Research Topics
Genomes and GenesSpecies | MARIA KENNEYSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control studyM Cristina Kenney
Gavin Herbert Eye Institute, Univeresity of California Irvine, Hewitt Hall, Room 2028, 843 Health Science Rd, Irvine, CA 92697, USA
BMC Med Genet 14:4. 2013..abstract:..
Altered expression of aquaporins in bullous keratopathy and Fuchs' dystrophy corneasM Cristina Kenney
Department of Ophthalmology, University of California Irvine, Medical Center, 101 The City Drive, Orange, CA 92868, USA
J Histochem Cytochem 52:1341-50. 2004..Although both have vision-disrupting corneal edema, the mechanisms of fluid accumulation may be different in each disease...- Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitroM Cristina Kenney
Department of Ophthalmology, College of Medicine, University of California, Irvine, 101 The City Drive, Building 55, Room 220, Orange, CA 92868, USA
Exp Eye Res 77:537-46. 2003..Our goal is to determine if the growth factors/cytokines that are elevated in PBK corneas alter the expression of extracellular matrix (ECM) and/or degradative enzymes in vitro... - Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cellsAneesh Neekhra
Department of Ophthalmology, School of Medicine, University of California, Irvine, California, USA
Invest Ophthalmol Vis Sci 48:1362-7. 2007..To determine the caspase pathways involved with 7-ketocholesterol (7kCh)-induced apoptosis in rat R28 cells... 
Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patientsM Cristina Kenney
Department of Ophthalmology, University of California, Irvine, Irvine, California, USA
Invest Ophthalmol Vis Sci 51:4289-97. 2010..To determine mitochondrial (mt)DNA variants in AMD and age-matched normal retinas...- Hypersensitive response to oxidative stress in keratoconus corneal fibroblastsMarilyn Chwa
Department of Ophthalmology, University of California, Irvine Medical Center, Orange, California 92868, USA
Invest Ophthalmol Vis Sci 49:4361-9. 2008..The purpose of this study was to explore whether KC cells have inherent, exaggerated hypersensitivity to oxidative stressors... - Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cellsSaurabh Luthra
Department of Ophthalmology, School of Medicine, University of California, Irvine, California 92868, USA
Invest Ophthalmol Vis Sci 47:5569-75. 2006..Elucidating the specific apoptotic pathways involved may have therapeutic potential for AMD and other retinal diseases... - Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblastsMarilyn Chwa
Department of Ophthalmology, University of California Irvine Medical Center, Irvine, California, USA
Invest Ophthalmol Vis Sci 47:1902-10. 2006..In addition, the stressed KC fibroblasts possessed characteristics similar to those found in the intact KC corneas (increased catalase activity, ROS production, and apoptosis). These properties may play a role in the pathogenesis of KC... - Mitochondrial DNA haplogroups associated with age-related macular degenerationNitin Udar
Department of Ophthalmology, University of California Irvine, Orange, California 92868, USA
Invest Ophthalmol Vis Sci 50:2966-74. 2009..To examine the mtDNA control regions in normal and age-related macular degeneration (AMD) retinas. To identify the mtDNA variations associated with AMD... - Accumulation of mitochondrial DNA damage in keratoconus corneasShari R Atilano
Department of Ophthalmology, University of California Irvine Medical Center, Irvine, California, USA
Invest Ophthalmol Vis Sci 46:1256-63. 2005..CONCLUSIONS: KC corneas exhibit more mtDNA damage than do normal corneas. The previously reported increased oxidative stress and altered integrity of mtDNA may be related to each other and may be important in KC pathogenesis... - Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorderM Cristina Kenney
Department of Ophthalmology, University of California Irvine, Medical Center, 101 The City Drive, Orange, CA 92868, USA
Invest Ophthalmol Vis Sci 46:823-32. 2005..Protein levels or enzyme activities were analyzed when RNA levels were different... - Elements of the nitric oxide pathway can degrade TIMP-1 and increase gelatinase activityDonald J Brown
Department of Ophthalmology, College of Medicine, University of California, Irvine, Orange, CA, USA
Mol Vis 10:281-8. 2004..This study examines whether a peroxynitrite donor (3-morpholinosydomine N-ethylcarbamide, SIN-1) or nitric oxide donor (S-nitroso-N-acetylpenicillamine, SNAP) could alter TIMP-1 and/or MMP-2 in vitro... - Hydrogen peroxide causes mitochondrial DNA damage in corneal epithelial cellsShari R Atilano
Department of Ophthalmology, University of California, Irvine Medical Center, Irvine, CA 92868, USA
Cornea 28:426-33. 2009..In addition, we compared the integrity of mtDNA found in epithelial cells isolated from keratoconus (KC) and normal (NL) corneas... - Toxicity of triamcinolone acetonide on retinal neurosensory and pigment epithelial cellsRaja Narayanan
Department of Ophthalmology, School of Medicine, University of California, Irvine, California 92697, USA
