and Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 89:1352-8. 2004
  3. ncbi request reprint Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression
    Philip A Kern
    Central Arkansas Veterans Healthcare System and the Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Diabetes 52:1779-85. 2003
  4. ncbi request reprint Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone
    Gina B Di Gregorio
    Research, Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Diabetes 54:2305-13. 2005
  5. ncbi request reprint The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver
    Philip A Kern
    The Central Arkansas Veterans Healthcare System, and the Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, 598 151 LR, 4300 West 7th Street, Little Rock, AR 72205, USA
    Toxicology 171:117-25. 2002
  6. pmc Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone
    Aiwei Yao-Borengasser
    The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 92:2590-7. 2007
  7. pmc Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness
    Aiwei Yao-Borengasser
    Research, 598 151, Central Arkansas Veterans Healthcare System, Department of Medicine, 4300 West 7th Street, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 93:4431-9. 2008
  8. pmc Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation
    Vijayalakshmi Varma
    The Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th Street, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 92:666-72. 2007
  9. pmc Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation
    Michael Spencer
    Division of Endocrinology, CTW 521, Univ of Kentucky, Lexington, KY 40536, USA
    Am J Physiol Endocrinol Metab 299:E1016-27. 2010
  10. pmc Matrix metalloproteinase-9 is increased in obese subjects and decreases in response to pioglitazone
    Resat Unal
    Division of Endocrinology, Department of Medicine, University of Kentucky, and Barnstable Brown Diabetes and Obesity Center, Lexington, Kentucky 40536, USA
    J Clin Endocrinol Metab 95:2993-3001. 2010

Research Grants

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    P A Kern
    Division of Endocrinology, Department of Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    Am J Physiol Endocrinol Metab 280:E745-51. 2001
    ..Plasma IL-6 was significantly associated with plasma nonesterified fatty acid levels (r = 0.49, P < 0.002). Thus the local expression of TNF and plasma IL-6 are higher in subjects with obesity-related insulin resistance...
  2. ncbi request reprint Perilipin expression in human adipose tissue is elevated with obesity
    Philip A Kern
    Central Arkansas Veterans Healthcare System and Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 89:1352-8. 2004
    ..Thus, perilipin was elevated in obese subjects, perhaps as a compensatory mechanism to limit basal lipolysis. However, there was no relationship between perilipin and insulin resistance...
  3. ncbi request reprint Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression
    Philip A Kern
    Central Arkansas Veterans Healthcare System and the Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Diabetes 52:1779-85. 2003
    ..Thus, adiponectin expression from adipose tissue is higher in lean subjects and women, and is associated with higher degrees of insulin sensitivity and lower TNF-alpha expression...
  4. ncbi request reprint Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone
    Gina B Di Gregorio
    Research, Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Diabetes 54:2305-13. 2005
    ..Thus, treatment with pioglitazone reduces expression of CD68 and MCP-1 in adipose tissue, apparently by reducing macrophage numbers, resulting in reduced inflammatory cytokine production and improvement in S(I)...
  5. ncbi request reprint The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver
    Philip A Kern
    The Central Arkansas Veterans Healthcare System, and the Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, 598 151 LR, 4300 West 7th Street, Little Rock, AR 72205, USA
    Toxicology 171:117-25. 2002
    ..In adipocytes, these changes occurred post-transcriptionally, as there were no changes in mRNA levels. In addition, a high fat diet per se also resulted in a decrease in GSH-Px activity in liver...
  6. pmc Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone
    Aiwei Yao-Borengasser
    The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 92:2590-7. 2007
    ..Retinol binding protein 4 (RBP4) was recently found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance...
  7. pmc Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness
    Aiwei Yao-Borengasser
    Research, 598 151, Central Arkansas Veterans Healthcare System, Department of Medicine, 4300 West 7th Street, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 93:4431-9. 2008
    ..SCD-deficient mice are protected from obesity, and the ob/ob mouse has high levels of SCD. This study was designed to better characterize SCD1 gene and protein expression in humans with varying insulin sensitivity...
