MARIA KENNEY

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases
    M Cristina Kenney
    Gavin Herbert Eye Institute, Univ of California Irvine, Irvine, CA, USA Department of Pathology and Laboratory Medicine, Univ of California Irvine, Irvine, CA, USA Electronic address
    Biochim Biophys Acta 1842:208-19. 2014
  2. pmc Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration
    M Cristina Kenney
    Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e54339. 2013
  3. pmc Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study
    M Cristina Kenney
    Gavin Herbert Eye Institute, Univeresity of California Irvine, Hewitt Hall, Room 2028, 843 Health Science Rd, Irvine, CA 92697, USA
    BMC Med Genet 14:4. 2013
  4. doi request reprint Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients
    M Cristina Kenney
    Department of Ophthalmology, University of California, Irvine, Irvine, California, USA
    Invest Ophthalmol Vis Sci 51:4289-97. 2010
  5. ncbi request reprint Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells
    Aneesh Neekhra
    Department of Ophthalmology, School of Medicine, University of California, Irvine, California, USA
    Invest Ophthalmol Vis Sci 48:1362-7. 2007
  6. ncbi request reprint Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro
    M Cristina Kenney
    Department of Ophthalmology, College of Medicine, University of California, Irvine, 101 The City Drive, Building 55, Room 220, Orange, CA 92868, USA
    Exp Eye Res 77:537-46. 2003
  7. ncbi request reprint Altered expression of aquaporins in bullous keratopathy and Fuchs' dystrophy corneas
    M Cristina Kenney
    Department of Ophthalmology, University of California Irvine, Medical Center, 101 The City Drive, Orange, CA 92868, USA
    J Histochem Cytochem 52:1341-50. 2004
  8. doi request reprint Hypersensitive response to oxidative stress in keratoconus corneal fibroblasts
    Marilyn Chwa
    Department of Ophthalmology, University of California, Irvine Medical Center, Orange, California 92868, USA
    Invest Ophthalmol Vis Sci 49:4361-9. 2008
  9. ncbi request reprint Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells
    Saurabh Luthra
    Department of Ophthalmology, School of Medicine, University of California, Irvine, California 92868, USA
    Invest Ophthalmol Vis Sci 47:5569-75. 2006
  10. ncbi request reprint Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts
    Marilyn Chwa
    Department of Ophthalmology, University of California Irvine Medical Center, Irvine, California, USA
    Invest Ophthalmol Vis Sci 47:1902-10. 2006

Research Grants

Collaborators

Detail Information

Publications39

  1. doi request reprint Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases
    M Cristina Kenney
    Gavin Herbert Eye Institute, Univ of California Irvine, Irvine, CA, USA Department of Pathology and Laboratory Medicine, Univ of California Irvine, Irvine, CA, USA Electronic address
    Biochim Biophys Acta 1842:208-19. 2014
    ..Our data support the hypothesis that mtDNA haplogroups representing populations from different geographic origins may play a role in differential susceptibilities to diseases. ..
  2. pmc Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration
    M Cristina Kenney
    Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e54339. 2013
    ....
  3. pmc Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study
    M Cristina Kenney
    Gavin Herbert Eye Institute, Univeresity of California Irvine, Hewitt Hall, Room 2028, 843 Health Science Rd, Irvine, CA 92697, USA
    BMC Med Genet 14:4. 2013
    ..We also assessed for gender bias and additive risk with known high risk nuclear gene SNPs, ARMS2/LOC387715 (G > T; Ala69Ser, rs10490924) and CFH (T > C; Try402His, rs1061170)...
  4. doi request reprint Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients
    M Cristina Kenney
    Department of Ophthalmology, University of California, Irvine, Irvine, California, USA
    Invest Ophthalmol Vis Sci 51:4289-97. 2010
    ..To determine mitochondrial (mt)DNA variants in AMD and age-matched normal retinas...
