Research Topics
Species | J A KellumSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) StudyJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
Arch Intern Med 167:1655-63. 2007..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death...
Oliguria as predictive biomarker of acute kidney injury in critically ill patientsJohn R Prowle
Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidleberg, Victoria 3084, Australia
Crit Care 15:R172. 2011..During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development of AKI has not been prospectively evaluated...- Clinical review: blood purification for sepsisThomas Rimmelé
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Crit Care 15:205. 2011.... - Clinical review: anticoagulation for continuous renal replacement therapy--heparin or citrate?Heleen M Oudemans-van Straaten
Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091 AC Amsterdam, The Netherlands
Crit Care 15:202. 2011..Citrate can, however, with inadequate use cause metabolic derangements. Full advantages of citrate can only be realized if its risks are well controlled. These observations suggest a greater role for citrate... - Bench-to-bedside review: Chloride in critical illnessNor azim Mohd Yunos
Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, VIC 33084, Australia
Crit Care 14:226. 2010..Finally, the review examines the potential intensive care unit practice implications of a better understanding of chloride... 
Clinical review: extracorporeal blood purification in severe sepsisRamesh Venkataraman
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 7:139-45. 2003..Here, we discuss the various modalities of extracorporeal blood purification, the existing evidence, and future prospects...- Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network StudyPaul M Palevsky
VA Pittsburgh Healthcare System, University Drive, Pittsburgh, PA 15240, USA
Crit Care 13:310. 2009..Finally, we address the implications of the ATN Study results for clinical practice from the perspective of the study investigators... - RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysisEric A J Hoste
The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 10:R73. 2006.... - Cost of acute renal replacement therapy in the intensive care unit: results from The Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) studyNattachai Srisawat
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Crit Care 14:R46. 2010..The aim of this study was to estimate the cost difference between CRRT and IRRT in the intensive care unit (ICU)... - Lactate versus non-lactate metabolic acidosis: a retrospective outcome evaluation of critically ill patientsKyle J Gunnerson
Virginia Commonwealth University Reanimation Engineering Shock Center Laboratory, Department of Anesthesiology/Critical Care, Medical College of Virginia/Virginia Commonwealth University, 1200 East Broad Street, Richmond, VA 23298, USA
Crit Care 10:R22. 2006..Overall, patients with metabolic acidosis were nearly twice as likely to die as patients without metabolic acidosis... - Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injuryRavindra L Mehta
Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
Crit Care 11:R31. 2007..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI... - Extracorporeal liver support: a continuing challengeRam M Subramanian
Department of Pulmonary and Critical Care, University of Chicago, Chicago, IL 60637, USA
Crit Care 11:106. 2007..Thus, if these treatments do result in clinical improvement, then other therapeutic mechanisms must be involved... - Consensus development in acute renal failure: The Acute Dialysis Quality InitiativeJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Curr Opin Crit Care 11:527-32. 2005..The general lack of consensus with regard to definitions, prevention, and treatment of acute renal failure has limited progress in this field... - Primary prevention of acute renal failure in the critically illJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Curr Opin Crit Care 11:537-41. 2005..To date, no therapy apart from renal replacement therapy has been shown to improve survival or enhance recover. Thus, efforts to prevent acute renal failure are eagerly sought... - Application of blood purification to non-renal organ failureJ A Kellum
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Int J Artif Organs 28:445-9. 2005..The focus of these reviews is on clinical evidence as well as recommendations for future research... - Determinants of plasma acid-base balanceJohn A Kellum
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 608 Scaife Hall, Pittsburgh, PA 15213 2582, USA
Crit Care Clin 21:329-46. 2005..All changes in blood pH, in health and in disease, occur through changes in these three variables. This article reviews the physical-chemical approach to acid-base balance and considers clinical implications for these findings... - Renal support in acute kidney injuryJohn Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Lancet 368:344-5. 2006 - Hyperchloremic acidosis increases circulating inflammatory molecules in experimental sepsisJohn A Kellum
University of Pittsburgh, School of Medicine, Department of Critical Care Medicine, 3550 Terrace St, Pittsburgh, PA 15261, USA
Chest 130:962-7. 2006..7 cells. However, evidence that hyperchloremic acidosis leads to increased inflammation in vivo has been limited to nitric oxide... - Science review: extracellular acidosis and the immune response: clinical and physiologic implicationsJohn A Kellum