  8. pmc Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation
    Vijayalakshmi Varma
    The Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th Street, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 92:666-72. 2007
    ..Visfatin (VF) is a recently described adipokine preferentially secreted by visceral adipose tissue (VAT) with insulin mimetic properties...
  9. pmc Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation
    Michael Spencer
    Division of Endocrinology, CTW 521, Univ of Kentucky, Lexington, KY 40536, USA
    Am J Physiol Endocrinol Metab 299:E1016-27. 2010
    ..Thus adipose tissue of insulin-resistant humans demonstrated increased fibrosis, M2 macrophage abundance, and TGF-β activity...
  10. pmc Matrix metalloproteinase-9 is increased in obese subjects and decreases in response to pioglitazone
    Resat Unal
    Division of Endocrinology, Department of Medicine, University of Kentucky, and Barnstable Brown Diabetes and Obesity Center, Lexington, Kentucky 40536, USA
    J Clin Endocrinol Metab 95:2993-3001. 2010
    ..The study investigated the regulation of matrix metalloproteinases (MMP)-9 in obesity-associated insulin resistance in humans...
  11. ncbi request reprint Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression
    Lili Yue
    Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 279:47626-32. 2004
    ..These results indicate for the first time that adipose tissue expression of apoE is modulated by physiologic regulators of insulin sensitivity...
  12. pmc Translational regulation of lipoprotein lipase in adipocytes: depletion of cellular protein kinase Calpha activates binding of the C subunit of protein kinase A to the 3'-untranslated region of the lipoprotein lipase mRNA
    Resat Unal
    The Central Arkansas Veterans Healthcare System, Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Biochem J 413:315-22. 2008
    ....
  13. ncbi request reprint Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity
    Gina B Di Gregorio
    Research, 151LR, Central Arkansas Healthcare System, 4300 W 7th St, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 287:E182-7. 2004
    ..Thus these data show that IL-6(-/-) mice do not demonstrate obesity, fasting hyperglycemia, or abnormal lipid metabolism, although HF IL-6(-/-) mice demonstrate elevated glucose after a GTT...
  14. pmc Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action
    Vijayalakshmi Varma
    Division of Endocrinology, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Am J Physiol Endocrinol Metab 296:E1300-10. 2009
    ..Thus in obesity both adipose tissue and skeletal muscle inflammation may contribute to insulin resistance...
  15. pmc Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects
    Neeraj K Sharma
    Medicine and Research Services, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Endocrinology 111J 1 LR, John L McClellan Memorial Veterans Hospital, 4300 West 7th Street, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 93:4532-41. 2008
    ..We hypothesized that ER stress was also activated and associated with reduced insulin sensitivity (SI) in human obesity...
  16. ncbi request reprint The translational regulation of lipoprotein lipase by epinephrine involves an RNA binding complex including the catalytic subunit of protein kinase A
    Gouri Ranganathan
    Central Arkansas Veterans Healthcare System, and Department of Medicine, Division of Endocrinology, and the Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 277:43281-7. 2002
    ..These studies demonstrate a dual role for PKA to simultaneously inhibit LPL-mediated lipogenesis through inhibition of LPL translation...
  17. ncbi request reprint Pioglitazone induces apoptosis of macrophages in human adipose tissue
    Angela M Bodles
    The Central Arkansas Veterans Healthcare System, and the Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Lipid Res 47:2080-8. 2006
    ....
  18. ncbi request reprint Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation
    Lori L Hensley
    The Central Arkansas Veterans HealthCare System and Department of Medicine, Division of Endocrinology, University of Arkansas for Medicla Sciences, Little Rock, 72205, USA
    J Biol Chem 278:32702-9. 2003
    ..Therefore, these data suggest that the absence of the 3'-UTR results in a translationally unrepressed LPL, resulting in a moderate overexpression of adipose LPL activity...
