R D Kenagy

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency
    Richard D Kenagy
    Department of Surgery, University of Washington, Seattle, Wash Electronic address
    J Vasc Surg 64:202-209.e6. 2016
  2. pmc Cell death-associated ADAMTS4 and versican degradation in vascular tissue
    Richard D Kenagy
    Center for Cardiovascular Biology, PO Box 358050, University of Washington School of Medicine, 815 Mercer St, Seattle, WA 98109
    J Histochem Cytochem 57:889-97. 2009
  3. pmc Versican degradation and vascular disease
    Richard D Kenagy
    Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Department of Surgery, Seattle, WA 98109 4714, USA
    Trends Cardiovasc Med 16:209-15. 2006
  4. pmc Accumulation and loss of extracellular matrix during shear stress-mediated intimal growth and regression in baboon vascular grafts
    Richard D Kenagy
    Department of Vascular Surgery, University of Washington, 1959 N E Pacific St Box 356410, Seattle, WA 98195 6410, USA
    J Histochem Cytochem 53:131-40. 2005
  5. ncbi request reprint The role of plasminogen, plasminogen activators, and matrix metalloproteinases in primate arterial smooth muscle cell migration
    R D Kenagy
    Department of Surgery and Pathology, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 16:1373-82. 1996
  6. ncbi request reprint The urokinase receptor mediates basic fibroblast growth factor-dependent smooth muscle cell migration through baboon aortic explants
    R D Kenagy
    Department of Surgery, School of Medicine, University of Washington, Box 356410, AA404, Health Sciences Building, Seattle, WA 98195 6410, USA
    Atherosclerosis 162:63-7. 2002
  7. ncbi request reprint Increased plasmin and serine proteinase activity during flow-induced intimal atrophy in baboon PTFE grafts
    Richard D Kenagy
    Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle 98195 6410, USA
    Arterioscler Thromb Vasc Biol 22:400-4. 2002
  8. ncbi request reprint Blockade of smooth muscle cell migration and proliferation in baboon aortic explants by interleukin-1beta and tumor necrosis factor-alpha is nitric oxide-dependent and nitric oxide-independent
    R D Kenagy
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Vasc Res 37:381-9. 2000
  9. ncbi request reprint Primate smooth muscle cell migration from aortic explants is mediated by endogenous platelet-derived growth factor and basic fibroblast growth factor acting through matrix metalloproteinases 2 and 9
    R D Kenagy
    Department of Surgery, University of Washington, Seattle 98195 6410, USA
    Circulation 96:3555-60. 1997
  10. ncbi request reprint Membrane-type matrix metalloproteinase-1 and -3 activity in primate smooth muscle cells
    K I Shofuda
    Division of Vascular Surgery, Department of Surgery, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195-6410, USA
    FASEB J 15:2010-2. 2001