Critical Care Medicine and Medicine, The Mechanisms And Novel Therapies for Resuscitation and Acute illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 8:331-6. 2004..Finally, we discuss potential clinical implications... - Acute renal failure, interdisciplinary knowledge and the need for standardizationJohn A Kellum
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213-2582, USA
Curr Opin Crit Care 11:525-6. 2005 
Definition and classification of acute kidney injuryJohn A Kellum
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Nephron Clin Pract 109:c182-7. 2008..The RIFLE criteria provide a uniform definition of AKI and have now been validated in numerous studies...- Acute kidney injuryJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 36:S141-5. 2008..The RIFLE criteria provide a uniform definition of acute kidney injury and have now been validated in numerous studies... - Fluids for prevention and management of acute kidney injuryJ A Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Int J Artif Organs 31:96-110. 2008..This systematic review focuses on fluids for prevention and management of acute kidney injury. We have reviewed the available evidence and have made recommendations for clinical practice and future studies... - Fluid management in acute kidney injuryJ A Kellum
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Int J Artif Organs 31:94-5. 2008 - Acute Dialysis Quality Initiative (ADQI): methodologyJ A Kellum
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
Int J Artif Organs 31:90-3. 2008..We further recognize that additional research will be needed and have proposed specific studies that will help move this field forward... - Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi processJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Scaife Hall, Room 608, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Clin J Am Soc Nephrol 3:887-94. 2008..An international, consensus-based, prioritized research agenda was sought to guide clinical and translational research in acute kidney injury... - Feasibility study of cytokine removal by hemoadsorption in brain-dead humansJohn A Kellum
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 36:268-72. 2008..Inflammatory cytokines occur in the circulation and in the tissues after brain death and have been associated with dysfunction of donor organs before and after transplantation... - A targeted extracorporeal therapy for endotoxemia: the time has comeJohn A Kellum
The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, Terrace Street, Pittsburgh, PA 15261, USA
Crit Care 11:137. 2007..Multiple small trials, often limited by methodological quality, show that polymyxin B hemo-perfusion may have favorable effects on survival and hemodynamics. Further study of this therapy would seem justified... - The concept of acute kidney injury and the RIFLE criteriaJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA, and Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
Contrib Nephrol 156:10-6. 2007..The term acute kidney injury has subsequently been proposed to distinguish this new concept from the older terminology of failure... - What can be done about acute renal failure?J A Kellum
Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Minerva Anestesiol 70:181-8. 2004..Recent data suggest that NAC can reduce the incidence of ARF secondary to radio-contrast agents and improved techniques for RRT and, perhaps, new drugs aimed at improving cellular repair, will improve outcome from ARF in the future... - Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear factor-kappaB DNA binding, and improves short-term survival in lethal endotoxemiaJohn A Kellum
Mechanisms and Novel Therapies for Resuscitation and Acute Illness MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 32:801-5. 2004..Because adsorptive capacity of hollow-fiber dialyzers is limited, we sought to determine whether hemoadsorption using high surface area beads would result in greater mediator removal and improved survival in experimental sepsis... - Acute kidney injury: epidemiology and assessmentJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Scand J Clin Lab Invest Suppl 241:6-11. 2008..Patients with AKI who are treated with RRT, still have a mortality of 50-60 %. Of surviving patients, 5-20 % remain dialysis-dependent at hospital discharge... - Closing the gap on unmeasured anionsJohn A Kellum
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 7:219-20. 2003 - Genetic variation and risk of sepsisJ A Kellum
The CRISMA Laboratory Clinical Research, Investigation and Systems Modeling of Acute illness, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine Pittsburgh, Pennsylvania 15261, USA
Minerva Anestesiol 69:245-53. 2003..g. tumor necrosis factor) has lent credence to this hypothesis. Yet discovery of the actual relationship between risks of infection / severe sepsis and individual genotypes will require larger, more rigorously designed studies... - Blood purification in non-renal critical illnessJohn A Kellum
University of Pittsburgh School of Medicine, Department of Critical Care Medicine, PA 15213, USA
Blood Purif 21:6-13. 2003..However, extracorporeal therapies are being used or investigated in the management of many other disease processes including systemic inflammation, liver disease, cardiac disease and thrombotic diseases... - The Acute Dialysis Quality Initiative: methodologyJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Adv Ren Replace Ther 9:245-7. 2002..The system involves preconference, conference, and postconference activities designed to classify existing consensus, identify areas of controversy, summarize existing evidence, and outline future research objectives... - Use of vasopressor agents in critically ill patientsJohn A Kellum
Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Curr Opin Crit Care 8:236-41. 2002..When used at doses necessary to reverse distributive shock, less potent vasoconstrictors (eg, dopamine) do not appear to be safer than more potent ones (eg, norepinephrine) and do not appear to be as effective... - Effect of hemofiltration filter adsorption on circulating IL-6 levels in septic ratsJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh Medical Center, PA, USA
Crit Care 6:429-33. 2002..We sought to distinguish clearance from adsorption as the principal mechanism responsible for reducing circulating IL-6 levels with hemofiltration... - Developing a consensus classification system for acute renal failureJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Curr Opin Crit Care 8:509-14. 2002..Recommendations for validating a classification system are also considered... - A drug to prevent renal failure?John A Kellum
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15260, USA
Lancet 362:589-90. 2003 - Acute Dialysis Quality Initiative: methodologyJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Curr Opin Crit Care 8:500-1. 2002..This brief report details the process of the Acute Dialysis Quality Initiative and its goals and methodology... - Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsisJohn A Kellum
MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Chest 125:243-8. 2004..To determine the effects of hyperchloremic acidosis, induced by dilute HCl infusion, on BP and circulating inflammatory mediators in an experimental model of severe sepsis in the rat... - Lactic and hydrochloric acids induce different patterns of inflammatory response in LPS-stimulated RAW 264.7 cellsJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Am J Physiol Regul Integr Comp Physiol 286:R686-92. 2004..7 cells. HCl is essentially proinflammatory as assessed by NO release, IL-6-to-IL-10 ratios, and NF-kappa B DNA binding. By contrast, lactic acidosis is anti-inflammatory... - Septic acute kidney injury in critically ill patients: clinical characteristics and outcomesSean M Bagshaw
Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
Clin J Am Soc Nephrol 2:431-9. 2007..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT... - Diuretics in acute kidney injuryV Karajala
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Minerva Anestesiol 75:251-7. 2009..There have been many studies both supporting and criticizing diuretic use in AKI for improving overall patient outcomes... - Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cellsMingchen Song
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh Pennsylvania, USA
J Pharmacol Exp Ther 308:307-16. 2004..Moreover, the findings presented here suggest that an unusual combination of biochemical effects (inhibition of lipid peroxidation and GSH depletion) might account for the anti-inflammatory effects of EP... - The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cellsMeaghan E Killeen
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 615 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
J Pharmacol Exp Ther 316:1070-9. 2006..7 cells. These data suggest that phase 2 inducers may exert anti-inflammatory effects by inhibiting secretion of the cytokine-like nuclear protein HMGB1... - Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survivalRaghavan Murugan
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 77:527-35. 2010..29) was also present in those never admitted to an intensive care unit. Hence acute kidney injury is common even among patients with non-severe pneumonia and is associated with higher immune response and an increased risk of death... - Determinants of blood pH in health and diseaseJ A Kellum
University of Pittsburgh Medical Center, Division of Critical Care, Pittsburgh, Pennsylvania 15213 2582, USA
Crit Care 4:6-14. 2000..All changes in blood pH, in health and in disease, occur through changes in these three variables. Clinical implications for these findings are also discussed... - Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic ratsJose L Gómez
MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Chest 131:1295-300. 2007..To determine if animals with abnormally low albumin levels are more susceptible to the effects of hypercapnia on BP compared to normal animals... - Blood purification in sepsis: a new paradigmZhiyong Peng
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Contrib Nephrol 165:322-8. 2010..Finally, the emerging paradigm of sepsis-induced immune suppression provides additional rationale for the development of extracorporeal blood purification therapy for sepsis... - Is there a difference between strong ion gap in healthy volunteers and intensive care unit patients?Kyle J Gunnerson
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Crit Care 25:520-4. 2010..Thus, we conducted this pilot study to examine differences in quantitative acid-base variables between healthy adult volunteers and stable ICU patients with no suspected acid-base abnormalities... - Risk prediction with procalcitonin and clinical rules in community-acquired pneumoniaDavid T Huang
