J A Kellum

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
    Arch Intern Med 167:1655-63. 2007
  2. pmc Hepatorenal syndrome: the 8th International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Mitra K Nadim
    Department of Medicine, University of Southern California, 1520 San Pablo Street, Suite 4300, Los Angeles, CA 90033, USA
    Crit Care 16:R23. 2012
  3. pmc All-cause and cause-specific mortality associated with diabetes in prevalent hemodialysis patients
    Abdus Sattar
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    BMC Nephrol 13:130. 2012
  4. pmc Oliguria as predictive biomarker of acute kidney injury in critically ill patients
    John R Prowle
    Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidleberg, Victoria 3084, Australia
    Crit Care 15:R172. 2011
  5. pmc Clinical review: blood purification for sepsis
    Thomas Rimmelé
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 15:205. 2011
  6. pmc Clinical review: anticoagulation for continuous renal replacement therapy--heparin or citrate?
    Heleen M Oudemans-van Straaten
    Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091 AC Amsterdam, The Netherlands
    Crit Care 15:202. 2011
  7. pmc Bench-to-bedside review: Chloride in critical illness
    Nor azim Mohd Yunos
    Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, VIC 33084, Australia
    Crit Care 14:226. 2010
  8. pmc Clinical review: extracorporeal blood purification in severe sepsis
    Ramesh Venkataraman
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:139-45. 2003
  9. pmc Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study
    Paul M Palevsky
    VA Pittsburgh Healthcare System, University Drive, Pittsburgh, PA 15240, USA
    Crit Care 13:310. 2009
  10. pmc RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
    Eric A J Hoste
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 10:R73. 2006

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
    Arch Intern Med 167:1655-63. 2007
    ..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death...
  2. pmc Hepatorenal syndrome: the 8th International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Mitra K Nadim
    Department of Medicine, University of Southern California, 1520 San Pablo Street, Suite 4300, Los Angeles, CA 90033, USA
    Crit Care 16:R23. 2012
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  3. pmc All-cause and cause-specific mortality associated with diabetes in prevalent hemodialysis patients
    Abdus Sattar
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    BMC Nephrol 13:130. 2012
    ..In order to better understand the influence of diabetes on outcomes in hemodialysis, we examine the risk of death of diabetic participants in the HEMODIALYSIS (HEMO) study...
  4. pmc Oliguria as predictive biomarker of acute kidney injury in critically ill patients
    John R Prowle
    Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidleberg, Victoria 3084, Australia
    Crit Care 15:R172. 2011
    ..During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development of AKI has not been prospectively evaluated...
  5. pmc Clinical review: blood purification for sepsis
    Thomas Rimmelé
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 15:205. 2011
    ....
  6. pmc Clinical review: anticoagulation for continuous renal replacement therapy--heparin or citrate?
    Heleen M Oudemans-van Straaten
    Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091 AC Amsterdam, The Netherlands
    Crit Care 15:202. 2011
    ..Citrate can, however, with inadequate use cause metabolic derangements. Full advantages of citrate can only be realized if its risks are well controlled. These observations suggest a greater role for citrate...
  7. pmc Bench-to-bedside review: Chloride in critical illness
    Nor azim Mohd Yunos
    Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, VIC 33084, Australia
    Crit Care 14:226. 2010
    ..Finally, the review examines the potential intensive care unit practice implications of a better understanding of chloride...
  8. pmc Clinical review: extracorporeal blood purification in severe sepsis
    Ramesh Venkataraman
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:139-45. 2003
    ..Here, we discuss the various modalities of extracorporeal blood purification, the existing evidence, and future prospects...
  9. pmc Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study
    Paul M Palevsky
    VA Pittsburgh Healthcare System, University Drive, Pittsburgh, PA 15240, USA
    Crit Care 13:310. 2009
    ..Finally, we address the implications of the ATN Study results for clinical practice from the perspective of the study investigators...
  10. pmc RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
    Eric A J Hoste
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 10:R73. 2006
    ..RIFLE, a newly developed international consensus classification for acute kidney injury, defines three grades of severity--risk (class R), injury (class I) and failure (class F)--but has not yet been evaluated in a clinical series...
