Kristen Kennedy

Summary

Affiliation: University of Texas at Dallas
Location: DALLAS, United States
URL: http://vitallongevity.utdallas.edu/people/center-scientists/kristen.html
Publications:
Kennedy, K. M., Rodrigue, K.M., Devous, M. D., Sr., Hebrank, A. C., Bischof, G. N., & Park, D. C. (2012). Beta-Amyloid Burden is Associated with Altered Functional Activation During Encoding Across the Adult Lifespan. NeuroImage.

Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Sr., Rieck, J. R., Hebrank, A. C., Diaz-Arrastia, R., Mathews, D., & Park, D. C. (2012). ß-Amyloid Burden in Healthy Aging: Regional Distribution and Cognitive Consequences. Neurology, 78, 387-395.

Park, J., Carp, J., Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Huang, C. M., Rieck, J. R., Polk, T., & Park, D. C. (2012). Neural broadening or neural attenuation? Age-related dedifferentiation in the face network in a large lifespan sample. Journal of Neuroscience, 32, 2154-2158.

Peiying, L., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Park. D. C., & Lu, H. (in press). A comparison of physiologic modulators of fMRI signals. Human Brain Mapping.

Raz, N., Yang, Y., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Ghisletta, P. (2012). White Matter Deterioration in 15 months: Latent Growth Curve Models in Healthy Adults. Neurobiology of Aging, 33(2): 429.e1-429.e5, doi:10.1016/j.neurobiolaging.2010.11.018.

Shing, Y. L., Rodrigue, K. M., Kennedy, K. M., Fandakova, Y., Bodammer, N., Werkle-Bergner, M., Lindenberger, U., Raz, N. (2011). Hippocampal subfield volumes: Age, vascular risk, and correlation with associative memory. Frontiers in Aging Neuroscience, Feb 4;3:2. PMC303501.

Rodrigue, K. M. & Kennedy, K. M. (2011). The cognitive consequences of structural changes to the aging brain. In K. W. Schaie, S. L. Willis (Eds.) Handbook of the Psychology of Aging, 7th ed., Ch 5, 73-92, New York: Elsevier

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2011). Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging doi:10.1016/j.neurobiolaging.2009.05.015.

Lu, H., Xu, F., Rodrigue, K. M., Kennedy, K. M., Cheng, Y., Flicker, B., Hebrank, A. C., Uh, J., & Park, D. C. (2011). Alterations in cerebral metabolic rate and vascular function across the adult lifespan. Cerebral Cortex, 21: 1426-1434, doi: 10.1093/cercor/bhq224.

Raz, N., Ghisletta, P., Rodrigue, K. M. Kennedy, K. M., & Lindenberger, U. (2010). Trajectories of brain aging in middle-aged and older adults: Regional and individual differences. NeuroImage, 51, 501–511.

Ghisletta, P., Kennedy, K. M., Rodrigue, K.M., Lindenberger, U., & Raz, N. (2010). Adult Age Differences and Cognitive Resources in Perceptual-Motor Skill Acquisition: Application of a Multilevel Exponential Model. Journals of Gerontology: Psychological Sciences, 65B, (2), 163-173.

Rodrigue, K. M., Kennedy, K.M., & Park, D. C. (2009). Beta-amyloid deposition and the aging brain. Neuropsychology Review, 19, 436-450.

Kennedy, K.M., & Raz, N. (2009). Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Research, 1297, 41-56.

Kennedy, K. M., Rodrigue, K. M., Land, S., & Raz, N. (2009). BDNF val66met polymorphism influences age differences in microstructure of the corpus callosum. Frontiers in Human Neuroscience, 3:19. doi:10.3389/neuro.09.019.2009.

Kennedy, K.M. & Raz, N. (2009). Aging White Matter and Cognition: Differential Effects of Regional Variations in Diffusion Properties on Memory, Executive Functions, and Speed. Neuropsychologia, 47(3), 916-927.

Kennedy, K.M., Rodrigue, K.M., Head, D., Gunning-Dixon, F., Raz, N. (2009). Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning. Neuropsychology, 23(4), 475-491.

Head, D., Kennedy, K. M., Rodrigue, K. M., Raz, N. (2009). Age-Differences in Perseveration: Cognitive and Neuroanatomical Mediators of Performance on the Wisconsin Card Sorting Test. Neuropsychologia, 47(4), 1200-1203.