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Ann Emerg Med 52:48-58.e2. 2008..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65... - Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsisSachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 177:1242-7. 2008..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown... - Metabolic acidosis in the critically ill: lessons from physical chemistryJ A Kellum
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
Kidney Int Suppl 66:S81-6. 1998..This approach emphasizes the application of accepted physical chemical principles and identification of independent and dependent acid-base variables. In aqueous solutions, water dissociation is the major source of free hydrogen ions... - Hemofiltration in sepsis: where do we go from here?J A Kellum
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Crit Care 4:69-71. 2000..Clinical as well as technical difficulties remain important considerations to future studies. These issues are discussed and the brief history of hemofiltration in sepsis is reviewed... - Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantationRaghavan Murugan
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 36:1810-6. 2008..We test the hypothesis that increased inflammatory response is associated with fewer organs transplanted and decreased recipient survival... - Differences in immune response may explain lower survival among older men with pneumoniaMichael C Reade
Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 37:1655-62. 2009..We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response... - Do hospitals provide lower quality of care to black patients for pneumonia?Florian B Mayr
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 38:759-65. 2010..We examined racial differences in emergency department and intensive care unit care processes to determine whether differences persist after adjusting for case-mix and variation in care across hospitals... - Acute renal failure in critically ill patients: a multinational, multicenter studyShigehiko Uchino
Department of Intensive Care, Austin Hospital, Melbourne, Australia
JAMA 294:813-8. 2005..87; 95% CI, 1.07-3.28; P = .03). CONCLUSION: In this multinational study, the period prevalence of ARF requiring RRT in the ICU was between 5% and 6% and was associated with a high hospital mortality rate... - Recovery from acute kidney injury: determinants and predictorsNattachai Srisawat
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Contrib Nephrol 165:284-91. 2010..This review will describe the current understanding of the renal recovery process, and the role of clinical severity scores and novel biomarkers such as NGAL, HGF, and cystatin C in predicting renal recovery... - Defining and classifying acute renal failure: from advocacy to consensus and validation of the RIFLE criteriaRinaldo Bellomo
Department of Intensive Care and Department of Medicine, Austin Hospital and University of Melbourne, Heidelberg, Melbourne, Australia
Intensive Care Med 33:409-13. 2007..This editorial aims to summarize and interpret recent findings concerning the application of the RIFLE criteria to the assessment of the epidemiology and the prediction of the outcome of ARF... - Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) GroupRinaldo Bellomo
Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
Crit Care 8:R204-12. 2004..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies... - Hemoadsorption to improve organ recovery from brain-dead organ donors: a novel therapy for a novel indication?Ramesh Venkataraman
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Blood Purif 22:143-9. 2004..As a 'proof of concept' we tested the ability of a novel hemoadsorbent to remove S100B in vitro using two human glioblastoma cell lines. Our results indicate a >80% reduction in S100B after 2 h of circulation with the sorbent... - The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumoniaSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
FASEB J 23:2403-11. 2009..These data indicate that polymorphisms associated with higher MIF expression may have a beneficial effect in community-acquired pneumonia... - Acid-base and electrolyte analysis in critically ill patients: are we ready for the new millennium?Kyle J Gunnerson
Virginia Commonwealth University Reanimation Engineering Shock Center, Department of Anesthesiology, Virginia Commonwealth University Medical College of Virginia, Richmond, Virginia, USA
Curr Opin Crit Care 9:468-73. 2003..Although acid-base and electrolyte disorders may be a result of the underlying pathophysiology (eg, renal failure, respiratory failure, shock), they may also result from the way in which we manage critically ill patients... - Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injurySean M Bagshaw
Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
J Crit Care 24:129-40. 2009..The aim of this study is to evaluate the relationship between timing of renal replacement therapy (RRT) in severe acute kidney injury and clinical outcomes... - The prevalence of anemia and its association with 90-day mortality in hospitalized community-acquired pneumoniaMichael C Reade
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
BMC Pulm Med 10:15. 2010..Our objective was to examine the development and progression of anemia and its association with 90d mortality in 1893 subjects with CAP presenting to the emergency departments of 28 US academic and community hospitals... - Preload responsiveness is associated with increased interleukin-6 and lower organ yield from brain-dead donorsRaghavan Murugan
