Genomes and Genes
Affiliation: University of Pennsylvania
- Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsivenessWilliam J Joiner
Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
PLoS Genet 9:e1003605. 2013..We propose that processes selectively contributing to sleep homeostasis and neural inertia may be impaired in pathophysiological conditions such as coma and persistent vegetative states. ..
- A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertiaEliot B Friedman
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS ONE 5:e11903. 2010....
- Is hydrogen sulfide-induced suspended animation general anesthesia?Rosie Q Li
Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Pharmacol Exp Ther 341:735-42. 2012..Combinations of H(2)S and isoflurane can be lethal, suggesting extreme care in the combination of these gases in clinical situations...
- An essential role for orexins in emergence from general anesthesiaMax B Kelz
Department of Anesthesiology and Critical Care, Mahoney Institute for Neurological Sciences, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 105:1309-14. 2008..These findings support the concept that emergence depends, in part, on recruitment and stabilization of wake-active regions of brain...
- Inhaled anesthetic potency in aged Alzheimer miceShannon L Bianchi
Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Anesth Analg 110:427-30. 2010..General anesthesia may exacerbate symptoms of and the pathology underlying AD, so minimizing anesthetic exposure may be important. This requires knowledge of whether the continuing AD pathogenesis alters anesthetic potency...
- Selective loss of catecholaminergic wake active neurons in a murine sleep apnea modelYan Zhu
Center for Sleep and Neurobiology and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 27:10060-71. 2007..It is anticipated that severe obstructive sleep apnea in humans destroys catecholaminergic wake neurons...
- Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restorationMax B Kelz
Department of Pharmacology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
Sci Aging Knowledge Environ 2002:re1. 2002..We also review some new work with neural stem cells and their application to restorative neurobiology. Finally, we discuss the use of cell-specific molecular profiles to better understand the basics of neuronal cell biology...
- An essential role for DeltaFosB in the nucleus accumbens in morphine actionVenetia Zachariou
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
Nat Neurosci 9:205-11. 2006..Together, these experiments demonstrated that DeltaFosB in the NAc, partly through the repression of dynorphin expression, mediates several major features of opiate addiction...
- Inducible, reversible hair loss in transgenic miceJingshan Chen
Laboratory of Molecular Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven 06508, USA
Transgenic Res 11:241-7. 2002..Moreover, since overexpression of several other transgenes failed to cause skin pathology, the present findings also indicate types of molecular abnormalities that may cause reversible hair loss...
- Inducible and brain region-specific CREB transgenic miceNorio Sakai
Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
Mol Pharmacol 61:1453-64. 2002..Finally, there was a significant reduction in cocaine-induced locomotor activity in the CREB bitransgenic mice. These results are consistent with a role for CREB in mediating adaptive changes that occur in response to drugs of abuse...
- Arousal, orexins and anesthesiaMAX KELZ; Fiscal Year: 2007..Together with his current skill set, these new tools will help transition him towards becoming an independent physician-scientist by bridging the interface between sleep neurobiology and anesthetic action. ..
- NEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSISMAX KELZ; Fiscal Year: 2010....