Kathleen A Kelly

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Chemokine expression patterns differ within anatomically distinct regions of the genital tract during Chlamydia trachomatis infection
    Heather K Maxion
    Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California 90095 1732, USA
    Infect Immun 70:1538-46. 2002
  2. pmc Two different homing pathways involving integrin β7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following Chlamydia muridarum infection
    Kathleen A Kelly
    Department of Pathology and Laboratory Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Am J Reprod Immunol 61:438-45. 2009
  3. pmc Differential regulation of CD4 lymphocyte recruitment between the upper and lower regions of the genital tract during Chlamydia trachomatis infection
    K A Kelly
    Department of Pathology, University of California, Los Angeles, Los Angeles, California, USA
    Infect Immun 68:1519-28. 2000
  4. pmc The combination of the gastrointestinal integrin (α4β7) and selectin ligand enhances T-Cell migration to the reproductive tract during infection with Chlamydia trachomatis
    Kathleen A Kelly
    Department of Pathology and Laboratory Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Am J Reprod Immunol 61:446-52. 2009
  5. ncbi request reprint Chlamydia trachomatis infection induces mucosal addressin cell adhesion molecule-1 and vascular cell adhesion molecule-1, providing an immunologic link between the fallopian tube and other mucosal tissues
    K A Kelly
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, USA
    J Infect Dis 184:885-91. 2001
  6. ncbi request reprint Cellular immunity and Chlamydia genital infection: induction, recruitment, and effector mechanisms
    Kathleen A Kelly
    Department of Pathology and Laboratory Medicine, David Geffen Medical Center at University of California Los Angeles, Los Angeles, California 90095 1732, USA
    Int Rev Immunol 22:3-41. 2003
  7. pmc Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model
    Kaori Shimazaki
    Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    FEMS Immunol Med Microbiol 55:240-9. 2009
  8. pmc The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection
    Heather K Maxion
    David Geffen School of Medicine at UCLA, Department of Pathology and Laboratory Medicine, Los Angeles, CA 90095 1732, USA
    Infect Immun 72:6330-40. 2004
  9. pmc Targeting vault nanoparticles to specific cell surface receptors
    Valerie A Kickhoefer
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1737, USA
    ACS Nano 3:27-36. 2009
  10. pmc Identification of dendritic cell subsets responding to genital infection by Chlamydia muridarum
    Raymond J Moniz
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, 90095, USA
    FEMS Immunol Med Microbiol 55:226-36. 2009

