Michael Kelner

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Absence of MGST1 mRNA and protein expression in human neuroblastoma cell lines and primary tissue
    Michael J Kelner
    Department of Pathology, University of California at San Diego, La Jolla, CA 92039, USA Electronic address
    Free Radic Biol Med 69:167-71. 2014
  2. doi request reprint Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model
    Michael J Kelner
    University of California San Diego, San Diego, CA 92103, USA
    Cancer Chemother Pharmacol 63:19-26. 2008
  3. doi request reprint Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil
    Michael J Kelner
    Department of Pathology, University of California, San Diego, USA
    Invest New Drugs 26:407-15. 2008
  4. ncbi request reprint Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression
    Michael J Kelner
    Department of Pathology, University of California, 8320 UCSD Medical Center, 200 West Arbor Drive, San Diego, CA, USA
    Biochim Biophys Acta 1678:163-9. 2004
  5. ncbi request reprint Heterologous expression of carbonyl reductase: demonstration of prostaglandin 9-ketoreductase activity and paraquat resistance
    M J Kelner
    Department of Pathology, UCSD, San Diego, CA 92103 8320, USA
    Life Sci 61:2317-22. 1997
  6. ncbi request reprint Enhanced antitumor activity of irofulven in combination with antimitotic agents
    Michael J Kelner
    Department of Pathology, University of California, San Diego 92103, USA
    Invest New Drugs 20:271-9. 2002
  7. ncbi request reprint Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C
    Michael J Kelner
    Department of Pathology 8320, UCSD Medical Center, 200 West Arbor Drive, San Diego, CA 92103, USA
    Cancer Chemother Pharmacol 49:412-8. 2002
  8. ncbi request reprint Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung carcinoma xenograft
    M J Kelner
    Department of Pathology, University of California, San Diego, La Jolla 92093, USA
    Anticancer Drugs 11:217-24. 2000
  9. ncbi request reprint Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents
    M J Kelner
    Department of Pathology, University of California, 200 West Arbor Drive, San Diego, CA 92103 8320, USA
    Gene 248:109-16. 2000
  10. ncbi request reprint Characterization of acylfulvene histiospecific toxicity in human tumor cell lines
    M J Kelner
    Department of Pathology, UCSD Medical Center, San Diego, CA 92103, USA
    Cancer Chemother Pharmacol 41:237-42. 1998