  11. pmc Cost of acute renal replacement therapy in the intensive care unit: results from The Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) study
    Nattachai Srisawat
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Crit Care 14:R46. 2010
    ..The aim of this study was to estimate the cost difference between CRRT and IRRT in the intensive care unit (ICU)...
  12. pmc Lactate versus non-lactate metabolic acidosis: a retrospective outcome evaluation of critically ill patients
    Kyle J Gunnerson
    Virginia Commonwealth University Reanimation Engineering Shock Center Laboratory, Department of Anesthesiology Critical Care, Medical College of Virginia Virginia Commonwealth University, 1200 East Broad Street, Richmond, VA 23298, USA
    Crit Care 10:R22. 2006
    ..The relative incidence of each type of disorder is unknown. We therefore designed this study to determine the nature and clinical significance of metabolic acidosis in critically ill patients...
  13. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
    ..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI...
  14. pmc Extracorporeal liver support: a continuing challenge
    Ram M Subramanian
    Department of Pulmonary and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Crit Care 11:106. 2007
    ..Thus, if these treatments do result in clinical improvement, then other therapeutic mechanisms must be involved...
  15. ncbi request reprint Primary prevention of acute renal failure in the critically ill
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 11:537-41. 2005
    ..To date, no therapy apart from renal replacement therapy has been shown to improve survival or enhance recover. Thus, efforts to prevent acute renal failure are eagerly sought...
  16. ncbi request reprint Consensus development in acute renal failure: The Acute Dialysis Quality Initiative
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Curr Opin Crit Care 11:527-32. 2005
    ..The general lack of consensus with regard to definitions, prevention, and treatment of acute renal failure has limited progress in this field...
  17. ncbi request reprint Renal support in acute kidney injury
    John Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Lancet 368:344-5. 2006
  18. ncbi request reprint Application of blood purification to non-renal organ failure
    J A Kellum
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 28:445-9. 2005
    ..The focus of these reviews is on clinical evidence as well as recommendations for future research...
  19. ncbi request reprint Hyperchloremic acidosis increases circulating inflammatory molecules in experimental sepsis
    John A Kellum
    University of Pittsburgh, School of Medicine, Department of Critical Care Medicine, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Chest 130:962-7. 2006
    ..7 cells. However, evidence that hyperchloremic acidosis leads to increased inflammation in vivo has been limited to nitric oxide...
  20. ncbi request reprint Determinants of plasma acid-base balance
    John A Kellum
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 608 Scaife Hall, Pittsburgh, PA 15213 2582, USA
    Crit Care Clin 21:329-46. 2005
    ..All changes in blood pH, in health and in disease, occur through changes in these three variables. This article reviews the physical-chemical approach to acid-base balance and considers clinical implications for these findings...
  21. ncbi request reprint Acute renal failure, interdisciplinary knowledge and the need for standardization
    John A Kellum
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Curr Opin Crit Care 11:525-6. 2005
  22. ncbi request reprint The concept of acute kidney injury and the RIFLE criteria
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA, and Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Contrib Nephrol 156:10-6. 2007
    ..The term acute kidney injury has subsequently been proposed to distinguish this new concept from the older terminology of failure...
  23. doi request reprint Acute kidney injury: epidemiology and assessment
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Scand J Clin Lab Invest Suppl 241:6-11. 2008
    ..Patients with AKI who are treated with RRT, still have a mortality of 50-60 %. Of surviving patients, 5-20 % remain dialysis-dependent at hospital discharge...
  24. doi request reprint Acute kidney injury
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:S141-5. 2008
    ..The RIFLE criteria provide a uniform definition of acute kidney injury and have now been validated in numerous studies...
  25. ncbi request reprint Fluids for prevention and management of acute kidney injury
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 31:96-110. 2008
    ..This systematic review focuses on fluids for prevention and management of acute kidney injury. We have reviewed the available evidence and have made recommendations for clinical practice and future studies...
  26. ncbi request reprint Fluid management in acute kidney injury
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 31:94-5. 2008
  27. ncbi request reprint Acute Dialysis Quality Initiative (ADQI): methodology
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Int J Artif Organs 31:90-3. 2008
    ..We further recognize that additional research will be needed and have proposed specific studies that will help move this field forward...
