Research Topics
| Keith KelleySummaryAffiliation: University of Illinois Country: USA Publications
Research Grants
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Detail Information
Publications
Central interleukin-1 receptors as mediators of sicknessK W Kelley
Laboratory of Immunophysiology, University of Illinois, Urbana 61801, USA
Ann N Y Acad Sci 823:234-46. 1997..It will now be important to determine if similar central IL-1 pathways are activated during SLE and whether these central inflammatory cytokines are involved in the neurologic complications that often accompany this disease...- Insulin growth factor-I inhibits apoptosis in hematopoietic progenitor cells. Implications in thymic agingK W Kelley
Department of Animal Sciences, University of Illinois, Urbana 61801, USA
Ann N Y Acad Sci 840:518-24. 1998..Collectively, these data establish that hematopoietic progenitor cells are important targets for IGF-I, and this is likely to be important in understanding thymic aging... - It's time for psychoneuroimmunologyK W Kelley
Laboratory of Immunophysiology, University of Illinois, Urbana, Illinois 61801, USA
Brain Behav Immun 15:1-6. 2001..Our research is needed to minimize human afflictions and to learn how patients can better participate in their own health management. That is why the time for psychoneuroimmunology is now... 
Protein hormones and immunityKeith W Kelley
Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, 227 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
Brain Behav Immun 21:384-92. 2007..Homeostasis during inflammation is achieved by a balance between cytokines and endocrine hormones...- Cytokine-induced sickness behaviorKeith W Kelley
Department of Animal Sciences, Laboratory of Immunophysiology, University of Illinois, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana 61801, USA
Brain Behav Immun 17:S112-8. 2003..Advances that have been made during the past decade should now be extended to clinical studies in an attempt to alleviate sickness symptoms and improve quality of life for cancer patients... - C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblastsKlemen Strle
Laboratories of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
Endocrinology 147:4363-73. 2006..These results establish that the resistance of muscle progenitor cells to IGF-I, which is caused by inflammatory stimuli, is mediated by the JNK stress kinase pathway... - Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramideKlemen Strle
University of Illinois, Laboratory of Immunophysiology, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
Endocrinology 145:4592-602. 2004.... - Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptorWen-Hong Shen
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
Cancer Res 62:4746-56. 2002..These data also highlight growth factor receptor adaptor molecules, such as insulin receptor substrate-1, rather than the receptors themselves as targets for antitumor therapeutic strategies... - Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1betaKlemen Strle
Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Enviromental Sciences, University of Illinois, Urbana, IL 61801, USA
Am J Physiol Endocrinol Metab 294:E709-18. 2008..Collectively, these data demonstrate that IL-10 acts in a novel, nonclassical, protective manner in nonhematopoietic cells to inhibit the IL-1beta receptor-induced JNK kinase pathway, resulting in prevention of IGF-I resistance... - Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblastsKlemen Strle
Laboratories of Integrative Immunophysiology, College of Medicine, University of Illinois, Urbana, IL 61801, United States
J Neuroimmunol 188:48-55. 2007..Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I... - Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neuronsRobert H McCusker
250 Edward R Madigan Laboratory, Urbana, IL 61801 3873, USA
J Neuroimmunol 179:186-90. 2006..IGF-I enhanced expression of BDNF receptors (Trk-B) and increased the ability of BDNF to induce ERK1/2 phosphorylation. This IGF-I-induced increase in BDNF responsiveness describes a new interaction between these peptides in the brain... - IL-10 promotes survival of microglia without activating AktKlemen Strle
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, 207 ERML, 1201 W. Gregory Dr, Urbana, IL 61801, USA
J Neuroimmunol 122:9-19. 2002..These data establish that IL-10 activates Stat3 and inhibits the mitochondrial pathway of cell death without activating the Akt cell survival pathway... - Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-GuerinJason C O'Connor
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 3873, USA
J Neurosci 29:4200-9. 2009..Together, these data demonstrate that IFNgamma, with TNFalpha, is necessary for induction of IDO and depressive-like behavior in mice after BCG infection... - IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblastsSuzanne R Broussard
Laboratories of Immunophysiology, 207 Edward R Madigan Laboratory, University of Illinois at Urbana Champaign, 1201 West Gregory Drive, Urbana, IL 61801, USA
J Immunol 172:7713-20. 2004..Collectively, the results are consistent with the notion that very low concentrations of IL-1beta significantly impair myogenesis, but they are unable to do so in the absence of the growth factor IGF-I... - Twenty years of research on cytokine-induced sickness behaviorRobert Dantzer
Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana Champaign, IL 61801, USA
Brain Behav Immun 21:153-60. 2007..The time is ripe to begin to move these fundamental discoveries in mice to man and some of the pharmacological tools are already available to antagonize the detrimental actions of cytokines... - Tumor necrosis factor alpha inhibits insulin-like growth factor I-induced hematopoietic cell survival and proliferationWen Hong Shen
