Cynthia J Kenyon

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
    Cynthia Kenyon
    University of California, San Francisco, CA 94158, USA
    Philos Trans R Soc Lond B Biol Sci 366:9-16. 2011
  2. pmc Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans
    Marta M Gaglia
    Neuroscience Graduate Program and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 8:e1003133. 2012
  3. pmc A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans
    David Cristina
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 5:e1000450. 2009
  4. pmc A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans
    Arjumand Ghazi
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 5:e1000639. 2009
  5. pmc Widespread protein aggregation as an inherent part of aging in C. elegans
    Della C David
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 8:e1000450. 2010
  6. pmc Could a hormone point the way to life extension?
    Cynthia Kenyon
    is at the University of California, San Francisco, United States
    elife 1:e00286. 2012
  7. doi A pathway that links reproductive status to lifespan in Caenorhabditis elegans
    Cynthia Kenyon
    Department of Biochemistry and Biophysics, University of California, San Francisco, California, USA
    Ann N Y Acad Sci 1204:156-62. 2010
  8. doi The genetics of ageing
    Cynthia J Kenyon
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Nature 464:504-12. 2010
  9. ncbi The two isoforms of the Caenorhabditis elegans leukocyte-common antigen related receptor tyrosine phosphatase PTP-3 function independently in axon guidance and synapse formation
    Brian D Ackley
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    J Neurosci 25:7517-28. 2005

Research Grants

Collaborators

  • Seung Jae Lee
  • Yishi Jin
  • Arjumand Ghazi
  • Marta M Gaglia
  • Della C David
  • David Cristina
  • Brian D Ackley
  • Dongyeop Lee
  • Dae Eun Jeong
  • Eun A Ryu
  • Noah Ollikainen
  • Michael P Cary
  • Jonathan C Trinidad
  • Alma L Burlingame
  • Adam Lunceford
  • Michael Cary
  • Catherine Clarke
  • Robert J Harrington
  • Lisa Williams
  • Martin L Hudson
  • Andrew D Chisholm

Detail Information

Publications10

  1. pmc The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
    Cynthia Kenyon
    University of California, San Francisco, CA 94158, USA
    Philos Trans R Soc Lond B Biol Sci 366:9-16. 2011
    ..This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here...
  2. pmc Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans
    Marta M Gaglia
    Neuroscience Graduate Program and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 8:e1003133. 2012
    ..elegans. This situation is reminiscent of the complex regulation of physiology by the mammalian hypothalamus, which also receives innervations from sensory systems, most notably the visual and olfactory systems...
  3. pmc A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans
    David Cristina
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 5:e1000450. 2009
    ..Loss of fstr-1/2 does not suppress the phenotypes of all long-lived mitochondrial mutants. Thus, although different mitochondrial perturbations activate similar transcriptional and physiological responses, they do so in different ways...
  4. pmc A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans
    Arjumand Ghazi
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 5:e1000639. 2009
    ..Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues...
  5. pmc Widespread protein aggregation as an inherent part of aging in C. elegans
    Della C David
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 8:e1000450. 2010
    ..Together our findings indicate that widespread protein insolubility and aggregation is an inherent part of aging and that it may influence both lifespan and neurodegenerative disease...
  6. pmc Could a hormone point the way to life extension?
    Cynthia Kenyon
    is at the University of California, San Francisco, United States
    elife 1:e00286. 2012
    ..Mice that have been genetically modified to produce high levels of fibroblast growth factor-21 live longer than mice with normal levels of this hormone...
  7. doi A pathway that links reproductive status to lifespan in Caenorhabditis elegans
    Cynthia Kenyon
    Department of Biochemistry and Biophysics, University of California, San Francisco, California, USA
    Ann N Y Acad Sci 1204:156-62. 2010
    ....
  8. doi The genetics of ageing
    Cynthia J Kenyon
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Nature 464:504-12. 2010
    ..Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions...
  9. ncbi The two isoforms of the Caenorhabditis elegans leukocyte-common antigen related receptor tyrosine phosphatase PTP-3 function independently in axon guidance and synapse formation
    Brian D Ackley
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    J Neurosci 25:7517-28. 2005
    ..Overexpression of PTP-3A is able to bypass the requirement for nid-1 for the localization of SYD-2 and RIM. We propose that PTP-3A acts as a molecular link between the extracellular matrix and alpha-liprin during synaptogenesis...

