Research Topics
| Kristen M KellySummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Combined photodynamic and photothermal induced injury enhances damage to in vivo model blood vesselsKristen M Kelly
Beckman Laser Institute, University of California, Irvine, California 92612, USA
Lasers Surg Med 34:407-13. 2004..The objective was to evaluate a novel methodology for selective vascular damage, combined photodynamic (PDT) and photothermal (PDL) treatment, using the in vivo chick chorioallantoic membrane (CAM) model...- Description and analysis of treatments for port-wine stain birthmarksKristen M Kelly
Beckman Laser Institute, Irvine, CA 92612, USA
Arch Facial Plast Surg 7:287-94. 2005.... - Thermal responses of ex vivo human skin during multiple cryogen spurts and 1,450 nm laser pulsesRong Zhang
Beckman Laser Institute, University of California, Irvine, 92612, USA
Lasers Surg Med 38:137-41. 2006..The objective of this study is to measure temperature variations at the epidermal-dermal junction in ex vivo human skin during three clinically relevant multiple cryogen spurt-laser pulse sequences (MCS-LPS)... - Cutaneous effects of cryogen spray cooling on in vivo human skinNicole Datrice
Beckman Laser Institute, Irvine, California 92612, USA
Dermatol Surg 32:1007-12. 2006..CONCLUSION: Acute erythema, urticaria, and, less commonly, transient hyperpigmentation were observed after CSC exposure. Permanent skin injury was not observed and is unlikely... - Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimensTia K Smith
Beckman Laser Institute, University of California, Irvine, California 92612, USA
Lasers Surg Med 38:532-9. 2006..PDT/PDL can enhance diminution of microvascular blood flow. Our results suggest that PDT and PDT/PDL should be evaluated as alternative therapeutic options for treatment of hypervascular skin lesions including port wine stain birthmarks... - Evaluation of single versus multiple cryogen spray cooling spurts on in vitro model human skinAlia T Tuqan
Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, CA, 92612, USA
Lasers Med Sci 20:80-6. 2005..For a constant preset Deltat(c) of 40 ms, delivering cryogen in patterns of shorter MCS increased the actual Deltat(c) and consequently the observed epidermal cryo-injury as compared to an SCS... 
Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domainRolf B Saager
University of California Irvine, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA
J Biomed Opt 16:126013. 2011..This method was subsequently applied to the determination of PpIX concentration from in vivo normal skin where the model-based correction determined a concentration of 1.6 μg/ml, which is in agreement with literature...- Use of erythema index imaging for systematic analysis of port wine stain skin response to laser therapyByungjo Jung
Beckman Laser Institute, University of California, Irvine, CA, USA
Lasers Surg Med 37:186-91. 2005.... - Preclinical in vivo evaluation of NPe6-mediated photodynamic therapy on normal vasculatureWesley J Moy
Beckman Laser Institute and Medical Clinic, Department of Surgery, University of California, Irvine, California 92612, USA
Lasers Surg Med 44:158-62. 2012..The objective of the current study was to evaluate a PDT protocol that involves use of an alternate intravascular photosensitizer mono-L-aspartylchlorin-e6 (NPe6) activated by an array of low-cost light emitting diodes... - Wide-field functional imaging of blood flow and hemoglobin oxygen saturation in the rodent dorsal window chamberAustin J Moy
Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
Microvasc Res 82:199-209. 2011..Compared with intravital microscopy, wide-field functional imaging requires simple instrumentation, is inexpensive, and can give detailed metabolic information over a wide field of view... - Vascular effects of photodynamic and pulsed dye laser therapy protocolsJennifer Channual
Beckman Laser Institute, University of California, Irvine, California 92612, USA
Lasers Surg Med 40:644-50. 2008..Here, we evaluate PDT alone, PDL alone, and PDT+PDL protocols using an optimized in vivo rodent dorsal window chamber model... - Skin model surface temperatures during single and multiple cryogen spurts used in laser dermatologic surgeryJulio C Ramirez-San-Juan
Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
Lasers Surg Med 36:141-6. 2005.... - Spatial frequency domain imaging of port wine stain biochemical composition in response to laser therapy: a pilot studyAmaan Mazhar
Beckman Laser Institute, University of California, Irvine, California 92612, USA
Lasers Surg Med 44:611-21. 2012..Herein, we present a pilot study using a newly developed, light emitting diode (LED) based spatial frequency domain imaging (SFDI) device to record quantitatively biochemical compositional changes in PWS after laser therapy... 