  28. doi request reprint Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi process
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Scaife Hall, Room 608, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 3:887-94. 2008
    ..An international, consensus-based, prioritized research agenda was sought to guide clinical and translational research in acute kidney injury...
  29. ncbi request reprint Feasibility study of cytokine removal by hemoadsorption in brain-dead humans
    John A Kellum
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 36:268-72. 2008
    ..Inflammatory cytokines occur in the circulation and in the tissues after brain death and have been associated with dysfunction of donor organs before and after transplantation...
  30. pmc A targeted extracorporeal therapy for endotoxemia: the time has come
    John A Kellum
    The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 11:137. 2007
    ..Multiple small trials, often limited by methodological quality, show that polymyxin B hemo-perfusion may have favorable effects on survival and hemodynamics. Further study of this therapy would seem justified...
  31. pmc Science review: extracellular acidosis and the immune response: clinical and physiologic implications
    John A Kellum
    Critical Care Medicine and Medicine, The Mechanisms And Novel Therapies for Resuscitation and Acute illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 8:331-6. 2004
    ..Finally, we discuss potential clinical implications...
  32. ncbi request reprint Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis
    John A Kellum
    MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Chest 125:243-8. 2004
    ..To determine the effects of hyperchloremic acidosis, induced by dilute HCl infusion, on BP and circulating inflammatory mediators in an experimental model of severe sepsis in the rat...
  33. pmc Effect of hemofiltration filter adsorption on circulating IL-6 levels in septic rats
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, PA, USA
    Crit Care 6:429-33. 2002
    ..We sought to distinguish clearance from adsorption as the principal mechanism responsible for reducing circulating IL-6 levels with hemofiltration...
  34. pmc Closing the gap on unmeasured anions
    John A Kellum
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 7:219-20. 2003
  35. ncbi request reprint Genetic variation and risk of sepsis
    J A Kellum
    The CRISMA Laboratory Clinical Research, Investigation and Systems Modeling of Acute illness, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine Pittsburgh, Pennsylvania 15261, USA
    Minerva Anestesiol 69:245-53. 2003
    ..g. tumor necrosis factor) has lent credence to this hypothesis. Yet discovery of the actual relationship between risks of infection / severe sepsis and individual genotypes will require larger, more rigorously designed studies...
  36. ncbi request reprint The Acute Dialysis Quality Initiative: methodology
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Adv Ren Replace Ther 9:245-7. 2002
    ..The system involves preconference, conference, and postconference activities designed to classify existing consensus, identify areas of controversy, summarize existing evidence, and outline future research objectives...
  37. ncbi request reprint Blood purification in non-renal critical illness
    John A Kellum
    University of Pittsburgh School of Medicine, Department of Critical Care Medicine, PA 15213, USA
    Blood Purif 21:6-13. 2003
    ..However, extracorporeal therapies are being used or investigated in the management of many other disease processes including systemic inflammation, liver disease, cardiac disease and thrombotic diseases...
  38. ncbi request reprint Use of vasopressor agents in critically ill patients
    John A Kellum
    Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:236-41. 2002
    ..When used at doses necessary to reverse distributive shock, less potent vasoconstrictors (eg, dopamine) do not appear to be safer than more potent ones (eg, norepinephrine) and do not appear to be as effective...
  39. ncbi request reprint Developing a consensus classification system for acute renal failure
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:509-14. 2002
    ..Recommendations for validating a classification system are also considered...
  40. ncbi request reprint Acute Dialysis Quality Initiative: methodology
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 8:500-1. 2002
    ..This brief report details the process of the Acute Dialysis Quality Initiative and its goals and methodology...
  41. ncbi request reprint A drug to prevent renal failure?
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15260, USA
    Lancet 362:589-90. 2003
  42. ncbi request reprint Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear factor-kappaB DNA binding, and improves short-term survival in lethal endotoxemia
    John A Kellum
    Mechanisms and Novel Therapies for Resuscitation and Acute Illness MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:801-5. 2004
    ..Because adsorptive capacity of hollow-fiber dialyzers is limited, we sought to determine whether hemoadsorption using high surface area beads would result in greater mediator removal and improved survival in experimental sepsis...
