Ann Kennedy

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint The Bowman-Birk inhibitor from soybeans as an anticarcinogenic agent
    A R Kennedy
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Clin Nutr 68:1406S-1412S. 1998
  2. pmc Induction of cytokine gene expression in human thyroid epithelial cells irradiated with HZE particles (iron ions)
    Jenine K Sanzari
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Radiat Res 172:437-43. 2009
  3. pmc Relative biological effectiveness of simulated solar particle event proton radiation to induce acute hematological change in the porcine model
    Jenine K Sanzari
    Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    J Radiat Res 55:228-44. 2014
  4. doi request reprint Ground-based microgravity and proton radiation exposure alters leukocyte activity
    Jenine K Sanzari
    Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072
    J Radiat Res 55:i94. 2014
  5. doi request reprint Acute effects of solar particle event radiation
    Ann R Kennedy
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Radiat Res 55:i66-i67. 2014
  6. pmc Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure
    Jenine K Sanzari
    Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e71757. 2013
  7. ncbi request reprint Factors that modify radiation-induced carcinogenesis
    Ann R Kennedy
    University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Health Phys 97:433-45. 2009
  8. pmc Effects of dietary antioxidant supplementation on the development of malignant lymphoma and other neoplastic lesions in mice exposed to proton or iron-ion radiation
    Ann R Kennedy
    Department of Radiation Oncology, Universtiy of Pennsylvania School of Medicine, Philadelphia, PA 19104 6072, USA
    Radiat Res 169:615-25. 2008
  9. ncbi request reprint Protection against adverse biological effects induced by space radiation by the Bowman-Birk inhibitor and antioxidants
    Ann R Kennedy
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 166:327-32. 2006
  10. ncbi request reprint Countermeasures against space radiation induced oxidative stress in mice
    A R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Radiat Environ Biophys 46:201-3. 2007

