Jeffrey S Kennedy

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Induction of human T cell-mediated immune responses after primary and secondary smallpox vaccination
    Jeffrey S Kennedy
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Infect Dis 190:1286-94. 2004
  2. pmc Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers
    Shixia Wang
    Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Vaccine 26:3947-57. 2008
  3. ncbi request reprint Identification of vaccinia CD8+ T-cell epitopes conserved among vaccinia and variola viruses restricted by common MHC class I molecules, HLA-A2 or HLA-B7
    Masanori Terajima
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, 01655, USA
    Hum Immunol 67:512-20. 2006
  4. ncbi request reprint Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:2212-9. 2005
  5. pmc Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses
    Masanori Terajima
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    J Exp Med 197:927-32. 2003
  6. pmc The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteers
    Jeffrey S Kennedy
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
    Vaccine 26:4420-4. 2008
  7. pmc Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers
    Shixia Wang
    Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Vaccine 26:1098-110. 2008
  8. pmc Clinical and immunologic responses to multiple doses of IMVAMUNE (Modified Vaccinia Ankara) followed by Dryvax challenge
    Sharon E Frey
    Department of Medicine, Saint Louis University School of Medicine and National Institute of Allergy and Infectious Diseases Vaccine Treatment and Evaluation Unit, 1100 S Grand Blvd DRC 8, St Louis, MO 63104, USA
    Vaccine 25:8562-73. 2007
  9. pmc Immunological memory after exposure to variola virus, monkeypox virus, and vaccinia virus
    Sumathi Sivapalasingam
    Division of Infectious Disease, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 195:1151-9. 2007
  10. ncbi request reprint Dose-related effects of smallpox vaccine
    Sharon E Frey
    Department of Medicine, National Institute of Allergy and Infectious Diseases Vaccine and Treatment Evaluation Unit, Saint Louis University School of Medicine, St Louis, USA
    N Engl J Med 346:1275-80. 2002

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Induction of human T cell-mediated immune responses after primary and secondary smallpox vaccination
    Jeffrey S Kennedy
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Infect Dis 190:1286-94. 2004
    ..Postvaccination cell-mediated immune (CMI) responses have not been compared by use of controlled trials in previously vaccinated (vaccinia-nonnaive) and nonvaccinated (vaccinia-naive) individuals...
  2. pmc Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers
    Shixia Wang
    Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Vaccine 26:3947-57. 2008
    ....
  3. ncbi request reprint Identification of vaccinia CD8+ T-cell epitopes conserved among vaccinia and variola viruses restricted by common MHC class I molecules, HLA-A2 or HLA-B7
    Masanori Terajima
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, 01655, USA
    Hum Immunol 67:512-20. 2006
    ..Combined with previous reports by us and others, these results show that there are some vaccinia viral proteins containing multiple epitopes restricted by different MHC molecules of humans and mice...
  4. ncbi request reprint Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:2212-9. 2005
    ..Identification of T cell epitopes on VV will enable further studies to increase our understanding of the role of CD8+ T cells in VV infection and assist in the design of new protective strategies...
  5. pmc Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses
    Masanori Terajima
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    J Exp Med 197:927-32. 2003
    ..This information will be useful for studies of human T cell memory and for the design and analyses of the immunogenicity of experimental vaccinia vaccines...
  6. pmc The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteers
    Jeffrey S Kennedy
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
    Vaccine 26:4420-4. 2008
    ..Questions remain regarding the cause of the vasculitis, but the unique DTH observation may have contributed to the high level of immune responses previously reported for this vaccine...
  7. pmc Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers
    Shixia Wang
    Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Vaccine 26:1098-110. 2008
    ....
  8. pmc Clinical and immunologic responses to multiple doses of IMVAMUNE (Modified Vaccinia Ankara) followed by Dryvax challenge
    Sharon E Frey
    Department of Medicine, Saint Louis University School of Medicine and National Institute of Allergy and Infectious Diseases Vaccine Treatment and Evaluation Unit, 1100 S Grand Blvd DRC 8, St Louis, MO 63104, USA
    Vaccine 25:8562-73. 2007
    ..IMVAMUNE vaccination prior to Dryvax reduced virus replication at the Dryvax site, decreased the size of the primary cutaneous lesion, and decreased the time to healing but did not completely ameliorate the immune response...
  9. pmc Immunological memory after exposure to variola virus, monkeypox virus, and vaccinia virus
    Sumathi Sivapalasingam
    Division of Infectious Disease, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 195:1151-9. 2007
    ..Survivors of variola virus infection demonstrated VV-specific CD4 memory cell responses and neutralizing antibodies >40 years after infection...
  10. ncbi request reprint Dose-related effects of smallpox vaccine
    Sharon E Frey
    Department of Medicine, National Institute of Allergy and Infectious Diseases Vaccine and Treatment Evaluation Unit, Saint Louis University School of Medicine, St Louis, USA
    N Engl J Med 346:1275-80. 2002
    ....
  11. ncbi request reprint Immune status in a primary smallpox vaccinee who failed to develop an immunization site reaction
    John M Kelso
    JAMA 293:677-8. 2005
  12. ncbi request reprint Safety and immunogenicity of new cell-cultured smallpox vaccine compared with calf-lymph derived vaccine: a blind, single-centre, randomised controlled trial
    Richard N Greenberg
    Medicine Service, Department of Veterans Affairs Medical Center, Lexington, KY, USA
    Lancet 365:398-409. 2005
    ..We aimed to compare the safety and immunogenicity of the new cell-cultured smallpox vaccine (CCSV) to that of the calf-lymph derived vaccine (as a positive control) in 350 healthy, adult volunteers...
  13. ncbi request reprint ACAM2000: a newly licensed cell culture-based live vaccinia smallpox vaccine
    Richard N Greenberg
    University of Kentucky School of Medicine, Department of Medicine, Room MN 672, 800 Rose Street, Lexington, KY 40536 0084, USA
    Expert Opin Investig Drugs 17:555-64. 2008
    ..Federally funded work by Acambis, Inc. resulted in FDA approval for ACAM2000 in August 2007...
  14. ncbi request reprint Clonal vaccinia virus grown in cell culture as a new smallpox vaccine
    Richard Weltzin
    Acambis Inc, 38 Sidney Street, Cambridge, Massachusetts 02139, USA
    Nat Med 9:1125-30. 2003
    ..The vaccines were equivalent in their ability to produce major cutaneous reactions ('takes') and to induce neutralizing antibody and cell-mediated immunity against vaccinia virus...
  15. pmc A live, attenuated recombinant West Nile virus vaccine
    Thomas P Monath
    Acambis, 38 Sidney Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:6694-9. 2006
    ..ChimeriVax-WN02 rapidly elicits strong immune responses after a single dose, and is a promising candidate warranting further evaluation for prevention of WN disease...