JONGSOOK KEMPER

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. pmc Controlling SIRT1 expression by microRNAs in health and metabolic disease
    Jiyoung Lee
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, IL 61801, USA
    Aging (Albany NY) 2:527-34. 2010
  2. pmc Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP
    Jongsook Kim Kemper
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Mol Cell Biol 24:7707-19. 2004
  3. pmc FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
    Jongsook Kim Kemper
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Cell Metab 10:392-404. 2009
  4. pmc Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications
    Jongsook Kim Kemper
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, IL 61801, USA
    Biochim Biophys Acta 1812:842-50. 2011
  5. pmc Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes
    Ji Miao
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    Mol Endocrinol 25:1159-69. 2011
  6. pmc Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner
    Deepthi Kanamaluru
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Mol Cell Biol 31:1540-50. 2011

Research Grants

  1. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2003
  2. Regulation of cholesterol catabolism by bile acids
    Jongsook Kim Kemper; Fiscal Year: 2010
  3. MOLECULAR REGULATION OF FXR ACTIVITY
    JONGSOOK KEMPER; Fiscal Year: 2009
  4. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2009
  5. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2007
  6. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2006
  7. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2005
  8. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2004
  9. MOLECULAR REGULATION OF FXR ACTIVITY
    Jongsook Kim Kemper; Fiscal Year: 2010

Collaborators

  • Sung E Choi
  • Deepthi Kanamaluru
  • Ji Miao
  • Jiyoung Lee
  • Linda Yang
  • Sun Mi Seok
  • Timothy D Veenstra
  • Timothy M Willson
  • Zhen Xiao
  • William J Zuercher
  • H Eric Xu
  • Dong Hyun Kim
  • Yong Xu
  • Sungsoon Fang

Detail Information

Publications6

  1. pmc Controlling SIRT1 expression by microRNAs in health and metabolic disease
    Jiyoung Lee
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, IL 61801, USA
    Aging (Albany NY) 2:527-34. 2010
    ..The FXR/miR-34a pathway and other miRs controlling SIRT1 may be useful therapeutic targets for age-related diseases, including metabolic disorders...
  2. pmc Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP
    Jongsook Kim Kemper
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Mol Cell Biol 24:7707-19. 2004
    ..Our study establishes the first link between a Swi/Snf complex and regulation of cholesterol metabolism...
  3. pmc FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
    Jongsook Kim Kemper
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Cell Metab 10:392-404. 2009
    ..Small molecules that inhibit FXR acetylation by targeting SIRT1 or p300 may be promising therapeutic agents for metabolic disorders...
  4. pmc Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications
    Jongsook Kim Kemper
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, IL 61801, USA
    Biochim Biophys Acta 1812:842-50. 2011
    ..This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease...
  5. pmc Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes
    Ji Miao
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    Mol Endocrinol 25:1159-69. 2011
    ..These data suggest that SHP may act as a ligand-regulated receptor in metabolic pathways. Modulation of SHP activity by synthetic ligands may be a useful therapeutic strategy...
  6. pmc Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner
    Deepthi Kanamaluru
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Mol Cell Biol 31:1540-50. 2011
    ..Targeting posttranslational modifications of SHP may be an effective therapeutic strategy by controlling selected groups of genes to treat SHP-related human diseases, such as metabolic syndrome, cancer, and infertility...

Research Grants10

  1. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2003
    ....
  2. Regulation of cholesterol catabolism by bile acids
    Jongsook Kim Kemper; Fiscal Year: 2010
    ..These studies will help us understand how SHP activity is modulated and may suggest new approaches for treating metabolic diseases. ..
  3. MOLECULAR REGULATION OF FXR ACTIVITY
    JONGSOOK KEMPER; Fiscal Year: 2009
    ..The studies may also facilitate the design of therapeutic agents for treating these metabolic disorders. ..
  4. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2009
    ..These studies will help us understand how SHP activity is modulated and may suggest new approaches for treating metabolic diseases. ..
  5. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2007
    ....
  6. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2006
    ....
  7. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2005
    ....
  8. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2004
    ....
  9. MOLECULAR REGULATION OF FXR ACTIVITY
    Jongsook Kim Kemper; Fiscal Year: 2010
    ..The studies may also facilitate the design of therapeutic agents for treating these metabolic disorders. ..