Phouthone Keohavong

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Molecular analysis of mutations in the human HPRT gene
    Phouthone Keohavong
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 100 Technology Drive, Bridgeside Point, Pittsburgh, PA, 15219, USA
    Methods Mol Biol 1105:291-301. 2014
  2. ncbi request reprint K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation
    Phouthone Keohavong
    Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Bridgeside Point, Pittsburgh, PA 15219 3130, USA
    Anticancer Res 31:2877-82. 2011
  3. ncbi request reprint HPRT gene alterations in umbilical cord blood T-lymphocytes in newborns of mothers exposed to tobacco smoke during pregnancy
    Phouthone Keohavong
    Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Mutat Res 572:156-66. 2005
  4. ncbi request reprint Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China
    Phouthone Keohavong
    Department of Environmental and Occupational Health and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Carcinogenesis 26:303-8. 2005
  5. ncbi request reprint Analysis of p53 mutations in cells taken from paraffin-embedded tissue sections of ductal carcinoma in situ and atypical ductal hyperplasia of the breast
    Phouthone Keohavong
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Cancer Lett 212:121-30. 2004
  6. ncbi request reprint Detection of K-ras and p53 mutations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis
    Phouthone Keohavong
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Anal Biochem 324:92-9. 2004
  7. ncbi request reprint K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China
    Phouthone Keohavong
    Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Lung Cancer 41:21-7. 2003
  8. ncbi request reprint Polymorphisms in DNA repair genes XPD and XRCC1 and p53 mutations in lung carcinomas of never-smokers
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Mol Carcinog 45:828-32. 2006
  9. ncbi request reprint Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Carcinogenesis 24:1671-6. 2003
  10. ncbi request reprint Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic types
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Lung Cancer 40:141-50. 2003