Research Grants37

  1. Regulation of aging by germline stem cells in C. elegans
    Cynthia Kenyon; Fiscal Year: 2004
    ..In addition, our findings may yield insights into the ways that stem cells can influence endocrine signaling in vertebrates. ..
  2. Regulation of aging by germline stem cells in C. elegans
    Cynthia Kenyon; Fiscal Year: 2003
    ..In addition, our findings may yield insights into the ways that stem cells can influence endocrine signaling in vertebrates. ..
  3. ANTERO POSTERIOR PATTERN FORMATION IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 1999
    ..Together these studies should help to define the molecular mechanisms that regulate and execute these migrations. ..
  4. GENETIC ANALYSIS OF PATTERN FORMATION IN CAENORHABDITIS
    Cynthia Kenyon; Fiscal Year: 1993
    ....
  5. GENETIC ANALYSIS OF PATTERN FORMATION IN CAENORHABDITIS
    Cynthia Kenyon; Fiscal Year: 1992
    ....
  6. GENETIC ANALYSIS OF AGING IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 1999
    ..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..
  7. Lifespan regulation by the DAF-12 nuclear hormone receptor in C. elegans
    Cynthia J Kenyon; Fiscal Year: 2010
    ..This study, which takes place within a single, genetically-tractable, species, provides a fantastic opportunity to identify mechanisms that can produce extreme differences in lifespan ..
  8. Regulation of aging by germline stem cells in C. elegans
    Cynthia Kenyon; Fiscal Year: 2002
    ..In addition, our findings may yield insights into the ways that stem cells can influence endocrine signaling in vertebrates. ..
  9. GENETIC ANALYSIS OF AGING IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 2002
    ..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..
  10. GENETIC ANALYSIS OF AGING IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 2003
    ..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..
  11. Regulation of aging by germline stem cells in C. elegans
    Cynthia Kenyon; Fiscal Year: 2005
    ..In addition, our findings may yield insights into the ways that stem cells can influence endocrine signaling in vertebrates. ..
  12. Regulation of aging by germline stem cells in C. elegans
    Cynthia Kenyon; Fiscal Year: 2006
    ..In addition, our findings may yield insights into the ways that stem cells can influence endocrine signaling in vertebrates. ..
  13. Lifespan regulation by the DAF-12 nuclear hormone receptor in C. elegans
    Cynthia Kenyon; Fiscal Year: 2007
    ..This study, which takes place within a single, genetically-tractable, species, provides a fantastic opportunity to identify mechanisms that can produce extreme differences in lifespan ..
  14. Signals from the reproductive system that regulate aging in C. elegans
    Cynthia Kenyon; Fiscal Year: 2009
    ..We propose to learn how signals from the reproductive system influence lifespan, in hopes of finding new ways to increase youthfulness and health, and to combat age-related disease, in humans. ..
  15. Lifespan regulation by the DAF-12 nuclear hormone receptor in C. elegans
    Cynthia Kenyon; Fiscal Year: 2009
    ..This study, which takes place within a single, genetically-tractable, species, provides a fantastic opportunity to identify mechanisms that can produce extreme differences in lifespan ..
  16. Signals from the reproductive system that regulate aging in C. elegans
    Cynthia J Kenyon; Fiscal Year: 2010
    ..We propose to learn how signals from the reproductive system influence lifespan, in hopes of finding new ways to increase youthfulness and health, and to combat age-related disease, in humans. ..
  17. ANTERO POSTERIOR PATTERN FORMATION IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 2001
    ..Together these studies should help to define the molecular mechanisms that regulate and execute these migrations. ..
  18. GENETIC ANALYSIS OF AGING IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 2001
    ..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..
  19. GENETIC ANALYSIS OF PATTERN FORMATION IN CAENORHABDITIS
    Cynthia Kenyon; Fiscal Year: 1990
    ....
  20. GENETIC ANALYSIS OF PATTERN FORMATION IN CAENORHABDITIS
    Cynthia Kenyon; Fiscal Year: 1991
    ....
  21. GENETIC ANALYSIS OF AGING IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 2000
    ..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..
  22. ANTERO POSTERIOR PATTERN FORMATION IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 2000
    ..Together these studies should help to define the molecular mechanisms that regulate and execute these migrations. ..