  43. doi request reprint Definition and classification of acute kidney injury
    John A Kellum
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Nephron Clin Pract 109:c182-7. 2008
    ..The RIFLE criteria provide a uniform definition of AKI and have now been validated in numerous studies...
  44. ncbi request reprint What can be done about acute renal failure?
    J A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Minerva Anestesiol 70:181-8. 2004
    ..Recent data suggest that NAC can reduce the incidence of ARF secondary to radio-contrast agents and improved techniques for RRT and, perhaps, new drugs aimed at improving cellular repair, will improve outcome from ARF in the future...
  45. ncbi request reprint Lactic and hydrochloric acids induce different patterns of inflammatory response in LPS-stimulated RAW 264.7 cells
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 286:R686-92. 2004
    ..7 cells. HCl is essentially proinflammatory as assessed by NO release, IL-6-to-IL-10 ratios, and NF-kappa B DNA binding. By contrast, lactic acidosis is anti-inflammatory...
  46. ncbi request reprint Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    Clin J Am Soc Nephrol 2:431-9. 2007
    ..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT...
  47. ncbi request reprint Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells
    Mingchen Song
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh Pennsylvania, USA
    J Pharmacol Exp Ther 308:307-16. 2004
    ..Moreover, the findings presented here suggest that an unusual combination of biochemical effects (inhibition of lipid peroxidation and GSH depletion) might account for the anti-inflammatory effects of EP...
  48. ncbi request reprint Diuretics in acute kidney injury
    V Karajala
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Minerva Anestesiol 75:251-7. 2009
    ..There have been many studies both supporting and criticizing diuretic use in AKI for improving overall patient outcomes...
  49. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
    ..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death...
  50. ncbi request reprint The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells
    Meaghan E Killeen
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 615 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    J Pharmacol Exp Ther 316:1070-9. 2006
    ..7 cells. These data suggest that phase 2 inducers may exert anti-inflammatory effects by inhibiting secretion of the cytokine-like nuclear protein HMGB1...
  51. pmc Determinants of blood pH in health and disease
    J A Kellum
    University of Pittsburgh Medical Center, Division of Critical Care, Pittsburgh, Pennsylvania 15213 2582, USA
    Crit Care 4:6-14. 2000
    ..All changes in blood pH, in health and in disease, occur through changes in these three variables. Clinical implications for these findings are also discussed...
  52. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  53. pmc Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia
    David T Huang
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Emerg Med 52:48-58.e2. 2008
    ..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65...
  54. doi request reprint Blood purification in sepsis: a new paradigm
    Zhiyong Peng
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Contrib Nephrol 165:322-8. 2010
    ..Finally, the emerging paradigm of sepsis-induced immune suppression provides additional rationale for the development of extracorporeal blood purification therapy for sepsis...
  55. doi request reprint Is there a difference between strong ion gap in healthy volunteers and intensive care unit patients?
    Kyle J Gunnerson
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Crit Care 25:520-4. 2010
    ..Thus, we conducted this pilot study to examine differences in quantitative acid-base variables between healthy adult volunteers and stable ICU patients with no suspected acid-base abnormalities...
  56. ncbi request reprint Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats
    Jose L Gómez
    MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Chest 131:1295-300. 2007
    ..To determine if animals with abnormally low albumin levels are more susceptible to the effects of hypercapnia on BP compared to normal animals...
  57. ncbi request reprint Metabolic acidosis in the critically ill: lessons from physical chemistry
    J A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Kidney Int Suppl 66:S81-6. 1998
    ..This approach emphasizes the application of accepted physical chemical principles and identification of independent and dependent acid-base variables. In aqueous solutions, water dissociation is the major source of free hydrogen ions...
  58. pmc Hemofiltration in sepsis: where do we go from here?
    J A Kellum
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 4:69-71. 2000
    ..Clinical as well as technical difficulties remain important considerations to future studies. These issues are discussed and the brief history of hemofiltration in sepsis is reviewed...