Invest Ophthalmol Vis Sci 47:722-8. 2006..The results of this in vitro study cannot be directly extrapolated to clinical practice, but, based on these data, further studies may be warranted... - Effects of tenascin-C on normal and diabetic retinal endothelial cells in cultureRaquel Castellon
Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California Los Angeles Medical School Affiliate, Los Angeles, California, USA
Invest Ophthalmol Vis Sci 43:2758-66. 2002..Because TN-C may promote neovascularization, its potential angiogenic effects were examined in vitro in normal and diabetic retinal endothelial cells (RECs)... - Trypan blue: effect on retinal pigment epithelial and neurosensory retinal cellsRaja Narayanan
Department of Ophthalmology, University of California, Irvine, California 92697-4375, USA
Invest Ophthalmol Vis Sci 46:304-9. 2005..Clinical studies must be conducted to determine the safety and efficacy of staining of the inner limiting membrane with trypan blue... - Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitroAna L Gramajo
Department of Ophthalmology, University of California, Irvine, California, USA
Invest Ophthalmol Vis Sci 51:1164-70. 2010..To assess oxysterol-induced mitochondrial DNA (mtDNA) damage and mitochondrial dysfunction in cultured human retinal pigment epithelial cells (ARPE- 19)... - Differential effects of nicotine on retinal and vascular cells in vitroA Jayaprakash Patil
Department of Ophthalmology, Gavin S Herbert Eye Institute, University of California Irvine, Medical Center, 101 The City Drive, Orange, CA 92868, United States
Toxicology 259:69-76. 2009..Understanding the mechanisms of cell death may have potential therapeutic implications in the treatment of cigarette smoking related retinal diseases such as age-related macular degeneration (AMD)... - Toxicity of indocyanine green (ICG) in combination with light on retinal pigment epithelial cells and neurosensory retinal cellsRaja Narayanan
Department of Ophthalmology, University of California-Irvine, 118 Med Surge I, Irvine, CA 92697-4375, USA
Curr Eye Res 30:471-8. 2005..ICG needs to be used with caution as it decreases the mitochondrial dehydrogenase activity and increases the DNA synthesis in retinal cells, markers for cell toxicity and dysfunction... - Effects of benzo(e)pyrene on the retinal neurosensory cells and human microvascular endothelial cells in vitroA Jayaprakash Patil
Department of Ophthalmology, Gavin S Herbert Eye Institute, University of California, Irvine, California, USA
Curr Eye Res 34:672-82. 2009..To study the effects of benzo(e)pyrene (B(e)P), a toxic component of cigarette smoke, on retinal neurosensory (R28) cells and human microvascular endothelial cells (HMVEC)... - Effects of Benzo(e)Pyrene, a toxic component of cigarette smoke, on human retinal pigment epithelial cells in vitroAshish Sharma
Department of Ophthalmology, School of Medicine, University of California, Irvine, California 92868, USA
Invest Ophthalmol Vis Sci 49:5111-7. 2008.... - Protective effects of memantine and epicatechin on catechol-induced toxicity on Müller cells in vitroSaffar Mansoor
Department of Ophthalmology, School of Medicine, University of California, Irvine, United States
Toxicology 271:107-14. 2010..However, memantine and epicatechin can partially reverse the cytotoxic effect of catechol. Their administration may reduce or prevent Müller cells degeneration in AMD or other retinal degenerative disorders... - SOD1 haplotypes in familial keratoconusNitin Udar
Department of Ophthalmology, The Eye Institute, University of California Irvine, Orange, CA, USA
Cornea 28:902-7. 2009..The goal of this study was to determine if the 2 families (families A and H) shared a common haplotype by identifying closely linked new microsatellite markers flanking the SOD1 gene... - Evaluation of in vitro effects of bevacizumab (Avastin) on retinal pigment epithelial, neurosensory retinal, and microvascular endothelial cellsSaurabh Luthra
Department of Ophthalmology, University of California, Irvine, 92697, USA
Retina 26:512-8. 2006..This report is consistent with the recent report of lack of toxicity of intravitreal bevacizumab in rabbits as well as the lack of apparent toxicity in clinical use... - Keratoconus--no association with the transforming growth factor beta-induced gene in a cohort of American patientsNitin Udar
Jules Stein Eye Institute, School of Medicine, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
Cornea 23:13-7. 2004..Given this strong evidence of the involvement of this gene in corneal dystrophies, we investigated possible mutations within this gene in 15 probands of families with keratoconus... - Second-harmonic imaging microscopy of normal human and keratoconus corneaNaoyuki Morishige
The Eye Institute, School of Medicine, University of California Irvine Medical Center, Orange, California
Invest Ophthalmol Vis Sci 48:1087-94. 2007..The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas... - Inhibition of apoptosis in human retinal pigment epithelial cells treated with benzo(e)pyrene, a toxic component of cigarette smokeSaffar Mansoor