Collaborators

Detail Information

Publications26

  1. pmc Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency
    Richard D Kenagy
    Department of Surgery, University of Washington, Seattle, Wash Electronic address
    J Vasc Surg 64:202-209.e6. 2016
    ....
  2. pmc Cell death-associated ADAMTS4 and versican degradation in vascular tissue
    Richard D Kenagy
    Center for Cardiovascular Biology, PO Box 358050, University of Washington School of Medicine, 815 Mercer St, Seattle, WA 98109
    J Histochem Cytochem 57:889-97. 2009
    ....
  3. pmc Versican degradation and vascular disease
    Richard D Kenagy
    Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Department of Surgery, Seattle, WA 98109 4714, USA
    Trends Cardiovasc Med 16:209-15. 2006
    ....
  4. pmc Accumulation and loss of extracellular matrix during shear stress-mediated intimal growth and regression in baboon vascular grafts
    Richard D Kenagy
    Department of Vascular Surgery, University of Washington, 1959 N E Pacific St Box 356410, Seattle, WA 98195 6410, USA
    J Histochem Cytochem 53:131-40. 2005
    ..Neointimal atrophy occurs with an apparent loss of proteoglycans and evidence of versican degradation...
  5. ncbi request reprint The role of plasminogen, plasminogen activators, and matrix metalloproteinases in primate arterial smooth muscle cell migration
    R D Kenagy
    Department of Surgery and Pathology, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 16:1373-82. 1996
    ..These data demonstrate that proteinases of the matrix metalloproteinase and plasminogen/plasminogen activator families play an important role in the migration of primate arterial SMCs through the extracellular matrix...
  6. ncbi request reprint The urokinase receptor mediates basic fibroblast growth factor-dependent smooth muscle cell migration through baboon aortic explants
    R D Kenagy
    Department of Surgery, School of Medicine, University of Washington, Box 356410, AA404, Health Sciences Building, Seattle, WA 98195 6410, USA
    Atherosclerosis 162:63-7. 2002
    ....
  7. ncbi request reprint Increased plasmin and serine proteinase activity during flow-induced intimal atrophy in baboon PTFE grafts
    Richard D Kenagy
    Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle 98195 6410, USA
    Arterioscler Thromb Vasc Biol 22:400-4. 2002
    ..These data suggest that serine proteinases, including plasmin, may be largely responsible for extracellular matrix degradation in this primate model of flow-induced intimal atrophy...
  8. ncbi request reprint Blockade of smooth muscle cell migration and proliferation in baboon aortic explants by interleukin-1beta and tumor necrosis factor-alpha is nitric oxide-dependent and nitric oxide-independent
    R D Kenagy
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Vasc Res 37:381-9. 2000
    ..IL-1beta and TNFalpha may act directly to limit injury-induced intimal hyperplasia by decreasing SMC migration and proliferation...
  9. ncbi request reprint Primate smooth muscle cell migration from aortic explants is mediated by endogenous platelet-derived growth factor and basic fibroblast growth factor acting through matrix metalloproteinases 2 and 9
    R D Kenagy
    Department of Surgery, University of Washington, Seattle 98195 6410, USA
    Circulation 96:3555-60. 1997
    ..We have recently shown that migration of SMCs from baboon aortic explants depends on the activity of MMPs, but the identity of the stimulatory MMPs and the role of bFGF and PDGF in this primate system are not known...
  10. ncbi request reprint Membrane-type matrix metalloproteinase-1 and -3 activity in primate smooth muscle cells
    K I Shofuda
    Division of Vascular Surgery, Department of Surgery, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195-6410, USA
    FASEB J 15:2010-2. 2001
    ..The present study demonstrates that MT1- and MT3-MMPs have different enzymatic activities but may nevertheless affect SMC function in the same way...
  11. ncbi request reprint Control of smooth muscle cell function by membrane-type matrix metalloproteinases
    K I Shofuda
    Department of Surgery, University of Washington School of Medicine, Seattle 98195-6410, USA
    Ann N Y Acad Sci 947:337-40. 2001
    ..The cells, which underwent this change, showed reduced adhesion to matrices and increased migration in a Boyden chamber...
  12. ncbi request reprint MMP9 production by human monocyte-derived macrophages is decreased on polymerized type I collagen
    S Lepidi
    Department of Surgery, University of Washington School of Medicine, Seattle, USA
    J Vasc Surg 34:1111-8. 2001
    ..In addition, cells in contact with the collagen matrix are potentially more responsive to soluble mediators such as platelet-derived growth factor, interleukin 1beta, and tumor necrosis factor alpha...
  13. ncbi request reprint Activation of metalloproteinases and their association with integrins: an auxiliary apoptotic pathway in human endothelial cells
    B Levkau
    Department of Pathology, University of Washington, Seattle, WA, USA
    Cell Death Differ 9:1360-7. 2002
    ..This 'auxiliary' apoptotic pathway may interrupt ECM-mediated survival signaling, and thus accelerate the efficient execution of the cell death program...
  14. ncbi request reprint Prevention of aneurysm development and rupture by local overexpression of plasminogen activator inhibitor-1