  19. ncbi request reprint Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation
    Aiwei Yao-Borengasser
    Department of Medicine, Division of Endocrinology, Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Diabetes 55:2811-8. 2006
    ..These results suggest that increased adipogenesis and/or lipogenesis in subcutaneous fat, mediated by the LPIN1 gene, may prevent lipotoxicity in muscle, leading to improved insulin sensitivity...
  20. pmc Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance
    Vijayalakshmi Varma
    Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Diabetes 57:432-9. 2008
    ..We examined the relationship between the expression of thrombospondin (TSP)1, an antiangiogenic factor and regulator of transforming growth factor-beta activity, obesity, adipose inflammation, and insulin resistance...
  21. ncbi request reprint The stimulation of tumor necrosis factor and inhibition of glucose transport and lipoprotein lipase in adipose cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Philip A Kern
    Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Metabolism 51:65-8. 2002
    ..Because TCDD is concentrated in adipose tissue, these studies provide a possible physiologic mechanism for epidemiologic studies that link dioxin to diabetes...
  22. ncbi request reprint Regulation of lipoprotein lipase by protein kinase C alpha in 3T3-F442A adipocytes
    Gouri Ranganathan
    Central Arkansas Veterans Healthcare System and Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 277:38669-75. 2002
    ..Together, these data indicate that PKC alpha and RAF1 are important in the translational regulation of LPL in adipocytes and that the mechanism of regulation is probably through an ERK-independent pathway...
  23. pmc Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans
    Neda Rasouli
    Central Arkansas Veterans Healthcare System, 111J, 4300 West 7th Street, Little Rock, AR 72205, USA
    Arterioscler Thromb Vasc Biol 29:1328-35. 2009
    ..We hypothesized that scavenger receptors are present in human adipose tissue resident macrophages, and their gene expression is regulated by adiponectin and thaizolidinediones...
  24. pmc The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity
    Robert H Coker
    Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 94:4258-66. 2009
    ..It has been difficult to distinguish the independent effects of caloric restriction versus exercise training on insulin resistance...
  25. pmc Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines
    Swapan K Das
    Endocrinology Section, Medicine and Research Services, Central Arkansas Veterans Healthcare System, John L McClellan Memorial Veterans Hospital, 4300 W 7th St, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 295:E393-400. 2008
    ..Together, our data suggest that improved insulin sensitivity with pioglitazone is not mediated by a reduction in endoplasmic reticulum stress...
  26. pmc Visceral fat and adiponectin: associations with insulin resistance are tissue-specific in women
    Robert H Coker
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Metab Syndr Relat Disord 7:61-7. 2009
    ....
  27. ncbi request reprint Expression of FOXC2 in adipose and muscle and its association with whole body insulin sensitivity
    Gina B Di Gregorio
    The Central Arkansas Veterans Healthcare System, Department of Medicine, Little Rock 72205, USA
    Am J Physiol Endocrinol Metab 287:E799-803. 2004
    ..Thus adipose FOXC2 is more highly expressed in insulin-resistant subjects, and this effect is independent of obesity. This association between FOXC2 and insulin resistance may be related to the role of FOXC2 in PKA signaling...
  28. ncbi request reprint Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue
    Neda Rasouli
    The Central Arkansas Veterans Healthcare System, Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, 111J LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 288:E930-4. 2005
    ..This reduction in IMCL was not due to an increase in muscle lipid oxidation but to a diversion of lipid from ectopic sites into subcutaneous adipose tissue...
  29. ncbi request reprint Role of A kinase anchor proteins in the tissue-specific regulation of lipoprotein lipase
    Gouri Ranganathan
    The Central Arkansas Veterans Healthcare System, and Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Mol Endocrinol 19:2527-34. 2005
    ..BAT and muscle do not express significant AKAP 121/149, and this likely explains some of the tissue-specific differences in LPL regulation...
