Affiliation: University of Massachusetts Medical School
Country: USA


  1. Zelic M, Kelliher M. Analyzing Necroptosis Using an RIPK1 Kinase Inactive Mouse Model of TNF Shock. Methods Mol Biol. 2018;1857:125-134 pubmed publisher
    ..Here, we describe procedures utilizing kinase inactive Ripk1D138N/D138N mice to analyze necroptosis induction in vitro in bone-marrow derived macrophages (BMDMs) and in vivo in a murine model of TNF-induced shock. ..
  2. Roderick J, Hermance N, Zelic M, Simmons M, Polykratis A, Pasparakis M, et al. Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis. Proc Natl Acad Sci U S A. 2014;111:14436-41 pubmed publisher
    ..Therefore, RIPK1 regulates hematopoiesis and prevents inflammation by suppressing RIPK3 activation. ..
  3. O Donnell J, Lehman J, Roderick J, Martinez Marin D, Zelic M, Doran C, et al. Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity. J Immunol. 2018;200:737-748 pubmed publisher
    ..These mouse genetic studies reveal that chronic necroptosis may underlie human fibrotic and autoimmune disorders. ..