Kristen Kennedy

Summary

Affiliation: University of Texas at Dallas
Location: DALLAS, United States
URL: http://vitallongevity.utdallas.edu/people/center-scientists/kristen.html
Publications:
Kennedy, K. M., Rodrigue, K.M., Devous, M. D., Sr., Hebrank, A. C., Bischof, G. N., & Park, D. C. (2012). Beta-Amyloid Burden is Associated with Altered Functional Activation During Encoding Across the Adult Lifespan. NeuroImage.

Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Sr., Rieck, J. R., Hebrank, A. C., Diaz-Arrastia, R., Mathews, D., & Park, D. C. (2012). ß-Amyloid Burden in Healthy Aging: Regional Distribution and Cognitive Consequences. Neurology, 78, 387-395.

Park, J., Carp, J., Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Huang, C. M., Rieck, J. R., Polk, T., & Park, D. C. (2012). Neural broadening or neural attenuation? Age-related dedifferentiation in the face network in a large lifespan sample. Journal of Neuroscience, 32, 2154-2158.

Peiying, L., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Park. D. C., & Lu, H. (in press). A comparison of physiologic modulators of fMRI signals. Human Brain Mapping.

Raz, N., Yang, Y., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Ghisletta, P. (2012). White Matter Deterioration in 15 months: Latent Growth Curve Models in Healthy Adults. Neurobiology of Aging, 33(2): 429.e1-429.e5, doi:10.1016/j.neurobiolaging.2010.11.018.

Shing, Y. L., Rodrigue, K. M., Kennedy, K. M., Fandakova, Y., Bodammer, N., Werkle-Bergner, M., Lindenberger, U., Raz, N. (2011). Hippocampal subfield volumes: Age, vascular risk, and correlation with associative memory. Frontiers in Aging Neuroscience, Feb 4;3:2. PMC303501.

Rodrigue, K. M. & Kennedy, K. M. (2011). The cognitive consequences of structural changes to the aging brain. In K. W. Schaie, S. L. Willis (Eds.) Handbook of the Psychology of Aging, 7th ed., Ch 5, 73-92, New York: Elsevier

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2011). Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging doi:10.1016/j.neurobiolaging.2009.05.015.

Lu, H., Xu, F., Rodrigue, K. M., Kennedy, K. M., Cheng, Y., Flicker, B., Hebrank, A. C., Uh, J., & Park, D. C. (2011). Alterations in cerebral metabolic rate and vascular function across the adult lifespan. Cerebral Cortex, 21: 1426-1434, doi: 10.1093/cercor/bhq224.

Raz, N., Ghisletta, P., Rodrigue, K. M. Kennedy, K. M., & Lindenberger, U. (2010). Trajectories of brain aging in middle-aged and older adults: Regional and individual differences. NeuroImage, 51, 501–511.

Ghisletta, P., Kennedy, K. M., Rodrigue, K.M., Lindenberger, U., & Raz, N. (2010). Adult Age Differences and Cognitive Resources in Perceptual-Motor Skill Acquisition: Application of a Multilevel Exponential Model. Journals of Gerontology: Psychological Sciences, 65B, (2), 163-173.

Rodrigue, K. M., Kennedy, K.M., & Park, D. C. (2009). Beta-amyloid deposition and the aging brain. Neuropsychology Review, 19, 436-450.

Kennedy, K.M., & Raz, N. (2009). Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Research, 1297, 41-56.

Kennedy, K. M., Rodrigue, K. M., Land, S., & Raz, N. (2009). BDNF val66met polymorphism influences age differences in microstructure of the corpus callosum. Frontiers in Human Neuroscience, 3:19. doi:10.3389/neuro.09.019.2009.

Kennedy, K.M. & Raz, N. (2009). Aging White Matter and Cognition: Differential Effects of Regional Variations in Diffusion Properties on Memory, Executive Functions, and Speed. Neuropsychologia, 47(3), 916-927.

Kennedy, K.M., Rodrigue, K.M., Head, D., Gunning-Dixon, F., Raz, N. (2009). Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning. Neuropsychology, 23(4), 475-491.

Head, D., Kennedy, K. M., Rodrigue, K. M., Raz, N. (2009). Age-Differences in Perseveration: Cognitive and Neuroanatomical Mediators of Performance on the Wisconsin Card Sorting Test. Neuropsychologia, 47(4), 1200-1203.