  30. ncbi request reprint Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression
    Neda Rasouli
    Central Arkansas Veterans Healthcare System, 111J LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 290:E42-E46. 2006
    ..These data suggest that pioglitazone increases plasma adiponectin levels by posttranscriptional regulation in contrast to transcriptional regulation of adiponectin in relation to insulin sensitivity in NGT vs. IGT subjects...
  31. pmc The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment
    Gouri Ranganathan
    Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Lipid Res 47:2444-50. 2006
    ..These data support a more global concept suggesting that adipose lipid storage functions to prevent peripheral lipotoxicity...
  32. ncbi request reprint The prevention and treatment of metabolic syndrome and high-risk obesity
    Behzad Molavi
    The Central Arkansas Veterans Healthcare System, Arkansas 72205, USA
    Curr Opin Cardiol 21:479-85. 2006
    ..High-risk obesity is characterized by abdominal obesity with evidence of abnormal glucose and lipid metabolism, and a state of heightened inflammation...
  33. ncbi request reprint Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion
    Hua Wang
    Central Arkansas Veterans Healthcare System, Endocrinology 111J LR, 4300 West 7th Street, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 286:E1-7. 2004
    ..However, the associated allele and the effects on gene expression are opposite to those reported previously...
  34. ncbi request reprint Ectopic fat accumulation and metabolic syndrome
    Neda Rasouli
    The Central Arkansas Veterans Healthcare System, Little Rock, AR, USA
    Diabetes Obes Metab 9:1-10. 2007
    ..We review some of the current literature on the pathogenesis of metabolic syndrome with an emphasis on the role of ectopic lipid accumulation...
  35. ncbi request reprint Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes
    Neda Rasouli
    Central Arkansas Veterans Healthcare System, 111J LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 292:E359-65. 2007
    ..We did not find any evidence that either pioglitazone or metformin improved beta-cell function. Improved beta-cell compensation was observed primarily in the subgroup of subjects that had the lowest S(I) at baseline...
  36. pmc Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids
    Anannya Banga
    The Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 296:E480-9. 2009
    ....
  37. ncbi request reprint Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes
    Angela M Bodles
    The Central Arkansas Veterans Healthcare System, and Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Am J Physiol Endocrinol Metab 291:E1100-5. 2006
    ..Although there are differences in isoforms between species, in all cases pioglitazone served to increase the secretion of the HMW form of adiponectin...
  38. pmc Adipocytokines and the metabolic complications of obesity
    Neda Rasouli
    The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
    J Clin Endocrinol Metab 93:S64-73. 2008
    ..Adipocytokines play important roles in the pathogenesis of insulin resistance and associated metabolic complications such as dyslipidemia, hypertension, and premature heart disease...
  39. ncbi request reprint OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization
    Nathan E Wolins
    Department of Medicine, 660 S Euclid Ave, Campus Box 8127, St Louis, MO 63110, USA
    Diabetes 55:3418-28. 2006
    ..OXPAT likely contributes to adaptive responses to the fatty acid burden that accompanies fasting, insulin deficiency, and overnutrition, responses that are defective in obesity and type 2 diabetes...
  40. pmc Calcium is involved in formation of high molecular weight adiponectin
    Anannya Banga
    Central Arkansas Veterans Healthcare System and Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Metab Syndr Relat Disord 6:103-11. 2008
    ..Adiponectin, an adipocyte-specific secretory protein, is known to circulate as different isoforms in the blood stream...

Research Grants5

  1. Clinical and Translational Science Institute in Arkansas
    PHILIP KERN; Fiscal Year: 2006
    ....
  2. Regulation of lipoprotein lipase in adipocytes
    PHILIP KERN; Fiscal Year: 2007
    ..LPL is an important adipogenic enzyme in adipose tissue, and abnormalities in LPL result in inefficient lipoprotein metabolism, leading to atherosclerosis, especially in patients with diabetes. ..