J A Kellum

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The concept of acute kidney injury and the RIFLE criteria
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA, and Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Contrib Nephrol 156:10-6. 2007
  2. ncbi request reprint The first international consensus conference on continuous renal replacement therapy
    John A Kellum
    Department of Critical Care Medicine and Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Kidney Int 62:1855-63. 2002
  3. pmc Hemofiltration in sepsis: where do we go from here?
    J A Kellum
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 4:69-71. 2000
  4. ncbi request reprint Continuous versus intermittent renal replacement therapy: a meta-analysis
    John A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Division of Critical Care Medicine, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Intensive Care Med 28:29-37. 2002
  5. ncbi request reprint Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved short-term survival and acid-base balance with Hextend compared with saline
    John A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    Crit Care Med 30:300-5. 2002
  6. ncbi request reprint Diuretics in acute kidney injury
    V Karajala
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Minerva Anestesiol 75:251-7. 2009
  7. ncbi request reprint Fluids for prevention and management of acute kidney injury
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 31:96-110. 2008
  8. ncbi request reprint Fluid management in acute kidney injury
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 31:94-5. 2008
  9. ncbi request reprint Metabolic acidosis in the critically ill: lessons from physical chemistry
    J A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Kidney Int Suppl 66:S81-6. 1998
  10. pmc Determinants of blood pH in health and disease
    J A Kellum
    University of Pittsburgh Medical Center, Division of Critical Care, Pittsburgh, Pennsylvania 15213 2582, USA
    Crit Care 4:6-14. 2000

Collaborators

Detail Information

Publications76

  1. ncbi request reprint The concept of acute kidney injury and the RIFLE criteria
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA, and Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Contrib Nephrol 156:10-6. 2007
    ..The term acute kidney injury has subsequently been proposed to distinguish this new concept from the older terminology of failure...
  2. ncbi request reprint The first international consensus conference on continuous renal replacement therapy
    John A Kellum
    Department of Critical Care Medicine and Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Kidney Int 62:1855-63. 2002
    ..We sought to review the available evidence, make evidence-based practice recommendations, and delineate key questions for future study...
  3. pmc Hemofiltration in sepsis: where do we go from here?
    J A Kellum
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 4:69-71. 2000
    ..Clinical as well as technical difficulties remain important considerations to future studies. These issues are discussed and the brief history of hemofiltration in sepsis is reviewed...
  4. ncbi request reprint Continuous versus intermittent renal replacement therapy: a meta-analysis
    John A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Division of Critical Care Medicine, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Intensive Care Med 28:29-37. 2002
    ..As controversy exists regarding which modality should be used for most patients with critically illness, we sought to determine whether CRRT or IRRT is associated with better survival...
  5. ncbi request reprint Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved short-term survival and acid-base balance with Hextend compared with saline
    John A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    Crit Care Med 30:300-5. 2002
    ..To compare resuscitation with 0.9% saline with Hextend, a synthetic colloid in a balanced electrolyte solution, in terms of acid-base status and survival time in an experimental model of septic shock in the rat...
  6. ncbi request reprint Diuretics in acute kidney injury
    V Karajala
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Minerva Anestesiol 75:251-7. 2009
    ..There have been many studies both supporting and criticizing diuretic use in AKI for improving overall patient outcomes...
  7. ncbi request reprint Fluids for prevention and management of acute kidney injury
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 31:96-110. 2008
    ..This systematic review focuses on fluids for prevention and management of acute kidney injury. We have reviewed the available evidence and have made recommendations for clinical practice and future studies...
  8. ncbi request reprint Fluid management in acute kidney injury
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 31:94-5. 2008
  9. ncbi request reprint Metabolic acidosis in the critically ill: lessons from physical chemistry
    J A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Kidney Int Suppl 66:S81-6. 1998
    ..This approach emphasizes the application of accepted physical chemical principles and identification of independent and dependent acid-base variables. In aqueous solutions, water dissociation is the major source of free hydrogen ions...
  10. pmc Determinants of blood pH in health and disease
    J A Kellum
    University of Pittsburgh Medical Center, Division of Critical Care, Pittsburgh, Pennsylvania 15213 2582, USA
    Crit Care 4:6-14. 2000
    ..All changes in blood pH, in health and in disease, occur through changes in these three variables. Clinical implications for these findings are also discussed...
