Aaron S Kelly

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Younger age is associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, and University of Minnesota Amplatz Children s Hospital, Minneapolis, MN 55455, USA Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA Electronic address
    Atherosclerosis 234:410-4. 2014
  2. ncbi request reprint The effect of glucagon-like peptide-1 receptor agonist therapy on body mass index in adolescents with severe obesity: a randomized, placebo-controlled, clinical trial
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St, SE, MMC 715, Minneapolis, MN 55455, USA
    JAMA Pediatr 167:355-60. 2013
  3. pmc Endothelial function in children and adolescents with mucopolysaccharidosis
    Aaron S Kelly
    Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Medical School, 420 Delaware St S E, Minneapolis, MN 55455, USA
    J Inherit Metab Dis 36:221-5. 2013
  4. pmc Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: a randomized trial
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA
    Cardiovasc Diabetol 11:64. 2012
  5. pmc Hyperleptinemia and hypoadiponectinemia in extreme pediatric obesity
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Metab Syndr Relat Disord 10:123-7. 2012
  6. pmc Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 20:364-70. 2012
  7. doi request reprint Carvedilol-lisinopril combination therapy and endothelial function in obese individuals with hypertension
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Clin Hypertens (Greenwich) 14:85-91. 2012
  8. ncbi request reprint Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in children
    Aaron S Kelly
    Departments of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Cardiometab Syndr 1:248-52. 2006
  9. pmc Relation of circulating oxidized LDL to obesity and insulin resistance in children
    Aaron S Kelly
    Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Pediatr Diabetes 11:552-5. 2010
  10. pmc Circulating activated endothelial cells in pediatric obesity
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Pediatr 157:547-51. 2010

Detail Information

Publications46

  1. ncbi request reprint Younger age is associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, and University of Minnesota Amplatz Children s Hospital, Minneapolis, MN 55455, USA Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA Electronic address
    Atherosclerosis 234:410-4. 2014
    ....
  2. ncbi request reprint The effect of glucagon-like peptide-1 receptor agonist therapy on body mass index in adolescents with severe obesity: a randomized, placebo-controlled, clinical trial
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St, SE, MMC 715, Minneapolis, MN 55455, USA
    JAMA Pediatr 167:355-60. 2013
    ..Glucagon-like peptide-1 (GLP-1) receptor agonists induce weight loss by suppressing appetite and increasing satiety, but few studies have evaluated this therapy as a treatment for obesity...
  3. pmc Endothelial function in children and adolescents with mucopolysaccharidosis
    Aaron S Kelly
    Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Medical School, 420 Delaware St S E, Minneapolis, MN 55455, USA
    J Inherit Metab Dis 36:221-5. 2013
    ..Non-invasive methods of assessing vascular endothelial function may provide a measure of cardiovascular risk in MPS. We evaluated endothelial function, using digital reactive hyperemia, in youth with MPS and in healthy controls...
  4. pmc Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: a randomized trial
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA
    Cardiovasc Diabetol 11:64. 2012
    ..We compared the acute and chronic effects of the GLP-1 receptor agonist exenatide vs. metformin on endothelial function in patients with obesity and pre-diabetes...
  5. pmc Hyperleptinemia and hypoadiponectinemia in extreme pediatric obesity
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Metab Syndr Relat Disord 10:123-7. 2012
    ..Therefore, levels were compared in youth that were extremely obese (EO) to normal weight (NW), overweight (OW), and obese (OB) youth...
  6. pmc Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 20:364-70. 2012
    ..These preliminary data suggest that exenatide should be evaluated in larger, well-controlled trials for its ability to reduce BMI and improve cardiometabolic risk factors in youth with extreme obesity...
  7. doi request reprint Carvedilol-lisinopril combination therapy and endothelial function in obese individuals with hypertension
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Clin Hypertens (Greenwich) 14:85-91. 2012
    ..Levels of oxidative stress were not significantly different between treatments, suggesting that other mechanisms may be responsible for the improvement in endothelial function...
  8. ncbi request reprint Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in children
    Aaron S Kelly
    Departments of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Cardiometab Syndr 1:248-52. 2006
    ..Overweight children with components of the metabolic syndrome may be at elevated risk for future cardiovascular disease...