Deshmukh, A. B., Rodrigue, K. M., Kennedy, K. M., Land, S., Jacobs, B. S., Raz, N. (2009). Synergistic Effects of the MTHFR C677T Polymorphism and Hypertension on Spatial Navigation. Biological Psychology, 80, 240-245.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Land, S. (2009). Genetic and Vascular Modifiers of Age-Sensitive Cognitive Skills: Effects of COMT, BDNF, ApoE and Hypertension. Neuropsychology, 23(1), 105-116.

Kennedy, K. M., Hope, K., Raz, N. (2009). Lifespan Adult Faces: Norms for Age, Familiarity, Memorability, Mood, and Picture Quality. Experimental Aging Research, 35(2), 268-275.

Raz, N., Kennedy, K.M. (2009). A systems approach to age-related change: Neuroanatomical changes, their modifiers, and cognitive correlates. In: W. Jagust, M. D’Esposito (Eds.) Imaging the Aging Brain, Ch 4, 43-70. New York, NY: Oxford University Press.
Kennedy, K. M., Erickson, K. I., Rodrigue, K. M., Voss, M. W., Colcombe, S. J., Kramer, A. F., Acker, J. D., Raz, N. (2009). Age-Related Differences in Regional Brain Volumes: A Comparison of Optimized Voxel-Based Morphometry to Manual Volumetry. Neurobiology of Aging, 30(10), 1657-1676.

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., Land, S., Jacobs, B. S. (2008). Brain-Derived Neurotrophic Factor Val66Met and Blood Glucose: A Synergistic Effect on Memory. Frontiers in Human Neuroscience, 2:12. doi:10.3389/neuro.09.012.2008.

Head, D., Rodrigue, K. M., Kennedy, K.M., Raz, N. (2008). Neuroanatomical and Cognitive Mediators of Age-Related Differences in Episodic Memory. Neuropsychology, 22(4), 491-507.

Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K. M., Kennedy, K. M., Acker, J. D. (2008). Neuroanatomical Correlates of Fluid Intelligence in Healthy Adults and Persons with Vascular Risk Factors. Cerebral Cortex 18, 718-726.

Kennedy, K.M., Partridge, T., Raz, N. (2008). Age-Related Differences in Acquisition of Perceptual-Motor Skills: Working Memory as a Mediator. Aging, Neuropsychology and Cognition, 15 (2), 165-183.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Acker, J. D. (2007). Vascular Health and Longitudinal Changes in Brain and Cognition in Middle-Aged and Older Adults. Neuropsychology, 21(2), 149-157.

Kennedy, K. M., Rodrigue, K. M., Raz, N. (2007). Fragmented Pictures Revisited: Long-term Changes in Repetition Priming, Relation to Skill Learning, and the Role of Cognitive Resources. Gerontology, 53(3), 148-158.

Moffat, S. D., Kennedy, K. M., Rodrigue, K. M., Raz, N. (2007). Age-Differences in Human Spatial Navigation: Extra-Hippocampal Contributions. Cerebral Cortex, 17, 1274-1282.

Rodrigue, K. M., Kennedy, K. M., Raz, N. (2005). Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults. Journal of Gerontology: Psychological Science, 60(4), P174-P181.

Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D. Acker, J.D. (2005). Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences, and Modifiers. Cerebral Cortex, 15(11), 1676-1689.

Kennedy, K. M., Raz, N. (2005). Age, Sex, and Regional Brain Volumes Predict Perceptual-motor Skill Acquisition in Healthy Adults. Cortex, Special Issue: Cognition and the Ageing Brain, 41(4), 560-569.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Acker, J. D. (2004). Hormone replacement therapy and age-related brain shrinkage: Regional effects. NeuroReport, 15 (16), 2531-2534.

Raz, N., Rodrigue, K. M., Head, D., Kennedy, K. M., Acker, J. D. (2004). Differential Changes in the Medial Temporal Structures: A Five-Year Longitudinal Study. Neurology, 62 (3) 433-438.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Head, D., Gunning-Dixon, F., Acker, J. D. (2003). Aging of the Human Striatum: Longitudinal Evidence. American Journal of Neuroradiology, 24, 1849-1856.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Head, D., Dahle, C., Acker, J. D. (2003). Age-Related Changes in the Regional Metencephalic Volumes in Humans: A Five-Year Follow-Up. Neuroscience Letters, 349 (3), 163-166.