Research Grants

  1. GPX1 ENZYME REGULATION BY OXIDATIVE XENOBIOTICS
    Michael Kelner; Fiscal Year: 2002
  2. COORDINATED REGULATION OF ANTIOXIDANT ENZYMES
    Michael Kelner; Fiscal Year: 2005
  3. Halogenated Alkenes and Microsomal GSH-transferases
    Michael J Kelner; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. pmc Absence of MGST1 mRNA and protein expression in human neuroblastoma cell lines and primary tissue
    Michael J Kelner
    Department of Pathology, University of California at San Diego, La Jolla, CA 92039, USA Electronic address
    Free Radic Biol Med 69:167-71. 2014
    ....
  2. doi request reprint Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model
    Michael J Kelner
    University of California San Diego, San Diego, CA 92103, USA
    Cancer Chemother Pharmacol 63:19-26. 2008
    ..The aim of this study was to determine the antitumor activity of irofulven when administered in combination with 44 different DNA damaging agents, whose damage is in general detected and repaired by the genome repair pathway...
  3. doi request reprint Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil
    Michael J Kelner
    Department of Pathology, University of California, San Diego, USA
    Invest New Drugs 26:407-15. 2008
    ....
  4. ncbi request reprint Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression
    Michael J Kelner
    Department of Pathology, University of California, 8320 UCSD Medical Center, 200 West Arbor Drive, San Diego, CA, USA
    Biochim Biophys Acta 1678:163-9. 2004
    ..Overall, there was a good agreement between the mRNA content detected and previous reports of MGST1 activity with the exception of brain tissue...
  5. ncbi request reprint Heterologous expression of carbonyl reductase: demonstration of prostaglandin 9-ketoreductase activity and paraquat resistance
    M J Kelner
    Department of Pathology, UCSD, San Diego, CA 92103 8320, USA
    Life Sci 61:2317-22. 1997
    ..There was, however, a demonstrable increase in resistance to paraquat of a magnitude similar to that previously noted with transgenic cell lines overexpressing manganese superoxide dismutase...
  6. ncbi request reprint Enhanced antitumor activity of irofulven in combination with antimitotic agents
    Michael J Kelner
    Department of Pathology, University of California, San Diego 92103, USA
    Invest New Drugs 20:271-9. 2002
    ..These results indicate that the therapeutic activity of irofulven is enhanced when combined with taxanes, and warrant further evaluation of these combinations...
  7. ncbi request reprint Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C
    Michael J Kelner
    Department of Pathology 8320, UCSD Medical Center, 200 West Arbor Drive, San Diego, CA 92103, USA
    Cancer Chemother Pharmacol 49:412-8. 2002
    ..The potential application of administering irofulven in combination with aziridine-containing chemotherapeutic agents was evaluated in this study...
  8. ncbi request reprint Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung carcinoma xenograft
    M J Kelner
    Department of Pathology, University of California, San Diego, La Jolla 92093, USA
    Anticancer Drugs 11:217-24. 2000
    ..The development of this MRP+ xenograft model, in conjunction with the parent MV522 and MDR1/gp170+ xenograft models, will be useful for screening new classes of agents for activity against multidrug-resistant tumors...
  9. ncbi request reprint Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents
    M J Kelner
    Department of Pathology, University of California, 200 West Arbor Drive, San Diego, CA 92103 8320, USA
    Gene 248:109-16. 2000
    ..The ability of GPX2 to respond transcriptionally to redox stress is likely to be more physiologically relevant than post-transcriptional regulation which is dependent upon selenium availability...
  10. ncbi request reprint Characterization of acylfulvene histiospecific toxicity in human tumor cell lines
    M J Kelner
    Department of Pathology, UCSD Medical Center, San Diego, CA 92103, USA
    Cancer Chemother Pharmacol 41:237-42. 1998
    ..To elucidate the increased therapeutic efficacy of acylfulvene analogs, we compared them with the illudin compounds in terms of their in vitro cytotoxicity, cellular accumulation and DNA incorporation...
  11. ncbi request reprint Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3
    M J Kelner
    Department of Pathology, University of California, San Diego 92103 8320, USA
    Biochem Biophys Res Commun 249:53-5. 1998
    ..Chromosomal FISH studies placed the GPX4 gene at 19p13.3 location, and downstream of the 23 k-Da polypeptide DNA-directed RNA polymerase gene...
  12. ncbi request reprint Characterization of MGI 114 (HMAF) histiospecific toxicity in human tumor cell lines
    M J Kelner
    Department of Pathology, UCSD Medical Center, San Diego, CA 92103, USA
    Cancer Chemother Pharmacol 44:235-40. 1999
    ....
  13. ncbi request reprint Structural organization of the human glutathione reductase gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence
    M J Kelner
    Department of Pathology, University of California, San Diego, 200 West Arbor Drive, San Diego, California, 92103 8320, USA