  5. ncbi request reprint Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells
    Aneesh Neekhra
    Department of Ophthalmology, School of Medicine, University of California, Irvine, California, USA
    Invest Ophthalmol Vis Sci 48:1362-7. 2007
    ..To determine the caspase pathways involved with 7-ketocholesterol (7kCh)-induced apoptosis in rat R28 cells...
  6. ncbi request reprint Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro
    M Cristina Kenney
    Department of Ophthalmology, College of Medicine, University of California, Irvine, 101 The City Drive, Building 55, Room 220, Orange, CA 92868, USA
    Exp Eye Res 77:537-46. 2003
    ..Our goal is to determine if the growth factors/cytokines that are elevated in PBK corneas alter the expression of extracellular matrix (ECM) and/or degradative enzymes in vitro...
  7. ncbi request reprint Altered expression of aquaporins in bullous keratopathy and Fuchs' dystrophy corneas
    M Cristina Kenney
    Department of Ophthalmology, University of California Irvine, Medical Center, 101 The City Drive, Orange, CA 92868, USA
    J Histochem Cytochem 52:1341-50. 2004
    ..Although both have vision-disrupting corneal edema, the mechanisms of fluid accumulation may be different in each disease...
  8. doi request reprint Hypersensitive response to oxidative stress in keratoconus corneal fibroblasts
    Marilyn Chwa
    Department of Ophthalmology, University of California, Irvine Medical Center, Orange, California 92868, USA
    Invest Ophthalmol Vis Sci 49:4361-9. 2008
    ..The purpose of this study was to explore whether KC cells have inherent, exaggerated hypersensitivity to oxidative stressors...
  9. ncbi request reprint Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells
    Saurabh Luthra
    Department of Ophthalmology, School of Medicine, University of California, Irvine, California 92868, USA
    Invest Ophthalmol Vis Sci 47:5569-75. 2006
    ..To determine whether caspase or cathepsin pathways are activated in human retinal pigment epithelial cells (ARPE-19) after exposure to 7-ketocholesterol (7kCh)...
  10. ncbi request reprint Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts
    Marilyn Chwa
    Department of Ophthalmology, University of California Irvine Medical Center, Irvine, California, USA
    Invest Ophthalmol Vis Sci 47:1902-10. 2006
    ..To determine whether keratoconus (KC) corneal fibroblast cultures have increased reactive oxygen species (ROS) production and are more susceptible to stress-related challenges...
  11. doi request reprint Mitochondrial DNA haplogroups associated with age-related macular degeneration
    Nitin Udar
    Department of Ophthalmology, University of California Irvine, Orange, California 92868, USA
    Invest Ophthalmol Vis Sci 50:2966-74. 2009
    ..To examine the mtDNA control regions in normal and age-related macular degeneration (AMD) retinas. To identify the mtDNA variations associated with AMD...
  12. ncbi request reprint Accumulation of mitochondrial DNA damage in keratoconus corneas
    Shari R Atilano
    Department of Ophthalmology, University of California Irvine Medical Center, Irvine, California, USA
    Invest Ophthalmol Vis Sci 46:1256-63. 2005
    ..To determine whether keratoconus (KC) corneas have more mitochondrial (mt)DNA damage than do normal corneas...
  13. doi request reprint Hydrogen peroxide causes mitochondrial DNA damage in corneal epithelial cells
    Shari R Atilano
    Department of Ophthalmology, University of California, Irvine Medical Center, Irvine, CA 92868, USA
    Cornea 28:426-33. 2009
    ..In addition, we compared the integrity of mtDNA found in epithelial cells isolated from keratoconus (KC) and normal (NL) corneas...
