Research Topics
| Ann KennedySummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
The Bowman-Birk inhibitor from soybeans as an anticarcinogenic agentA R Kennedy
University of Pennsylvania School of Medicine, Philadelphia, USA
Am J Clin Nutr 68:1406S-1412S. 1998..34671; sponsor, Ann R Kennedy), and studies to evaluate BBIC as an anticarcinogenic agent in human populations began. Both BBI and BBIC prevent and suppress malignant transformation in vitro and carcinogenesis in vivo without toxicity...
Factors that modify radiation-induced carcinogenesisAnn R Kennedy
University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
Health Phys 97:433-45. 2009..It is known that dietary factors play an important role in determining the yields of radiation-induced cancers in animal model systems, and it is likely that they also influence radiation-induced cancer risks in human populations...
Effects of dietary antioxidant supplementation on the development of malignant lymphoma and other neoplastic lesions in mice exposed to proton or iron-ion radiationAnn R Kennedy
Department of Radiation Oncology, Universtiy of Pennsylvania School of Medicine, Philadelphia, PA 19104 6072, USA
Radiat Res 169:615-25. 2008..These results suggest that dietary supplements could be useful in the prevention of malignancies and other neoplastic lesions developing from exposure to space radiation...- Countermeasures against space radiation induced oxidative stress in miceA R Kennedy
Department of Radiation Oncology, University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
Radiat Environ Biophys 46:201-3. 2007.... - Protection against adverse biological effects induced by space radiation by the Bowman-Birk inhibitor and antioxidantsAnn R Kennedy
Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Radiat Res 166:327-32. 2006.... - Suppression of the later stages of radiation-induced carcinogenesis by antioxidant dietary formulationsAnn R Kennedy
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
Radiat Res 176:62-70. 2011.... - Selenomethionine protects against adverse biological effects induced by space radiationAnn R Kennedy
Department of Radiation Oncology, University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA, USA
Free Radic Biol Med 36:259-66. 2004.... - Effects of spermine-conjugated Bowman-Birk inhibitor (spermine-BBI) on carcinogenesis and cholesterol biosynthesis in miceAnn R Kennedy
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharm Res 20:1908-10. 2003.... - Effects of Bowman-Birk inhibitor on rat colon carcinogenesisAnn R Kennedy
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Nutr Cancer 43:174-86. 2002..No adverse side effects on the pancreas or animal growth were observed in rats treated with PBBI or BBIC. These results demonstrate that PBBI and BBIC may be used to prevent colon cancer without significant adverse side effects... - Effects of the Bowman-Birk inhibitor on growth, invasion, and clonogenic survival of human prostate epithelial cells and prostate cancer cellsAnn R Kennedy
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
Prostate 50:125-33. 2002..The Bowman-Birk inhibitor (BBI) is a soybean-derived serine protease inhibitor with demonstrated anticarcinogenic activity in both in vitro and in vivo systems... - L-selenomethionine modulates high LET radiation-induced alterations of gene expression in cultured human thyroid cellsJelena Stewart
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6072, USA
Oncol Rep 16:569-74. 2006..This study provides a basis for furthering our knowledge about radiation-induced molecular and cellular changes that lead to cellular transformation and death... - Effects of dietary supplements on the space radiation-induced reduction in total antioxidant status in CBA miceJun Guan
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Radiat Res 165:373-8. 2006..These results indicate that BBIC, L-SeM and the selected antioxidant combinations may serve as countermeasures for space radiation-induced adverse biological effects... - Induction of cytokine gene expression in human thyroid epithelial cells irradiated with HZE particles (iron ions)Jenine K Sanzari
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Radiat Res 172:437-43. 2009..It is concluded that SeM can regulate ionizing radiation-induced gene expression and may serve as an effective countermeasure for some of the acute inflammatory/immune responses induced by low-dose HZE-particle radiation... - Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survivalChris O Wambi
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Radiat Res 172:175-86. 2009..Taken together, oral supplementation with antioxidants appears to be an effective approach for radioprotection of hematopoietic cells and improvement of animal survival after proton TBI... - Dietary supplements reduce the cataractogenic potential of proton and HZE-particle radiation in miceJames G Davis
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
Radiat Res 173:353-61. 2010..These results indicate that BBIC and the antioxidant formulation evaluated in this study could be useful for protecting astronauts against space radiation-induced cataracts during or after long-term manned space missions... - Detection of Bowman-Birk inhibitor and anti-Bowman-Birk inhibitor antibodies in sera of humans and animals treated with Bowman-Birk inhibitor concentrateX Steven Wan
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Nutr Cancer 43:167-73. 2002..These results suggest that orally ingested BBI is absorbed by human subjects and animals and that some animals develop antibodies to BBI in response to treatment with BBIC... - Establishment of human cancer cell clones with different characteristics: a model for screening chemopreventive agentsJeffrey H Ware
Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
Anticancer Res 27:1-16. 2007.... - Evaluation of cancer chemopreventive agents using clones derived from a human prostate cancer cell lineJeffrey H Ware
Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