Department of Ophthalmology, School of Medicine, University of California, Irvine, CA 92868, USA
Invest Ophthalmol Vis Sci 51:2601-7. 2010..To study the inhibitory effects of some agents or drugs (inhibitors) on benzo(e)pyrene (B(e)P)-induced cell death and apoptosis on human retinal pigment epithelial (ARPE-19) cells in vitro... - Complement factor H polymorphism in age-related macular degenerationRaja Narayanan
Department of Ophthalmology, University of California Irvine Medical Center, Irvine, California, USA
Ophthalmology 114:1327-31. 2007..To determine the association between complement factor H (CFH) polymorphism T1277C (tyrosine-402 --> histidine-402) and phenotypic variations of age-related macular degeneration (AMD)... - Noninvasive corneal stromal collagen imaging using two-photon-generated second-harmonic signalsNaoyuki Morishige
The Eye Institute, University of California, Irvine Medical Center, Irvine, California, USA
J Cataract Refract Surg 32:1784-91. 2006..Human corneas had a unique organizational pattern with sutural lamellae to provide important biomechanical support that was not present in mouse or rabbit corneas... - 7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitroSaurabh Luthra
Ophthalmology, Drishti Eye Centre, Dehradun, India
Microvasc Res 75:343-50. 2008..Moreover, our data suggest that oxysterols such as 7kCh can damage HMVECs cells in part via caspase-dependent apoptosis and may play a role in vascular and retinal diseases... - Extracellular matrix and matrix metalloproteinase changes in human corneas after complicated laser-assisted in situ keratomileusis (LASIK)Ezra Maguen
Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA Medical School, Los Angeles, California 90048, USA
Cornea 21:95-100. 2002..To characterize extracellular matrix (ECM) and nine matrix metalloproteinase (MMP) changes in two corneas that underwent a complicated laser-assisted in situ keratomileusis (LASIK) procedure... - Evidence of oxidative stress in human corneal diseasesRajeev Buddi
The Eye Institute, Medical College of Wisconsin, Milwaukee, USA
J Histochem Cytochem 50:341-51. 2002..These results suggest that keratoconus corneas do not process reactive oxygen species in a normal manner, which may play a major role in the pathogenesis of this disease... - Oxysterol-induced toxicity in R28 and ARPE-19 cellsJohn M Ong
Molecular Eye Research Laboratory, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Neurochem Res 28:883-91. 2003..These in vitro findings provide evidence that cholesterol oxides can directly damage cultured retinal and RPE cells. The oxysterol-induced oxidative stress in these cells may be a factor in the pathology of retinal degenerative diseases... - SOD1: a candidate gene for keratoconusNitin Udar
Jules Stein Eye Institute, University of California Los Angeles, 92868, USA
Invest Ophthalmol Vis Sci 47:3345-51. 2006..To screen superoxide dismutase 1 (SOD1) on chromosome 21 as a possible candidate gene for familial keratoconus (KC)... - Extracellular matrix and Na+,K+-ATPase in human corneas following cataract surgery: comparison with bullous keratopathy and Fuchs' dystrophy corneasAlexander V Ljubimov
Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Cornea 21:74-80. 2002..These corneas were from patients who never developed pseudophakic or aphakic bullous keratopathy (PBK/ABK) after cataract surgery. PCS corneas were compared with PBK/ABK and Fuchs' dystrophy corneas... - Effects of angiogenic growth factor combinations on retinal endothelial cellsRaquel Castellon
Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA Medical School Affiliate, Los Angeles, CA 90048, USA
Exp Eye Res 74:523-35. 2002..Their effects, however, can be greatly augmented by other growth factors that alone exert little or no action. Therefore, diabetic retinal neovascularization may result from the additive or synergistic action of several growth factors... - Pseudophakic corneal edema: A review of mechanisms and treatmentsRaja Narayanan
LV Prasad Eye Institute, Banjara Hills, Hyderabad, India
Cornea 25:993-1004. 2006..CONCLUSIONS: Although newer treatment options have been suggested, penetrating keratoplasty still remains the most definitive treatment and has the highest success rate...
Research Grants
- METALLOPROTEINASES IN NORMAL & KERATOCONUS CORNEASMARIA KENNEY; Fiscal Year: 1993..Our data in normal ocular tissues will provide baseline data for future studies to investigate proteolytic activities in these pathological conditions...
- METALLOPROTEINASE IN NORMAL AND KERATOCONUS CORNEASMARIA KENNEY; Fiscal Year: 2000..In addition, these studies will also provide basic information on the regulation of MMP activity in the normal cornea and the consequences of protease action on corneal ECM structure and organization. ..
- EXTRACELLULAR MATRIX ABNORMALITIES IN CORNEAL EDEMAMARIA KENNEY; Fiscal Year: 2002....
- Abnormalities in Keratoconus CorneasMARIA KENNEY; Fiscal Year: 2003..These studies will provide fundamental insights into KC pathogensis and may provide a basis for therapy. ..