    E Allaire
    Department of Surgery, University of Washington, Seattle 98195 6410, USA
    Circulation 98:249-55. 1998
    ..To investigate this question, we overexpressed plasminogen activator inhibitor-1 (PAI-1), an inhibitor of t-PA and u-PA, in a rat model of aortic aneurysm...
  15. ncbi request reprint Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells
    Bernhard H Rauch
    Department of Surgery, University of Washington School of Medicine, Box 356410, 1959 NE Pacific St, Seattle, Wash 98195 6410, USA
    Circ Res 94:340-5. 2004
    ..This is followed by transactivation of the FGFR-1 and increased proliferation. Heparin may inhibit the mitogenic effects of thrombin and FXa in human SMCs by preventing bFGF binding to FGFR-1...
  16. pmc Induction of vascular atrophy as a novel approach to treating restenosis. A review
    Seung Kee Min
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    J Vasc Surg 47:662-70. 2008
    ..Possible molecular targets could include PDGF receptors, A20, and BMP4. Further studies are needed to determine the utility of such a therapeutic approach to vascular disease...
  17. pmc Bone morphogenetic protein 4: potential regulator of shear stress-induced graft neointimal atrophy
    Patrick C H Hsieh
    Department of Bioengineering, University of Washington, Seattle, WA 98195 6410, USA
    J Vasc Surg 43:150-8. 2006
    ..We have investigated the expression and function of BMPs 2, 4, and 5 in the graft neointima and in cultured baboon smooth muscle cells (SMCs)...
  18. ncbi request reprint Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells
    Esther Millette
    Department of Surgery, University of Washington School of Medicine, Seattle, WA 98195 6410, USA
    Trends Cardiovasc Med 16:25-8. 2006
    ..This review summarizes our latest findings and discusses the potential implications of this novel signaling mechanism for restenosis...
  19. ncbi request reprint Syndecan-4 is required for thrombin-induced migration and proliferation in human vascular smooth muscle cells
    Bernhard H Rauch
    University of Washington School of Medicine, Department of Surgery, Seattle, Washington 98195 6410, USA
    J Biol Chem 280:17507-11. 2005
    ..We conclude that thrombin-released bFGF binds to syndecan-4 and FGFR-1, which is required for thrombin-induced mitogenesis and migration...
  20. ncbi request reprint Flow-induced neointimal regression in baboon polytetrafluoroethylene grafts is associated with decreased cell proliferation and increased apoptosis
    Scott A Berceli
    Division of Vascular Surgery, University of Florida, FL, USA
    J Vasc Surg 36:1248-55. 2002
    ..This study was designed to investigate the smooth muscle cell (SMC) growth kinetics during early regression and evaluate the influence of nitric oxide (NO) in the regulation of this process...
  21. ncbi request reprint Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation
    Esther Millette
    University of Washington School of Medicine, Department of Surgery, Box 356410, 1959 NE Pacific St, Seattle, WA 98195 6410, USA
    Circ Res 96:172-9. 2005
    ..Our results provide support for a novel mechanism by which PDGF-BB induces the release of bFGF and activation of FGFR-1 followed by the sustained activation of ERK and proliferation of human SMCs...
  22. ncbi request reprint Arterial injury repair in nonhuman primates-the role of PDGF receptor-beta
    Michael J Englesbe
    Department of Surgery, Division of Vascular Surgery, University of Washington Medical Center, Seattle, Washington, USA
    J Surg Res 119:80-4. 2004
    ..Fundamental differences with the well-characterized rat arterial injury model have been found...
  23. ncbi request reprint Concomitant blockade of platelet-derived growth factor receptors alpha and beta induces intimal atrophy in baboon PTFE grafts
    Michael J Englesbe
    Department of Surgery, University of Washington Medical Center, Seattle, WA 98195, USA
    J Vasc Surg 39:440-6. 2004
    ....
  24. pmc Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery
    Seung Kee Min
    Department of Surgery, Seoul National University, Seoul, Korea
    J Vasc Surg 47:1039-47. 2008
    ..To study the effects of blood flow and wall tension separately and together, we applied tight or loose wraps on high-flow or normal-flow iliac arteries in baboons...
  25. pmc MMP-9 regulates both positively and negatively collagen gel contraction: a nonproteolytic function of MMP-9
    Olivier D Defawe
    Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, WA, USA
    Cardiovasc Res 66:402-9. 2005
    ..To investigate potential mechanisms for this observation, we investigated the role of MMP-9 in smooth muscle cell (SMC)-mediated collagen gel contraction, an in vitro model of constrictive remodeling...
  26. ncbi request reprint Cleavage of focal adhesion kinase in vascular smooth muscle cells overexpressing membrane-type matrix metalloproteinases
    Tomoko Shofuda
    Division of Vascular Surgery, Department of Surgery, University of Washington School of Medicine, Seattle, Wash 98195 6410, USA
    Arterioscler Thromb Vasc Biol 24:839-44. 2004
    ..Because integrin-mediated cell adhesion regulates these events, we have investigated the functional relationship between MT-MMPs and focal adhesion assembly...