Anticancer Res 26:4177-83. 2006..The successful use of clonal selection through fluctuation analysis of human cancer cells as a means for studying tumor progression has been previously reported... - Using electron beam radiation to simulate the dose distribution for whole body solar particle event proton exposureKeith A Cengel
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Radiat Environ Biophys 49:715-21. 2010..These studies will help to better define the topography of the time-dose-fractionation versus biological response landscape for astronaut exposure to an SPE... - Effect of the Bowman-Birk inhibitor (a soy protein) on in vitro bladder neck/urethral and penile corporal smooth muscle activityS Bruce Malkowicz
Division of Urology, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Neurourol Urodyn 22:54-7. 2003..There have been anecdotal reports from patients of improved voiding and sexual functions in the ongoing BBIC trials. The objective of this study was to quantify the effect of BBI and BBIC on urethral and corporal smooth muscle activity... - Three immunoassays based on monoclonal antibodies specific for prostate specific antigen (PSA), alpha-1-antichymotrypsin (ACT), and the PSA-ACT complexX Steven Wan
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
Prostate 56:131-41. 2003.... - In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cellsX Steven Wan
University of Pennsylvania, Philadelphia, PA 19104 6072, USA
Oncol Rep 10:2009-14. 2003.... - Biological countermeasures in space radiation healthAnn R Kennedy
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Gravit Space Biol Bull 16:37-44. 2003..Research related to the dietary additions of agents to minimize the risks of developing health-related problems which can result from exposure to space radiations is reviewed... - Protection against radiation-induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agentsX Steven Wan
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 64:1475-81. 2006..CONCLUSION: The combination of antioxidants evaluated in this study is likely be a promising countermeasure for protection against space radiation-induced adverse biologic effects... - Adaptation of the dichlorofluorescein assay for detection of radiation-induced oxidative stress in cultured cellsX Steven Wan
Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Radiat Res 160:622-30. 2003..These results indicate that the DCF assay optimized in this study is highly sensitive, linear and specific for measuring oxidative stress in irradiated cells... - Establishment and characterization of sublines of LNCaP human prostate cancer cellsX Steven Wan
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19083, USA
Oncol Rep 10:1569-75. 2003.... - Effects of selenomethionine on the gene expression profile of cloned human prostate cancer cells representing a phenotypic continuum of cancer progressionJelena Stewart
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6072, USA
Nutr Cancer 60:826-36. 2008.... - Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiationChris Wambi
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Radiat Res 169:384-96. 2008.... - Bowman-Birk inhibitor concentrate: a novel therapeutic agent for patients with active ulcerative colitisGary R Lichtenstein
Department of Medicine, Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Dig Dis Sci 53:175-80. 2008..22). No severe adverse events were observed. This trial suggests a potential benefit over placebo for both achieving clinical response and induction of remission in patients with active ulcerative colitis without apparent toxicity... - Attenuation of skeletal muscle atrophy via protease inhibitionCarl A Morris
Dept. of Physiology and the Pennsylvania Muscle Institute, Univ. of Pennsylvania School of Medicine, A-700 Richards Bldg, 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA
J Appl Physiol 99:1719-27. 2005..Thus BBI is a candidate therapeutic agent to minimize skeletal muscle atrophy and loss of strength associated with disuse, cachexia, sepsis, weightlessness, or the combination of age and inactivity... - Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivoNiklas Finnberg
Laboratory of Molecular Oncology and Cell Cycle Regulation, The Institute for Translational Medicine and Therapeutics, The Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Cancer Biol Ther 7:2023-33. 2008..In contrast to PR, GR may, in a cell type specific manner, trigger a more diverse non-random stress-response that mediates apoptosis partially independent of the extent of DNA damage... - Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley ratsJun Guan
U PA Sch Med, Philadelphia
Radiat Res 162:572-9. 2004.... - Detection of oxidative stress induced by low- and high-linear energy transfer radiation in cultured human epithelial cellsX Steven Wan
U PA Sch Med, Philadelphia
Radiat Res 163:364-8. 2005.... - Bowman-Birk inhibitor concentrate prevents atrophy, weakness, and oxidative stress in soleus muscle of hindlimb-unloaded miceSandrine Arbogast
Dept of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
J Appl Physiol 102:956-64. 2007..We conclude that dietary supplementation with BBIC protects skeletal muscle during prolonged unloading, promoting redox homeostasis in muscle fibers and blunting atrophy-induced weakness... - Development of the Bowman-Birk inhibitor for oral cancer chemoprevention and analysis of Neu immunohistochemical staining intensity with Bowman-Birk inhibitor concentrate treatmentWilliam B Armstrong
Department of Otolaryngology Head and Neck Surgery, Chao Family Comprehensive Cancer Center, University of California Irvine, 101 The City DriveSouth, Bldg 25, Suite 191, Orange, CA 92868, USA
Laryngoscope 113:1687-702. 2003.... - Standardization of a fluorometric assay for measuring oxidative stress in irradiated cellsX Steven Wan
U PA Sch Med, Philadelphia
Radiat Res 163:232-40. 2005....
Research Grants
- RADIATION BIOLOGY TRAINING GRANTAnn Kennedy; Fiscal Year: 2007..It is expected that graduates of the training program will continue with their research and academic careers in radiation biology and oncology. ..