  59. pmc Differences in immune response may explain lower survival among older men with pneumonia
    Michael C Reade
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 37:1655-62. 2009
    ..We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response...
  60. ncbi request reprint Defining and classifying acute renal failure: from advocacy to consensus and validation of the RIFLE criteria
    Rinaldo Bellomo
    Department of Intensive Care and Department of Medicine, Austin Hospital and University of Melbourne, Heidelberg, Melbourne, Australia
    Intensive Care Med 33:409-13. 2007
    ..This editorial aims to summarize and interpret recent findings concerning the application of the RIFLE criteria to the assessment of the epidemiology and the prediction of the outcome of ARF...
  61. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  62. pmc Do hospitals provide lower quality of care to black patients for pneumonia?
    Florian B Mayr
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 38:759-65. 2010
    ..We examined racial differences in emergency department and intensive care unit care processes to determine whether differences persist after adjusting for case-mix and variation in care across hospitals...
  63. doi request reprint Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation
    Raghavan Murugan
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:1810-6. 2008
    ..We test the hypothesis that increased inflammatory response is associated with fewer organs transplanted and decreased recipient survival...
  64. ncbi request reprint Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
    ....
  65. ncbi request reprint Hemoadsorption to improve organ recovery from brain-dead organ donors: a novel therapy for a novel indication?
    Ramesh Venkataraman
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Blood Purif 22:143-9. 2004
    ..As a 'proof of concept' we tested the ability of a novel hemoadsorbent to remove S100B in vitro using two human glioblastoma cell lines. Our results indicate a >80% reduction in S100B after 2 h of circulation with the sorbent...
  66. doi request reprint Recovery from acute kidney injury: determinants and predictors
    Nattachai Srisawat
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Contrib Nephrol 165:284-91. 2010
    ..This review will describe the current understanding of the renal recovery process, and the role of clinical severity scores and novel biomarkers such as NGAL, HGF, and cystatin C in predicting renal recovery...
  67. doi request reprint Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    J Crit Care 24:129-40. 2009
    ..The aim of this study is to evaluate the relationship between timing of renal replacement therapy (RRT) in severe acute kidney injury and clinical outcomes...
  68. pmc The prevalence of anemia and its association with 90-day mortality in hospitalized community-acquired pneumonia
    Michael C Reade
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Pulm Med 10:15. 2010
    ..Our objective was to examine the development and progression of anemia and its association with 90d mortality in 1893 subjects with CAP presenting to the emergency departments of 28 US academic and community hospitals...
  69. pmc The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FASEB J 23:2403-11. 2009
    ..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia...
  70. pmc Preload responsiveness is associated with increased interleukin-6 and lower organ yield from brain-dead donors
    Raghavan Murugan
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care Med 37:2387-93. 2009
    ..Using functional hemodynamic monitoring in brain-dead organ donors, we test the hypothesis that donor preload (fluid) responsiveness is associated with increased inflammatory response and lower organ yield for transplantation...
  71. ncbi request reprint Acid-base and electrolyte analysis in critically ill patients: are we ready for the new millennium?
    Kyle J Gunnerson
    Virginia Commonwealth University Reanimation Engineering Shock Center, Department of Anesthesiology, Virginia Commonwealth University Medical College of Virginia, Richmond, Virginia, USA
    Curr Opin Crit Care 9:468-73. 2003
    ..Although acid-base and electrolyte disorders may be a result of the underlying pathophysiology (eg, renal failure, respiratory failure, shock), they may also result from the way in which we manage critically ill patients...
  72. ncbi request reprint Cytokine removal with a novel adsorbent polymer
    Mingchen Song
    The MANTRA Laboratories, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Blood Purif 22:428-34. 2004
    ..We sought to characterize a novel adsorbent polymer in terms of cytokine removal...
  73. ncbi request reprint On-pump vs. off-pump coronary artery bypass surgery at a non-academic community hospital: have biocompatibility improvements eliminated the superiority of off-pump surgery?
    N J Madden
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, Univesity of Pittsburgh, Pittsburgh 15261, USA
    Int J Artif Organs 30:338-44. 2007
    ....