  9. pmc Relation of circulating oxidized LDL to obesity and insulin resistance in children
    Aaron S Kelly
    Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Pediatr Diabetes 11:552-5. 2010
    ..The purpose of this study was to assess the relation of oxidative stress, measured by circulating oxidized LDL, with measures of adiposity and insulin resistance in children...
  10. pmc Circulating activated endothelial cells in pediatric obesity
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Pediatr 157:547-51. 2010
    ..We characterized the state of the vascular endothelium in pediatric obesity by comparing circulating endothelial cell (CEC) number and activation phenotype in severely obese children to that of normal weight, overweight, and obese children...
  11. pmc Predicting cardiovascular risk in young adulthood from the metabolic syndrome, its component risk factors, and a cluster score in childhood
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA
    Int J Pediatr Obes 6:e283-9. 2011
    ..This study compared the MetS in late childhood (mean age 13) versus a cluster score of the MetS components as predictors of young adult (mean age 22) cardiovascular risk...
  12. ncbi request reprint In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children
    Aaron S Kelly
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Metabolism 56:1005-9. 2007
    ..These data suggest that in the absence of weight loss, exercise training alone does not improve the adipokine profile or levels of oxidative stress in overweight children...
  13. ncbi request reprint Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus
    Aaron S Kelly
    Department of Research, St Paul Heart Clinic, St Paul, MN, USA
    Vasc Med 12:311-8. 2007
    ..078). In conclusion, compared with glyburide, rosiglitazone improves endothelial function and CRP in patients with T2DM. These improvements are not associated with reductions in ADMA or markers of oxidative stress...
  14. ncbi request reprint Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise
    Aaron S Kelly
    University of Minnesota, Minneapolis, and St Paul Heart Clinic, St Paul, Minnesota, USA
    J Pediatr 145:731-6. 2004
    ..To assess subclinical inflammation, fasting insulin, and endothelial function before and after exercise in overweight children and adolescents...
  15. pmc Impact of pubertal development on endothelial function and arterial elasticity
    Kara L Marlatt
    Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN
    J Pediatr 163:1432-6. 2013
    ....
  16. pmc Endothelium-independent dilation in children and adolescents
    Kara L Marlatt
    Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Physiol Funct Imaging 31:390-3. 2011
    ..Peak response to NTG administration occurs between 4 and 5 min. The results demonstrate the importance of measuring EID up to 5-min post-NTG administration in youth...
  17. pmc Evaluation of gender differences in endothelium-independent dilation using peripheral arterial tonometry
    Meghan C McCue
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Physiol Funct Imaging 32:94-8. 2012
    ..Although most research examining vascular function and cardiovascular disease has focused on EDD, there is evidence that cardiovascular risk factors may impair EID...
  18. doi request reprint Postprandial endothelial function, inflammation, and oxidative stress in obese children and adolescents
    Andrea M Metzig
    Department of Pediatrics, Division of Epidemiology and Clinical Research, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 19:1279-83. 2011
    ..However, associations of postprandial hyperglycemia with endothelial function and oxidative stress may have implications for individuals with impaired glucose tolerance or frank type 2 diabetes...
  19. doi request reprint Multi-plane mechanical dyssynchrony in cardiac resynchronization therapy
    Christopher L Kaufman
    Department of Research, St Paul Heart Clinic, St Paul, Minnesota 55102, USA
    Clin Cardiol 33:E31-8. 2010
    ..The aims of this study were to assess the ability of several echo measures of dyssynchrony to predict CRT response and to characterize the global effect of CRT...
  20. ncbi request reprint Relationships of cardiac autonomic function with metabolic abnormalities in childhood obesity
    Christopher L Kaufman
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55102, USA
    Obesity (Silver Spring) 15:1164-71. 2007
    ..The objective was to examine cardiovascular autonomic (cANS) function and its potential relationships with leptin resistance, insulin resistance, oxidative stress, and inflammation in a pediatric sample with varying levels of obesity...
  21. pmc Circulating oxidized LDL and inflammation in extreme pediatric obesity
    Anne L Norris
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 19:1415-9. 2011
    ....
  22. pmc Cardiovascular risk and insulin resistance in childhood cancer survivors
    Julia Steinberger
    Department of Pediatrics, University of Minnesota Medical Center, Minneapolis, MN 55454, USA
    J Pediatr 160:494-9. 2012
    ..Increased cardiovascular (CV) risk has been reported in adults who are childhood cancer survivors (CCS). We sought to determine the emergence of CV risk factors in CCS while still children...