    Biochem Biophys Res Commun 269:366-8. 2000
    ..The 5' and 3' intron/exon splice junctions, with one exception, followed the general consensus sequences for intron spliced donor and acceptance sites...
  14. ncbi request reprint Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress
    M J Kelner
    Department of Pathology, University of California, San Diego, California 92103 8320, USA
    J Biol Chem 275:13000-6. 2000
    ..The identification that the first exon originally noted is in fact a minor alternative first exon far downstream of the primary first exon eliminates this conundrum...
  15. ncbi request reprint Synthesis and antitumor activity of amine analogs of irofulven
    Trevor C McMorris
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0358, USA
    Bioorg Med Chem Lett 17:6770-2. 2007
    ..Acylfulvenes, a class of semisynthetic analogs of Illudin S, show high toxicity toward prostate cancer cells. Here we probe the effect of changes in hydrophilic character of the analogs...
  16. doi request reprint Structure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene
    Trevor C McMorris
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093 0358, USA
    J Med Chem 53:1109-16. 2010
    ....
  17. ncbi request reprint Synthesis and biological activity of enantiomers of antitumor irofulven
    Trevor C McMorris
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093 0506, USA
    J Org Chem 69:619-23. 2004
    ..The enantiomer, (+)-irofulven, was prepared in a similar way starting with (S)-5-chloro-5-methyl-2-cyclopentenone. (+)-Irofulven was 5 to 6 times less toxic than (-)-irofulven to adenocarcinoma (MV 522) cells...
  18. ncbi request reprint Reaction of irofulven with zinc and acid
    Trevor C McMorris
    Department of Chemistry, University of California, San Diego, La Jolla, California 92093 0506, USA
    J Nat Prod 66:310-2. 2003
    ..These all have greatly reduced toxicity to human leukemia (HL60) cells compared to irofulven...
  19. ncbi request reprint Structure-activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring
    Trevor C McMorris
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093 0506, USA
    J Org Chem 68:9648-53. 2003
    ..These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds...
  20. ncbi request reprint Stability of levothyroxine sodium 0.4 microg/mL in 0.9% sodium chloride injection
    Kelli A Stadalman
    University of California, San Diego Medical Center, 9300 Campus Point Dr, Mail Code 7765, La Jolla, CA 92037 7765, USA
    Prog Transplant 19:354-6; quiz 357. 2009
    ..Intravenous levothyroxine therapy decreases vasopressor requirements and prevents cardiovascular collapse in hemodynamically unstable patients eligible for organ donation. The stability of levothyroxine when used in this manner is unknown...
  21. ncbi request reprint Sesquiterpenes from Omphalotus illudens
    Trevor C McMorris
    Department of Chemistry and Biochemistry, University of California, San Diego, CA 92093 0506, USA
    Phytochemistry 61:395-8. 2002
    ..Their structures were elucidated by spectroscopic techniques as well as by X-ray crystallographic analysis...
  22. ncbi request reprint Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3
    Lena Ekström
    Department of Pathology, UCSD, San Diego, CA, USA
    Biochim Biophys Acta 1627:79-84. 2003
    ..These results provide the first description of the basal regulation of these genes in humans...
  23. ncbi request reprint Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways
    Nicolaas G J Jaspers
    Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    DNA Repair (Amst) 1:1027-38. 2002
    ..We show that the semisynthetic illudin derivative hydroxymethylacylfulvene (HMAF, Irofulven), currently under clinical trial for anti-tumour therapy, acts via the same mechanism...
  24. ncbi request reprint Phase I/II study of continuous-infusion troxacitabine in refractory acute myeloid leukemia
    Gail J Roboz
    Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, NY 10021, USA
    J Clin Oncol 25:10-5. 2007
    ....
  25. doi request reprint Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease
    Nghia Nguyen
    Laboratory of Environmental Toxicology, Departments of Chemistry and Biochemistry and Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:7901-11. 2008
    ..Thus, the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans...

Research Grants3

  1. GPX1 ENZYME REGULATION BY OXIDATIVE XENOBIOTICS
    Michael Kelner; Fiscal Year: 2002
    ..These studies will provide critical information regarding cellular response to oxidative stress and aid in determining if a common regulatory mechanism exists for GSH-dependent enzymes. ..
  2. COORDINATED REGULATION OF ANTIOXIDANT ENZYMES
    Michael Kelner; Fiscal Year: 2005
    ..abstract_text> ..
  3. Halogenated Alkenes and Microsomal GSH-transferases
    Michael J Kelner; Fiscal Year: 2010
    ..4] To determine the relative contribution of MGST1 and MGST2 to cellular antioxidant capacity through studies utilizing human MGST1 and MGST2 null cells. ..