MICHELLE ALICE KELLIHER
Affiliation: University of Massachusetts Medical School
Zelic M, Kelliher M. Analyzing Necroptosis Using an RIPK1 Kinase Inactive Mouse Model of TNF Shock. Methods Mol Biol. 2018;1857:125-134 pubmed publisher
..Here, we describe procedures utilizing kinase inactive Ripk1D138N/D138N mice to analyze necroptosis induction in vitro in bone-marrow derived macrophages (BMDMs) and in vivo in a murine model of TNF-induced shock. ..
Roderick J, Hermance N, Zelic M, Simmons M, Polykratis A, Pasparakis M, et al
. Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis. Proc Natl Acad Sci U S A. 2014;111:14436-41 pubmed publisher
..Therefore, RIPK1 regulates hematopoiesis and prevents inflammation by suppressing RIPK3 activation. ..
O Donnell J, Lehman J, Roderick J, Martinez Marin D, Zelic M, Doran C, et al
. Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity. J Immunol. 2018;200:737-748 pubmed publisher
..These mouse genetic studies reveal that chronic necroptosis may underlie human fibrotic and autoimmune disorders. ..