  11. ncbi request reprint Genetic variation and risk of sepsis
    J A Kellum
    The CRISMA Laboratory Clinical Research, Investigation and Systems Modeling of Acute illness, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine Pittsburgh, Pennsylvania 15261, USA
    Minerva Anestesiol 69:245-53. 2003
    ..g. tumor necrosis factor) has lent credence to this hypothesis. Yet discovery of the actual relationship between risks of infection / severe sepsis and individual genotypes will require larger, more rigorously designed studies...
  12. ncbi request reprint Acute Dialysis Quality Initiative (ADQI): methodology
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Int J Artif Organs 31:90-3. 2008
    ..We further recognize that additional research will be needed and have proposed specific studies that will help move this field forward...
  13. ncbi request reprint Application of blood purification to non-renal organ failure
    J A Kellum
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 28:445-9. 2005
    ..The focus of these reviews is on clinical evidence as well as recommendations for future research...
  14. ncbi request reprint What can be done about acute renal failure?
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Minerva Anestesiol 70:181-8. 2004
    ..Recent data suggest that NAC can reduce the incidence of ARF secondary to radio-contrast agents and improved techniques for RRT and, perhaps, new drugs aimed at improving cellular repair, will improve outcome from ARF in the future...
  15. ncbi request reprint Incidence and definition of sepsis and associated organ dysfunction
    T T Dremsizov
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Artif Organs 27:352-9. 2004
    ..To discuss the incidence, outcome and predisposing factors to systemic inflammatory response syndrome (SIRS), sepsis, and multiple organ failure...
  16. ncbi request reprint Use of dopamine in acute renal failure: a meta-analysis
    J A Kellum
    Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
    Crit Care Med 29:1526-31. 2001
    ..CONCLUSIONS: The use of low-dose dopamine for the treatment or prevention of acute renal failure cannot be justified on the basis of available evidence and should be eliminated from routine clinical use...
  17. ncbi request reprint Plasma filtration on mediators of thrombotic microangiopathy: an in vitro study
    Z Y Peng
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 30:401-6. 2007
    ..Sepsis-induced thrombotic microangiopathy is successfully treated by plasma exchange therapy. However, certain putative mediators of thrombotic microangiopathy may not be removed by plasma filtration...
  18. ncbi request reprint The modern concept of homeostasis
    J A Kellum
    Departments of Anesthesiology CCM and Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Minerva Anestesiol 68:3-11. 2002
  19. pmc 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 176:1129-37. 2007
    ..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown...
  20. ncbi request reprint Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    Clin J Am Soc Nephrol 2:431-9. 2007
    ..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT...
  21. ncbi request reprint Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
    Arch Intern Med 167:1655-63. 2007
    ..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death...
  22. ncbi request reprint Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators
    Shigehiko Uchino
    Jikei University School of Medicine, Intensive Care Unit, Department of Anesthesiology, Tokyo, Japan
    Intensive Care Med 33:1563-70. 2007
    ..Little information is available regarding current practice in continuous renal replacement therapy (CRRT) for the treatment of acute renal failure (ARF) and the possible clinical effect of practice variation...
  23. ncbi request reprint Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats
    Jose L Gómez
    MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Chest 131:1295-300. 2007
    ..To determine if animals with abnormally low albumin levels are more susceptible to the effects of hypercapnia on BP compared to normal animals...
  24. ncbi request reprint Prevention of acute renal failure
    Ramesh Venkataraman
    The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Chest 131:300-8. 2007
    ..Increasing insight into mechanisms leading to ARF and the importance of facilitating renal recovery has prompted investigators to evaluate the role of newer therapeutic agents in the prevention of ARF...
  25. ncbi request reprint Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:1061-7. 2007
    ....
  26. pmc A targeted extracorporeal therapy for endotoxemia: the time has come
    John A Kellum
    The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 11:137. 2007
    ..Multiple small trials, often limited by methodological quality, show that polymyxin B hemo-perfusion may have favorable effects on survival and hemodynamics. Further study of this therapy would seem justified...
  27. ncbi request reprint Acid-base disorders and strong ion gap
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15216, USA
    Contrib Nephrol 156:158-66. 2007
    ..Attempts to identify the exact chemical nature of ions identified by the strong ion gap have only been of limited success and further study is needed...
  28. ncbi request reprint Prerenal azotemia: still a useful concept?