An overview of clinical and experimental treatment modalities for port wine stainsJennifer K Chen
Beckman Laser Institute and Medical Clinic, University of California, Irvine, California, USA
J Am Acad Dermatol 67:289-304. 2012....- Effects of motion on optical properties in the spatial frequency domainJohn Quan Nguyen
Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road, Irvine, California 92617 3010, USA
J Biomed Opt 16:126009. 2011.... - Treatment of hypertrophic scars and keloids with a radiofrequency device: a study of collagen effectsAzin Meshkinpour
Beckman Laser Institute, University of California, Irvine, CA 92612, USA
Lasers Surg Med 37:343-9. 2005..ThermaCool alone did not achieve clinical hypertrophic scar or keloid improvement. The collagen effects of this device should be evaluated further in order to optimize its therapeutic potential for all indications... - Combined benzoporphyrin derivative monoacid ring photodynamic therapy and pulsed dye laser for port wine stain birthmarksJoshua A Tournas
Beckman Laser Institute, University of California, Irvine, CA 92612, USA
Photodiagnosis Photodyn Ther 6:195-9. 2009..We propose an alternative treatment option, combined PDT+PDL and performed a proof-of-concept preliminary clinical trial... - Characterization of port wine stain skin erythema and melanin content using cross-polarized diffuse reflectance imagingByungjo Jung
Beckman Laser Institute, Irvine, California 92612 1475, USA
Lasers Surg Med 34:174-81. 2004..To address these issues, a cross-polarized diffuse reflectance imaging system and color image analysis method has been developed to evaluate quantitatively erythema and melanin content in PWS skin... - Evaluation of cryogen spray cooling exposure on in vitro model human skinBunsho Kao
Beckman Laser Institute and Medical Clinic, Irvine, California 92612, USA
Lasers Surg Med 34:146-54. 2004..CONCLUSIONS: Continuous CSC spurts of 80 milliseconds or less induce minimal, if any, epidermal or dermal damage and are unlikely to produce cryo-injury when used during dermatologic laser surgery... - Novel model for evaluation of epidermal preservation and dermal collagen remodeling following photorejuvenation of human skinBunsho Kao
Department of Dermatology and Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
Lasers Surg Med 32:115-9. 2003.... - Quantitative near infrared spectroscopic analysis of Q-Switched Nd:YAG treatment of generalized argyriaRolf B Saager
Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92617, USA
Lasers Surg Med 45:15-21. 2013..No reports have objectively monitored laser treatment of generalized argyria over large areas of skin, nor have long-term outcomes been evaluated... - Enhanced port-wine stain lightening achieved with combined treatment of selective photothermolysis and imiquimodAnne Marie Tremaine
Beckman Laser Institute, University of California, Irvine, Irvine, California 92697 2400, USA
J Am Acad Dermatol 66:634-41. 2012..Posttreatment vessel recurrence is thought to be a factor that limits efficacy of PDL treatment of PWS. Imiquimod 5% cream is an immunomodulator with antiangiogenic effects... - Evaluation of a long pulsed 1064-nm Nd:YAG laser for improvement in appearance of celluliteAnne Truitt
Department of Dermatology, University of California, Irvine School of Medicine, Irvine, CA 92697 2400, USA
J Cosmet Laser Ther 14:139-44. 2012..Cellulite is a common, unwanted condition, which is challenging to treat... - An overview of three promising mechanical, optical, and biochemical engineering approaches to improve selective photothermolysis of refractory port wine stainsGuillermo Aguilar
Department of Mechanical Engineering, University of California, Riverside, CA, USA
Ann Biomed Eng 40:486-506. 2012.... - Treatment of port-wine stain birthmarks using the 1.5-msec pulsed dye laser at high fluences in conjunction with cryogen spray coolingKristen M Kelly
Department of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine 92612, USA
Dermatol Surg 28:309-13. 2002..At this time it is not clear that the use of higher fluences improves treatment efficacy; however, as other aspects of PWS laser treatment are optimized, safe administration of higher fluences is likely to be advantageous... - Wide-field spatial mapping of in vivo tattoo skin optical properties using modulated imagingFrederick R Ayers
University of California Irvine, Beckman Laser Institute, Irvine, California 92612, USA
Lasers Surg Med 41:442-53. 2009..MI provides quantitative measurements of multi-colored tattooed skin which may help guide treatment and objectively assess response... - The horizon for treating cutaneous vascular lesionsAmit M Patel
Department of Dermatology, University of California, Irvine, CA 92612, USA
Semin Cutan Med Surg 31:98-104. 2012..Photodynamic therapy, antiangiogenic therapy, and evolving methods of sclerotherapy are promising areas of development that may mitigate limitations of current treatments and offer exciting options for patients and their physicians... - Prevention and treatment of skin agingJerry L McCullough
Department of Dermatology, University of California, Irvine, 92697 2400, USA
Ann N Y Acad Sci 1067:323-31. 2006.... - What is nonablative photorejuvenation of human skin?J Stuart Nelson
Department of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
Semin Cutan Med Surg 21:238-50. 2002.... - Comparing the effectiveness of 585-nm vs 595-nm wavelength pulsed dye laser treatment of port wine stains in conjunction with cryogen spray coolingCheng-Jen Chang
Department of Plastic Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan
Lasers Surg Med 31:352-8. 2002..Further study is required to optimize wavelength selection on an individual patient basis during PWS therapy in order to improve treatment results... - Synergistic photodynamic and photothermal treatment of port-wine stain?Sol Kimel
Lasers Surg Med 34:80-2. 2004 - Optimization of laser treatment safety in conjunction with cryogen spray coolingKristen M Kelly
Arch Dermatol 139:1372-3. 2003 - Further investigation of pigmentary changes after alexandrite laser hair removal in conjunction with cryogen spray coolingKristen M Kelly
Dermatol Surg 30:581-2. 2004 - Confocal microscopy study of nerves and blood vessels in untreated and treated port wine stains: preliminary observationsMona M Selim
Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA
Dermatol Surg 30:892-7. 2004..PWS blood vessel size correlated with pulsed dye laser response and may prove to be a useful prognostic indicator of therapeutic outcome... - The importance of long-term monitoring to evaluate the microvascular response to light-based therapiesBernard Choi
J Invest Dermatol 128:485-8. 2008