  14. ncbi request reprint Elements of the nitric oxide pathway can degrade TIMP-1 and increase gelatinase activity
    Donald J Brown
    Department of Ophthalmology, College of Medicine, University of California, Irvine, Orange, CA, USA
    Mol Vis 10:281-8. 2004
    ..This study examines whether a peroxynitrite donor (3-morpholinosydomine N-ethylcarbamide, SIN-1) or nitric oxide donor (S-nitroso-N-acetylpenicillamine, SNAP) could alter TIMP-1 and/or MMP-2 in vitro...
  15. ncbi request reprint Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder
    M Cristina Kenney
    Department of Ophthalmology, University of California Irvine, Medical Center, 101 The City Drive, Orange, CA 92868, USA
    Invest Ophthalmol Vis Sci 46:823-32. 2005
    ..Protein levels or enzyme activities were analyzed when RNA levels were different...
  16. ncbi request reprint Toxicity of triamcinolone acetonide on retinal neurosensory and pigment epithelial cells
    Raja Narayanan
    Department of Ophthalmology, School of Medicine, University of California, Irvine, California 92697, USA
    Invest Ophthalmol Vis Sci 47:722-8. 2006
    ..To study the toxicity of triamcinolone acetonide (Kenalog; Bristol-Meyers Squibb, Princeton, NJ) on retinal pigment epithelial (ARPE-19) and retinal neurosensory (R28) cells...
  17. doi request reprint Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro
    Ana L Gramajo
    Department of Ophthalmology, University of California, Irvine, California, USA
    Invest Ophthalmol Vis Sci 51:1164-70. 2010
    ..To assess oxysterol-induced mitochondrial DNA (mtDNA) damage and mitochondrial dysfunction in cultured human retinal pigment epithelial cells (ARPE- 19)...
  18. ncbi request reprint Trypan blue: effect on retinal pigment epithelial and neurosensory retinal cells
    Raja Narayanan
    Department of Ophthalmology, University of California, Irvine, California 92697 4375, USA
    Invest Ophthalmol Vis Sci 46:304-9. 2005
    ..To evaluate the toxicity of trypan blue on retinal cells in vitro...
  19. ncbi request reprint Effects of tenascin-C on normal and diabetic retinal endothelial cells in culture
    Raquel Castellon
    Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California Los Angeles Medical School Affiliate, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 43:2758-66. 2002
    ..Because TN-C may promote neovascularization, its potential angiogenic effects were examined in vitro in normal and diabetic retinal endothelial cells (RECs)...
  20. doi request reprint Differential effects of nicotine on retinal and vascular cells in vitro
    A Jayaprakash Patil
    Department of Ophthalmology, Gavin S Herbert Eye Institute, University of California Irvine, Medical Center, 101 The City Drive, Orange, CA 92868, United States
    Toxicology 259:69-76. 2009
    ..Understanding the mechanisms of cell death may have potential therapeutic implications in the treatment of cigarette smoking related retinal diseases such as age-related macular degeneration (AMD)...
  21. doi request reprint Effects of Benzo(e)Pyrene, a toxic component of cigarette smoke, on human retinal pigment epithelial cells in vitro
    Ashish Sharma
    Department of Ophthalmology, School of Medicine, University of California, Irvine, California 92868, USA
    Invest Ophthalmol Vis Sci 49:5111-7. 2008
    ....
  22. ncbi request reprint Effects of benzo(e)pyrene on the retinal neurosensory cells and human microvascular endothelial cells in vitro
    A Jayaprakash Patil
    Department of Ophthalmology, Gavin S Herbert Eye Institute, University of California, Irvine, California, USA
    Curr Eye Res 34:672-82. 2009
    ..To study the effects of benzo(e)pyrene (B(e)P), a toxic component of cigarette smoke, on retinal neurosensory (R28) cells and human microvascular endothelial cells (HMVEC)...
  23. ncbi request reprint Toxicity of indocyanine green (ICG) in combination with light on retinal pigment epithelial cells and neurosensory retinal cells
    Raja Narayanan
    Department of Ophthalmology, University of California Irvine, 118 Med Surge I, Irvine, CA 92697 4375, USA
    Curr Eye Res 30:471-8. 2005
    ..To evaluate the toxicity of indocyanine green (ICG) in combination with light...