  74. pmc The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Thorax 65:870-7. 2010
    ..Although diabetes mellitus is implicated in susceptibility to infection, the association of diabetes with the subsequent course and outcome is unclear...
  75. ncbi request reprint Acid-base disorders and strong ion gap
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15216, USA
    Contrib Nephrol 156:158-66. 2007
    ..Attempts to identify the exact chemical nature of ions identified by the strong ion gap have only been of limited success and further study is needed...
  76. pmc Prevalence and significance of coagulation abnormalities in community-acquired pneumonia
    Eric B Milbrandt
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Med 15:438-45. 2009
    ..These findings underscore the complexity of the coagulation response to infection and may offer insights into coagulation-based therapeutics in clinical sepsis trials...
  77. ncbi request reprint Defining acute renal failure: physiological principles
    Rinaldo Bellomo
    Department of Intensive Care and Division of Surgery, Austin and Repatriation Medical Centre, 3084 Heidelberg, Melbourne, Victoria, Australia
    Intensive Care Med 30:33-7. 2004
  78. ncbi request reprint Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?
    Tony Dremsizov
    606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
    Chest 129:968-78. 2006
    ....
  79. ncbi request reprint Continuous versus intermittent renal replacement therapy: a meta-analysis
    John A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Division of Critical Care Medicine, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Intensive Care Med 28:29-37. 2002
    ..As controversy exists regarding which modality should be used for most patients with critically illness, we sought to determine whether CRRT or IRRT is associated with better survival...
  80. ncbi request reprint Prevention of acute renal failure
    Ramesh Venkataraman
    The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Chest 131:300-8. 2007
    ..Increasing insight into mechanisms leading to ARF and the importance of facilitating renal recovery has prompted investigators to evaluate the role of newer therapeutic agents in the prevention of ARF...
  81. ncbi request reprint Acute Dialysis Quality Initiative II: the Vicenza conference
    Rinaldo Bellomo
    Intensive Care Unit, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Curr Opin Crit Care 8:505-8. 2002
    ..Accordingly, the second Acute Dialysis Quality Initiative conference in Vicenza, Italy, was organized, and its goals and rationale are presented in this report...
  82. pmc Understanding genetics of sepsis: will new technology help?
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care 13:141. 2009
    ..Careful attention should be paid to different aspects of study design and analyses as large, multicenter cohorts are assembled for genome-wide association studies...
  83. pmc Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia
    David T Huang
    Departments of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 136:823-31. 2009
    ..We sought to describe the pattern of MR-proADM in a broad CAP cohort, confirm its prognostic role, and compare its performance to procalcitonin, a novel biomarker of infection...
  84. doi request reprint N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantation
    Ibtesam A Hilmi
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
    Nephrol Dial Transplant 25:2328-33. 2010
    ..N-acetylcysteine (NAC) replenishes GSH stores. The aims of this study were to evaluate the efficacy of NAC in improving liver graft performance and reducing the incidence of post-operative acute kidney injury (AKI)...
  85. ncbi request reprint Disorders of acid-base balance
    John A Kellum
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory and the Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:2630-6. 2007
    ..Recent advances have brought a measure of parity between the newer and the older, descriptive approach to acid-base physiology...
  86. ncbi request reprint Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved short-term survival and acid-base balance with Hextend compared with saline
    John A Kellum
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    Crit Care Med 30:300-5. 2002
    ..To compare resuscitation with 0.9% saline with Hextend, a synthetic colloid in a balanced electrolyte solution, in terms of acid-base status and survival time in an experimental model of septic shock in the rat...
  87. ncbi request reprint Incidence and definition of sepsis and associated organ dysfunction
    T T Dremsizov
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Artif Organs 27:352-9. 2004
    ..To discuss the incidence, outcome and predisposing factors to systemic inflammatory response syndrome (SIRS), sepsis, and multiple organ failure...
  88. ncbi request reprint Use of dopamine in acute renal failure: a meta-analysis
    J A Kellum
    Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
    Crit Care Med 29:1526-31. 2001
    ..CONCLUSIONS: The use of low-dose dopamine for the treatment or prevention of acute renal failure cannot be justified on the basis of available evidence and should be eliminated from routine clinical use...