Deshmukh, A. B., Rodrigue, K. M., Kennedy, K. M., Land, S., Jacobs, B. S., Raz, N. (2009). Synergistic Effects of the MTHFR C677T Polymorphism and Hypertension on Spatial Navigation. Biological Psychology, 80, 240-245.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Land, S. (2009). Genetic and Vascular Modifiers of Age-Sensitive Cognitive Skills: Effects of COMT, BDNF, ApoE and Hypertension. Neuropsychology, 23(1), 105-116.

Kennedy, K. M., Hope, K., Raz, N. (2009). Lifespan Adult Faces: Norms for Age, Familiarity, Memorability, Mood, and Picture Quality. Experimental Aging Research, 35(2), 268-275.

Raz, N., Kennedy, K.M. (2009). A systems approach to age-related change: Neuroanatomical changes, their modifiers, and cognitive correlates. In: W. Jagust, M. D’Esposito (Eds.) Imaging the Aging Brain, Ch 4, 43-70. New York, NY: Oxford University Press.
Kennedy, K. M., Erickson, K. I., Rodrigue, K. M., Voss, M. W., Colcombe, S. J., Kramer, A. F., Acker, J. D., Raz, N. (2009). Age-Related Differences in Regional Brain Volumes: A Comparison of Optimized Voxel-Based Morphometry to Manual Volumetry. Neurobiology of Aging, 30(10), 1657-1676.

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., Land, S., Jacobs, B. S. (2008). Brain-Derived Neurotrophic Factor Val66Met and Blood Glucose: A Synergistic Effect on Memory. Frontiers in Human Neuroscience, 2:12. doi:10.3389/neuro.09.012.2008.

Head, D., Rodrigue, K. M., Kennedy, K.M., Raz, N. (2008). Neuroanatomical and Cognitive Mediators of Age-Related Differences in Episodic Memory. Neuropsychology, 22(4), 491-507.

Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K. M., Kennedy, K. M., Acker, J. D. (2008). Neuroanatomical Correlates of Fluid Intelligence in Healthy Adults and Persons with Vascular Risk Factors. Cerebral Cortex 18, 718-726.

Kennedy, K.M., Partridge, T., Raz, N. (2008). Age-Related Differences in Acquisition of Perceptual-Motor Skills: Working Memory as a Mediator. Aging, Neuropsychology and Cognition, 15 (2), 165-183.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Acker, J. D. (2007). Vascular Health and Longitudinal Changes in Brain and Cognition in Middle-Aged and Older Adults. Neuropsychology, 21(2), 149-157.

Kennedy, K. M., Rodrigue, K. M., Raz, N. (2007). Fragmented Pictures Revisited: Long-term Changes in Repetition Priming, Relation to Skill Learning, and the Role of Cognitive Resources. Gerontology, 53(3), 148-158.

Moffat, S. D., Kennedy, K. M., Rodrigue, K. M., Raz, N. (2007). Age-Differences in Human Spatial Navigation: Extra-Hippocampal Contributions. Cerebral Cortex, 17, 1274-1282.

Rodrigue, K. M., Kennedy, K. M., Raz, N. (2005). Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults. Journal of Gerontology: Psychological Science, 60(4), P174-P181.

Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D. Acker, J.D. (2005). Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences, and Modifiers. Cerebral Cortex, 15(11), 1676-1689.

Kennedy, K. M., Raz, N. (2005). Age, Sex, and Regional Brain Volumes Predict Perceptual-motor Skill Acquisition in Healthy Adults. Cortex, Special Issue: Cognition and the Ageing Brain, 41(4), 560-569.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Acker, J. D. (2004). Hormone replacement therapy and age-related brain shrinkage: Regional effects. NeuroReport, 15 (16), 2531-2534.

Raz, N., Rodrigue, K. M., Head, D., Kennedy, K. M., Acker, J. D. (2004). Differential Changes in the Medial Temporal Structures: A Five-Year Longitudinal Study. Neurology, 62 (3) 433-438.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Head, D., Gunning-Dixon, F., Acker, J. D. (2003). Aging of the Human Striatum: Longitudinal Evidence. American Journal of Neuroradiology, 24, 1849-1856.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Head, D., Dahle, C., Acker, J. D. (2003). Age-Related Changes in the Regional Metencephalic Volumes in Humans: A Five-Year Follow-Up. Neuroscience Letters, 349 (3), 163-166.

Kennedy, K. M., Rodrigue, K. M., Davis, S. F. (2000). So you want to teach less in hopes of teaching more? College Student Journal, 34 (4), 626-632.