  23. doi request reprint Intramural dyssynchrony from acute right ventricular apical pacing in human subjects with normal left ventricular function
    Alan J Bank
    St Paul Heart Clinic, 225 N Smith Ave, Suite 400, St Paul, MN 55102, USA
    J Cardiovasc Transl Res 3:321-9. 2010
    ....
  24. ncbi request reprint Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus
    Alan J Bank
    Department of Research, St Paul Heart Clinic, St Paul, Minnesota, USA
    Am J Hypertens 20:777-83. 2007
    ..We sought to compare the effects of carvedilol and metoprolol tartrate on endothelial function and oxidative stress in a head-to-head trial...
  25. ncbi request reprint Effect of oral glucose loading on endothelial function in normal-weight and overweight children
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Sci (Lond) 112:493-8. 2007
    ..6 compared with 20.2+/-2.0% respectively; P=0.019). In conclusion, these results suggest that acute elevation of glucose and insulin in overweight and normal-weight children are not associated with impairment in endothelial function...
  26. doi request reprint Intramural dyssynchrony and response to cardiac resynchronization therapy in patients with and without previous right ventricular pacing
    Alan J Bank
    St Paul Heart Clinic, 225 N Smith Ave 400, St Paul, MN 55102, USA
    Eur J Heart Fail 12:1317-24. 2010
    ..We assessed whether HF patients paced from the right ventricle (RVp) adversely remodel and respond to cardiac resynchronization therapy (CRT) in a similar way to HF patients without right ventricular pacing (nRVp)...
  27. pmc The influence of gender on carotid artery compliance and distensibility in children and adults
    Kara L Marlatt
    Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN, USA
    J Clin Ultrasound 41:340-6. 2013
    ..The purpose of our study was to evaluate the impact of gender on carotid arterial elasticity in a large sample of children and adults...
  28. doi request reprint Results of the Prospective Minnesota Study of ECHO/TDI in Cardiac Resynchronization Therapy (PROMISE-CRT) study
    Alan J Bank
    Minnesota Heart Failure Consortium, Minneapolis, Minnesota, USA
    J Card Fail 15:401-9. 2009
    ....
  29. doi request reprint Examining the time course of endothelium-independent dilation by nitroglycerin
    Andrea M Thelen
    St Paul Heart Clinic, Laboratory of Preventive Vascular Medicine, St Paul, MN, USA
    Ultrasound Med Biol 34:1217-20. 2008
    ..0001). The results of this study indicate that maximal EID occurs approximately five minutes after NTG administration. Measuring EID at three minutes after NTG administration likely underestimates the true dilation capacity of the artery...
  30. pmc Pilot study of vascular health in survivors of Hodgkin lymphoma
    Daniel A Mulrooney
    School of Public Health, Masonic Cancer Center, and University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 59:285-9. 2012
    ..Vascular-related toxicities have been reported among survivors of Hodgkin lymphoma (HL), but their genesis is not well understood...
  31. ncbi request reprint Effects of weight loss on insulin sensitivity and arterial stiffness in overweight adults
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Metabolism 55:907-11. 2006
    ..In overweight adults, 6 months of weight loss resulted in improvements in body composition, insulin sensitivity, lipid profile, and brachial artery compliance and distensibility...
  32. ncbi request reprint The cardiovascular effects of the thiazolidinediones: a review of the clinical data
    Aaron S Kelly
    Laboratory of Preventive Vascular Medicine, Department of Research, St Paul Heart Clinic, St Paul, MN 55102, USA
    J Diabetes Complications 21:326-34. 2007
    ....
  33. doi request reprint Diet revision in overweight children: effect on autonomic and vascular function
    Christopher L Kaufman
    School of Kinesiology, University of Minnesota, Minneapolis, MN, USA
    Clin Auton Res 18:105-8. 2008
    ..Changes in body composition in OW children due to dietary modification alone can result in modest improvements in indices of cardiac risk...
  34. doi request reprint Torsion and dyssynchrony differences between chronically paced and non-paced heart failure patients
    Kevin V Burns
    Department of Research, St Paul Heart Clinic, St Paul, MN 55102, USA
    J Card Fail 17:495-502. 2011
    ..Cardiac mechanics may differ between paced and nonpaced heart failure patients, and their optimal treatment may also differ...