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Crit Care Med 37:2387-93. 2009..Using functional hemodynamic monitoring in brain-dead organ donors, we test the hypothesis that donor preload (fluid) responsiveness is associated with increased inflammatory response and lower organ yield for transplantation... - Cytokine removal with a novel adsorbent polymerMingchen Song
The MANTRA Laboratories, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Blood Purif 22:428-34. 2004..Adsorption was decreased somewhat by extremely low temperature (4 degrees C). CONCLUSION: The adsorbent polymer removes cytokines with high efficiency, and binding is relatively unaffected by a variety of physical conditions... - On-pump vs. off-pump coronary artery bypass surgery at a non-academic community hospital: have biocompatibility improvements eliminated the superiority of off-pump surgery?N J Madden
The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, Univesity of Pittsburgh, Pittsburgh 15261, USA
Int J Artif Organs 30:338-44. 2007.... - Acid-base disorders and strong ion gapJohn A Kellum
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15216, USA
Contrib Nephrol 156:158-66. 2007..Attempts to identify the exact chemical nature of ions identified by the strong ion gap have only been of limited success and further study is needed... - Defining acute renal failure: physiological principlesRinaldo Bellomo
Department of Intensive Care and Division of Surgery, Austin and Repatriation Medical Centre, 3084 Heidelberg, Melbourne, Victoria, Australia
Intensive Care Med 30:33-7. 2004 - Understanding genetics of sepsis: will new technology help?Sachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, USA
Crit Care 13:141. 2009..Careful attention should be paid to different aspects of study design and analyses as large, multicenter cohorts are assembled for genome-wide association studies... - Midregional proadrenomedullin as a prognostic tool in community-acquired pneumoniaDavid T Huang
Departments of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Chest 136:823-31. 2009..We sought to describe the pattern of MR-proADM in a broad CAP cohort, confirm its prognostic role, and compare its performance to procalcitonin, a novel biomarker of infection... - Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?Tony Dremsizov
606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
Chest 129:968-78. 2006.... - The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studiesSachin Yende
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Thorax 65:870-7. 2010..Although diabetes mellitus is implicated in susceptibility to infection, the association of diabetes with the subsequent course and outcome is unclear... - Continuous versus intermittent renal replacement therapy: a meta-analysisJohn A Kellum
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Division of Critical Care Medicine, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
Intensive Care Med 28:29-37. 2002..As controversy exists regarding which modality should be used for most patients with critically illness, we sought to determine whether CRRT or IRRT is associated with better survival... - Acute Dialysis Quality Initiative II: the Vicenza conferenceRinaldo Bellomo
Intensive Care Unit, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Curr Opin Crit Care 8:505-8. 2002..Accordingly, the second Acute Dialysis Quality Initiative conference in Vicenza, Italy, was organized, and its goals and rationale are presented in this report... - N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantationIbtesam A Hilmi
Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
Nephrol Dial Transplant 25:2328-33. 2010..N-acetylcysteine (NAC) replenishes GSH stores. The aims of this study were to evaluate the efficacy of NAC in improving liver graft performance and reducing the incidence of post-operative acute kidney injury (AKI)... - Disorders of acid-base balanceJohn A Kellum
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory and the Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 35:2630-6. 2007..Recent advances have brought a measure of parity between the newer and the older, descriptive approach to acid-base physiology... - Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved short-term survival and acid-base balance with Hextend compared with salineJohn A Kellum
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
Crit Care Med 30:300-5. 2002..To compare resuscitation with 0.9% saline with Hextend, a synthetic colloid in a balanced electrolyte solution, in terms of acid-base status and survival time in an experimental model of septic shock in the rat... - Prevention of acute renal failureRamesh Venkataraman
The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
Chest 131:300-8. 2007..Increasing insight into mechanisms leading to ARF and the importance of facilitating renal recovery has prompted investigators to evaluate the role of newer therapeutic agents in the prevention of ARF... - Prevalence and significance of coagulation abnormalities in community-acquired pneumoniaEric B Milbrandt
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Mol Med 15:438-45. 2009..These findings underscore the complexity of the coagulation response to infection and may offer insights into coagulation-based therapeutics in clinical sepsis trials... - Incidence and definition of sepsis and associated organ dysfunctionT T Dremsizov