Kennedy, K. M., Rodrigue, K. M., Davis, S. F. (2000). So you want to teach less in hopes of teaching more? College Student Journal, 34 (4), 626-632.

Kennedy, K. M., Nowak, S., Sundaram, R., Thomas, J., Davis, S. F. (2000). Academic dishonesty and distance learning: Student and faculty views. College Student Journal, 34 (2), 309-314.

Emerson, A. E., Kennedy, K. M. (1996). Embarrassment as a determination of prosocial behavior: The “clumsy shopper” model. Proceedings of the Tenth National Conference on Undergraduate Research, 1, 37.

Publications

  1. Kennedy K, Partridge T, Raz N. Age-related differences in acquisition of perceptual-motor skills: working memory as a mediator. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2008;15:165-83 pubmed
    ..The third model provided the best fit to the data, indicating age differences in simple perceptual-motor skill are partially mediated by more complex abilities. ..
  2. Raz N, Rodrigue K, Kennedy K, Acker J. Hormone replacement therapy and age-related brain shrinkage: regional effects. Neuroreport. 2004;15:2531-4 pubmed
    ..Future large scale studies may benefit from applying regional rather than global measures in assessment of brain integrity. ..
  3. Rodrigue K, Kennedy K, Raz N. Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults. J Gerontol B Psychol Sci Soc Sci. 2005;60:P174-81 pubmed
    ..Moreover, those who maintained a processing speed comparable with that of the younger participants evidenced no age-related performance decrements on the mirror-drawing task. ..
  4. Kennedy K, Raz N. Age, sex and regional brain volumes predict perceptual-motor skill acquisition. Cortex. 2005;41:560-9 pubmed
    ..Thus, mirror-drawing represents a task that, despite its visual-spatial nature, favors women, and may exhibit sexually dimorphic brain substrates. ..
  5. Shing Y, Rodrigue K, Kennedy K, Fandakova Y, Bodammer N, Werkle Bergner M, et al. Hippocampal subfield volumes: age, vascular risk, and correlation with associative memory. Front Aging Neurosci. 2011;3:2 pubmed publisher
    ..We discuss the role of the DG in pattern separation and the formation of discrete memory representations. ..
  6. Rodrigue K, Kennedy K, Park D. Beta-amyloid deposition and the aging brain. Neuropsychol Rev. 2009;19:436-50 pubmed publisher
    ..We review studies of Abeta deposition imaging in AD, MCI, and normal adults, its cognitive consequences, and the role of genetic risk and cognitive reserve. ..
  7. Kennedy K, Erickson K, Rodrigue K, Voss M, Colcombe S, Kramer A, et al. Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry. Neurobiol Aging. 2009;30:1657-76 pubmed publisher
    ..It may be beneficial to use VBM as a first-pass strategy, followed by manual measurement of anatomically defined regions. ..
  8. Kennedy K, Raz N. Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Res. 2009;1297:41-56 pubmed publisher
    ..Although the causal role of vascular risk in brain aging is unclear, the observed pattern of effects suggests that vascular risk may drive the expansion of age-related white matter damage from anterior to posterior regions. ..
  9. Deshmukh A, Rodrigue K, Kennedy K, Land S, Jacobs B, Raz N. Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation. Biol Psychol. 2009;80:240-5 pubmed publisher
    ..These findings indicate that hypertension combined with a genetic vascular risk factor may significantly increase risk for cognitive impairment. ..