Research Grants

Collaborators

Detail Information

Publications24

  1. pmc Chemokine expression patterns differ within anatomically distinct regions of the genital tract during Chlamydia trachomatis infection
    Heather K Maxion
    Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California 90095 1732, USA
    Infect Immun 70:1538-46. 2002
    ..These data demonstrate that the upper and lower regions of the GT respond differently to Chlamydia infection...
  2. pmc Two different homing pathways involving integrin β7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following Chlamydia muridarum infection
    Kathleen A Kelly
    Department of Pathology and Laboratory Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Am J Reprod Immunol 61:438-45. 2009
    ..Chlamydia trachomatis causes STI and reproductive dysfunction worldwide which is not preventable with antibiotics. Identifying a population of endocervical T cells to target in vaccine development would enhance efficacy...
  3. pmc Differential regulation of CD4 lymphocyte recruitment between the upper and lower regions of the genital tract during Chlamydia trachomatis infection
    K A Kelly
    Department of Pathology, University of California, Los Angeles, Los Angeles, California, USA
    Infect Immun 68:1519-28. 2000
    ..Taken together, these data suggest that regulatory mechanisms of lymphocyte recruitment differ between the upper and lower regions of the GT and may influence the clearance of chlamydiae and the development of tubal pathology...
  4. pmc The combination of the gastrointestinal integrin (α4β7) and selectin ligand enhances T-Cell migration to the reproductive tract during infection with Chlamydia trachomatis
    Kathleen A Kelly
    Department of Pathology and Laboratory Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Am J Reprod Immunol 61:446-52. 2009
    ..Identifying a population of endocervical T-cells to target in vaccine development is likely to enhance efficacy of a vaccine and reduce reproductive tract dysfunction...
  5. ncbi request reprint Chlamydia trachomatis infection induces mucosal addressin cell adhesion molecule-1 and vascular cell adhesion molecule-1, providing an immunologic link between the fallopian tube and other mucosal tissues
    K A Kelly
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, USA
    J Infect Dis 184:885-91. 2001
    ..Therefore, infection with C. trachomatis induces adhesion molecules that are associated with other mucosal tissues and inflammatory sites, which suggests that mucosal routes of immunization may be effective...
  6. ncbi request reprint Cellular immunity and Chlamydia genital infection: induction, recruitment, and effector mechanisms
    Kathleen A Kelly
    Department of Pathology and Laboratory Medicine, David Geffen Medical Center at University of California Los Angeles, Los Angeles, California 90095 1732, USA
    Int Rev Immunol 22:3-41. 2003
    ..An understanding of these events is important for the design of a protective vaccine and control of immunopathologic reactions...
  7. pmc Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model
    Kaori Shimazaki
    Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    FEMS Immunol Med Microbiol 55:240-9. 2009
    ..These findings support EMP2 as a potential preventative and therapeutic target for genital chlamydial infection...
  8. pmc The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection
    Heather K Maxion
    David Geffen School of Medicine at UCLA, Department of Pathology and Laboratory Medicine, Los Angeles, CA 90095 1732, USA
    Infect Immun 72:6330-40. 2004
    ..Taken together, these data suggest that innate immune cells contribute to control of ascending infection...
  9. pmc Targeting vault nanoparticles to specific cell surface receptors
    Valerie A Kickhoefer
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1737, USA
    ACS Nano 3:27-36. 2009
    ..The ability to target vaults to specific cells represents an essential advance toward using recombinant vaults as delivery vehicles...
  10. pmc Identification of dendritic cell subsets responding to genital infection by Chlamydia muridarum
    Raymond J Moniz
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, 90095, USA
    FEMS Immunol Med Microbiol 55:226-36. 2009
    ..cDCs are prepared for induction of antichlamydial T-cell responses, whereas pDCs have characteristics associated with the differentiation of non-Th1 cell subsets...
  11. pmc CD8⁺CXCR5⁺ T cells regulate pathology in the genital tract
    Janina Jiang
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Infect Dis Obstet Gynecol 2013:813238. 2013
    ..muridarum infection. Future studies will investigate the mechanism by which this cell type regulates genital tract pathology...
  12. pmc Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection
    Janina Jiang
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e47487. 2012
    ..We reported that CXCL13 was induced in fallopian tube tissue following C. trachomatis infection. Here, we examined the influence of the CXCL13-CXCR5 axis in chlamydial genital infection...
  13. ncbi request reprint COX-2 inhibition affects growth rate of Chlamydia muridarum within epithelial cells
    Wei Liu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Mailroom A7 149 CHS, Los Angeles, CA 90095 1732, USA
    Microbes Infect 8:478-86. 2006
    ..In addition, the absence of COX-2 did not significantly modify apoptosis in infected cells. In total, COX-2 deficiency reduces the infectious burden in vivo and may modulate transmission of the organism...
  14. pmc Vault nanocapsules as adjuvants favor cell-mediated over antibody-mediated immune responses following immunization of mice
    Upendra K Kar
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e38553. 2012
    ..The purpose of our study was to characterize immunity produced in response to OVA within vault nanoparticles and compare it to another nanocarrier...
  15. ncbi request reprint Epithelial membrane protein 2 modulates infectivity of Chlamydia muridarum (MoPn)
    Kaori Shimazaki
    Molecular Biology Institute, Los Angeles, CA 90095, USA
    Microbes Infect 9:1003-10. 2007
    ..These findings identify EMP2 as a candidate host protein involved in infection of C. muridarum (MoPn)...
  16. ncbi request reprint Dendritic cells derived from multiple myeloma patients efficiently internalize different classes of myeloma protein
    A W Butch
    Department of Pathology and Laboratory Medicine, UCLA Medical Center, 10833 Le Conte Ave, Mailroom A2 179 CHS, Los Angeles, CA 90095 1732, USA
    Exp Hematol 29:85-92. 2001
    ..This demonstrates the feasibility of using all classes of myeloma protein for producing DC vaccines, and defines culture conditions for optimizing antigen loading of DCs for induction of anti-myeloma responses...
  17. pmc A vault nanoparticle vaccine induces protective mucosal immunity
    Cheryl I Champion
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e5409. 2009
    ..Here we report the use of a recombinant nanoparticle as a vaccine delivery platform against mucosal infections requiring T cell-mediated immunity for eradication...
  18. pmc Chlamydia trachomatis infection does not enhance local cellular immunity against concurrent Candida vaginal infection
    K A Kelly
    Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California, USA
    Infect Immun 69:3451-4. 2001
    ..Together, these results suggest that host responses to these genital tract infections are independent and not influenced by the presence of the other...
  19. pmc CXCL13 expression in Chlamydia trachomatis infection of the female reproductive tract
    M King
    Division of Neonatology, Department of Pediatrics, David Geffen UCLA Medical Center, Los Angeles, California, USA
    Drugs Today (Barc) 45:125-34. 2009
    ..trachomatis...
  20. pmc Antigen-specific immunoglobulin E+ B cells are preferentially localized within germinal centres
    Kathleen A Kelly
    Department of Pathology and Laboratory Medicine, Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    Immunology 120:345-53. 2007
    ..Taken together, these data highlight the importance of GCs in the production of antigen-specific IgE antibody...
  21. ncbi request reprint Human follicular dendritic cells inhibit superantigen-induced T-cell proliferation by distinct mechanisms
    A W Butch
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72212, USA
    Blood 94:216-24. 1999
    ..These results indicate that FDCs regulate T-cell proliferation by two molecular mechanisms and that FDC:T-cell interactions may play a pivotal role in germinal center development...
  22. pmc A Chlamydia trachomatis-specific Th2 clone does not provide protection against a genital infection and displays reduced trafficking to the infected genital mucosa
    Raymond A Hawkins
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Infect Immun 70:5132-9. 2002
    ..The data show that the MoPn-specific Th2 cells are important for serum and vaginal antibody production and may accumulate in the GT during chronic infection...
  23. ncbi request reprint Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum
    Lynn Welter-Stahl
    Université Paris Denis Diderot, Institut Jacques Monod, 75251 Paris, France
    Cell Microbiol 8:1047-57. 2006
    ....
  24. ncbi request reprint Chlamydia trachomatis enhances the expression of matrix metalloproteinases in an in vitro model of the human fallopian tube infection
    Kevin A Ault
    Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City, USA
    Am J Obstet Gynecol 187:1377-83. 2002
    ..Our objective was to describe the production of two matrix metalloproteinases in response to chlamydial infection in vitro...