Kennedy, K. M., Nowak, S., Sundaram, R., Thomas, J., Davis, S. F. (2000). Academic dishonesty and distance learning: Student and faculty views. College Student Journal, 34 (2), 309-314.

Emerson, A. E., Kennedy, K. M. (1996). Embarrassment as a determination of prosocial behavior: The “clumsy shopper” model. Proceedings of the Tenth National Conference on Undergraduate Research, 1, 37.

Publications

  1. ncbi Hormone replacement therapy and age-related brain shrinkage: regional effects
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, 87 E Ferry St Detroit, MI 48202, USA
    Neuroreport 15:2531-4. 2004
  2. pmc Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI, USA
    Neuropsychologia 47:916-27. 2009
  3. pmc Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension
    Naftali Raz
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychology 23:105-16. 2009
  4. pmc Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychology 23:475-91. 2009
  5. pmc Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk
    Kristen M Kennedy
    Center for Brain Health, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA
    Brain Res 1297:41-56. 2009
  6. pmc BDNF Val66Met Polymorphism Influences Age Differences in Microstructure of the Corpus Callosum
    Kristen M Kennedy
    Center for Brain Health, School of Behavioral and Brain Sciences, The University of Texas at Dallas Dallas, TX, USA
    Front Hum Neurosci 3:19. 2009
  7. pmc Beta-amyloid deposition and the aging brain
    Karen M Rodrigue
    Center for BrainHealth, School of Behavioral and Brain Sciences, The University of Texas at Dallas, 2200 W Mockingbird Ln, Dallas, TX 75235, USA
    Neuropsychol Rev 19:436-50. 2009
  8. pmc Trajectories of brain aging in middle-aged and older adults: regional and individual differences
    Naftali Raz
    Institute of Gerontology, Wayne State University, USA
    Neuroimage 51:501-11. 2010
  9. pmc Hippocampal subfield volumes: age, vascular risk, and correlation with associative memory
    Yee Lee Shing
    Center for Lifespan Psychology, Max Planck Institute for Human Development Berlin, Germany
    Front Aging Neurosci 3:2. 2011
  10. pmc Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test
    Denise Head
    Department of Psychology, Washington University, St Louis, USA
    Neuropsychologia 47:1200-3. 2009