  24. doi request reprint Protective effects of memantine and epicatechin on catechol-induced toxicity on Müller cells in vitro
    Saffar Mansoor
    Department of Ophthalmology, School of Medicine, University of California, Irvine, United States
    Toxicology 271:107-14. 2010
    ..However, memantine and epicatechin can partially reverse the cytotoxic effect of catechol. Their administration may reduce or prevent Müller cells degeneration in AMD or other retinal degenerative disorders...
  25. pmc Second-harmonic imaging microscopy of normal human and keratoconus cornea
    Naoyuki Morishige
    The Eye Institute, School of Medicine, University of California Irvine Medical Center, Orange, California
    Invest Ophthalmol Vis Sci 48:1087-94. 2007
    ..The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas...
  26. doi request reprint SOD1 haplotypes in familial keratoconus
    Nitin Udar
    Department of Ophthalmology, The Eye Institute, University of California Irvine, Orange, CA, USA
    Cornea 28:902-7. 2009
    ..The goal of this study was to determine if the 2 families (families A and H) shared a common haplotype by identifying closely linked new microsatellite markers flanking the SOD1 gene...
  27. ncbi request reprint Keratoconus--no association with the transforming growth factor beta-induced gene in a cohort of American patients
    Nitin Udar
    Jules Stein Eye Institute, School of Medicine, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Cornea 23:13-7. 2004
    ..Given this strong evidence of the involvement of this gene in corneal dystrophies, we investigated possible mutations within this gene in 15 probands of families with keratoconus...
  28. ncbi request reprint Evaluation of in vitro effects of bevacizumab (Avastin) on retinal pigment epithelial, neurosensory retinal, and microvascular endothelial cells
    Saurabh Luthra
    Department of Ophthalmology, University of California, Irvine, 92697, USA
    Retina 26:512-8. 2006
    ..To evaluate the short-term in vitro safety of bevacizumab (Avastin) in human retinal pigment epithelial (ARPE-19), rat neurosensory retinal (R28), and human microvascular endothelial (HMVECad) cells...
  29. pmc Noninvasive corneal stromal collagen imaging using two-photon-generated second-harmonic signals
    Naoyuki Morishige
    The Eye Institute, University of California, Irvine Medical Center, Irvine, California, USA
    J Cataract Refract Surg 32:1784-91. 2006
    ..To investigate the feasibility of using femtosecond-pulse lasers to produce second-harmonic generated (SHG) signals to noninvasively assess corneal stromal collagen organization...
  30. doi request reprint Inhibition of apoptosis in human retinal pigment epithelial cells treated with benzo(e)pyrene, a toxic component of cigarette smoke
    Saffar Mansoor
    Department of Ophthalmology, School of Medicine, University of California, Irvine, CA 92868, USA
    Invest Ophthalmol Vis Sci 51:2601-7. 2010
    ..To study the inhibitory effects of some agents or drugs (inhibitors) on benzo(e)pyrene (B(e)P)-induced cell death and apoptosis on human retinal pigment epithelial (ARPE-19) cells in vitro...
  31. ncbi request reprint Complement factor H polymorphism in age-related macular degeneration
    Raja Narayanan
    Department of Ophthalmology, University of California Irvine Medical Center, Irvine, California, USA
    Ophthalmology 114:1327-31. 2007
    ..To determine the association between complement factor H (CFH) polymorphism T1277C (tyrosine-402 --> histidine-402) and phenotypic variations of age-related macular degeneration (AMD)...
  32. ncbi request reprint Extracellular matrix and matrix metalloproteinase changes in human corneas after complicated laser-assisted in situ keratomileusis (LASIK)
    Ezra Maguen
    Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA Medical School, Los Angeles, California 90048, USA
    Cornea 21:95-100. 2002
    ..To characterize extracellular matrix (ECM) and nine matrix metalloproteinase (MMP) changes in two corneas that underwent a complicated laser-assisted in situ keratomileusis (LASIK) procedure...
