MAX KELZ

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness
    William J Joiner
    Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 9:e1003605. 2013
  2. pmc A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia
    Eliot B Friedman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e11903. 2010
  3. pmc Is hydrogen sulfide-induced suspended animation general anesthesia?
    Rosie Q Li
    Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 341:735-42. 2012
  4. pmc An essential role for orexins in emergence from general anesthesia
    Max B Kelz
    Department of Anesthesiology and Critical Care, Mahoney Institute for Neurological Sciences, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:1309-14. 2008
  5. ncbi request reprint Inhaled anesthetic potency in aged Alzheimer mice
    Shannon L Bianchi
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesth Analg 110:427-30. 2010
  6. ncbi request reprint Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model
    Yan Zhu
    Center for Sleep and Neurobiology and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:10060-71. 2007
  7. ncbi request reprint Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restoration
    Max B Kelz
    Department of Pharmacology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Sci Aging Knowledge Environ 2002:re1. 2002
  8. ncbi request reprint An essential role for DeltaFosB in the nucleus accumbens in morphine action
    Venetia Zachariou
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:205-11. 2006
  9. ncbi request reprint Inducible, reversible hair loss in transgenic mice
    Jingshan Chen
    Laboratory of Molecular Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven 06508, USA
    Transgenic Res 11:241-7. 2002
  10. ncbi request reprint Inducible and brain region-specific CREB transgenic mice
    Norio Sakai
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    Mol Pharmacol 61:1453-64. 2002

Research Grants

Collaborators

Detail Information

Publications10

  1. pmc Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness
    William J Joiner
    Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 9:e1003605. 2013
    ..We propose that processes selectively contributing to sleep homeostasis and neural inertia may be impaired in pathophysiological conditions such as coma and persistent vegetative states. ..
  2. pmc A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia
    Eliot B Friedman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e11903. 2010
    ....
  3. pmc Is hydrogen sulfide-induced suspended animation general anesthesia?
    Rosie Q Li
    Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 341:735-42. 2012
    ..Combinations of H(2)S and isoflurane can be lethal, suggesting extreme care in the combination of these gases in clinical situations...
  4. pmc An essential role for orexins in emergence from general anesthesia
    Max B Kelz
    Department of Anesthesiology and Critical Care, Mahoney Institute for Neurological Sciences, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:1309-14. 2008
    ..These findings support the concept that emergence depends, in part, on recruitment and stabilization of wake-active regions of brain...
  5. ncbi request reprint Inhaled anesthetic potency in aged Alzheimer mice
    Shannon L Bianchi
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesth Analg 110:427-30. 2010
    ..General anesthesia may exacerbate symptoms of and the pathology underlying AD, so minimizing anesthetic exposure may be important. This requires knowledge of whether the continuing AD pathogenesis alters anesthetic potency...
  6. ncbi request reprint Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model
    Yan Zhu
    Center for Sleep and Neurobiology and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:10060-71. 2007
    ..It is anticipated that severe obstructive sleep apnea in humans destroys catecholaminergic wake neurons...
  7. ncbi request reprint Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restoration
    Max B Kelz
    Department of Pharmacology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Sci Aging Knowledge Environ 2002:re1. 2002
    ..We also review some new work with neural stem cells and their application to restorative neurobiology. Finally, we discuss the use of cell-specific molecular profiles to better understand the basics of neuronal cell biology...
  8. ncbi request reprint An essential role for DeltaFosB in the nucleus accumbens in morphine action
    Venetia Zachariou
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:205-11. 2006
    ..Together, these experiments demonstrated that DeltaFosB in the NAc, partly through the repression of dynorphin expression, mediates several major features of opiate addiction...
  9. ncbi request reprint Inducible, reversible hair loss in transgenic mice
    Jingshan Chen
    Laboratory of Molecular Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven 06508, USA
    Transgenic Res 11:241-7. 2002
    ..Moreover, since overexpression of several other transgenes failed to cause skin pathology, the present findings also indicate types of molecular abnormalities that may cause reversible hair loss...
  10. ncbi request reprint Inducible and brain region-specific CREB transgenic mice
    Norio Sakai
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    Mol Pharmacol 61:1453-64. 2002
    ..Finally, there was a significant reduction in cocaine-induced locomotor activity in the CREB bitransgenic mice. These results are consistent with a role for CREB in mediating adaptive changes that occur in response to drugs of abuse...

Research Grants3

  1. Arousal, orexins and anesthesia
    MAX KELZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. NEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSIS
    MAX KELZ; Fiscal Year: 2010
    ....
  3. Arousal, orexins and anesthesia
    MAX KELZ; Fiscal Year: 2008
    ..Together with his current skill set, these new tools will help transition him towards becoming an independent physician-scientist by bridging the interface between sleep neurobiology and anesthetic action. ..