The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Int J Artif Organs 27:352-9. 2004..CONCLUSION: Recently there has been an increasing amount of information enabling characterization of the epidemiology of sepsis, which may help to direct appropriate care in the coming years... - Use of dopamine in acute renal failure: a meta-analysisJ A Kellum
Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
Crit Care Med 29:1526-31. 2001..CONCLUSIONS: The use of low-dose dopamine for the treatment or prevention of acute renal failure cannot be justified on the basis of available evidence and should be eliminated from routine clinical use... - Declining critical care research publications by authors from U.S. Institutions, 1990-1999D J Powner
Critical Care Medicine, Rutland Regional Medical Center, Rutland, Vermont 05701, USA
Acad Med 76:1261-3. 2001..Anecdotal concerns expressed by many faculty that rising clinical commitments necessitated by current health care and reimbursement pressures preclude research and educational academic activities are supported by these data... - The modern concept of homeostasisJ A Kellum
Departments of Anesthesiology/CCM and Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Minerva Anestesiol 68:3-11. 2002 - Plasma filtration on mediators of thrombotic microangiopathy: an in vitro studyZ Y Peng
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Int J Artif Organs 30:401-6. 2007..Sepsis-induced thrombotic microangiopathy is successfully treated by plasma exchange therapy. However, certain putative mediators of thrombotic microangiopathy may not be removed by plasma filtration... - Urinary biomarkers and renal recovery in critically ill patients with renal supportNattachai Srisawat
604 Scaife Hall, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Clin J Am Soc Nephrol 6:1815-23. 2011..Unfortunately, no reliable method to predict renal recovery exists. The discovery of biomarkers to aid in clinical risk prediction for recovery after AKI would represent a significant advance over current practice... - Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injuryLewis J Kaplan
Yale University School of Medicine, Department of Surgery, Section of Trauma, Critical Care, and Emergency General Surgery, USA
Crit Care Med 32:1120-4. 2004..The strong ion gap is most strongly predictive of mortality following major vascular trauma... - Costs and outcomes of acute kidney injury (AKI) following cardiac surgeryJoseph F Dasta
College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
Nephrol Dial Transplant 23:1970-4. 2008..We determined costs, resource use and mortality rate of patients. We used the serum creatinine component of the RIFLE system to classify AKI... - Comparison of acid-base models for prediction of hospital mortality after traumaLewis J Kaplan
Department of Surgery, Section of Trauma, Critical Care, and Surgical Emergencies, Yale University School of Medicine, New Haven, CT 06520, USA
Shock 29:662-6. 2008..Admission pH, HCO3-, and lactate were poor predictors of hospital mortality after trauma. An elevated SIG presaged mortality after injury and should be assessed on admission... - Defining and classifying AKI: one set of criteriaJohn A Kellum
Nephrol Dial Transplant 23:1471-2. 2008 - Sorbents in acute renal failure and the systemic inflammatory response syndromeJames F Winchester
RenalTech International, New York, NY 10021, USA
Blood Purif 21:79-84. 2003.... - Evaluation and initial management of acute kidney injuryJonathan Himmelfarb
Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
Clin J Am Soc Nephrol 3:962-7. 2008.... - Oliguria, volume overload, and loop diureticsSean M Bagshaw
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Crit Care Med 36:S172-8. 2008..This contradiction between clinical practice and available evidence would suggest there is equipoise and need for higher-quality evidence to better characterize the role of loop diuretics in ICU patients with AKI... - Sorbents in acute renal failure and end-stage renal disease: middle molecule and cytokine removalJames F Winchester
RenalTech International, New York, NY 10021, USA
Blood Purif 22:73-7. 2004..Sorbent devices added to hemodialysis, or the use of such devices alone in inflammatory states, including sepsis, ARF, cardiopulmonary bypass, pre-explantation of donor organs and ESRD, are being studied... - Novel approaches to the treatment of acute renal failureRamesh Venkataraman
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Scaife Hall, Room 642A, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Expert Opin Investig Drugs 12:1353-66. 2003..The prospect of these novel strategies, together with the ever-increasing understanding of the complex pathophysiology of ARF, offers the promise of effective and more physiological therapeutic interventions in this new millennium... - Normotensive ischemic acute renal failureRinaldo Bellomo
N Engl J Med 357:2205; author reply 2205-6. 2007
Research Grants
- Protocolized Goal-directed Resuscitation of Septic Shock to Prevent AKI (ProGReSSJohn A Kellum; Fiscal Year: 2010....
- Systems Engineering of Pheresis Intervention for SepsisJohn Kellum; Fiscal Year: 2009..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
- Systems Engineering of Pheresis Intervention for SepsisJohn Kellum; Fiscal Year: 2007..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
- Biological Markers of Recovery for the KidneyJohn Kellum; Fiscal Year: 2007..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
- Biological Markers of Recovery for the KidneyJohn A Kellum; Fiscal Year: 2010..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..