Research Topics
Genomes and GenesSpecies | Phouthone KeohavongSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammationPhouthone Keohavong
Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Bridgeside Point, Pittsburgh, PA 15219 3130, USA
Anticancer Res 31:2877-82. 2011..This study investigated potential impacts of inflammation on the incidence of lung tumors and K-ras mutations using a mouse model...- HPRT gene alterations in umbilical cord blood T-lymphocytes in newborns of mothers exposed to tobacco smoke during pregnancyPhouthone Keohavong
Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
Mutat Res 572:156-66. 2005.... - Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, ChinaPhouthone Keohavong
Department of Environmental and Occupational Health and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
Carcinogenesis 26:303-8. 2005.... - Analysis of p53 mutations in cells taken from paraffin-embedded tissue sections of ductal carcinoma in situ and atypical ductal hyperplasia of the breastPhouthone Keohavong
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
Cancer Lett 212:121-30. 2004..p53 mutations are therefore present in DCIS and ADH of the breast, considered as pre-malignant precursors to breast cancer, and some of them may represent early events in breast cancer development... - Detection of K-ras and p53 mutations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysisPhouthone Keohavong
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
Anal Biochem 324:92-9. 2004..This method may be applicable to the analysis of epithelial cells from clinically normal sputum or BAL samples from individuals with a high risk for developing lung cancer... - K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in ChinaPhouthone Keohavong
Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
Lung Cancer 41:21-7. 2003.... - Polymorphisms in DNA repair genes XPD and XRCC1 and p53 mutations in lung carcinomas of never-smokersWei Min Gao
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
Mol Carcinog 45:828-32. 2006.... - Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancerWei Min Gao
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
Carcinogenesis 24:1671-6. 2003..These results suggest that individuals who smoke and have the XPD codon 312 Asp/Asp genotype may be at a greater risk of p53 mutations, especially if combined with other polymorphisms that may result in deficient DNA repair... 
Aberrant gene promoter methylation in sputum from individuals exposed to smoky coal emissionsYang Liu
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
Anticancer Res 28:2061-6. 2008..Here, the promoter methylation of p16, MGMT, RASSF1A and DAPK genes was investigated in sputum of individuals exposed to smoky coal emissions in Xuan Wei, China, where the lung cancer rate more than 6 times the Chinese national average...- Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic typesWei-Min Gao
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
Lung Cancer 40:141-50. 2003..Mutation in p53 was not found to be related to patient survival in this group of patients, while tumor size and degree of differentiation were poor survival predictors... - No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancerWei-Min Gao
Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
Cancer Epidemiol Biomarkers Prev 13:673-5. 2004 - Mutation and polymorphism in the EGFR-TK domain associated with lung cancerWeiping Zhang
Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
J Thorac Oncol 1:635-47. 2006..Somatic EGFR mutations are predictors of response to treatment with EGFR tyrosine kinase (TK) inhibitors (TKIs) for lung cancer, especially among never smokers. EGFR mutations may occur independently of other genetic alterations... 
Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokersYang Liu
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
BMC Cancer 7:74. 2007..We compare the results with the smoking status of the patients and the mutation status of the K-ras, p53, and EGFR genes determined previously on these same lung tumors...- Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancerLi-fang Zhang
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
Biomarkers 8:156-61. 2003..Therefore, K-ras mutations may provide useful diagnostic markers for lung cancer... - Analysis of K-RAS and P53 mutations in sputum samplesWeimin Gao
Department of Environmental and Occupational Health, University of Pittsburgh, PA, USA
Methods Mol Biol 291:217-33. 2005..This chapter describes methods to identify P53 and K-RAS mutations present in low fractions of epithelial cells among the excess of other cell types in sputum samples from lung cancer patients... 
Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non-small cell lung cancer patientsWeimin Gao
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
Mol Carcinog 48:633-41. 2009..Therefore, p53 mutations are frequent in tumor-surrounding histologically normal tissue, and some of them might be involved in lung carcinogenesis...- Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patientsYang Liu
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
Neoplasia 8:46-51. 2006..Our results suggest an association between tobacco smoking and an increased incidence of aberrant promoter methylation of the p16 and MGMT genes in non-small cell lung cancer... - Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesisLaura P Stabile
Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Mol Cancer Ther 7:1913-22. 2008..These preclinical results show that blocking the HGF/c-Met interaction with a single monoclonal antibody delivered systemically can have profound inhibitory effects on development of lung tumors... - Molecular analysis of mutations in the human HPRT genePhouthone Keohavong
Department of Environmental and Occupational Health, University of Pittsburgh, PA, USA
Methods Mol Biol 291:161-70. 2005..Establishment of and comparisons with mutational spectra hold the promise of identifying exposures to mutation-inducing genotoxicants from their distinctive pattern of gene-specific DNA damage at this easily analyzed reporter gene...