More Information

Publications26

  1. Head D, Kennedy K, Rodrigue K, Raz N. Age differences in perseveration: cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test. Neuropsychologia. 2009;47:1200-3 pubmed publisher
    ..We conclude that age-related increase in perseveration is indeed differentially dependent on the integrity of prefrontal cortex and on declines in selected cognitive processes dependent on this region. ..
  2. Kennedy K, Raz N. Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia. 2009;47:916-27 pubmed publisher
    ..The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause. ..
  3. Raz N, Rodrigue K, Kennedy K, Land S. Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension. Neuropsychology. 2009;23:105-16 pubmed publisher
    ..The findings indicate that age-related cognitive performance is differentially affected by distinct genetic factors and their interactions with vascular health status. ..
  4. Kennedy K, Rodrigue K, Head D, Gunning Dixon F, Raz N. Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning. Neuropsychology. 2009;23:475-91 pubmed publisher
    ..The results indicate that age-related differences in perceptual priming and skill learning have dissociable cognitive and neural correlates. ..
  5. Raz N, Lindenberger U, Rodrigue K, Kennedy K, Head D, Williamson A, et al. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex. 2005;15:1676-89 pubmed
    ..No sex differences in age trends except for the caudate were observed. We found no evidence of neuroprotective effects of larger brain size or educational attainment. ..
  6. Kennedy K, Rodrigue K, Land S, Raz N. BDNF Val66Met polymorphism influences age differences in microstructure of the Corpus Callosum. Front Hum Neurosci. 2009;3:19 pubmed publisher
    ..Those individuals with a genetic predisposition for decreased BDNF expression may not be able to fully benefit from BDNF-based plasticity and repair mechanisms. ..
  7. Raz N, Lindenberger U, Ghisletta P, Rodrigue K, Kennedy K, Acker J. Neuroanatomical correlates of fluid intelligence in healthy adults and persons with vascular risk factors. Cereb Cortex. 2008;18:718-26 pubmed
    ..VR was independently associated with smaller prefrontal volumes and lower fluid intelligence. Thus, prefrontal and medial-temporal systems may play different roles in age-related differences and changes in cognitive performance. ..
  8. Raz N, Rodrigue K, Kennedy K, Acker J. Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults. Neuropsychology. 2007;21:149-57 pubmed
    ..Thus, poor vascular health contributes to age-related declines in brain and cognition, and some of the age-related declines may be limited to persons with elevated vascular risk. ..
  9. Kennedy K, Rodrigue K, Raz N. Fragmented pictures revisited: long-term changes in repetition priming, relation to skill learning, and the role of cognitive resources. Gerontology. 2007;53:148-58 pubmed
    ..Contrary to cross-sectional results, this longitudinal study suggests perceptual repetition priming is not an age-invariant phenomenon and advanced age and reduced availability of cognitive resources may contribute to its decline. ..
  10. Head D, Rodrigue K, Kennedy K, Raz N. Neuroanatomical and cognitive mediators of age-related differences in episodic memory. Neuropsychology. 2008;22:491-507 pubmed publisher
    ..No direct effects of age on episodic memory remained once these factors were taken into account. These analyses highlight the value of a multivariate approach with the understanding of complex relationships in cognitive and brain aging. ..
  11. Raz N, Ghisletta P, Rodrigue K, Kennedy K, Lindenberger U. Trajectories of brain aging in middle-aged and older adults: regional and individual differences. Neuroimage. 2010;51:501-11 pubmed publisher
    ..In corpus callosum, shrinkage rate was greater in persons with hypertension, and in the pons, women and carriers of the ApoEepsilon4 allele exhibited declines not noted in the whole sample. ..
  12. Kennedy K, Foster C, Rodrigue K. Increasing beta-amyloid deposition in cognitively healthy aging predicts nonlinear change in BOLD modulation to difficulty. Neuroimage. 2018;183:142-149 pubmed publisher
  13. Kennedy K, Reese E, Horn M, Sizemore A, Unni A, Meerbrey M, et al. BDNF val66met polymorphism affects aging of multiple types of memory. Brain Res. 2015;1612:104-17 pubmed publisher
    ..This article is part of a Special Issue entitled Memory & Aging. ..
  14. Kennedy K, Rodrigue K, Bischof G, Hebrank A, Reuter Lorenz P, Park D. Age trajectories of functional activation under conditions of low and high processing demands: an adult lifespan fMRI study of the aging brain. Neuroimage. 2015;104:21-34 pubmed publisher
  15. Kennedy K, Rodrigue K, Devous M, Hebrank A, Bischof G, Park D. Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan. Neuroimage. 2012;62:1-8 pubmed publisher
  16. Rieck J, Rodrigue K, Boylan M, Kennedy K. Age-related reduction of BOLD modulation to cognitive difficulty predicts poorer task accuracy and poorer fluid reasoning ability. Neuroimage. 2017;147:262-271 pubmed publisher
    ..Age-related preservation of coupled modulation in both cognitive control regions and regions typically associated with default network may be a salient marker of how the brain adapts to maintain cognitive function as we age. ..
  17. Kennedy K, Boylan M, Rieck J, Foster C, Rodrigue K. Dynamic range in BOLD modulation: lifespan aging trajectories and association with performance. Neurobiol Aging. 2017;60:153-163 pubmed publisher