University of Illinois, Laboratory of Immunophysiology, Department of Animal Sciences, 207 Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
Endocrinology 145:3101-5. 2004..These results support the general concept that proinflammatory cytokines impair the actions of hormones on hematopoietic cells, leading to IGF-I receptor resistance... - Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1Saebyeol Jang
Division of Nutritional Sciences, University of Illinois at Urbana Champaign, 1207 West Gregory Drive, Urbana, IL 61801, USA
Proc Natl Acad Sci U S A 105:7534-9. 2008..Taken together, these data suggest luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia. Thus, luteolin may be useful for mitigating neuroinflammation... - From inflammation to sickness and depression: when the immune system subjugates the brainRobert Dantzer
Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
Nat Rev Neurosci 9:46-56. 2008..Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like the more traditional psychosocial factors... - From hormones to immunity: the physiology of immunologyKeith W Kelley
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
Brain Behav Immun 18:95-113. 2004..Wasting of AIDS patients is given as an important clinical example of how TNFalpha from an activated immune system reduces IGF-I sensitivity in multiple physiologic systems, including muscle, nervous and hematopoietic tissues... - Exaggerated expression of skeletal muscle-derived interleukin-6, but not TNFalpha, in mice lacking interleukin-10Kimberly A Huey
Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
J Neuroimmunol 199:56-62. 2008..These results provide the first in vivo evidence that endogenous IL-10 attenuates IL-6 expression by skeletal muscle in response to LPS... - Autistic children: a neuroimmune perspectiveRobert Dantzer
Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, 212 ERML, 1201 W Gregory Drive, Urbana, IL 61801, USA
Brain Behav Immun 22:804-5. 2008 - Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblastsSuzanne R Broussard
Laboratory of Immunophysiology, Department of Animal Sciences and Pathology, College of Medicine, University of Illinois at Urbana Champaign, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
Endocrinology 144:2988-96. 2003..These data are consistent with the notion that very low physiological concentrations of TNFalpha interfere with both protein synthesis and muscle cell development by inducing a state of IGF-I receptor resistance... - TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-IKarine Palin
Department of Animal Sciences, Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, University of Illinois at Urbana Champaign, IL, USA
J Neuroimmunol 187:55-60. 2007..c.v., 300 ng/mouse). These results establish that sickness behavior induced by central TNFalpha via the TNF-R1 (p55) is directly opposed by IGF-I in the brain... - LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-gamma-independent manner by a JNK signaling pathway in primary murine microgliaYunxia Wang
Department of Animal Sciences, Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 227 Edward R Madigan Laboratory, 1201 W Gregory Drive, Urbana, IL 61801 3873, USA
Brain Behav Immun 24:201-9. 2010..Inhibition of the JNK pathway may provide a new therapy for inflammatory depression... - Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behaviorFrancois Frenois
Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 212 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
Psychoneuroendocrinology 32:516-31. 2007.... - Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesisWen Hong Shen
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
J Biol Chem 279:7438-46. 2004.... - IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetesJason C O'Connor
Department of Animal Sciences, University of Illinois at Urbana Champain, Urbana, IL 61801, USA
J Immunol 174:4991-7. 2005..Taken together, these results indicate that IL-1beta-mediated innate immunity is augmented in db/db mice both at the periphery and in the brain, and the mechanism is due to diabetes-associated loss of IL-1beta counterregulation... - alpha-Tocopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged miceBrian M Berg
Division of Nutritional Sciences, University of Illinois, Urbana 61801, USA
J Nutr 135:1157-63. 2005..Taken together, these findings suggest that adequate intake of dietary alpha-T and selenium may help promote recovery from gram-negative bacterial infection in the aged... - Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice culturesXin Fu
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
J Neuroinflammation 7:43. 2010..It is unknown whether direct activation of the brain with LPS is sufficient to activate IDO and induce depressive-like behavior... - Insulin-like growth factor-I and the cytokines IL-3 and IL-4 promote survival of progenitor myeloid cells by different mechanismsWilliam Burgess
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, 207 ERML, 1201 W. Gregory Dr, Urbana, IL 61801, USA
J Neuroimmunol 135:82-90. 2003.... - alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brainJonathan P Godbout
Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
J Neuroimmunol 149:101-9. 2004..Taken together, these data indicate that alpha-tocopherol can mitigate inflammatory cytokine production in the brain... - IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cellsWen Hong Shen
Laboratory of Immunophysiology, University of Illinois, Urbana, IL 61801, USA
J Immunol 172:7272-81. 2004..In this manner, Akt serves as a critical bridge that links proximal receptor signaling events to more distal cell cycle machinery... - The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behaviorKarine Palin
Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana Champaign, 227 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801 3873, USA
Psychopharmacology (Berl) 201:549-56. 2009..TNFalpha activates neutral sphingomyelinase through the TNF-R1 adapter protein FAN (factor associated with neutral sphingomyelinase activation), but a behavioral role of FAN in the brain has never been reported... - Alpha-tocopherol attenuates lipopolysaccharide-induced sickness behavior in miceBrian M Berg
Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
Brain Behav Immun 18:149-57. 2004..001) 24h post LPS. Collectively, these data indicate that alpha-T improved the oxidative status after exposure to LPS, which may explain its ability to ameliorate symptoms of sickness... - Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinologyJason C O'Connor
Integrative Immunology and Behavior Program, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Cell Immunol 252:91-110. 2008..We also highlight that IGF-I can induce resistance or reduce sensitivity to brain TNFalpha and discuss how TNFalpha, IL-1beta, and IGF-I interact to regulate several aspects of behavior and cognition... - IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdeltaEric L Deszo
Department of Animal Sciences, College of Agriculture, Consumer and Environmental Sciences, 1207 West Gregory Dr, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Cell Signal 16:271-80. 2004..We conclude from these data that IL-4-dependent CD11b expression relies predominantly on enhanced activation of ERK1/2, while IL-4-dependent CD86 expression utilizes the JAK/STAT6 pathway... - Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behaviorJason C O'Connor
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
J Immunol 182:3202-12. 2009.... - Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitutionRichard A French
Laboratory of Immunophysiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Endocrinology 143:690-9. 2002.... - Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behaviorMaite Moreau
INRA, UMR 1286 PsyNuGen, Bâtiment UFR Pharmacie, Case courrier 34, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, CNRS, UMR 5226, IFR8, F 33076 Bordeaux, France
Brain Behav Immun 22:1087-95. 2008.... - Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in miceRose Marie Bluthé
Integrative Neurobiology, CNRS INRA University Victor Segalen, Bordeaux, France
Brain Behav Immun 20:57-63. 2006..These findings indicate that IGF-I is more potent in attenuating sickness behavior induced by TNFalpha than that caused by IL-1beta, which is consistent with the relative specificity of the TNFalpha/IGF-I interactions in the brain... - In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brainRozenn Mingam
PsyNuGen, INRA, UMR1286, CNRS, UMR5226, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33077 Bordeaux, France
Brain Behav Immun 22:234-44. 2008..These results show that P2X7R plays a key role in the brain cytokine response to immune stimuli, which certainly applies also to cytokine-dependent alterations in brain functions including sickness behavior... - Conditioned taste aversion with lipopolysaccharide and peptidoglycan does not activate cytokine gene expression in the spleen and hypothalamus of miceCecile Mormede
INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 3307 Bordeaux Cedex, France
Brain Behav Immun 18:186-200. 2004..This modulation of the NFkappaB and MAPK signalling pathways is interpreted in terms of a possible conditioned sensitisation of the immune system... - A global view of twenty years of Brain, Behavior, and ImmunityRobert Ader
Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Brain Behav Immun 21:20-2. 2007 - Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profileChristopher B Guest
Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
PLoS ONE 3:e1606. 2008..Taken together, these findings indicate an important new role for CaMKKalpha in the differentiation of monocytic cells... - Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behaviorPatricia Parnet
Laboratory of Integrative Neurobiology, INRA INSERM U394, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
J Neuroimmunol 125:5-14. 2002..Finally, modulation of IL-1 action on its receptor by various opposing factors including glucocorticoids and anti-inflammatory cytokines is discussed... - A new look for brain, behavior, and immunityKeith W Kelley
Brain Behav Immun 17:1-2. 2003 - Pentoxifylline and insulin-like growth factor-I (IGF-I) abrogate kainic acid-induced cognitive impairment in miceRose Marie Bluthé
Integrative Neurobiology, CNRS INRA University Victor Segalen, Bordeaux, France
J Neuroimmunol 169:50-8. 2005..These findings indicate that endogenous TNFalpha is probably involved in the detrimental effects of kainate on cognition and that exogenous IGF-I can oppose these effects, probably by antagonizing TNFalpha-induced neurotoxicity...
Research Grants
- CYTOKINE AND HORMONE INTERACTIONS IN COMORBIDITY OF AIDSKeith Kelley; Fiscal Year: 2005..abstract_text> ..
- Neuroimmune Mechanisms of Depressive-Like Behavior During AgingKeith Kelley; Fiscal Year: 2007....
- CYTOKINES, BEHAVIOR, AND MENTAL HEALTHKeith Kelley; Fiscal Year: 2007..These innovative experiments will advance our understanding of brain and immune communication systems that control the neurobiological basis of behavioral disorders ..
- Neuroimmune Mechanisms of Depressive-Like Behavior During AgingKeith W Kelley; Fiscal Year: 2010....
- CYTOKINES, BEHAVIOR, AND MENTAL HEALTHKeith Kelley; Fiscal Year: 2002..These experiments are needed to understand the critical signaling molecules that are likely to regulate the events that lead to debilitating and costly inflammatory afflictions in the brain. ..
- Neuroimmune Mechanisms of Depressive-Like Behavior During AgingKeith W Kelley; Fiscal Year: 2010....