    John A Kellum
    Crit Care Med 35:1630-1. 2007
  29. ncbi request reprint Normotensive ischemic acute renal failure
    Rinaldo Bellomo
    N Engl J Med 357:2205; author reply 2205-6. 2007
  30. pmc Evaluation and initial management of acute kidney injury
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 3:962-7. 2008
    ....
  31. doi request reprint Acute kidney injury: epidemiology and assessment
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Scand J Clin Lab Invest Suppl 241:6-11. 2008
    ..Patients with AKI who are treated with RRT, still have a mortality of 50-60 %. Of surviving patients, 5-20 % remain dialysis-dependent at hospital discharge...
  32. doi request reprint Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation
    Raghavan Murugan
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:1810-6. 2008
    ..We test the hypothesis that increased inflammatory response is associated with fewer organs transplanted and decreased recipient survival...
  33. doi request reprint The future of extracorporeal support
    Dinna Cruz
    Department of Nephrology, Ospedale San Bortolo, and International Renal Research Institute Vicenza, Vicenza, Italy
    Crit Care Med 36:S243-52. 2008
    ..This article provides a brief overview of current and future direction in extracorporeal support in the critical care setting...
  34. doi request reprint Oliguria, volume overload, and loop diuretics
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Crit Care Med 36:S172-8. 2008
    ..This contradiction between clinical practice and available evidence would suggest there is equipoise and need for higher-quality evidence to better characterize the role of loop diuretics in ICU patients with AKI...
  35. doi request reprint Acute kidney injury
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:S141-5. 2008
    ..The RIFLE criteria provide a uniform definition of acute kidney injury and have now been validated in numerous studies...
  36. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  37. pmc Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia
    David T Huang
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Emerg Med 52:48-58.e2. 2008
    ..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65...
  38. ncbi request reprint The Acute Dialysis Quality Initiative II: the Vicenza conference
    Rinaldo Bellomo
    Department of Intensive Care, Austin and Repatriation Hospital, Melbourne, Australia
    Adv Ren Replace Ther 9:290-3. 2002
    ..These developments have set the stage for the first conference and have now driven the spirit of the second. Once again, the final objectives are the development of evidence-based guidelines and directions for future research...
  39. doi request reprint Defining and classifying AKI: one set of criteria
    John A Kellum
    Nephrol Dial Transplant 23:1471-2. 2008
  40. doi request reprint Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi process
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Scaife Hall, Room 608, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 3:887-94. 2008
    ..An international, consensus-based, prioritized research agenda was sought to guide clinical and translational research in acute kidney injury...
  41. doi request reprint Comparison of acid-base models for prediction of hospital mortality after trauma
    Lewis J Kaplan
    Department of Surgery, Section of Trauma, Critical Care, and Surgical Emergencies, Yale University School of Medicine, New Haven, CT 06520, USA
    Shock 29:662-6. 2008
    ..Admission pH, HCO3-, and lactate were poor predictors of hospital mortality after trauma. An elevated SIG presaged mortality after injury and should be assessed on admission...
  42. doi request reprint Costs and outcomes of acute kidney injury (AKI) following cardiac surgery
    Joseph F Dasta
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Nephrol Dial Transplant 23:1970-4. 2008
    ..We determined costs, resource use and mortality rate of patients. We used the serum creatinine component of the RIFLE system to classify AKI...
  43. ncbi request reprint Feasibility study of cytokine removal by hemoadsorption in brain-dead humans
    John A Kellum
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 36:268-72. 2008
    ..Inflammatory cytokines occur in the circulation and in the tissues after brain death and have been associated with dysfunction of donor organs before and after transplantation...
  44. ncbi request reprint Disorders of acid-base balance
    John A Kellum
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory and the Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:2630-6. 2007
    ..Recent advances have brought a measure of parity between the newer and the older, descriptive approach to acid-base physiology...
  45. ncbi request reprint Defining and classifying acute renal failure: from advocacy to consensus and validation of the RIFLE criteria
    Rinaldo Bellomo
    Department of Intensive Care and Department of Medicine, Austin Hospital and University of Melbourne, Heidelberg, Melbourne, Australia
    Intensive Care Med 33:409-13. 2007
    ..This editorial aims to summarize and interpret recent findings concerning the application of the RIFLE criteria to the assessment of the epidemiology and the prediction of the outcome of ARF...