  89. ncbi request reprint Declining critical care research publications by authors from U.S. Institutions, 1990-1999
    D J Powner
    Critical Care Medicine, Rutland Regional Medical Center, Rutland, Vermont 05701, USA
    Acad Med 76:1261-3. 2001
    ..Anecdotal concerns expressed by many faculty that rising clinical commitments necessitated by current health care and reimbursement pressures preclude research and educational academic activities are supported by these data...
  90. ncbi request reprint The modern concept of homeostasis
    J A Kellum
    Departments of Anesthesiology CCM and Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Minerva Anestesiol 68:3-11. 2002
  91. ncbi request reprint Plasma filtration on mediators of thrombotic microangiopathy: an in vitro study
    Z Y Peng
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J Artif Organs 30:401-6. 2007
    ..Sepsis-induced thrombotic microangiopathy is successfully treated by plasma exchange therapy. However, certain putative mediators of thrombotic microangiopathy may not be removed by plasma filtration...
  92. pmc Urinary biomarkers and renal recovery in critically ill patients with renal support
    Nattachai Srisawat
    604 Scaife Hall, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 6:1815-23. 2011
    ..Unfortunately, no reliable method to predict renal recovery exists. The discovery of biomarkers to aid in clinical risk prediction for recovery after AKI would represent a significant advance over current practice...
  93. pmc Evaluation and initial management of acute kidney injury
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 3:962-7. 2008
    ....
  94. ncbi request reprint Sorbents in acute renal failure and end-stage renal disease: middle molecule and cytokine removal
    James F Winchester
    RenalTech International, New York, NY 10021, USA
    Blood Purif 22:73-7. 2004
    ..Sorbent devices added to hemodialysis, or the use of such devices alone in inflammatory states, including sepsis, ARF, cardiopulmonary bypass, pre-explantation of donor organs and ESRD, are being studied...
  95. doi request reprint Defining and classifying AKI: one set of criteria
    John A Kellum
    Nephrol Dial Transplant 23:1471-2. 2008
  96. ncbi request reprint Novel approaches to the treatment of acute renal failure
    Ramesh Venkataraman
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Scaife Hall, Room 642A, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Expert Opin Investig Drugs 12:1353-66. 2003
    ..The prospect of these novel strategies, together with the ever-increasing understanding of the complex pathophysiology of ARF, offers the promise of effective and more physiological therapeutic interventions in this new millennium...
  97. doi request reprint Comparison of acid-base models for prediction of hospital mortality after trauma
    Lewis J Kaplan
    Department of Surgery, Section of Trauma, Critical Care, and Surgical Emergencies, Yale University School of Medicine, New Haven, CT 06520, USA
    Shock 29:662-6. 2008
    ..Admission pH, HCO3-, and lactate were poor predictors of hospital mortality after trauma. An elevated SIG presaged mortality after injury and should be assessed on admission...
  98. doi request reprint Costs and outcomes of acute kidney injury (AKI) following cardiac surgery
    Joseph F Dasta
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Nephrol Dial Transplant 23:1970-4. 2008
    ..We determined costs, resource use and mortality rate of patients. We used the serum creatinine component of the RIFLE system to classify AKI...
  99. ncbi request reprint Normotensive ischemic acute renal failure
    Rinaldo Bellomo
    N Engl J Med 357:2205; author reply 2205-6. 2007
  100. ncbi request reprint Sorbents in acute renal failure and the systemic inflammatory response syndrome
    James F Winchester
    RenalTech International, New York, NY 10021, USA
    Blood Purif 21:79-84. 2003
    ....
  101. ncbi request reprint Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury
    Lewis J Kaplan
    Yale University School of Medicine, Department of Surgery, Section of Trauma, Critical Care, and Emergency General Surgery, USA
    Crit Care Med 32:1120-4. 2004
    ..This study determines whether acid-base data obtained in the emergency department correlate with outcome from major vascular injury...

Research Grants11

  1. Protocolized Goal-directed Resuscitation of Septic Shock to Prevent AKI (ProGReSS
    John A Kellum; Fiscal Year: 2010
    ....
  2. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  3. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  4. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2007
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  5. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2007
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..