Research Grants10

  1. T-CELL MEDIATED IMMUNITY IN CHLAMYDIAL GENITAL INFECTION
    Kathleen Kelly; Fiscal Year: 2003
    ..Also, using IL-10 knockout and transgenic mice we will determine whether IL-10 producing T cell subsets influence anti-Chlamydia immunity and the development of upper GT injury. ..
  2. T-cell mediated immunity in chlamydia genital infection
    Kathleen A Kelly; Fiscal Year: 2010
    ....
  3. T-cell mediated immunity in chlamydia genital infection
    Kathleen Kelly; Fiscal Year: 2009
    ....
  4. CELLULAR TRAFFICKING TO INFLAMED FEMALE GENITAL MUCOSA
    Kathleen Kelly; Fiscal Year: 2007
    ..Insight into CXCL13 secretion will impact public health and the welfare of women in the US by aiding the development of therapeutics to prevent tubal infertility. ..
  5. T-CELL MEDIATED IMMUNITY IN CHLAMYDIAL GENITAL INFECTION
    Kathleen Kelly; Fiscal Year: 2007
    ..Also, using IL-10 knockout and transgenic mice we will determine whether IL-10 producing T cell subsets influence anti-Chlamydia immunity and the development of upper GT injury, ..
  6. T-CELL MEDIATED IMMUNITY IN CHLAMYDIAL GENITAL INFECTION
    Kathleen Kelly; Fiscal Year: 2006
    ..Also, using IL-10 knockout and transgenic mice we will determine whether IL-10 producing T cell subsets influence anti-Chlamydia immunity and the development of upper GT injury. ..
  7. Novel ways to prevent upper GT infection
    Kathleen A Kelly; Fiscal Year: 2010
    ..trachomatis STIs. ..