  46. ncbi request reprint Hyperchloremic acidosis increases circulating inflammatory molecules in experimental sepsis
    John A Kellum
    University of Pittsburgh, School of Medicine, Department of Critical Care Medicine, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Chest 130:962-7. 2006
    ..7 cells. However, evidence that hyperchloremic acidosis leads to increased inflammation in vivo has been limited to nitric oxide...
  47. ncbi request reprint Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis
    John A Kellum
    MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Chest 125:243-8. 2004
    ..To determine the effects of hyperchloremic acidosis, induced by dilute HCl infusion, on BP and circulating inflammatory mediators in an experimental model of severe sepsis in the rat...
  48. ncbi request reprint Lactic and hydrochloric acids induce different patterns of inflammatory response in LPS-stimulated RAW 264.7 cells
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 286:R686-92. 2004
    ..7 cells. HCl is essentially proinflammatory as assessed by NO release, IL-6-to-IL-10 ratios, and NF-kappa B DNA binding. By contrast, lactic acidosis is anti-inflammatory...
  49. ncbi request reprint Acid-base and electrolyte analysis in critically ill patients: are we ready for the new millennium?
    Kyle J Gunnerson
    Virginia Commonwealth University Reanimation Engineering Shock Center, Department of Anesthesiology, Virginia Commonwealth University Medical College of Virginia, Richmond, Virginia, USA
    Curr Opin Crit Care 9:468-73. 2003
    ..Although acid-base and electrolyte disorders may be a result of the underlying pathophysiology (eg, renal failure, respiratory failure, shock), they may also result from the way in which we manage critically ill patients...
  50. ncbi request reprint Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells
    Mingchen Song
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh Pennsylvania, USA
    J Pharmacol Exp Ther 308:307-16. 2004
    ..Moreover, the findings presented here suggest that an unusual combination of biochemical effects (inhibition of lipid peroxidation and GSH depletion) might account for the anti-inflammatory effects of EP...
  51. ncbi request reprint A drug to prevent renal failure?
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15260, USA
    Lancet 362:589-90. 2003
  52. ncbi request reprint Novel approaches to the treatment of acute renal failure
    Ramesh Venkataraman
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Scaife Hall, Room 642A, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Expert Opin Investig Drugs 12:1353-66. 2003
    ..The prospect of these novel strategies, together with the ever-increasing understanding of the complex pathophysiology of ARF, offers the promise of effective and more physiological therapeutic interventions in this new millennium...
  53. pmc Closing the gap on unmeasured anions
    John A Kellum
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:219-20. 2003
  54. ncbi request reprint Sorbents in acute renal failure and the systemic inflammatory response syndrome
    James F Winchester
    RenalTech International, New York, NY 10021, USA
    Blood Purif 21:79-84. 2003
    ....
  55. ncbi request reprint Blood purification in non-renal critical illness
    John A Kellum
    University of Pittsburgh School of Medicine, Department of Critical Care Medicine, PA 15213, USA
    Blood Purif 21:6-13. 2003
    ..However, extracorporeal therapies are being used or investigated in the management of many other disease processes including systemic inflammation, liver disease, cardiac disease and thrombotic diseases...
  56. ncbi request reprint Developing a consensus classification system for acute renal failure
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:509-14. 2002
    ..Recommendations for validating a classification system are also considered...
  57. ncbi request reprint Acute Dialysis Quality Initiative: methodology
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 8:500-1. 2002
    ..This brief report details the process of the Acute Dialysis Quality Initiative and its goals and methodology...
  58. pmc Effect of hemofiltration filter adsorption on circulating IL-6 levels in septic rats
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, PA, USA
    Crit Care 6:429-33. 2002
    ..We sought to distinguish clearance from adsorption as the principal mechanism responsible for reducing circulating IL-6 levels with hemofiltration...
  59. ncbi request reprint Use of vasopressor agents in critically ill patients
    John A Kellum
    Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:236-41. 2002
    ..When used at doses necessary to reverse distributive shock, less potent vasoconstrictors (eg, dopamine) do not appear to be safer than more potent ones (eg, norepinephrine) and do not appear to be as effective...
  60. ncbi request reprint Sorbents in acute renal failure and end-stage renal disease: middle molecule and cytokine removal
    James F Winchester
    RenalTech International, New York, NY 10021, USA
    Blood Purif 22:73-7. 2004
    ..Sorbent devices added to hemodialysis, or the use of such devices alone in inflammatory states, including sepsis, ARF, cardiopulmonary bypass, pre-explantation of donor organs and ESRD, are being studied...