Detail Information

Publications22

  1. ncbi Hormone replacement therapy and age-related brain shrinkage: regional effects
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, 87 E Ferry St Detroit, MI 48202, USA
    Neuroreport 15:2531-4. 2004
    ..Future large scale studies may benefit from applying regional rather than global measures in assessment of brain integrity...
  2. pmc Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI, USA
    Neuropsychologia 47:916-27. 2009
    ..The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause...
  3. pmc Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension
    Naftali Raz
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychology 23:105-16. 2009
    ..The findings indicate that age-related cognitive performance is differentially affected by distinct genetic factors and their interactions with vascular health status...
  4. pmc Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychology 23:475-91. 2009
    ..The results indicate that age-related differences in perceptual priming and skill learning have dissociable cognitive and neural correlates...
  5. pmc Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk
    Kristen M Kennedy
    Center for Brain Health, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA
    Brain Res 1297:41-56. 2009
    ..Although the causal role of vascular risk in brain aging is unclear, the observed pattern of effects suggests that vascular risk may drive the expansion of age-related white matter damage from anterior to posterior regions...
  6. pmc BDNF Val66Met Polymorphism Influences Age Differences in Microstructure of the Corpus Callosum
    Kristen M Kennedy
    Center for Brain Health, School of Behavioral and Brain Sciences, The University of Texas at Dallas Dallas, TX, USA
    Front Hum Neurosci 3:19. 2009
    ..Those individuals with a genetic predisposition for decreased BDNF expression may not be able to fully benefit from BDNF-based plasticity and repair mechanisms...
  7. pmc Beta-amyloid deposition and the aging brain
    Karen M Rodrigue
    Center for BrainHealth, School of Behavioral and Brain Sciences, The University of Texas at Dallas, 2200 W Mockingbird Ln, Dallas, TX 75235, USA
    Neuropsychol Rev 19:436-50. 2009
    ..We review studies of Abeta deposition imaging in AD, MCI, and normal adults, its cognitive consequences, and the role of genetic risk and cognitive reserve...
  8. pmc Trajectories of brain aging in middle-aged and older adults: regional and individual differences
    Naftali Raz
    Institute of Gerontology, Wayne State University, USA
    Neuroimage 51:501-11. 2010
    ..In corpus callosum, shrinkage rate was greater in persons with hypertension, and in the pons, women and carriers of the ApoEepsilon4 allele exhibited declines not noted in the whole sample...
  9. pmc Hippocampal subfield volumes: age, vascular risk, and correlation with associative memory
    Yee Lee Shing
    Center for Lifespan Psychology, Max Planck Institute for Human Development Berlin, Germany
    Front Aging Neurosci 3:2. 2011
    ..We discuss the role of the DG in pattern separation and the formation of discrete memory representations...
  10. pmc Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test
    Denise Head
    Department of Psychology, Washington University, St Louis, USA
    Neuropsychologia 47:1200-3. 2009
    ..We conclude that age-related increase in perseveration is indeed differentially dependent on the integrity of prefrontal cortex and on declines in selected cognitive processes dependent on this region...
  11. pmc Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation
    Awantika Deshmukh
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, United States
    Biol Psychol 80:240-5. 2009
    ..These findings indicate that hypertension combined with a genetic vascular risk factor may significantly increase risk for cognitive impairment...
  12. pmc Neuroanatomical and cognitive mediators of age-related differences in episodic memory
    Denise Head
    Department of Psychology, Division of Biology and Biomedical Sciences, Washington University in St Louis, MO 63130, USA
    Neuropsychology 22:491-507. 2008
    ..No direct effects of age on episodic memory remained once these factors were taken into account. These analyses highlight the value of a multivariate approach with the understanding of complex relationships in cognitive and brain aging...
  13. ncbi Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Cereb Cortex 15:1676-89. 2005
    ..No sex differences in age trends except for the caudate were observed. We found no evidence of neuroprotective effects of larger brain size or educational attainment...
  14. ncbi Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults
    Karen M Rodrigue
    Institute of Gerontology, Wayne State University, 226 Knapp Building, 87 E Ferry St, Detroit MI 48202, USA
    J Gerontol B Psychol Sci Soc Sci 60:P174-81. 2005
    ..Moreover, those who maintained a processing speed comparable with that of the younger participants evidenced no age-related performance decrements on the mirror-drawing task...
  15. ncbi Age, sex and regional brain volumes predict perceptual-motor skill acquisition
    Kristen M Kennedy
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Cortex 41:560-9. 2005
    ..Thus, mirror-drawing represents a task that, despite its visual-spatial nature, favors women, and may exhibit sexually dimorphic brain substrates...
  16. ncbi Fragmented pictures revisited: long-term changes in repetition priming, relation to skill learning, and the role of cognitive resources
    Kristen M Kennedy
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Gerontology 53:148-58. 2007
    ..The common assumption, based on cross-sectional studies, is that these processes are only mildly (if at all) affected by age...
  17. ncbi Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, US
    Neuropsychology 21:149-57. 2007
    ..Thus, poor vascular health contributes to age-related declines in brain and cognition, and some of the age-related declines may be limited to persons with elevated vascular risk...
  18. pmc Neuroanatomical correlates of fluid intelligence in healthy adults and persons with vascular risk factors
    Naftali Raz
    Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
    Cereb Cortex 18:718-26. 2008
    ..VR was independently associated with smaller prefrontal volumes and lower fluid intelligence. Thus, prefrontal and medial-temporal systems may play different roles in age-related differences and changes in cognitive performance...
  19. ncbi Age-related differences in acquisition of perceptual-motor skills: working memory as a mediator
    Kristen M Kennedy
    Department of Psychology, Wayne State University, Detroit, MI 48202, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:165-83. 2008
    ..The third model provided the best fit to the data, indicating age differences in simple perceptual-motor skill are partially mediated by more complex abilities...
  20. pmc Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry
    Kristen M Kennedy
    Institute of Gerontology, Department of Psychology, Wayne State University, Detroit, MI, USA
    Neurobiol Aging 30:1657-76. 2009
    ..It may be beneficial to use VBM as a first-pass strategy, followed by manual measurement of anatomically defined regions...
  21. pmc Alterations in cerebral metabolic rate and blood supply across the adult lifespan
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cereb Cortex 21:1426-34. 2011
    ....
  22. pmc Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan
    Kristen M Kennedy
    Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, 1600 Viceroy Dr, Ste 800, Dallas, TX 75235, USA
    Neuroimage 62:1-8. 2012
    ....