Thomas J Kelly

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi request reprint Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases
    Thomas Kelly
    Department of Pathology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Cancer Res 65:5778-84. 2005
  2. ncbi request reprint High heparanase activity in multiple myeloma is associated with elevated microvessel density
    Thomas Kelly
    Departments of Pathology, Myeloma Institute for Research and Therapy, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Cancer Res 63:8749-56. 2003
  3. pmc Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis
    Thomas Kelly
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    J Bone Miner Res 25:1295-304. 2010
  4. ncbi request reprint Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy
    Thomas Kelly
    Department of Pathology, Slot 753, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205 7199, USA
    Drug Resist Updat 8:51-8. 2005
  5. ncbi request reprint Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer
    Yan Huang
    Department of Pathology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Cancer Res 64:2712-6. 2004
  6. ncbi request reprint Seprase, a membrane-bound protease, alleviates the serum growth requirement of human breast cancer cells
    Johnna D Goodman
    Department of Pathology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Clin Exp Metastasis 20:459-70. 2003
  7. ncbi request reprint Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis
    Ralph D Sanderson
    Department of Pathology and Arkansas Cancer Research Center, University of Arkansas, for Medical Sciences, Little Rock, AR, USA
    Matrix Biol 23:341-52. 2004
  8. ncbi request reprint Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies
    Ralph D Sanderson
    Department of Pathology and the Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Cell Biochem 96:897-905. 2005
  9. ncbi request reprint Synergistic enhancement of selective nanophotothermolysis with gold nanoclusters: potential for cancer therapy
    Vladimir P Zharov
    Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Lasers Surg Med 37:219-26. 2005
  10. ncbi request reprint Heparanase promotes the spontaneous metastasis of myeloma cells to bone
    Yang Yang
    Department of Pathology, Myeloma Institute for Research and Therapy, Center for Orthopaedic Research, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 105:1303-9. 2005

Research Grants

Detail Information

Publications14

  1. ncbi request reprint Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases
    Thomas Kelly
    Department of Pathology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Cancer Res 65:5778-84. 2005
    ..This novel role for heparanase as a promoter of osteolysis before tumor metastasis suggests that therapies designed to block heparanase function may disrupt the early progression of bone-homing tumors...
  2. ncbi request reprint High heparanase activity in multiple myeloma is associated with elevated microvessel density
    Thomas Kelly
    Departments of Pathology, Myeloma Institute for Research and Therapy, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Cancer Res 63:8749-56. 2003
    ....
  3. pmc Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis
    Thomas Kelly
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    J Bone Miner Res 25:1295-304. 2010
    ..05). Together these data suggest that syndecan-1 shed by tumor cells exerts biologic effects distal to the primary tumor and that it participates in driving osteoclastogenesis and the resulting bone destruction...
  4. ncbi request reprint Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy
    Thomas Kelly
    Department of Pathology, Slot 753, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205 7199, USA
    Drug Resist Updat 8:51-8. 2005
    ....
  5. ncbi request reprint Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer
    Yan Huang
    Department of Pathology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Cancer Res 64:2712-6. 2004
    ..42 vessels/mm(2) as compared with 50.5 +/- 12.9 vessels/mm(2) for tumors of control-transfected cells that do not express seprase. Seprase-expressing cells are better able to attract blood vessels and exhibit rapid tumor growth...
  6. ncbi request reprint Seprase, a membrane-bound protease, alleviates the serum growth requirement of human breast cancer cells
    Johnna D Goodman
    Department of Pathology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Clin Exp Metastasis 20:459-70. 2003
    ..Seprase may contribute to the pathogenesis of breast cancer by promoting growth of the primary tumor and by facilitating the growth of breast cancer cells in metastases at other sites of the body...
  7. ncbi request reprint Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis
    Ralph D Sanderson
    Department of Pathology and Arkansas Cancer Research Center, University of Arkansas, for Medical Sciences, Little Rock, AR, USA
    Matrix Biol 23:341-52. 2004
    ..Understanding the role of heparan sulfate and heparanase in the regulation of tumor behavior may lead to new therapeutic approaches for treating cancer...
  8. ncbi request reprint Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies
    Ralph D Sanderson
    Department of Pathology and the Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Cell Biochem 96:897-905. 2005
    ..Assessing or monitoring the remodeling of HSPGs has important implications for tumor diagnosis and patient prognosis while therapeutic manipulation of the remodeling process represents an exciting new possibility for treating cancer...
  9. ncbi request reprint Synergistic enhancement of selective nanophotothermolysis with gold nanoclusters: potential for cancer therapy
    Vladimir P Zharov
    Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Lasers Surg Med 37:219-26. 2005
    ..We developed a new approach that enhances selective photothermolysis of tumor through laser activation of synergistic phenomena around nanoclusters, which are self-assembled into cancer cells...
  10. ncbi request reprint Heparanase promotes the spontaneous metastasis of myeloma cells to bone
    Yang Yang
    Department of Pathology, Myeloma Institute for Research and Therapy, Center for Orthopaedic Research, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 105:1303-9. 2005
    ..These studies describe a novel experimental animal model for examining the spontaneous metastasis of bone-homing tumors and indicate that heparanase is a critical determinant of myeloma dissemination and growth in vivo...
  11. pmc Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells
    Behjatolah Monzavi-Karbassi
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Int J Oncol 37:615-22. 2010
    ....
  12. pmc In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells
    Ekaterina I Galanzha
    Phillips Classic Laser and Nanomedicine Laboratories, Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Nat Nanotechnol 4:855-60. 2009
    ....
  13. pmc Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells
    Akihiro Naito
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas 72205 7199, USA
    Cancer Sci 99:1584-8. 2008
    ..Our results indicate that decreasing mtDNA content induces EMT, enabling the progressive phenotypes observed in cancer...
  14. ncbi request reprint Deficiency in surface expression of E-selectin ligand promotes lung colonization in a mouse model of breast cancer
    Behjatolah Monzavi-Karbassi
    Arkansas Cancer Research Center and Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Int J Cancer 117:398-408. 2005
    ..These results strongly suggest that loss of sLe(x) may facilitate the metastatic process by contributing to escape from the primary tumor mass...

Research Grants1

  1. STUDENT PARTNERS IN CANCER RESEARCH AND EDUCATION
    Thomas Kelly; Fiscal Year: 2004
    ..Overall, these students will be able to communicate the importance of cancer detection, prevention, and appropriate treatment in their professional and every-day personal lives, regardless of their eventual specialization or practice. ..