  61. ncbi request reprint Hemoadsorption to improve organ recovery from brain-dead organ donors: a novel therapy for a novel indication?
    Ramesh Venkataraman
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Blood Purif 22:143-9. 2004
    ..As a 'proof of concept' we tested the ability of a novel hemoadsorbent to remove S100B in vitro using two human glioblastoma cell lines. Our results indicate a >80% reduction in S100B after 2 h of circulation with the sorbent...
  62. ncbi request reprint Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear factor-kappaB DNA binding, and improves short-term survival in lethal endotoxemia
    John A Kellum
    Mechanisms and Novel Therapies for Resuscitation and Acute Illness MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:801-5. 2004
    ..Because adsorptive capacity of hollow-fiber dialyzers is limited, we sought to determine whether hemoadsorption using high surface area beads would result in greater mediator removal and improved survival in experimental sepsis...
  63. pmc RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
    Eric A J Hoste
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 10:R73. 2006
    ..RIFLE, a newly developed international consensus classification for acute kidney injury, defines three grades of severity--risk (class R), injury (class I) and failure (class F)--but has not yet been evaluated in a clinical series...
  64. ncbi request reprint Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?
    Tony Dremsizov
    606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
    Chest 129:968-78. 2006
    ....
  65. ncbi request reprint The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells
    Meaghan E Killeen
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 615 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    J Pharmacol Exp Ther 316:1070-9. 2006
    ..7 cells. These data suggest that phase 2 inducers may exert anti-inflammatory effects by inhibiting secretion of the cytokine-like nuclear protein HMGB1...
  66. ncbi request reprint Primary prevention of acute renal failure in the critically ill
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 11:537-41. 2005
    ..To date, no therapy apart from renal replacement therapy has been shown to improve survival or enhance recover. Thus, efforts to prevent acute renal failure are eagerly sought...
  67. ncbi request reprint Consensus development in acute renal failure: The Acute Dialysis Quality Initiative
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Curr Opin Crit Care 11:527-32. 2005
    ..The general lack of consensus with regard to definitions, prevention, and treatment of acute renal failure has limited progress in this field...
  68. ncbi request reprint Acute renal failure, interdisciplinary knowledge and the need for standardization
    John A Kellum
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Curr Opin Crit Care 11:525-6. 2005
  69. ncbi request reprint Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
    ....
  70. ncbi request reprint Determinants of plasma acid-base balance
    John A Kellum
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 608 Scaife Hall, Pittsburgh, PA 15213 2582, USA
    Crit Care Clin 21:329-46. 2005
    ..All changes in blood pH, in health and in disease, occur through changes in these three variables. This article reviews the physical-chemical approach to acid-base balance and considers clinical implications for these findings...
  71. pmc Science review: extracellular acidosis and the immune response: clinical and physiologic implications
    John A Kellum
    Critical Care Medicine and Medicine, The Mechanisms And Novel Therapies for Resuscitation and Acute illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 8:331-6. 2004
    ..Finally, we discuss potential clinical implications...
  72. ncbi request reprint Cytokine removal with a novel adsorbent polymer
    Mingchen Song
    The MANTRA Laboratories, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Blood Purif 22:428-34. 2004
    ..We sought to characterize a novel adsorbent polymer in terms of cytokine removal...
  73. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  74. ncbi request reprint Acute renal failure in the critically ill: impact on morbidity and mortality
    Eric A Hoste
    Intensive Care Unit, Ghent University Hospital, Gent, Belgium
    Contrib Nephrol 144:1-11. 2004
  75. ncbi request reprint Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury
    Lewis J Kaplan
    Yale University School of Medicine, Department of Surgery, Section of Trauma, Critical Care, and Emergency General Surgery, USA
    Crit Care Med 32:1120-4. 2004
    ..This study determines whether acid-base data obtained in the emergency department correlate with outcome from major vascular injury...
  76. ncbi request reprint The Acute Dialysis Quality Initiative: methodology
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Adv Ren Replace Ther 9:245-7. 2002
    ..The system involves preconference, conference, and postconference activities designed to classify existing consensus, identify areas of controversy, summarize existing evidence, and outline future research objectives...