Research Grants

  1. RADIATION BIOLOGY TRAINING GRANT
    Ann Kennedy; Fiscal Year: 2007

Collaborators

Detail Information

Publications42

  1. ncbi request reprint The Bowman-Birk inhibitor from soybeans as an anticarcinogenic agent
    A R Kennedy
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Clin Nutr 68:1406S-1412S. 1998
    ..34671; sponsor, Ann R Kennedy), and studies to evaluate BBIC as an anticarcinogenic agent in human populations began. Both BBI and BBIC prevent and suppress malignant transformation in vitro and carcinogenesis in vivo without toxicity...
  2. pmc Induction of cytokine gene expression in human thyroid epithelial cells irradiated with HZE particles (iron ions)
    Jenine K Sanzari
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Radiat Res 172:437-43. 2009
    ..It is concluded that SeM can regulate ionizing radiation-induced gene expression and may serve as an effective countermeasure for some of the acute inflammatory/immune responses induced by low-dose HZE-particle radiation...
  3. pmc Relative biological effectiveness of simulated solar particle event proton radiation to induce acute hematological change in the porcine model
    Jenine K Sanzari
    Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    J Radiat Res 55:228-44. 2014
    ....
  4. doi request reprint Ground-based microgravity and proton radiation exposure alters leukocyte activity
    Jenine K Sanzari
    Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072
    J Radiat Res 55:i94. 2014
    ..Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure. PLoS One. 2013;8(8):e71757. doi:10.1371/journal.pone.0071757. ..
  5. doi request reprint Acute effects of solar particle event radiation
    Ann R Kennedy
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Radiat Res 55:i66-i67. 2014
    ..For high dose rate SPE proton radiation, the threshold value for retching was 75 cGy, and for ferret vomiting, it was 1 Gy. ..
  6. pmc Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure
    Jenine K Sanzari
    Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e71757. 2013
    ..This investigation is one of the first to report on combined proton radiation and simulated microgravity effects on hematopoietic, specifically immune cells. ..
  7. ncbi request reprint Factors that modify radiation-induced carcinogenesis
    Ann R Kennedy
    University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Health Phys 97:433-45. 2009
    ..It is known that dietary factors play an important role in determining the yields of radiation-induced cancers in animal model systems, and it is likely that they also influence radiation-induced cancer risks in human populations...
  8. pmc Effects of dietary antioxidant supplementation on the development of malignant lymphoma and other neoplastic lesions in mice exposed to proton or iron-ion radiation
    Ann R Kennedy
    Department of Radiation Oncology, Universtiy of Pennsylvania School of Medicine, Philadelphia, PA 19104 6072, USA
    Radiat Res 169:615-25. 2008
    ..These results suggest that dietary supplements could be useful in the prevention of malignancies and other neoplastic lesions developing from exposure to space radiation...
  9. ncbi request reprint Protection against adverse biological effects induced by space radiation by the Bowman-Birk inhibitor and antioxidants
    Ann R Kennedy
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 166:327-32. 2006
    ....
  10. ncbi request reprint Countermeasures against space radiation induced oxidative stress in mice
    A R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Radiat Environ Biophys 46:201-3. 2007
    ....
  11. ncbi request reprint Selenomethionine protects against adverse biological effects induced by space radiation
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA, USA
    Free Radic Biol Med 36:259-66. 2004
    ....
  12. ncbi request reprint Effects of spermine-conjugated Bowman-Birk inhibitor (spermine-BBI) on carcinogenesis and cholesterol biosynthesis in mice
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharm Res 20:1908-10. 2003
    ....
  13. ncbi request reprint Effects of the Bowman-Birk inhibitor on growth, invasion, and clonogenic survival of human prostate epithelial cells and prostate cancer cells
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Prostate 50:125-33. 2002
    ..The Bowman-Birk inhibitor (BBI) is a soybean-derived serine protease inhibitor with demonstrated anticarcinogenic activity in both in vitro and in vivo systems...
  14. ncbi request reprint Effects of Bowman-Birk inhibitor on rat colon carcinogenesis
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nutr Cancer 43:174-86. 2002
    ..No adverse side effects on the pancreas or animal growth were observed in rats treated with PBBI or BBIC. These results demonstrate that PBBI and BBIC may be used to prevent colon cancer without significant adverse side effects...
  15. ncbi request reprint Suppression of the later stages of radiation-induced carcinogenesis by antioxidant dietary formulations
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Radiat Res 176:62-70. 2011
    ....
  16. ncbi request reprint L-selenomethionine modulates high LET radiation-induced alterations of gene expression in cultured human thyroid cells
    Jelena Stewart
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6072, USA
    Oncol Rep 16:569-74. 2006
    ..This study provides a basis for furthering our knowledge about radiation-induced molecular and cellular changes that lead to cellular transformation and death...
  17. ncbi request reprint Effects of dietary supplements on the space radiation-induced reduction in total antioxidant status in CBA mice
    Jun Guan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 165:373-8. 2006
    ..These results indicate that BBIC, L-SeM and the selected antioxidant combinations may serve as countermeasures for space radiation-induced adverse biological effects...
  18. pmc Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival
    Chris O Wambi
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Radiat Res 172:175-86. 2009
    ..Taken together, oral supplementation with antioxidants appears to be an effective approach for radioprotection of hematopoietic cells and improvement of animal survival after proton TBI...
  19. pmc Using electron beam radiation to simulate the dose distribution for whole body solar particle event proton exposure
    Keith A Cengel
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Radiat Environ Biophys 49:715-21. 2010
    ..These studies will help to better define the topography of the time-dose-fractionation versus biological response landscape for astronaut exposure to an SPE...
  20. doi request reprint Dietary supplements reduce the cataractogenic potential of proton and HZE-particle radiation in mice
    James G Davis
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Radiat Res 173:353-61. 2010
    ..These results indicate that BBIC and the antioxidant formulation evaluated in this study could be useful for protecting astronauts against space radiation-induced cataracts during or after long-term manned space missions...