Detail Information

Publications21

  1. doi request reprint Molecular analysis of mutations in the human HPRT gene
    Phouthone Keohavong
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 100 Technology Drive, Bridgeside Point, Pittsburgh, PA, 15219, USA
    Methods Mol Biol 1105:291-301. 2014
    ..Establishment of and comparisons with mutational spectra hold the promise of identifying exposures to mutation-inducing genotoxicants from their distinctive pattern of gene-specific DNA damage at this easily analyzed reporter gene. ..
  2. ncbi request reprint K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation
    Phouthone Keohavong
    Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Bridgeside Point, Pittsburgh, PA 15219 3130, USA
    Anticancer Res 31:2877-82. 2011
    ..This study investigated potential impacts of inflammation on the incidence of lung tumors and K-ras mutations using a mouse model...
  3. ncbi request reprint HPRT gene alterations in umbilical cord blood T-lymphocytes in newborns of mothers exposed to tobacco smoke during pregnancy
    Phouthone Keohavong
    Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Mutat Res 572:156-66. 2005
    ....
  4. ncbi request reprint Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China
    Phouthone Keohavong
    Department of Environmental and Occupational Health and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Carcinogenesis 26:303-8. 2005
    ....
  5. ncbi request reprint Analysis of p53 mutations in cells taken from paraffin-embedded tissue sections of ductal carcinoma in situ and atypical ductal hyperplasia of the breast
    Phouthone Keohavong
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Cancer Lett 212:121-30. 2004
    ..p53 mutations are therefore present in DCIS and ADH of the breast, considered as pre-malignant precursors to breast cancer, and some of them may represent early events in breast cancer development...
  6. ncbi request reprint Detection of K-ras and p53 mutations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis
    Phouthone Keohavong
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Anal Biochem 324:92-9. 2004
    ..This method may be applicable to the analysis of epithelial cells from clinically normal sputum or BAL samples from individuals with a high risk for developing lung cancer...
  7. ncbi request reprint K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China
    Phouthone Keohavong
    Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Lung Cancer 41:21-7. 2003
    ....
  8. ncbi request reprint Polymorphisms in DNA repair genes XPD and XRCC1 and p53 mutations in lung carcinomas of never-smokers
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Mol Carcinog 45:828-32. 2006
    ....
  9. ncbi request reprint Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Carcinogenesis 24:1671-6. 2003
    ..These results suggest that individuals who smoke and have the XPD codon 312 Asp/Asp genotype may be at a greater risk of p53 mutations, especially if combined with other polymorphisms that may result in deficient DNA repair...
  10. ncbi request reprint Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic types
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Lung Cancer 40:141-50. 2003
    ..Mutation in p53 was not found to be related to patient survival in this group of patients, while tumor size and degree of differentiation were poor survival predictors...
  11. pmc Aberrant gene promoter methylation in sputum from individuals exposed to smoky coal emissions
    Yang Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Anticancer Res 28:2061-6. 2008
    ..Here, the promoter methylation of p16, MGMT, RASSF1A and DAPK genes was investigated in sputum of individuals exposed to smoky coal emissions in Xuan Wei, China, where the lung cancer rate more than 6 times the Chinese national average...
  12. ncbi request reprint No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Cancer Epidemiol Biomarkers Prev 13:673-5. 2004
  13. pmc Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers
    Yang Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    BMC Cancer 7:74. 2007
    ..We compare the results with the smoking status of the patients and the mutation status of the K-ras, p53, and EGFR genes determined previously on these same lung tumors...
  14. ncbi request reprint Mutation and polymorphism in the EGFR-TK domain associated with lung cancer
    Weiping Zhang
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
    J Thorac Oncol 1:635-47. 2006
    ..Somatic EGFR mutations are predictors of response to treatment with EGFR tyrosine kinase (TK) inhibitors (TKIs) for lung cancer, especially among never smokers. EGFR mutations may occur independently of other genetic alterations...
  15. pmc Prevention of tobacco carcinogen-induced lung cancer in female mice using antiestrogens
    Laura P Stabile
    Department of Pharmacology and Chemical Biology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Carcinogenesis 33:2181-9. 2012
    ..ERĪ² expressed by inflammatory and neoplastic epithelial cells in the lung may signal in response to local estrogen production...
  16. ncbi request reprint Analysis of K-RAS and P53 mutations in sputum samples
    Weimin Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, PA, USA
    Methods Mol Biol 291:217-33. 2005
    ..This chapter describes methods to identify P53 and K-RAS mutations present in low fractions of epithelial cells among the excess of other cell types in sputum samples from lung cancer patients...
  17. doi request reprint Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non-small cell lung cancer patients
    Weimin Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Mol Carcinog 48:633-41. 2009
    ..Therefore, p53 mutations are frequent in tumor-surrounding histologically normal tissue, and some of them might be involved in lung carcinogenesis...
  18. ncbi request reprint Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer
    Li Fang Zhang
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Biomarkers 8:156-61. 2003
    ..Therefore, K-ras mutations may provide useful diagnostic markers for lung cancer...
  19. pmc Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients
    Yang Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Neoplasia 8:46-51. 2006
    ..Our results suggest an association between tobacco smoking and an increased incidence of aberrant promoter methylation of the p16 and MGMT genes in non-small cell lung cancer...
  20. pmc Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis
    Laura P Stabile
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Mol Cancer Ther 7:1913-22. 2008
    ..These preclinical results show that blocking the HGF/c-Met interaction with a single monoclonal antibody delivered systemically can have profound inhibitory effects on development of lung tumors...
  21. ncbi request reprint Molecular analysis of mutations in the human HPRT gene
    Phouthone Keohavong
    Department of Environmental and Occupational Health, University of Pittsburgh, PA, USA
    Methods Mol Biol 291:161-70. 2005
    ..Establishment of and comparisons with mutational spectra hold the promise of identifying exposures to mutation-inducing genotoxicants from their distinctive pattern of gene-specific DNA damage at this easily analyzed reporter gene...