  35. doi request reprint Signs of early sub-clinical atherosclerosis in childhood cancer survivors
    Donald R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, 55455 Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, 55455
    Pediatr Blood Cancer 61:532-7. 2014
    ..The effect of cancer treatments on vascular structure and function in childhood cancer survivors (CCS) has not been examined...
  36. doi request reprint Effects of the left ventricular assist device on the compliance and distensibility of the carotid artery
    Danielle L Templeton
    School of Kinesiology, University of Minnesota, Minneapolis, USA
    Heart Vessels 28:377-84. 2013
    ..Chronic continuous-flow LVAD support is associated with lower carotid artery compliance and distensibility, which may place further strain on the left ventricle...
  37. ncbi request reprint Cardiac resynchronization therapy: role of patient selection
    Alan J Bank
    Department of Research, St Paul Heart Clinic, 255 North Smith Avenue, Suite 100, St Paul, MN 55102, USA
    Curr Cardiol Rep 8:336-42. 2006
    ....
  38. ncbi request reprint Lower relative bone mineral content in obese adolescents: role of non-weight bearing exercise
    Danielle L Templeton
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Pediatr Exerc Sci 22:557-68. 2010
    ..Weight-bearing aerobic exercise would be a better option for optimizing bone health in this population...
  39. ncbi request reprint Comparison of B-mode and echo tracking methods of assessing flow-mediated dilation
    Aaron S Kelly
    University of Minnesota, Minneapolis, Minnesota 55102, USA
    Ultrasound Med Biol 30:1447-9. 2004
    ..75 +/- 0.65 mm, 4.00 +/- 0.63 mm and 6.91 +/- 2.85%, respectively. Results, as displayed by Bland-Altman graphs, indicate a strong agreement between B-mode and echo tracking methods of assessing brachial artery diameter changes via FMD...
  40. ncbi request reprint Evaluation of traditional and novel measures of cardiac function to detect anthracycline-induced cardiotoxicity in survivors of childhood cancer
    Andrew C Dietz
    Division of Hematology Oncology BMT, Department of Pediatrics, University of California San Diego and Rady Children s Hospital, 3020 Children s Way, MC5035, San Diego, CA, 92123, USA
    J Cancer Surviv 8:183-9. 2014
    ..This study aimed to evaluate these modalities in detection of anthracycline-induced cardiac toxicity...
  41. ncbi request reprint The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction
    Alan J Bank
    St Paul Heart Clinic, St Paul, MN 55102, USA
    Vasc Med 11:251-7. 2006
    ..In conclusion, treatment with quinapril, in combination with sildenafil, improved ED in men with suboptimal response to sildenafil alone. Atorvastatin demonstrated a trend toward improved ED in this group...
  42. ncbi request reprint Aerobic-exercise training improves ventilatory efficiency in overweight children
    Christopher Kaufman
    School of Kinesiology, University of Minnesota, MN 55455, USA
    Pediatr Exerc Sci 19:82-92. 2007
    ..8 +/- 0.80 to 31.0 +/- 0.53 vs. control = 30.3 +/- 0.88 to 31.7 +/- 0.91, p < .05). Aerobic-exercise training might help reverse the decrements in cardiopulmonary function observed over time in overweight children...
  43. ncbi request reprint Xanthine oxidase and cardiovascular risk in obese children
    Harrison K Tam
    1 Department of Experimental and Clinical Pharmacology, University of Minnesota, College of Pharmacy, Minneapolis, MN
    Child Obes 10:175-80. 2014
    ..The aim of this study was to determine whether differential XO activity is associated with endothelial dysfunction, CVD risk factors, or cytokine levels...
  44. ncbi request reprint Tissue Doppler imaging and left ventricular dyssynchrony in heart failure
    Alan J Bank
    Research Division, St Paul Heart Clinic, 255 North Smith Avenue, Ste 100, St Paul, MN 55102, USA
    J Card Fail 12:154-62. 2006
    ..However, recent data support the use of mechanical rather than electrical dyssynchrony as the major criterion for receiving CRT...
  45. ncbi request reprint Sorting through the relations among metabolic syndrome, insulin resistance, and endothelial dysfunction
    Aaron S Kelly
    Am J Cardiol 101:127-8. 2008
  46. ncbi request reprint Cardiovascular risk at the extremes of body composition
    Julia Steinberger
    J Pediatr 149:739-40. 2006