  21. ncbi request reprint Establishment of human cancer cell clones with different characteristics: a model for screening chemopreventive agents
    Jeffrey H Ware
    Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Anticancer Res 27:1-16. 2007
    ....
  22. ncbi request reprint Evaluation of cancer chemopreventive agents using clones derived from a human prostate cancer cell line
    Jeffrey H Ware
    Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Anticancer Res 26:4177-83. 2006
    ..The successful use of clonal selection through fluctuation analysis of human cancer cells as a means for studying tumor progression has been previously reported...
  23. ncbi request reprint Detection of Bowman-Birk inhibitor and anti-Bowman-Birk inhibitor antibodies in sera of humans and animals treated with Bowman-Birk inhibitor concentrate
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nutr Cancer 43:167-73. 2002
    ..These results suggest that orally ingested BBI is absorbed by human subjects and animals and that some animals develop antibodies to BBI in response to treatment with BBIC...
  24. ncbi request reprint Biological countermeasures in space radiation health
    Ann R Kennedy
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Gravit Space Biol Bull 16:37-44. 2003
    ..Research related to the dietary additions of agents to minimize the risks of developing health-related problems which can result from exposure to space radiations is reviewed...
  25. ncbi request reprint In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells
    X Steven Wan
    University of Pennsylvania, Philadelphia, PA 19104 6072, USA
    Oncol Rep 10:2009-14. 2003
    ....
  26. ncbi request reprint Effect of the Bowman-Birk inhibitor (a soy protein) on in vitro bladder neck/urethral and penile corporal smooth muscle activity
    S Bruce Malkowicz
    Division of Urology, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurourol Urodyn 22:54-7. 2003
    ..There have been anecdotal reports from patients of improved voiding and sexual functions in the ongoing BBIC trials. The objective of this study was to quantify the effect of BBI and BBIC on urethral and corporal smooth muscle activity...
  27. ncbi request reprint Three immunoassays based on monoclonal antibodies specific for prostate specific antigen (PSA), alpha-1-antichymotrypsin (ACT), and the PSA-ACT complex
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Prostate 56:131-41. 2003
    ....
  28. ncbi request reprint Protection against radiation-induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agents
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 64:1475-81. 2006
    ..To evaluate the protective effects of antioxidant agents against space radiation-induced oxidative stress in cultured human epithelial cells...
  29. pmc Effects of selenomethionine on the gene expression profile of cloned human prostate cancer cells representing a phenotypic continuum of cancer progression
    Jelena Stewart
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6072, USA
    Nutr Cancer 60:826-36. 2008
    ....
  30. pmc Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation
    Chris Wambi
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Radiat Res 169:384-96. 2008
    ....
  31. ncbi request reprint Establishment and characterization of sublines of LNCaP human prostate cancer cells
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19083, USA
    Oncol Rep 10:1569-75. 2003
    ....
  32. ncbi request reprint Adaptation of the dichlorofluorescein assay for detection of radiation-induced oxidative stress in cultured cells
    X Steven Wan
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 160:622-30. 2003
    ..These results indicate that the DCF assay optimized in this study is highly sensitive, linear and specific for measuring oxidative stress in irradiated cells...
  33. ncbi request reprint Bowman-Birk inhibitor concentrate: a novel therapeutic agent for patients with active ulcerative colitis
    Gary R Lichtenstein
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Dig Dis Sci 53:175-80. 2008
    ..22). No severe adverse events were observed. This trial suggests a potential benefit over placebo for both achieving clinical response and induction of remission in patients with active ulcerative colitis without apparent toxicity...
  34. ncbi request reprint Attenuation of skeletal muscle atrophy via protease inhibition
    Carl A Morris
    Dept of Physiology and the Pennsylvania Muscle Institute, Univ of Pennsylvania School of Medicine, A 700 Richards Bldg, 3700 Hamilton Walk, Philadelphia, PA 19104 6085, USA
    J Appl Physiol 99:1719-27. 2005
    ..Thus BBI is a candidate therapeutic agent to minimize skeletal muscle atrophy and loss of strength associated with disuse, cachexia, sepsis, weightlessness, or the combination of age and inactivity...
  35. pmc Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo
    Niklas Finnberg
    Laboratory of Molecular Oncology and Cell Cycle Regulation, The Institute for Translational Medicine and Therapeutics, The Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 7:2023-33. 2008
    ..In contrast to PR, GR may, in a cell type specific manner, trigger a more diverse non-random stress-response that mediates apoptosis partially independent of the extent of DNA damage...
  36. ncbi request reprint Development of the Bowman-Birk inhibitor for oral cancer chemoprevention and analysis of Neu immunohistochemical staining intensity with Bowman-Birk inhibitor concentrate treatment
    William B Armstrong
    Department of Otolaryngology Head and Neck Surgery, Chao Family Comprehensive Cancer Center, University of California Irvine, 101 The City DriveSouth, Bldg 25, Suite 191, Orange, CA 92868, USA
    Laryngoscope 113:1687-702. 2003
    ....
  37. ncbi request reprint Bowman-Birk inhibitor concentrate prevents atrophy, weakness, and oxidative stress in soleus muscle of hindlimb-unloaded mice
    Sandrine Arbogast
    Dept of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    J Appl Physiol 102:956-64. 2007
    ..We conclude that dietary supplementation with BBIC protects skeletal muscle during prolonged unloading, promoting redox homeostasis in muscle fibers and blunting atrophy-induced weakness...
  38. ncbi request reprint Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats
    Jun Guan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Radiat Res 162:572-9. 2004
    ....
  39. ncbi request reprint Detection of oxidative stress induced by low- and high-linear energy transfer radiation in cultured human epithelial cells
    X Steven Wan
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 163:364-8. 2005
    ....
  40. ncbi request reprint Standardization of a fluorometric assay for measuring oxidative stress in irradiated cells
    X Steven Wan
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 163:232-40. 2005
    ....

Research Grants5

  1. RADIATION BIOLOGY TRAINING GRANT
    Ann Kennedy; Fiscal Year: 2007
    ..It is expected that graduates of the training program will continue with their research and academic careers in radiation biology and oncology. ..