  33. ncbi request reprint Evidence of oxidative stress in human corneal diseases
    Rajeev Buddi
    The Eye Institute, Medical College of Wisconsin, Milwaukee, USA
    J Histochem Cytochem 50:341-51. 2002
    ..These results suggest that keratoconus corneas do not process reactive oxygen species in a normal manner, which may play a major role in the pathogenesis of this disease...
  34. ncbi request reprint 7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro
    Saurabh Luthra
    Ophthalmology, Drishti Eye Centre, Dehradun, India
    Microvasc Res 75:343-50. 2008
    ..Moreover, our data suggest that oxysterols such as 7kCh can damage HMVECs cells in part via caspase-dependent apoptosis and may play a role in vascular and retinal diseases...
  35. ncbi request reprint Oxysterol-induced toxicity in R28 and ARPE-19 cells
    John M Ong
    Molecular Eye Research Laboratory, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Neurochem Res 28:883-91. 2003
    ..These in vitro findings provide evidence that cholesterol oxides can directly damage cultured retinal and RPE cells. The oxysterol-induced oxidative stress in these cells may be a factor in the pathology of retinal degenerative diseases...
  36. ncbi request reprint SOD1: a candidate gene for keratoconus
    Nitin Udar
    Jules Stein Eye Institute, University of California Los Angeles, 92868, USA
    Invest Ophthalmol Vis Sci 47:3345-51. 2006
    ..To screen superoxide dismutase 1 (SOD1) on chromosome 21 as a possible candidate gene for familial keratoconus (KC)...
  37. ncbi request reprint Extracellular matrix and Na+,K+-ATPase in human corneas following cataract surgery: comparison with bullous keratopathy and Fuchs' dystrophy corneas
    Alexander V Ljubimov
    Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cornea 21:74-80. 2002
    ..These corneas were from patients who never developed pseudophakic or aphakic bullous keratopathy (PBK/ABK) after cataract surgery. PCS corneas were compared with PBK/ABK and Fuchs' dystrophy corneas...
  38. ncbi request reprint Effects of angiogenic growth factor combinations on retinal endothelial cells
    Raquel Castellon
    Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA Medical School Affiliate, Los Angeles, CA 90048, USA
    Exp Eye Res 74:523-35. 2002
    ..Their effects, however, can be greatly augmented by other growth factors that alone exert little or no action. Therefore, diabetic retinal neovascularization may result from the additive or synergistic action of several growth factors...
  39. ncbi request reprint Pseudophakic corneal edema: A review of mechanisms and treatments
    Raja Narayanan
    LV Prasad Eye Institute, Banjara Hills, Hyderabad, India
    Cornea 25:993-1004. 2006
    ..To review the pathological mechanisms and treatments for pseudophakic corneal edema (PCE), one of the most common indications for penetrating keratoplasty...

Research Grants28

  1. METALLOPROTEINASES IN NORMAL & KERATOCONUS CORNEAS
    MARIA KENNEY; Fiscal Year: 1993
    ..Our data in normal ocular tissues will provide baseline data for future studies to investigate proteolytic activities in these pathological conditions...
  2. METALLOPROTEINASE IN NORMAL AND KERATOCONUS CORNEAS
    MARIA KENNEY; Fiscal Year: 2000
    ..In addition, these studies will also provide basic information on the regulation of MMP activity in the normal cornea and the consequences of protease action on corneal ECM structure and organization. ..
  3. EXTRACELLULAR MATRIX ABNORMALITIES IN CORNEAL EDEMA
    MARIA KENNEY; Fiscal Year: 2002
    ....
  4. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..These studies will provide fundamental insights into KC pathogensis and may provide a basis for therapy. ..